Cristian González-Ruiz

Cristian González-Ruiz
National Autonomous University of Mexico | UNAM · Facultad de Estudios Superiores Iztacala

PhD
Neuroscientist at UNAM-Facultad de Estudios Superiores de Iztacala Project: Mild cognitive impairment

About

10
Publications
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106
Citations
Introduction
Study of molecular mechanisms of mild cognitive impairment and changes in cognitive skills. Study new treatments for mild cognitive impairment with potential to enhance cognitive skills. Other projects: Study of plasma polypyrrole as spinal cord injury treatment and polyphenols as treatments for muscle atrophy.

Publications

Publications (10)
Article
Skeletal muscle (SkM) is a highly dynamic tissue that responds to physiological adaptations or pathological conditions, and SkM mitochondria play a major role in bioenergetics, regulation of intracellular calcium homeostasis, pro-oxidant/antioxidant balance, and apoptosis. Flavonoids are polyphenolic compounds with the ability to modulate molecular...
Article
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Treating addiction and withdrawal syndrome remains a research area of great interest since it is a persistent public health problem. Opiates account for the majority of addiction and withdrawal problems (at least 56% of reported people who consume drugs). Development of opiate addiction results mainly from activation of the mu-opioid receptor (MOR)...
Article
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The skeletal muscle mass reduces 30–60% after spinal cord injury, this is mostly due to protein degradation through ubiquitin–proteasome system. In this work, we propose that the flavanol (−)-epicatechin, due its widespread biological effects on muscle health, can prevent muscle mass decrease after spinal cord injury. Thirty-six female Long Evans r...
Article
Full-text available
Traumatic spinal cord injury (TSCI) can cause paralysis and permanent disability. Rehabilitation (RB) is currently the only accepted treatment, although its beneficial effect is limited. The development of biomaterials has provided therapeutic possibilities for TSCI, where our research group previously showed that the plasma-synthesized polypyrrole...
Article
Background The age-related decline in mass, strength and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization and death. Methods To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and fra...
Article
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Mild cognitive impairment (MCI) is defined as inter-stage between normal cognitive aging and major neurocognitive disorder (MND). This state of decay is a crucial factor in treatment to prevent the progression to MND. In this study, our group developed a virtual screening process to evaluate 2568 phytochemical compounds against 5 key proteins assoc...
Article
Despite the development of vaccines against COVID-19 disease and the multiple efforts to find efficient drugs as treatment for this virus, there are too many social, political, economic, and health inconveniences to incorporate a fully accessible plan of prevention and therapy against SARS-CoV-2. In this sense, it is necessary to find nutraceutical...
Article
Full-text available
There are several theories of how a drug interacts with a receptor. This review discuss the theories considered the most relevant to elucidate the mechanisms that govern drug-receptor interactions such as the occupational theory proposed by A. J. Clark, who stablished that drug-receptor interactions can be interpreted as processes that obey the law...
Article
Spinal Cord Injury (SCI) is a condition that produces a partial or total loss of physiological functions below the lesion. SCI typically leads to severe muscle atrophy, which limits the recovery from SCI. With muscle atrophy, the muscle fiber size diameter is reduced as cell mass decreases through increased protein turnover/degradation, loss of org...

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