Cristina Cuesta Apausa- Pharmacy
- PhD Student at Biomedical Research Institute of Salamanca
Cristina Cuesta Apausa
- Pharmacy
- PhD Student at Biomedical Research Institute of Salamanca
About
16
Publications
758
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
87
Citations
Introduction
Skills and Expertise
Current institution
Biomedical Research Institute of Salamanca
Current position
- PhD Student
Publications
Publications (16)
Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent functional recovery based on plasma creatinine (pCr) normalization. However, structural sequelae pass largely unnoticed due to the abs...
Acute kidney injury (AKI) is a risk factor for new AKI episodes, chronic kidney disease, cardiovascular events and death, as renal repair may be deficient and maladaptive, and activate proinflammatory and profibrotic signals. AKI and AKI recovery definitions are based on changes in plasma creatinine, a parameter mostly associated to glomerular filt...
Background. Acute kidney injury (AKI) is a risk factor for new AKI episodes and progression to chronic kidney disease, cardiovascular events and death, as under certain circumstances renal repair is maladaptive leading to proinflammatory and profibrotic signals. The definition for AKI recovery is based on increases in plasma creatinine, but it only...
Transforming growth factor beta 1 (TGF-β1) is one of the most studied cytokines involved in renal tubulo-interstitial fibrosis, which is characterized by myofibroblast abundance and proliferation, and high buildup of extracellular matrix in the tubular interstitium leading to organ failure. Endoglin (Eng) is a 180-kDa homodimeric transmembrane prot...
Upregulated synthesis of extracellular matrix (ECM) proteins by myofibroblasts is a common phenomenon in the development of fibrosis. Although the role of TGF-β in fibrosis development has been extensively studied, the involvement of other members of this superfamily of cytokines, the bone morphogenetic proteins (BMPs) in organ fibrosis has given c...
The involvement of Ras-GTPases in the development of renal fibrosis has been addressed in the last decade. We have previously shown that H- and N-Ras isoforms participate in the regulation of fibrosis. Herein, we assessed the role of K-Ras in cellular processes involved in the development of fibrosis: proliferation, migration and extracellular matr...
