Cristina Pérez-Arnaiz

Universidad de Burgos | UBU · Department of Chemistry

Cancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers of the type [Pt(dmba)(L)] (d...

We present here a combined spectroscopic and theoretical analysis of the binding of N,N’-bis(2-(1-piperazino)ethyl)-3,4,9,10-perylenetetracarboxylic acid diimide dichloride (PZPERY) to different biosubstrates. Absorbance titrations and circular dichroism experiments, melting studies and isothermal calorimetry (ITC) titrations reveal a picture where...

A series of diiron complexes with two cyclopentadienyls, two carbonyls, and one bridging vinyl‐aminoalkylidene as ligands, [3a–h]CF3SO3 and [4a–d]CF3SO3, was synthesized in 66–94% yields from diiron μ‐aminocarbyne precursors. The subsequent reactions with pyrrolidine led to selective fragmentation to aminoalkylidene‐ferracyclopentenone derivatives...

The synthesized 2-(hydroxy-1-naphtyl)imidazo-[4,5-f][1,10]phenanthroline (HNAIP) ligand and its new iridium ([Ir(ppy)2(HNAIP)]Cl) and rhodium ([Rh(ppy)2(HNAIP)]Cl) complexes, being ppy = 2-phenylpiridinate, show cytotoxic effects in SW480 (colon adenocarcinoma) and A549 (epithelial lung adenocarcinoma) cells. They all are cytotoxic in the tested ce...

The proposed in vivo formation of G‐quadruplex DNA (G4 DNA) in promoter regions of oncogenes and in telomeres has prompted the development of small molecules with high affinity and selectivity for these structures. Herein we report the synthesis of a new di‐substituted bipyridine ligand and the corresponding complexes with Ni2+ and VO2+. Both these...

Given the potent anticancer properties of cis-diamminedichloroplatinum(II) and knowing its mode of action, we synthesized four new cis-[PtCl2(N^N)] organoplatinum complexes, two with N-substituted pbi ligands (pbiR = 1-R-2-(2-pyridyl)benzimidazole) (namely, 1 and 2) and two more with 4,4'-disubstituted bpy ligands (bpy = 2,2'-bipyridine) (namely, 3...

Background: Stabilization of G-quadruplex helices by small ligands has attracted growing attention because they inhibit the activity of the enzyme telomerase, which is overexpressed in >80% cancer cells. TMPyP4, one of the most studied G-quadruplex ligands, is used as a model to show that the ligands can exhibit different binding features with dif...

For the first time, careful T-Jump relaxation kinetics experiments conducted in the microsecond timescale at pH = 7.5 and 25 °C in dilute solutions of Human Telomeric DNA, have evinced two different equilibria. The set of data recorded concurs with two G-quadruplex ↔ G-triplex equilibria coexisting in the presence of both Na+ and K+-buffering ions.

Essential processes for living cells such as transcription and replication depend on the formation of specific protein-DNA recognition complexes. Proper formation of such complexes requires suitable fitting between the protein surface and the DNA surface. Adopting doxorubicin (DOX) as a model probe, we report here that Ag3 clusters (Ag-AQCs) inhibi...

Doxorubicin (DOX) is an important anthracycline antibiotic whose intricate features of binding to DNAs, not yet fully understood, have been the object of intense debate. The dimerization equilibrium has been studied at pH = 7.0, I = 2.5 mM and T = 25ºC. A thermodynamic and kinetic study of the binding of doxorubicin to DNA, carried out by circular...