Cristina Nerín

Cristina Nerín
University of Zaragoza | UNIZAR · Department of Analytical Chemistry

PhD in Anal. Chem.,

About

434
Publications
105,934
Reads
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13,843
Citations
Citations since 2017
152 Research Items
7693 Citations
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201720182019202020212022202305001,0001,500
201720182019202020212022202305001,0001,500
201720182019202020212022202305001,0001,500
Introduction
Cristina Nerín currently works at the Department of Analytical Chemistry, University of Zaragoza. Cristina does research in Analytical Chemistry, Environmental Chemistry, Materials Chemistry and Food Packaging.
Additional affiliations
January 2008 - present
Independent Researcher
Independent Researcher
Position
  • Universidade de São Paulo
January 1994 - present
January 1985 - present
University of Zaragoza
Position
  • Professor (Full)

Publications

Publications (434)
Article
Plastic recycling is the main solution to reduce the plastic waste. High-density polyethylene has not been recycled yet successfully as food contact material due to the amount of chemicals present in post-consumer material together with its high chemical sorption capacity. The migration of two post-consumer recycled HDPE milk bottles were studied t...
Chapter
Nowadays, food industries offer products of nutritional and sensory quality to the consumers in which the packaging plays a fundamental role for the achievement of this objective. However, it can also become a serious problem if some aspects are not controlled, such as the mass transfer through it, known as migration. Migration has a great toxicolo...
Article
Full-text available
Although most new biomaterials for food industry applications are labelled '100% natural fabrication' and 'chemical-free', certain compounds may migrate from those materials to the food, compromising the organoleptic characteristics and safety of the product. In this work, the degree of compound migration from dishes made with four different biomat...
Article
Full-text available
A software-based procedure consisting of colour measurement of mushrooms was developed for assessing the effectiveness of a new antioxidant active packaging. As active agents, sodium metabisulphite combined with citric acid, green tea extract combined with a-tocopherol and purple carrot extract were evaluated. After obtaining the image of mushrooms...
Article
Widespread use of plastics poses a serious environmental hazard to our planet and should be substituted by eco-friendly and biodegradable alternatives, simultaneously reducing waste of perishable food products and the risk of transmission of pathogenic microbes. In our study, we describe how the water solubility of the antimicrobial surfactant ethy...
Chapter
The Seveso accident is described and analyzed from the point of view of safety and emergency planning. The main reasons that drove it as a major accident and the first Seveso Directive are discussed. Additional major accidents such as those from Bhopal, which involved isocyanate, or from Basel, where the release of toxic substances from Sandoz caus...
Article
Polypropylene (PP) is one of the most used polymers, especially in single-use packaging, as well as in the healthcare industry, which causes serious environmental problems. Its correct destination is essential, and in this sense, recycling is part of the solution. However, regulatory agencies, such as the Food and Drug Administration (FDA), restric...
Article
Full-text available
Aiming at the development of a greener ethylene removal alternative, the goal of this study was to scale up and ensure the safety of α-cyclodextrin nanosponges (α-CD-NS) for further use as ethylene scavengers. The solvent-free synthesis of α-CD-NS was successfully scaled up using α-cyclodextrin and N,N′-carbonyldiimidazole as cross-linkers (1:4 mol...
Article
This article studies the migration of MOAH from hot melt adhesives used in multilayer laminates into food simulants. First, the initial concentration of a group of compounds selected as MOAH markers in several adhesives was determined by headspace solid phase microextraction coupled to gas chromatography mass spectrometry (HS-SPME-GC-MS), using the...
Article
Full-text available
The identification of migrates from food contact materials (FCMs) is challenging due to the complex matrices and limited availability of commercial standards. The use of machine-learning-based prediction tools can help in the identification of such compounds. This study presents a workflow to identify nonvolatile migrates from FCMs based on liquid...
Article
Within the scope of sustainability, this work tackles both food waste and food safety by studying the ethylene scavenging potencial of α-cyclodextrin nanosponges produced by solvent-free synthesis and the food safety evaluation of the compostable packaging for food contact applications where the nanosponges will be incorporated.
Article
A non-targeted method was developed for screening the semi-volatile compounds of different mechanically recycled PET intended for food contact materials. The data was further analyzed by multiple chemometrics methods to obtain the difference level, and the potential influence factors were investigated. The results showed that total dissolution with...
Article
Full-text available
An analysis method was developed to detect chemical markers of mineral oil aromatic hydrocarbons (MOAH) from offset printing inks in food packaging materials. 16 aromatic hydrocarbons were used as target analytes and different solid phase extraction procedures (SPE) and gas chromatography coupled to mass spectrometry (GC-MS) were tested. The concen...
Article
Full-text available
The use of ion mobility separation (IMS) in conjunction with high-resolution mass spectrometry has proved to be a reliable and useful technique for the characterization of small molecules from plastic products. Collision cross-section (CCS) values derived from IMS can be used as a structural descriptor to aid compound identification. One limitation...
Article
Full-text available
Polymeric films based on polylactide (PLA) with the addition of poly(ethylene glycol) (PEG) and a chloroformic extract of propolis were obtained. In the case of the studied films, polylactide (PLA) played the role of polymeric matrix and poly(ethylene glycol) was used as a plasticizer, while the extract of propolis was incorporated as a compound th...
Article
Full-text available
Four commercially available silicone cupcake molds have been studied. An evaluation of the post-cure treatment applied to the silicone molds was carried out and the loss of volatile organic compounds after cure treatment was quantified. The two higher quality molds showed losses at the 0.5% (w/w) (recommended by BfR standard), while the two lower q...
Article
Full-text available
The chemicals in food contact materials (FCMs) can migrate into food and endanger human health. In this study, we developed a database of traveling wave collision cross section in nitrogen (TWCCSN2) values for extractables and leachables from FCMs. The database contains a total of 1038 TWCCSN2 values from 675 standards including those commonly used...
Article
Full-text available
This research aimed to study the migration of mineral oil aromatic hydrocarbons (MOAH) from primary carton packages to dry foods, using 16 aromatic hydrocarbons as model substances, covering a wide range of molecular masses and chemical structures. Migration experiments were performed using modified polyphenylene oxide as a food simulant and cousco...
Article
Full-text available
One-hundred and seven different volatile compounds were identified in the samples of Arctostaphylos uva-ursi collected from nine locations in Spain. This plant is commonly brewed and used as tea. Volatile compounds profile was detected using solid-phase microextraction gas chromatography-mass spectrometry. The most interesting compounds detected fr...
Article
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Macerates of kibbles, seeds and leaves of Ceratonia siliqua L. were prepared and analysed to apply them for the development of a new multilayer active packaging. The profile of forty-three different bioactive volatile compounds was obtained employing headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography-mass spectrometry (GC...
Article
Full-text available
Recycling of polymers is one of the alternatives to reduce the impact of polymers presence on the environmental. However, the contaminants, defined as non-intentionally added substances, present in recycled material may migrate into food and also change its molecular structure. This work addresses the extractability/migration of contaminants from p...
Article
Full-text available
There are numerous approaches and methodologies for assessing the identity and quantities of non-intentionally added substances (NIAS) in food contact materials (FCMs). They can give different results and it can be difficult to make meaningful comparisons. The initial approach was to attempt to prepare a prescriptive methodology but as this proved...
Article
Background: The flowers and peels of cactus Opuntia ficus-indica (OFI) are by-products generally discarded. Their beneficial properties have been linked to the chemical composition without taking into account its transformations during digestion. This study evaluated and compared the phenolic composition, antioxidant and antiacetylcholinesterase a...
Article
Full-text available
The synthetic chemicals in food contact materials can migrate into food and endanger human health. In this study, the traveling wave collision cross section in nitrogen values of more than 400 chemicals in food contact materials were experimentally derived by traveling wave ion mobility spectrometry. A support vector machine-based collision cross s...
Article
With increasing attention to recycled polyethylene (PE), its safety as a food contact material has become non-negligible. In this study, we report an untargeted gas chromatography coupled to mass spectrometer (GC-MS) analysis combined with multivariate data analysis for discriminating recycled PE from virgin PE. 80 (semi-)volatile migrants were ide...
Article
Biodegradable materials are increasingly being used in manufacturing processes due to their environmental benefits. In this work, a study has been performed to assess the migration of compounds from biodegradable multilayer teacups to a tea solution. Liquid chromatography in conjunction with ion-mobility quadrupole time-of-flight mass spectrometry...
Article
Full-text available
Two antioxidant bio-based packaging materials incorporated with an 8% aqueous solution of carob seed ethanol macerate (CSE) or 8% aqueous solution of carob seed acetone macerate (CSA) were developed. Fresh salmon fillets were packaged in active and control films and stored at refrigeration temperature at 4 ± 1 °C. The quality was evaluated by senso...
Article
Full-text available
Biopolymers based on polylactic acid (PLA) and starch have numerous advantages, such as coming from renewable sources or being compostable, though they can have deficiencies in mechanical properties, and for this reason, polyester resins are occasionally added to them in order to improve their properties. In this work, migration from a PLA sample a...
Article
Full-text available
The characterization and quantification of phenolic compounds in bearberry leaves were performed using hyphenated ion mobility spectroscopy (IMS) and a quadrupole time-of-flight mass spectrometer. A higher identification confidence level was obtained by comparing the measured collision cross section (TWCCSN2) with predicted values using a machine l...
Article
The present work reports an experimental study on the optimization of phenolic compounds extraction from Citrus ✕ paradisi peels and the development of active packaging. Response surface methodology (RSM) was applied to investigate the effect of microwave-assisted extraction (MAE) for the recovery of total phenolic compounds (TPC). The TPC in the o...
Article
Full-text available
An exhaustive migration study of eight corks, made of ethylene-vinyl acetate, was carried out to identify any non-volatile and volatile compounds using an untargeted approach. The challenge associated with the structural elucidation of unknowns was undertaken using both ultra-high-performance liquid chromatography coupled to an ion-mobility separat...
Article
Full-text available
The electrospun nanosystems containing poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and 1 wt% Fe doped ZnO nanoparticles (NPs) (with the content of dopant in the range of 0–1 wt% Fe) deposited onto polylactic acid (PLA) film were prepared for food packaging application. They were investigated by scanning electron microscopy (SEM), energy dis...
Article
Oligomers are potential migrants from polymers or biopolymers intended to food packaging and they have to be under control. In order to comply with European regulation 10/2011, their concentration in migration must be below 0.01 μg g⁻¹. In this work, fabric phase sorptive extraction (FPSE) was explored as an effective method for extraction and pre-...
Article
Full-text available
ABSTRACT Polyurethane adhesives are used to bond agglomerated cork and natural disk cork to produce cork stoppers that are used in champagne bottles. These adhesives are manufactured by reacting polyols with an excess of diiso- cyanates. Isocyanates are highly reactive compounds that have a propensity to form non-intentionally added substances (...
Article
Full-text available
High-density polyethylene (HDPE) milk bottles are well-distinguished from other plastics in the mix-collected plastic waste and have potential to be closed-loop recycled. To evaluate this option, volatile substances present in various recycled HDPE (rHDPE) pellets and flakes from postconsumer milk bottles were analysed for similarities between diff...
Preprint
Full-text available
Recycling of polymers is one of the alternatives to reduce the impact of polymers presence on the environmental. However, the contaminants, defined as non-intentionally added substances, present in recycled material may migrate into food and also change its molecular structure. This work addresses the extractability/migration of contaminants from p...
Article
Headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME–GC–MS) was used to analyze the volatile compounds of minced pork meat during storage. The origin of aromatic hydrocarbons in pork was verified by migration test. Principal component analysis (PCA) and orthogonal partial least squares discriminant analys...
Article
Plastic recycling is one of the important ways to mitigate plastic pollution. However, chemicals present in recycled plastics is one of the key qualities affecting their potential uses and deserves more attention. 475 migrants coming from 15 postconsumer recycled polyolefins were identified by direct immersion-solid-phase micro-extraction gas chrom...
Article
Full-text available
PurposeAiming to exploit the remediation of olive cake and leaves, a comparative study between these extracts from the same trees has been carried out to explore them as a source of bioactive compounds with added value.Methods Olive cake (OCE) and leaf (OLE) methanolic extracts were chemically characterized by UPLC-QTOF-MS, and tested for their in...
Article
Background Nowadays, consumers are more aware about what they eat and how it is packaged. Food quality is of paramount importance and consumers are eager to be constantly updated about the perishability and shelf-life of the food products they buy. These needs gave rise to intelligent packaging (IP) materials and devices that can communicate with a...
Article
Nowadays, polypropylene is one of the most common polymers used in the food packaging industry due to its good functionality and relatively low cost. Nevertheless, usage of plastic disposable packaging can be a generator of plastic pollution having negative environmental effects. A feasible solution for this issue would be to recycle. The polypropy...
Article
Oligomers, are, in general, unknown components of the polymer. These oligomers can migrate from the polymer into the food and become a non-intentionally added substance to the food. In this work, ion mobility time-of-flight mass spectrometry has been used to identify oligomers migrating from kitchenware. The structure elucidation of oligomers from...
Article
Grapefruit (Citrus × paradisi, Algerian variety) essential oil obtained by hydro‐distillation was evaluated as a substitute for vitamin E for margarine. The obtained IC50 values were: 39.92 ± 0.18, 15.09 ± 0.02 and 4.42 ± 0.03 mg/mL by the 2,2‐ diphenyl‐1‐picrylhydrazyl method, the reducing power and the β‐carotene/linoleic acid tests, respectively...
Article
Full-text available
A big challenge for today’s industry is antimicrobial preservation and the safety of food. An effective solution to this problem can be a modern invention such as antimicrobial packaging. In the presented research the antimicrobial activity of two new active films incorporating silver, as IONPURE IPL, and ethyl lauroyl arginate (LAE) were evaluated...
Article
Full-text available
The aim of this work was to select and identify the best markers of aromatic hydrocarbon mineral oil (MOAH) in food packaging. For this purpose a series of mineral oils was initially analyzed. Polycyclic Aromatic Hydrocarbons (PAHs) and the alkylated isomers of Methylnaphthalene (MNS), Diisopropylnaphtalene (DIPNs), Dibenzothiophenes (DBTS), Methyl...
Article
The stability, surface micromorphology, and volatile organic compounds (VOCs) of silicone rubber baking molds (SRBMs) were tested while using the molds under severe conditions: baking at 175 °C, microwaving at 800 W, and freezing at –18 °C. Moreover, migration tests of SRBMs to food simulants (isooctane, 95% ethanol, and Tenax®) at 70 °C for 2 h (a...
Article
The influences of temperature, exposure time, different types of polypropylene (PP), (3-Aminopropyl) triethoxysilane (KH550) used as coupling agent, sterilizing conditions on copper migration from nano‑copper/PP composite films into food/ food simulants were explored. Results showed that copper migrated more easily from polypropylene (PPH) films wi...
Article
Two antioxidant active packaging systems containing rosemary oleoresin and green tea extract for meat preservation were compared. Minced pork was packaged in active films and its quality was evaluated by sensory analysis, color, thiobarbituric acid reactive substances (TBARS) and total volatile basic nitrogen content (TVB-N). The active films coate...
Article
Ion mobility time-of-flight mass spectrometry has been used for the identification the PA 6 and PA 66 oligomers through their accurate m/z, CCS values and fragmentation pattern. An extraction method for the oligomers from sunflower oil, cooked beans, soup and whole milk has been developed with recoveries ranging from 87 to 102 %.
Article
The use of packaging materials at very high temperatures, such as in-pack cooking, could lead to the formation of odorous compounds and also to the transference of migrants to food. In this work, the effect of high temperature or microwave cooking has been studied for 2 different cooking bags. The study was performed by gas-chromatography coupled t...
Article
A method of headspace gas chromatography coupled to mass spectrometry (HS-GC-MS) followed by multivariate statistical analysis was applied to identify recycled and virgin polyethylene (PE). Under the optimized conditions, a total of 47 volatile organic compounds (VOCs) were detected, which can be categorized as aliphatic hydrocarbons, additives, co...
Article
The intake of toxic compounds through the diet as a result of migration processes from food packaging is of increasing concern. It has been shown that the surfactant commercially known as surfynol, which is commonly used in food-contact materials, is capable of migrating from multilayer containers into the food, reaching potentially harmful concent...
Article
Two essential oils and seven vegetable oils were tested in an in situ generator of hydroxyl radicals for determining their antioxidant capacity. Then twenty-two different active LDPE films were prepared by incorporating both the essential oils and vegetable oils. The antioxidant capacity, heat-sealing properties and aroma of developed films were de...
Article
Macerates of fruits and leaves of Pistacia lentiscus L. were prepared and analysed with the aim of applying them for active packaging. The profile of forty-four different bioactive volatile compounds was obtained by means of gas chromatography-mass spectrometry and solid-phase microextraction gas chromatography-mass spectrometry. Antioxidant capaci...
Article
In this study, the ultrasonic-assisted dispersive solid phase extraction (UA-d-SPE) method coupled to gas chromatography-mass spectrometry (GC-MS) was applied for the analysis of phthalate esters in drinking water and distilled herbal beverages (Rosa, Mentha, Cichorium). A new nanocomposite based on layered double hydroxide supported on graphene ox...
Article
Artificial insemination is common practice in mass livestock farming. Recently, it was shown that chemicals leaching from multilayer plastic bags affect the fertility of boars, although common quality tests did not show any impact on the sperm. It is not clear whether this incidence was a single case or whether it could be a systematic problem. The...
Article
New bamboo-based biopolymers are used as food packaging materials, but it must be evaluated to ensure consumers safety. In this study, migration from a commercial bamboo-based biopolymer to ethanol 10% (v/v), acetic acid 3% (w/v) and ethanol 95% (v/v) was studied. The migrants were determined from three different perspectives. Volatile and semi-vol...
Article
The concern for environmental conservation is increasing, and a very important factor to consider is the search for alternatives to the use of plastics in the food packaging industry. A good option is the manufacture of containers of biodegradable materials, such as the so-called biomaterials made of vegetable fibre such as wheat, wood, bamboo or p...
Article
Migration of N,N-Bis(2-hydroxyethyl) alkyl(C8–C18)amines from five different polypropylene capsules to Tenax® and coffee powder have been studied. A single step extraction-cleanup procedure using salting out liquid-liquid extraction (SALLE) method followed by ultra-high performance liquid chromatography- tandem mass spectrometry (UHPLC-MS/MS) was a...
Article
Towards a more rigorous inspection of food contact materials, the importance of sample preparation for non-target screening should be addressed. Direct immersion – solid-phase micro-extraction coupled to gas chromatography mass spectrometry (DI-SPME-GC-MS) was optimized for non-target screening of migrants in 3% acetic acid, 10 % ethanol, and 95 %...
Article
Full-text available
Antimicrobially active packaging has emerged as an effective technology to reduce microbial growth in food products increasing both their shelf-life and microbial safety for the consumer while maintaining their quality and sensorial properties. In the last years, a great effort has been made to develop more efficient, long-lasting and eco-friendly...
Article
Full-text available
Food packaging is of high societal value because it conserves and protects food, makes food transportable and conveys information to consumers. It is also relevant for marketing, which is of economic significance. Other types of food contact articles, such as storage containers, processing equipment and filling lines, are also important for food pr...
Article
Full-text available
Nowadays, food packaging is a crucial tool for preserving food quality and has become an inseparable part of our daily life. Strong consumer demand and market trends enforce more advanced and creative forms of food packaging. New packaging development requires safety evaluations that always implicate the application of complex analytical methods. T...
Article
Multilayer materials used in food packaging are commonly manufactured with a polyurethane adhesive layer in its structure that may contain cyclic esters oligomers as potential migrants. However, little is known about their toxicity. In this work, two cyclic esters of polyurethane are evaluated in migration from 20 multilayer packaging samples. They...
Article
Sealants, incorporated in the lids of food cans to ensure the can is hermetically sealed, are formulated from a wide variety of compounds. These compounds and associated non-intentionally added substances (NIAS) could migrate to the food contained in the can. In this work, ion mobility quadrupole time-of-flight mass spectrometry coupled to ultra-hi...
Article
Seven commercial samples, consisted of plastic bags, tetrabrik and box, were evaluated by gas chromatography-olfactometry-mass spectrometry (GC-O-MS) to find the compounds responsible for off-odors in different PP, PE, multilayer cardboard and paper materials used for food contact. Migration assays were carried out with Tenax as food simulant to an...