Cristiane Decat Bergerot

Cristiane Decat Bergerot
City of Hope National Medical Center

PhD

About

171
Publications
20,421
Reads
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608
Citations
Additional affiliations
March 2017 - present
City of Hope National Medical Center
Position
  • Fellow
October 2014 - October 2015
Centro de Câncer de Brasília (Cettro)
Centro de Câncer de Brasília (Cettro)
Position
  • Medical Professional
July 2012 - August 2012
City of Hope National Medical Center
Position
  • Visiting researcher

Publications

Publications (171)
Article
Background Preserving health-related quality of life (HRQOL) is an important goal during renal cell carcinoma treatment. We report HRQOL outcomes from a phase II trial (NCT03173560). Patients and Methods HRQOL data were collected during a multicenter, randomized, open-label phase II study comparing the safety and efficacy of 2 different starting d...
Article
Background: In a previous randomized phase I trial, addition of CBM-588 to the nivolumab/ipilimumab (N/I) regimen showed improved objective response rate, clinical benefit rate, and progression free survival compared to N/I alone in patients (pts) with metastatic renal cell carcinoma (mRCC; Meza et al., ASCO 2021). Furthermore, genomic alterations...
Article
e24020 Background: Various guidelines regarding cancer screening intervals for older adults exist. They often differ based on age cut-offs. There is limited national data about factors impacting adherence to these guideline-based intervals. Using a national-representative dataset, self-reported screening rates between men and women for breast (Mamm...
Article
Purpose: Patients with cancer experience a wide array of distress symptoms (emotional, practical, physical, and functional), which often hinders their quality of life and survival. Unfortunately, only a small proportion of these patients request assistance for these problems. This study explored the relationship between requests for supportive car...
Article
Patients with cancer face a trajectory marked by emotional and physical distress that can be associated with both diagnosis and treatment. Fear of cancer recurrence or progression has been considered one of the most common unmet needs reported by patients diagnosed with both localized and metastatic disease. Fear of cancer recurrence or progression...
Article
Two studies incorporating data from millions of patients highlight the need for consistent screening and access to supportive care.
Article
Full-text available
Purpose: The HOLA COVID-19 study sought to evaluate the impact of COVID-19 on oncology practices across Latin America (LATAM), challenges faced by physicians, and how practices and physicians adapted while delivering care to patients with cancer. Methods: This international cross-sectional study of oncology physicians in LATAM included a 43-item...
Article
The goal of FIPOL (Training and Resources in Psychosocial Oncology for Latin America) is to support the development of psychosocial oncology (PO) in Latin American countries FIPOL aims to increase global awareness of academic opportunities in PO and behavioral medicine and facilitates exchanges and collaborations between Spanish‐speaking clinicians...
Article
336 Background: SBRT in indicated for the management of locally recurrent and oligometastatic mRCC as per National Comprehensive Cancer Network guidelines. Our study evaluates both the efficacy of radiotherapy (RT) in prolonging systemic treatment along with RT toxicity in the oligoprogressive RCC setting. Methods: A single institution retrospectiv...
Article
324 Background: mRCC is associated with high rates of distress, high levels of symptom burden, and broad impairments in quality of life. In the setting of localized breast cancer, a smartphone application directed at enhancing mindfulness has been developed from a Mindfulness-Based Cancer Recovery program demonstrated to mitigate these factors (Utk...
Article
386 Background: Aberrant alternative splicing (AS) events have been implicated in the initiation and progression of various cancers; however, the detailed nature of their role in RCC is yet to be fully elucidated. Our study aims to characterize AS events in RCC tumors using a novel AS pipeline (Bisbee). Methods: We retrospectively identified patien...
Article
328 Background: Previous studies have shown that a significant proportion of patients with metastatic genitourinary cancers harbor inaccurate expectations of cure prior to starting treatment with immunotherapy. This study sought to compare changes in perceptions of immunotherapy reported before, and three months after, the start of therapy, as well...
Article
561 Background: Recently published data suggests that the presence of a TERT promoter mutation is predictive of superior overall survival (OS) in patients (pts) with advanced/metastatic bladder cancer (mUC) treated with an immune checkpoint inhibitor (ICI) (Kouchkovsky et al, JITC 2021). We aim to validate the results of this study in a large indep...
Article
327 Background: Patients with cancer may possess limited knowledge of emerging modalities in oncology, including genomic profiling (GP) tests, which can create barriers to shared decision making. Effective provider communication can address such barriers but little is understood regarding patients’ perceptions of GP. Methods: In this cross-sectiona...
Article
313 Background: Treatment decisions for patients with cancer have changed during the COVID-19 pandemic due to the increased risk of infection among this population. In recognition of the impact of COVID-19 in Brazil, this study sought to explore the potential consequences of this disruption to oncology care by comparing the prevalence and place of...
Article
O presente estudo teve o objetivo de avaliar a relação entre o distress, a qualidade de vida e a prática espiritual e religiosa (ER) em pacientes recém-diagnosticados com câncer, na primeira linha de tratamento quimioterápico. Trata-se de um estudo transversal, que avaliou 100 pacientes quanto ao distress (Termômetro de Distress), qualidade de vida...
Article
Key points • A high number of mental health cancer care providers from low–middle-income countries (LMICs) reported that they are working during the COVID-19 as both clinicians and researchers • Less than 50% of providers surveyed were taking care of patients with comorbid cancer and COVID-19. They also reported that this pandemic had drastically...
Article
There may be a racial bias in the mental health diagnosis of cancer patients at large, urban cancer centers. Additionally, there may be a temporal relationship of mental health diagnosis and decreased survival.
Article
Clinical levels of fear of cancer recurrence reported by patients with localized prostate cancer may not decrease, even over an extended time frame (9 years). A lower level of education, years since radical prostatectomy, early biochemical recurrence, and current therapy are important predictors of persistent clinical levels of fear of cancer recur...
Article
Full-text available
Purpose To ascertain renal cell carcinoma (RCC) financial toxicity on COVID-19 during the COVID-19 crisis as patients are struggling with therapeutic and financial implications. Methods An online survey was conducted from March 22 to March 25, 2020. It included baseline demographic, clinicopathologic, treatment-related information, anxiety levels...
Article
11014 Background: The well-being of oncology providers (OP) is in jeopardy with increasing workload, limited resources, and personal challenges that result from the COVID-19 pandemic. We aim to evaluate the impact of COVID-19 on work-related (WR) satisfaction and fatigue among OP in Latin America. Methods: We conducted an international cross-sectio...
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Full-text available
1537 Background: The severe acute respiratory syndrome 2 (SARS-cov-2) virus causing COVID-19 has brought great challenges to global health services affecting cancer care delivery, outcomes, and increasing the burden in oncology providers (OP). Our study aimed to describe the challenges that OP faced while delivering cancer care in Latin America. Me...
Article
Objective Emotional problem‐related distress is a common issue faced by patients with cancer. However, patients suffering with this emotional burden do not typically seek assistance. This study sought to determine the prevalence of emotional problem‐related distress by cancer type, and identify factors correlated with the level of assistance reques...
Article
314 Background: Renal cell carcinoma (RCC) is the most common type of kidney cancer, constituting 80% to 85% of primary renal neoplasms. Preserving health-related quality of life (HRQOL) is an important goal during RCC treatment, but HRQOL analyses in prospective clinical trials in RCC are limited. We report changes in HRQOL, a secondary endpoint o...
Article
75 Background: Exposure to bright white light (BWL) has been shown to improve outcomes including fatigue, depression, and sleep disturbances among the general older population but the benefit has not been demonstrated as yet in prostate cancer. Older men with prostate cancer on androgen deprivation therapy (ADT) are at risk for obese frailty (compo...
Article
Objective Older patients diagnosed with cancer are at increased risk of physical and emotional distress, however, prescription utilization patterns largely remain to be elucidated. Our objective was to comprehensively assess prescription patterns and predictors in older patients with bladder cancer. Methods A total of 10,516 older patients diagnos...
Article
Full-text available
Resumo Neste estudo, avaliou-se a associação entre ansiedade/depressão (AD) e sintomas físicos reportados por pacientes oncológicos em quimioterapia. Pacientes foram avaliados quanto ao distress (Termômetro de Distress), AD (Escala de Ansiedade e Depressão), qualidade de vida (Functional Assessment of Chronic Illness Therapy-General) e sintomas (Es...
Article
Introduction Bladder cancer patients are at increased risk of physical and emotional distress, however, prescription utilization patterns largely remain to be elucidated. Our objective was to comprehensively assess prescription patterns and predictors in bladder cancer patients. Methods A total of 10,516 patients diagnosed with clinical stage T1-T...
Article
Countries in Latin America and the Caribbean have become hotspots of the novel coronavirus (COVID-19) pandemic, exacerbating socioeconomic inequalities and overwhelming fragmented health systems. Studies from the United States and Europe have highlighted the disproportionate effects of COVID-19 on patients with cancer and the disruption it has caus...
Article
Objective Emotional symptoms are frequently reported among patients with cancer. We evaluated the association between emotional symptoms and problem‐related distress in a sample of patients with cancer about to initiate chemotherapy within a private hospital in Brazil. Methods Patients were assessed before initiating chemotherapy, treatment mid‐po...
Article
Background: Patient-reported outcomes have been used to assess treatment effectiveness and actively engage patients in their disease management. This study was designed to describe the patient-reported performance status (PS) and the provider-reported PS. Methods: Patients with metastatic genitourinary cancers were recruited from a single cancer...
Article
Purpose: Patients with cancer commonly report distress and fear of cancer recurrence (FCR) impacting quality of life and clinical outcomes. This study aims to test the association between emotional well-being and clinical characteristics of survivors with localized renal cell carcinoma (RCC). Materials and methods: Survivors with localized RCC w...
Article
Background: While providers are challenged with treatment decisions during the coronavirus disease 2019 (COVID-19) crisis, decision making ultimately falls in the hands of patients-at present, their perspective is poorly understood. Objective: To ascertain renal cell carcinoma (RCC) patients' perspectives on COVID-19 and understand the associate...
Article
Objetivos: Descrever as características sociodemográficas e clínicas dos pacientes oncológicos atendidos em unidades de pronto-socorro. Método: descritivo, transversal, realizado na unidade de pronto-socorro de um hospital público geral do munícipio de São Paulo. Resultados: amostra não probabilística, com 44 pacientes. Os cânceres mais prevalentes...
Article
Patients with cancer represent a vulnerable population and are at greater risk of developing serious complications as a result of a COVID-19 infection. In response, oncology societies around the world have proposed changes to their standards of care. These changes have helped guide health care providers in prioritizing clinical management of patien...
Article
5083 Background: In metastatic renal cell carcinoma, the systemic therapy landscape has expanded to include multiple VEGF inhibitors, immunotherapies, and combination therapy. Little is known about patient expectations and preferences when making decisions about systemic therapy. We sought to gather independent data from online kidney cancer patien...
Article
5084 Background: The use of cannabis and cannabinoid related products has become increasingly common among cancer patients. We sought to gather independent data from online kidney cancer patient communities to assess frequency of use of marijuana and CBD-oil and estimate influence on treatment duration and side-effects. Methods: The KCCure online s...
Article
Objectives Our objective was to assess the incidence of Alzheimer's Disease and related dementia diagnosis following treatment for muscle-invasive bladder cancer and impact on survival outcomes. Materials and Methods A total of 4814 patients diagnosed with clinical stage T2-T4a, N0, M0 bladder cancer between January 1, 2002 to December 31, 2011 us...
Article
Full-text available
OBJECTIVE To evaluate an educational program based on the principles of self-management with a conventional educational program through quality of life, anxiety and depression instruments within 12 months of starting cancer treatment. METHOD An experimental, randomized, controlled study conducted with head and neck cancer patients treated at a uni...
Article
663 Background: Genomic profiling (GP) is becoming more widespread in oncologic care, yet little is known regarding patients’ motivations to pursue or accept such testing. The current study examined patients’ reasons to pursue GP in the context of advanced genitourinary disease, and their potential association with demographic characteristics and p...
Article
665 Background: Despite promotion of a shared decision-making model of care in oncology, studies suggest that many patients with advanced cancer still possess inaccurate perceptions of their prognosis. Such inaccuracies can influence treatment choices, patient satisfaction and care planning. Novel immunotherapies and targeted treatments, which can...
Article
649 Background: Fear of cancer recurrence (FCR) is considered one of the most pervasive and burdensome sources of distress for patients. Whereas it can be considered an adaptive response to real threats associated with diagnosis, treatment and disease, numerous studies have suggested that elevated levels can be dysfunctional. Despite this extensive...
Article
645 Background: Recent efforts have sought to characterize differences in clinical and pathological characteristics across ethnicities in mRCC (Batai et al CGUC 2018), however, the relationship between ethnicity and treatment outcomes has yet to be explored. We sought to compare survival outcomes across ethnic groups for patients receiving 1L TT fo...
Article
Full-text available
Background Despite the advent of checkpoint inhibitors (CPIs) for advanced genitourinary (GU) cancers, existing studies suggest that durable complete responses are observed in fewer than 10% of patients. This study sought to evaluate the association between expectations of cure reported by patients with advanced GU cancers initiating immunotherapy...
Article
Patients with advanced genitourinary cancers face many challenges throughout their disease trajectory, and many will experience clinically relevant psychosocial distress. Certain groups, including female gender, younger age (and older age for suicide), unmarried status, and non–clear cell histology, remain at a higher risk, and evidence suggests th...
Article
31 Background: Little is known regarding patients’ beliefs concerning genomic profiling (GP) and its potential association with emotional well-being. We examined essential components of shared decision-making in the context of GP and their relationship to symptoms of anxiety (SAnx) and of depression (SDep) among patients with metastatic genitourina...
Article
195 Background: Assessing patient-reported outcomes (PROs) is a critical element of comprehensive cancer care. Performance status (PS) is a widely used clinical measure to assess patients’ general well-being and, in clinical trials, provide insight into patients’ quality of life (QOL). This study compared PS as reported by clinicians and by patient...
Article
63 Background: Comprehensive genomic profiling (CGP) has been used to guide treatment selection in metastatic renal cell carcinoma (mRCC). This study sought to determine if genomic alterations guided treatment and contributed to improved outcomes. Methods: From a single institution, patients (pts) diagnosed with mRCC who had CGP in the course of cl...
Article
Objective: Utilizing the Cancer and Aging Research Group (CARG) chemotherapy toxicity risk score before starting treatment in older adults with cancer is guideline-recommended. However, this has not been tested in most developing countries. We investigated the use of a Portuguese version of the CARG score, including the association between this sc...
Article
Objective: As the association between obesity and cancer receives increasing attention, studies have begun to examine the potential impact of excess weight on psychosocial domains during treatment and survivorship. The current study will examine the effect of weight status on psychosocial outcomes among patients diagnosed with breast cancer, prost...
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Full-text available
The favorable prognosis of testicular cancer does not minimize immediate and late biopsychosocial implications. This study sought to determine these needs, and to evaluate the evidence of validation of a brief and specific scale for this population. A sample of 29 survivors of testicular cancer (n = 29) was assessed for distress (Distress Thermomet...
Article
622 Background: Current evidence indicates improved outcome with IO in mRCC patients (pts) with PBRM1 loss of function mutations (Miao et al., Nature, 2018). We seek to demonstrate an association between PBRM1 mutation and treatment duration with IO and TT in a retrospective cohort. Methods: Consecutive patients with mRCC who had genomic profiling...
Article
591 Background: Over the past 15 years, considerable progress has been made in systemic therapy options for genitourinary (GU) cancers. In diseases such as metastatic renal cell carcinoma (RCC) and urothelial cancer (UC), immunotherapeutic strategies such as programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibition have elicited dur...
Article
Patient-reported outcome measures (PROMs) have widely been used to assess treatment-related symptoms in clinical trials and provide insight into the patients’ perspective during treatment. This mini-review sought to outline the benefits of measuring patient-reported outcomes, describe the most common measures used in recent pivotal studies in metas...
Article
Purpose: Several studies have described the content of Twitter conversations about lung, breast, and prostate cancer, but little is known about how the public uses Twitter to discuss kidney cancer. We sought to characterize the content of conversations on Twitter about kidney cancer and the participants engaged in these dialogues. Methods: This...
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Full-text available
Despite numerous therapeutic advances in renal cell carcinoma (RCC), little is known about patients' perspectives on cancer care. An international survey was conducted to identify points of frustration associated with cancer care reported by patients with RCC. Data were obtained from an online survey, conducted from April 1 to June 15, 2017, throug...
Article
115 Background: In Brazil, 60.5% of patients are diagnosed with an advanced stage of cancer. Patients with incurable cancer and their partners experience high rates of distress. This study aimed to assess problem-related distress among patients with stage IV cancer and their partners. Methods: A descriptive study was conducted at a large public hos...
Article
47 Background: Treatment strategies for advanced renal cell carcinoma (aRCC) have improved over the past 15 years. Durable responses are now achievable, giving rise to the possibility of cure in a small proportion of this population. However, it is not clear how patients are coping with more protracted courses of treatment. We sought to determine s...
Article
31 Background: Palliative care in the ICU is recognized as a vital aspect of care delivery but less evidence exists regarding utilization in ambulatory care. Family meetings are considered a relevant strategy to discuss concerns around patients’ illness and treatment. This pilot study sought to describe preliminary results of the Patient and Family...
Article
Full-text available
Objective: To evaluate the impact of breast cancer and the quality of life of women survivors and to identify associations between sociodemographic and clinical variables. Method: This was a cross-sectional, analytical, quantitative study conducted with women receiving outpatient post-treatment care at a public institution of the city of São Pau...
Article
228 Background: Genomic profiling (GP) plays an important role in the care of patients diagnosed with advanced cancer, and has been used to guide clinical decision making. As age has been associated with low health literacy, we sought to determine comprehension of the goals and objectives of GP between younger (age < 65) and older (age ≥65) with ge...
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Full-text available
The development of international guidelines for distress assessment gave greater visibility to the importance of psychosocial issues within Oncology services. This study sought to identify the instruments used in Brazil, to describe the procedures for implementing this program and to present the preliminary results of a public hospital. In Brazil t...
Article
Over the last fourteen years, distress has been considered the 6th vital sign in oncology care. It has also been used to identify patients in need of psychosocial support and improve quality of life (1). Since the initial publication of the National Comprehensive Cancer Network (NCCN) distress guidelines in 1999, multiple studies have been publishe...