Constantinos Constantinides

University of Bath | UB · Department of Psychology

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-methyl-D-aspartate receptors (NMDAR) play a central role in synaptic plasticity and cognition, and are implicated in the pathophysi...

The attached conference poster provides further (preliminary) results and conclusions in relation to the conference abstract.

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizoph...

Background: Schizophrenia is a complex neurodevelopmental, heritable disorder with a reduced life expectancy of approximately 15 years. Research has also shown advanced structural brain ageing in patients with schizophrenia. However, whether advanced brain ageing in schizophrenia is genetically driven remains unclear. Here, we hypothesised that hig...

Purpose Achondroplasia (ACH) is the most common form of skeletal dysplasia, resulting in disproportionate short stature and medical complications. We review the literature on physical functioning, psychosocial function, and quality of life (QoL) in ACH individuals compared to average stature individuals or other short stature conditions. Studies th...