Cristina Cejudo Bastante

Universidad de Cádiz | UCA · Department of Chemical Engineering and Food Technology

Three-dimensional printing is a type of additive manufacturing of great interest in biomedical engineering. The production in situ of customized structures, tissues, implants, or other devices represents a great advance in this field. In addition, the use of polymers functionalized with bioactive substances that improve treatment represents even gr...

Red wines produced in warm climates generally possess a lower content of phenolic compounds and color structure than those produced in colder climates, which hinders bottle evolution. To improve these properties, cold maceration could be a useful procedure. To study the effect of this technique, Tempranillo, Merlot and Syrah grape varieties cultiva...

Supercritical fluid extraction (SFE), using CO2, is a novel, sustainable and very efficient technique for the recovery of highly apolar compounds. However, the recovery of phenolic com- pounds requires the use of different co-solvent combinations such as water and ethanol to enhance the recovery of these compounds through the optimization of a numb...

The addition of natural substances with pharmacoactive properties to polymeric biomedical devices would provide beneficial regarding the assimilation of these endoprostheses when implanted into a patient's body. The added drug would facilitate endothelization by regulating the inflammatory processes that such interventions entail, preventing contam...

Identifying new polymers from natural resources that can be effectively functionalized can have a substantial impact on biomedical devices and food preservation fields. Some of these polymers would be made of biodegradable, renewable and compostable materials, and present the kind of porosity required to effectively carry active compounds that conf...

The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO2 (scCO2), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable filaments of thermoplastic polyurethane (TPU) and polylac...

Cardiovascular diseases remain the leading cause of death worldwide, mainly triggered by the formation of atherosclerotic plaques that reduce blood flow. Angiogenic cell therapy based on endothelial colony forming cells (ECFCs) constitutes a promising alternative to promote vascular revascularization; however, under the oxidative environment that p...

Some citrus by-products such as orange peel contains valuable compounds that could be recovered and restored into the food chain. In this study, an efficient valorization of orange peel has been investigated using green extraction, fractionation, and impregnation techniques. The first step included its extraction using CO2 and ethanol under differe...

A supercritical solvent impregnation (SSI) technique was employed to incorporate, by batch- and semicontinuous-modes, bioactive olive leaf extract (OLE) into a food-grade multilayer polyethylene terephthalate/polypropylene (PET/PP) film for active food packaging applications. The inclusion of OLE in the polymer surfaces significantly modified the c...

Borage (Borago officinalis L.) seed oil is an important source of γ–linolenic acid, which is normally used as a treatment against different pathologies. Since the fractionation of this interesting seed oil has many environmental, economic and biological benefits, two borage fractionation techniques after extraction with CO2 under supercritical cond...

The objective of the present work was to develop a bioactive transdermal patch functionalized with Annona leaf extracts (ALE) by means of supercritical impregnation technique. The potential of six different Annona leaf extracts (ALE) obtained with the enhanced solvent system formed by carbon dioxide + ethanol/acetone was evaluated taking into accou...

Polylactic Acid (PLA) filaments impregnated with ethanolic mango leaves extract (MLE) with pharmacological properties were obtained by supercritical impregnation. The effects of pressure, temperature and amount of extract on the response variables, i.e., swelling, extract loading and bioactivity of the PLA filaments, were determined. The analysis o...

Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic and antipyretic effects. If it is administered in a controlled form by means of different dosing devices, it acts throughout the patient’s recovery period improving its efficacy. This study intends to support the use of supercritical solvent impregnation (SSI)...

The manufacture of functionalized bioabsorbable polymeric implants is gaining attention in recent years. These devices administer gradually and locally drugs or biomolecules to treat several diseases and they disappear once they perform their function. In this work, ketoprofen, an anti-inflammatory drug with analgesic and antipyretic effects, was l...

Nuts are very important foods for human nutrition due to their high content of mono-and polyunsaturated fatty acids. However, they are substrates very sensitive to oxidation, appearing rancidity that affects both the taste and the smell, that led to the consumer's rejection. To avoid this, the food industry uses some strategies that sometimes subst...

Supercritical solvent impregnation (SSI) has been used to develop a transdermal delivery system consisting of an alginate dressing loaded with mango bioactive compounds. A mango leaf extract (MLE) was produced using CO2 + 50% ethanol at high pressure (200 bar) and temperature (80 °C). The extract presented antidiabetic activity as α-glucosidase inh...

There is an increasing demand for the use of new food packaging materials. In this study, natural jute fibers impregnated with a Petit Verdot Red Grape Pomace Extract (RGPE) was proposed as a new active food packaging material. Pressurized Liquid Extraction (PLE) and Enhanced Solvent Extraction (ESE) techniques were employed to obtain the bioactive...

Antioxidant and antimicrobial free-standing films composed of nanofibrillated cellulose (NFC) and a polyphenolic-rich extract, viz. mango leaf extract (MLE), were produced via supercritical solvent impregnation (SSI) and conventional solvent casting film-processing methodologies. The CO2-assisted impregnation of NFC with MLE created robust films wi...

New antioxidant films based on ethylene vinyl alcohol (EVOH) copolymer containing betalain-rich red beet were successfully manufactured and characterized to develop bioactive packaging for food products. Two types of red beet (powder and extract) at different proportions (0.1, 0.5, 1.0, 1.5, 2.0 and 2.5 % (w/w)) were incorporated into EVOH films, w...

The promising prospective in the use of natural extracts has encouraged researchers to study techniques for its incorporation into polymers. This study has focused on supercritical solvent impregnation (SSI) of polyethylene terephthalate/polypropylene (PET/PP) films with olive leaf extract (OLE). The % co-solvent and the ratio OLE/polymer (w/w) wer...

Nuts, in general, are healthy foods rich in unsaturated fatty acids, protein, fiber, antioxidant minerals, B group vitamins, vitamin E, and other phytochemicals (tocopherol, phenolic compounds). Their consumption have been associated with a reduced risk of cardiovascular disease. Unsaturated fatty acids, such as oleic acid and linoleic acid, play a...

Pyrethrum is one of the oldest natural insecticides and it is obtained in a process of drying and powdering of flower heads of a white-flowered perennial plant, Chrysanthemum cinerariaefolium. Pyrethrum extract is a highly viscous liquid and it is highly lipophilic . Pyrethrins are widely used as insecticides for cold-blooded animals. On the other...

Poly(ethyleneterephthalate)/polypropylene(PET/PP)filmscontainingoliveleafextract(OLE)wereobtainedby supercriticalsolventimpregnation(SSI)inbatch(BM)andsemi-continuous(SM)modes.Thestudyfocusedon the impact of pressure, temperature, CO2 flow and OLE on the properties of the impregnated films. Thermal analysisofnon-impregnatedsamplesrevealedadecreasei...

Escape ClassRoom "CSI 1.0" is an educational escape room proposed as an interactive analytical chemistry exercise for the evaluation of undergraduate students at the end of the subject. This approach is a new form of live action learning activity in which the students have to solve an analytical problem, namely, "an alleged crime". From this initia...

An olive leaf extract (OLE) obtained by enhanced solvent extraction (ESE) with high antioxidant was used as the active substance in supercritical solvent impregnation (SSI) of PET/PP films. The extract was characterised by UPLC-QTOF-MS and it was then compared with the profile of the impregnated polyphenols for different operational conditions, nam...

The preservation of food is one of the main concerns of food industry, and finding alternatives to substitute the chemical additives is one of their highest challenges, due to the growing concern of population in consuming chemical-free foods. The active packaging is one of the most innovative techniques used with this aim. One of the procedures to...

La utilización del CO2 supercrítico para la impregnación de sustancias activas en matrices porosas ha adquirido gran interés. En este caso, la utilización de extractos de hollejo de uva tinta, con reconocida actividad antioxidante y antimicrobiana, como agente en envases activos alimentarios ha sido el objeto de estudio, siendo la matriz impregnada...

Background: The two main acetification methodologies generally employed in the production of vinegar (surface and submerged cultures) were studied and compared for the production of orange vinegar. Polyphenols (UPLC/DAD) and volatiles compounds (SBSE-GC/MS) were considered as the main variables in the comparative study. Sensory characteristics of...

Among the different techniques employed to develop active packaging, supercritical solvent impregnation (SSI) of natural extracts is an innovative approach. When developing a method to obtain polyethylene terephthalate/polypropylene (PET/PP) films with antioxidant capacity, several parameters (pressure, temperature, depressurization rate, presence...

Fresh tomato and tomato products are widely consumed products. Their beneficial properties are not only present in fresh products but also in fermented ones. Therefore, the production of fresh tomato derivatives could be a good alternative to get a higher diversification and to make a good use of possible overproductions. Tomato vinegar from tomato...

RD Group objectives: To study and to take advantage of special properties of supercritical fluids to develop separation and reaction processes as alternative green technologies to conventional processes.

Since some years, food industry has developed a huge offer of manufactured products which facilitate the consume of food, such as fresh and freeze fourth range products or prepared dishes. The preservation of its organoleptic characteristics and microbiological quality as long as possible is crucial. To guarantee that, food industry has turn to alt...

Several experiments were conducted to developed orange based vinegar by surface culture. The addition of sugar (sucrose and concentrated must) and the presence/absence of peel in the raw material (squeezed juice, peeled orange, non-peeled orange plus squeezed juice) have been studied during the development of the final product. Polyphenolic and vol...