Crescenzio Gallo

Crescenzio Gallo
Università degli studi di Foggia | UNIFG · Department of Clinical and Experimental Medicine

M.Sc. Computer Science

About

133
Publications
84,158
Reads
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572
Citations
Introduction
My main research interests focus on the methodological issues related to network architectures, automatic data analysis and processing and its relations with the formalization of architectural models, theoretical analysis and application of advanced computational algorithms for artificial neural networks, with applications to the economic/industrial (semiconductor yield management) and biological fields (DNA microarray data analysis, viability and Raman/NMR spectra, Heart Rate Variability).
Additional affiliations
April 2012 - present
Università degli studi di Foggia
Position
  • Analysis of biological experimental data
Description
  • We analyze from both the biological, statistical and computer-science point of view a series of experimental data collected in the Odontological Clinic
November 2011 - present
University of Naples Federico II
Position
  • Analysis of Arabidopsis DNA micorarray gene expression data
Description
  • We process post Arabidopsis DNA microarray gene expression data to search biologically significant clusters of genes with a coarse/fine grain clustering algorithm.
Education
January 2006 - August 2007
University of Milan
Field of study
  • Information and Communication Technology
September 1974 - September 1978
Università degli Studi di Bari Aldo Moro
Field of study
  • Information Technology

Publications

Publications (133)
Article
Obesity is a pathology characterized by an excessive accumulation of adipose tissue and it is a condition associated with complex alterations affecting different organs and systems. Obesity has great influences on cardiovascular and respiratory morbidity and mortality and impairs the multiple aspects of metabolism. Since micro-RNAs (miRNAs) are tho...
Article
The concentration curve represents the relationship between cumulative relative fractions of statistical units and cumulative relative fractions of intensity of a transferable phenomenon between statistical units. In this article, the Lorenz curve is studied through a mathematical approach and ideally approximated to an arc belonging to a particula...
Article
Full-text available
The aim of this study is to describe the features, the outcomes, and the clinical issues related to Remdesivir administration of a cohort of 220 patients (pts) with COVID-19 hospitalized throughout the last two pandemic waves in Italy. One hundred and nine pts were enrolled from 1 September 2020, to 28 February 2021 (Group A) and 111 from March 1 t...
Article
Full-text available
Continuous positive airway pressure (CPAP) is the “gold-standard” therapy for obstructive sleep apnea (OSA), but the main problem is the poor adherence. Therefore, we have searched for the causes of poor adherence to CPAP therapy by applying predictive machine learning (ML) methods. The study was conducted on OSAs in night-time therapy with CPAP. A...
Preprint
Full-text available
Introduction COVID-19 pneumonia causes ARDS-like manifestations that can result in significant lung damage and death. We have tried to identify radiological phenotypes that could help us understand this disease and the best treatment approaches. Methods This retrospective study was conducted on COVID-19 hospitalised patients admitted to our Units...
Article
COVID-19 pneumonia causes ARDS-like manifestations that can result in significant lung damage and death. We have tried to identify radiological phenotypes that could help us understand this disease and the best treatment approach. Therefore, a retrospective study was conducted on COVID-19 hospitalised patients admitted to our Units from March to De...
Article
Purpose : To asses trueness of the intaglio surface of milled dentures fabricated according to a fully digital protocol starting from intraoral scans in a clinical study by means of 3-dimensional (3D) digital analysis. Materials and Methods Ten maxillary and 10 mandibular dentures, designed on intraoral scans and milled in-house, were studied. Int...
Article
Full-text available
Objectives The SARS-CoV-2 pandemic has been heavily experienced in Italy. The severe restriction rules notably attenuated the hospital care burden. The association of high viral replication with disease severity suggests a potential role of a lower viral load in the mild clinical scenario. Methods The reverse-transcription-polymerase-chain-reactio...
Preprint
The topic of efficiency analysis of independent organisational units has long been a major challenge for researchers and scientists around the world. In fact, in the current economic context of increasing competitiveness and dynamism, it is essential to know both the degree of efficiency compared to competitors, and the efficiency of the various in...
Article
The topic of efficiency analysis of independent organisational units has long been a major challenge for researchers and scientists around the world. In fact, in the current economic context of increasing competitiveness and dynamism, it is essential to know both the degree of efficiency compared to competitors, and the efficiency of the various in...
Article
Full-text available
The semiconductor manufacturing process involves long and complex activities, with intensive use of resources. Producers compete through the introduction of new technologies for increasing yield and reducing costs. So, yield improvement is becoming increasingly important since advanced production technologies are complex and interrelated. In partic...
Article
Full-text available
The treatment of cystic fibrosis (CF) patients homozygous for the F508del mutation with Orkambi ® , a combination of a corrector (lumacaftor) and a potentiator (ivacaftor) of the mutated CFTR protein, has resulted in some amelioration of the respiratory function. However, also a great variability in the clinical response was observed. The aim of th...
Article
Full-text available
Machine learning consists in the creation and development of algorithms that allow a machine to learn itself, gradually improving its behavior over time. This learning is more effective, the more representative is the features of the dataset used to describe the problem. An important objective is therefore the correct selection (and, possibly, redu...
Article
Full-text available
An algorithm using the heuristic technique of Simulated Annealing to solve a scheduling problem is presented, focusing on the scheduling issues. The approximated method is examined together with its key parameters (freezing, tempering, cooling, number of contours to be explored), and the choices made in identifying these parameters are illustrated...
Article
Full-text available
The role of colony stimulating factors (CSFs) in cystic fibrosis (CF) circulating neutrophils has not been thoroughly evaluated, considering that the neutrophil burden of lung inflammation in these subjects is very high. the aim of this study was to assess granulocyte-cSf (G-cSf) and granulocyte-macrophage- cSf (GM-cSf) levels in cf patients in var...
Conference Paper
Full-text available
Blockchain technology allows to develop product certification processes, offering greater guarantees on the history of food, from the collection of raw materials to the flow between operators in the supply chain and up to the final consumer. This new technology can therefore represent a strategic element for the agro-food supply chains (and not onl...
Article
Objective: Hallux valgus is a forefoot deformity usually revealed with a weight-bearing radiograph of the foot. The aim of this study is to describe a new ultrasonographic method to assess metatarsal heads in hallux valgus patients. Methods: We enrolled 38 patients with hallux valgus candidates to surgery. We assessed the ultrasonographic distance...
Book
Il libro ha l'obiettivo di descrivere il panorama tecnico-giuridico scaturito da un processo di digitalizzazione e di alta connettività che ha coinvolto l'intera società. Partendo dalle problematiche del copyright e dal nuovo panorama europeo sulla privacy, si arriva ad aspetti tecnico-giuridici della sicurezza digitale, del documento digitale, del...
Article
Full-text available
Introduction:: Obstructive sleep apnea syndrome has become an important public health concern. Polysomnography is traditionally considered an established and effective diagnostic tool providing information on the severity of obstructive sleep apnea syndrome and the degree of sleep fragmentation. However, the numerous steps in the polysomnography t...
Article
Full-text available
Machine learning consists in the creation and development of algorithms that allow a machine to learn itself, gradually improving its behavior over time. This learning is more effective, the more representative is the features of the dataset used to describe the problem. An important objective is therefore the correct selection (and, possibly, redu...
Chapter
The possible applications of modeling and simulation in the field of bioinformatics are very extensive, ranging from understanding basic metabolic paths to exploring genetic variability. Experimental results carried out with DNA microarrays allow researchers to measure expression levels for thousands of genes simultaneously, across different condit...
Conference Paper
For some time now, the issue of cost-benefit analysis has been one of the major challenges facing researchers and scientists around the world. In the current economic context of growing competitiveness and dynamism, it is essential to know the impact of financial policies or programmes that may be difficult to measure or predict. Sensitivity Analys...
Article
Purpose A ¹H-MRS spectrum on a patient’s healthy brain differs on the pathological part of the same organ. L-Acetylaspartate (NAA), due to its high concentration in the brain, returns intense MRS spectrum signal, reducing its intensity more or less drastically in patients suffering from various brain diseases. Even cultures of brain cells have the...
Conference Paper
In today's constantly transforming world, agriculture management, as well as other economic sectors, is becoming more complex. For instance, supply chains are getting longer, also the number of intermediaries, documents request and the parties involved in the transactions, rises. For these reasons, it is increasingly becoming difficult for the cons...
Article
Introduction MicroRNAs (miRNAs) are small non coding RNAs which play a role in several cellular processes. MiRNA expression is influenced by oxidative stress, inflammatory cascade and hypoxia. Effects of different types of hypoxia (intermittent and chronic) have been poorly investigated. The aim of this study was to evaluate how intermittent and ch...
Presentation
Cancers that are known collectively as head and neck cancers usually begin in the squamous cells that line the moist, mucosal surfaces inside the head and neck (for example, inside the mouth, the nose, and the throat). These squamous cell cancers are often referred to as squamous cell carcinomas of the head and neck (SCCHN). The aim of this study i...
Article
For some time now, the issue of cost-benefit analysis has been one of the major challenges facing researchers and scientists around the world. In the current eco-nomic context of growing competitiveness and dynamism, it is essential to know the impact of financial policies or programmes that may be difficult to measure or predict. Sensitivity Analys...
Article
Orthodontic treatment has important correlations with periodontal changes. Various mechanical and biological factors are involved in determining such changes, but anatomical and morphological variables, generally addressed as periodontal biotype, play a key role. In measurement of such modifications, digital and non-contact reverse engineering tech...
Article
Full-text available
Olive tree is one of the most important crop at global scale. Apulia is the first olive-producing region in Italy, with a huge amount of farms that generate Integrated Pest Management (IPM) data. IPM requires the simultaneous use of different crop protection techniques to control pests through an ecological and economic approach. The crop protectio...
Article
Full-text available
Background The aim of this study was to investigate the effects of listening to tibetan music on endocrine, autonomic, cognitive and emotional responses in pre-operative anxiety in patients waiting for urologic surgery. Methods Sixty patients waiting for surgery were enrolled in a quiet room of the urologic ward. They were randomized in: music (M)...
Data
Supplementary Material S1: time-frequency of Tibetan music.
Chapter
The possible applications of modeling and simulation in the field of bioinformatics are very extensive, ranging from understanding basic metabolic paths to exploring genetic variability. Experimental results carried out with DNA microarrays allow researchers to measure expression levels for thousands of genes simultaneously, across different condit...
Chapter
Among the reliable technologies for the safe use of computer systems in networks, that of virtual private networks, or VPN (Virtual Private Network), is one of the segments in which we are witnessing a remarkable development. A development that, if from the commercial side it sees the progressive adoption by both private and public organizations, f...
Article
Full-text available
The Agri-Food sector is facing global challenges. The first challenge is feeding a world population that will reach 9.3 billion people in 2050, according to UN projections. The second challenge is the demand from consumers for high-quality products obtained through more sustainable, safe and clear agri-food chains. Integrated pest management (IPM)...
Article
Introduction: Sleep-disordered breathing causes a burden to the sufferer, the healthcare system, and the society. Most studies have focused on Obstructive Sleep Apnea (OSA), however, the prevalence of comorbidities in patients affected by Overlap Syndrome (OS) and Obesity Hypoventilation Syndrome (OHS) has not been carefully evaluated. Study obje...
Article
Full-text available
Background To evaluate if changes in lower incisor position following orthodontic treatment are correlated with development of gingival recessions. Material and Methods Pre- and post-treatment digital models and lateral cephalograms of 22 subjects were collected retrospectively. The clinical crown length, gingival scallop, and papilla height of th...
Article
Full-text available
Background The aim of this study is to evaluate determinants of maxillary canine impaction taking into account both canine position related variables and the pattern of facial growth. Material and Methods A retrospective clinical and radiographic analysis was carried out on 109 patients aged between 9 and 10 years at the time of first evaluation....
Article
This paper aims to start the study of the effects of the Kyoto Protocol on the agricultural and forestry sector. The emission levels of Greenhouse gases are greatly changed from a geographical point of view over the years after Kyoto Accord. Except for technical innovation, the design and timing of policy interventions is crucial for reducing innov...
Article
Full-text available
Background A treatment modality for Class II division 1 malocclusion is discussed. Orthodontic treatment of patients with deep bite and Class II malocclusion is an important challenge in clinical practice. The aim of this work is to compare the efficacy of anterior bite plane functional appliance (ABPFA) by assessing the changes in different times...
Conference Paper
The Agri-Food sector is facing global challenges. The first concerns feeding a world population that in 2050, according to UN projections, will reach 9.3 billion people. The second challenge is the request by consumers for high quality products obtained by more sustainable, safely and clear agri-food chains. The Integrated Pest Management (IPM) cou...
Article
Purpose: Healthy and safety food issues are more and more the purchasing process core of conscious consumer. “Type 1” wheat flour means higher protein and ash content. This paper aims at investigating the attributes usually referred to the characteristics of wheat flour known to consumers and at implementing a predictive model of purchasing that al...
Conference Paper
Many studies highlighted the request by farmers of Information and Communications Technology (ICT) tools able to provide and share useful information for daily crops management. In particular, the Farm Management Information Systems (FMISs) are attracting great interest. FMISs are tools able to facilitate farmers in the management and control of th...
Article
Aim: The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) potentiator ivacaftor (Kalydeco®) improves clinical outcome in G551D cystic fibrosis (CF) patients. Here, we have investigated whether ivacaftor has a clinical impact on non-G551D gating mutations and function of circulating leukocytes as well. Methods: Seven patients were treat...
Article
Background: The CFTR potentiator Kalydeco improves clinical outcome in G551D cystic fibrosis (CF) patients; we have considered the clinical impact of Kalydeco (150 mg every 12 h) on non-G551D gating mutations and on functions of circulating leukocytes as well. Methods: Two patients with deteriorated pulmonary function were treated for compassionat...
Article
Obstructive sleep apnea–hypopnea syndrome (OSA) is being identified increasingly as an important health issue. It is typified by repeated episodes of upper airway collapse during sleep leading to occasional hypoxaemia, sleep fragmentation and poor sleep quality. OSA is also being considered as an independent risk factor for hypertension, diabetes a...
Conference Paper
Full-text available
Introduzione La sindrome delle Apnee ostruttive (OSAS) è una patologia estremamente diffusa nella popolazione e per la sua diagnosi è necessario ricorrere ad indagini costose e che richiedono lunghi tempi di attesa. Diversi sistemi sono stati approntati per esaminare e diagnosticare la patologia: tuttavia ad oggi nessuno di essi si è dimostrato rea...
Article
OSA is increasingly being identified as an important health issue. It is typified by repeated episodes of upper airway collapse during sleep leading to occasional hypoxaemia, sleep fragmentation and poor sleep quality. OSA is also being considered as an independent risk factor for hypertension, diabetes, cardiovascular diseases, leading to increase...
Article
Full-text available
Obstructive sleep apnoea-hypopnea syndrome (OSA) is increasingly being identified as an important health issue. It is typified by repeated episodes of upper airway collapse during sleep leading to occasional hypoxaemia, sleep fragmentation and poor sleep quality. OSA is also being considered as an independent risk factor for hypertension, diabetes,...
Conference Paper
Full-text available
Changes in agricultural policies and availability of inputs have provided farmers with incentives to develop innovative management practices that reduce available resources and inputs. A plethora of recent works are on investigating the impact of the adoption of improved agriculture practices, and especially the conversion of land into more restric...
Article
Full-text available
Changes in agricultural policies and availability of inputs have provided farmers with incentives to develop innovative management practices that reduce available resources and inputs. A plethora of recent works are on investigating the impact of the adoption of improved agriculture practices, and especially the conversion of land into more restric...
Article
Few mutations in cis have been annotated for F508del homozygous patients. Here we describe a novel complex allele [F508del;A238V] and its effects on clinical parameters. Southern Italy patients that at a first analysis appeared homozygous for the F508del mutation (n=63) or compound heterozygous for the F508del and another mutation in the CFTR gene...
Technical Report
Full-text available
L’obiettivo di questo breve tutorial è di introdurre una potente classe di modelli matematici: le reti neurali artificiali. In realtà, questo è un termine molto generico che comprende molti diversi modelli di tipo matematico e varie tipologie di approcci. Scopo di questo tutorial non è di esaminarli tutti, ma di far comprendere le funzionalità e le...
Article
Aim: The aim of the present study was to investigate the diagnostic and prognostic potential of proteomic signatures in saliva of patients with oral squamous cell carcinoma (OSCC). Materials and methods: Data from SELDI-TOF mass spectrometry of saliva from 45 OSCC patients and 30 healthy controls were analyzed by means of univariate and multivar...
Conference Paper
Full-text available
Raman microspectroscopy is extensively used to investigate the composition and structure of a wide range of materials at microscopic level. In particular, it has been successfully applied to study the chemical content of biological samples (as biopolymers, cells and tissues) because it involves the detection of vibrational modes which are specific...
Article
Full-text available
Oral squamous cell carcinoma is a widespread cancer disease whose survival rate is strongly dependent on early diagnosis and on the degree of the malignancy. The conventional histopathology methods, which are currently the standard ones for diagnosis, are very invasive so that they can be hardly proposed as screening methods for an early and accura...
Chapter
Full-text available
The possible applications of modeling and simulation in the field of bioinformatics are very extensive, ranging from understanding basic metabolic paths to exploring genetic variability. Molecular biologists need robust computational tools to determine models that can learn to recognize DNA and amino acid sequences and assign protein structures to...
Chapter
Within technologies for the safe use of interconnected computer systems, Virtual Private Networks (VPNs) represent a segment with a remarkable development both from the commercial (both in the private sector and the public administration) and the technological side, where we see significant investments by vendors and system integrators. All these i...
Chapter
Full-text available
The purpose of this chapter is to introduce a powerful class of mathematical models: the artificial neural networks. This is a very general term that includes many different systems and various types of approaches, both from statistics and computer science. Our aim is not to examine them all (it would be a very long discussion), but to understand t...
Article
Full-text available
Prediction of various market indicators is an important issue in finance. This can be accomplished through computer models and related applications. It turned out that artificial models have both great advantages and some limitations for learning the data patterns and predicting future values of the financial phenomenon under analysis. In this pape...
Article
Full-text available
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would be sensitive to antibiotic therapy, we sought to evaluate the gene expression profiles of neutrophils in CF patients before treatment in comparison with non-CF healthy individuals and after antibiotic treatment. Genes involved in neutrophil-mediated...
Article
Full-text available
Air pollution is today a serious problem, caused mainly by human activity. Classical methods are not considered able to efficiently model complex phenomena as meteorology and air pollution because, usually, they make approximations or too rigid schematisations. Our purpose is a more flexible architecture (artificial neural network model) to impleme...
Article
Full-text available
The application of web marketing and definition of corporate strategies has become common practice in all companies, together with the use of mathematical models as a tool for planning and studying the dynamics of communication within the market. We apply an unsupervised artificial neural network for the classification of a series of olive farms to...
Conference Paper
Full-text available
Pesticides are chemical compounds widely used in agricultural and industrial activities, as well as domestic ones. A commercial pesticide is usually composed of active ingredients and formulants. Among the active ingredients, Deltamethrin is a pyrethroid chemical widely used for synthesizing pesticides products which are very effective in damaging...
Article
Full-text available
This manuscript is about synthetic eumelanin using the methods of Raman scattering and surface enhanced Raman scattering (SERS) to find what functional groups exist in eumelanin. The SERS signal of eumelanin is the first report and so the fundamental information about eumelanin structure may be expected. But the reviewer feels a few points should b...
Article
Full-text available
Objectives: A series of patients affected by desquamative gingivitis (DG) was investigated in order to evaluate relation patterns among clinical parameters relevant to plaque-induced periodontitis, periodontal microbiological data and the presence of DG lesions. Patients and methods: Eight oral lichen planus (OLP) and four mucous membrane pemphi...