Cristina Pérez-Arnaiz

Cristina Pérez-Arnaiz
Universidad de Burgos | UBU · Department of Chemistry

PhD in Chemistry

About

11
Publications
1,879
Reads
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310
Citations
Citations since 2017
8 Research Items
266 Citations
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Additional affiliations
September 2013 - present
Universidad de Burgos
Position
  • PhD Student

Publications

Publications (11)
Article
Cancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers of the type [Pt(dmba)(L)] (d...
Article
We present here a combined spectroscopic and theoretical analysis of the binding of N,N’-bis(2-(1-piperazino)ethyl)-3,4,9,10-perylenetetracarboxylic acid diimide dichloride (PZPERY) to different biosubstrates. Absorbance titrations and circular dichroism experiments, melting studies and isothermal calorimetry (ITC) titrations reveal a picture where...
Article
Full-text available
A series of diiron complexes with two cyclopentadienyls, two carbonyls, and one bridging vinyl‐aminoalkylidene as ligands, [3a–h]CF3SO3 and [4a–d]CF3SO3, was synthesized in 66–94% yields from diiron μ‐aminocarbyne precursors. The subsequent reactions with pyrrolidine led to selective fragmentation to aminoalkylidene‐ferracyclopentenone derivatives...
Article
The synthesized 2-(hydroxy-1-naphtyl)imidazo-[4,5-f][1,10]phenanthroline (HNAIP) ligand and its new iridium ([Ir(ppy)2(HNAIP)]Cl) and rhodium ([Rh(ppy)2(HNAIP)]Cl) complexes, being ppy = 2-phenylpiridinate, show cytotoxic effects in SW480 (colon adenocarcinoma) and A549 (epithelial lung adenocarcinoma) cells. They all are cytotoxic in the tested ce...
Article
The proposed in vivo formation of G‐quadruplex DNA (G4 DNA) in promoter regions of oncogenes and in telomeres has prompted the development of small molecules with high affinity and selectivity for these structures. Herein we report the synthesis of a new di‐substituted bipyridine ligand and the corresponding complexes with Ni2+ and VO2+. Both these...
Article
Full-text available
Given the potent anticancer properties of cis-diamminedichloroplatinum(II) and knowing its mode of action, we synthesized four new cis-[PtCl2(N^N)] organoplatinum complexes, two with N-substituted pbi ligands (pbiR = 1-R-2-(2-pyridyl)benzimidazole) (namely, 1 and 2) and two more with 4,4'-disubstituted bpy ligands (bpy = 2,2'-bipyridine) (namely, 3...
Article
Background: Stabilization of G-quadruplex helices by small ligands has attracted growing attention because they inhibit the activity of the enzyme telomerase, which is overexpressed in >80% cancer cells. TMPyP4, one of the most studied G-quadruplex ligands, is used as a model to show that the ligands can exhibit different binding features with dif...
Article
For the first time, careful T-Jump relaxation kinetics experiments conducted in the microsecond timescale at pH = 7.5 and 25 °C in dilute solutions of Human Telomeric DNA, have evinced two different equilibria. The set of data recorded concurs with two G-quadruplex ↔ G-triplex equilibria coexisting in the presence of both Na+ and K+-buffering ions.
Article
Full-text available
Essential processes for living cells such as transcription and replication depend on the formation of specific protein-DNA recognition complexes. Proper formation of such complexes requires suitable fitting between the protein surface and the DNA surface. Adopting doxorubicin (DOX) as a model probe, we report here that Ag3 clusters (Ag-AQCs) inhibi...
Article
Doxorubicin (DOX) is an important anthracycline antibiotic whose intricate features of binding to DNAs, not yet fully understood, have been the object of intense debate. The dimerization equilibrium has been studied at pH = 7.0, I = 2.5 mM and T = 25ºC. A thermodynamic and kinetic study of the binding of doxorubicin to DNA, carried out by circular...

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