Constantinos Constantinides

University of Bath | UB · Department of Psychology

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizoph...

Neuroimaging studies consistently show advanced brain age in schizophrenia, suggesting that brain structure is often ‘older’ than expected at a given chronological age. Whether advanced brain age is linked to genetic liability for schizophrenia remains unclear. In this pre-registered secondary data analysis, we utilised a recall-by-genotype approac...

Neuroimaging studies show advanced structural 'brain age' in schizophrenia and related psychotic disorders, potentially reflecting aberrant brain ageing or maturation. The extent to which altered brain age is associated with subthreshold psychotic experiences (PE) in youth remains unclear. We investigated the association between PE and brain-predic...

This file provides (A) further details on methods and sensitivity/additional analyses and (B) Supplementary Tables and Figures as reported/being referred to in the linked research article [Constantinides C., et al. Cortex 172, 1-13 (2024). https://doi.org/10.1016/j.cortex.2023.11.015]

The attached conference poster provides further (preliminary) results and conclusions in relation to the linked conference abstract [Constantinides C., et al. European Neuropsychopharmacology, 63:e302-e303, https://doi.org/10.1016/j.euroneuro.2022.07.534]

This file provides further details on methods and sensitivity/additional analyses as reported in the linked research article [Constantinides C., et al. Mol Psychiatry 28, 1201–1209 (2023). https://doi.org/10.1038/s41380-022-01897-w]

This file provides Supplementary Tables and Figures as being referred to in the linked research article [Constantinides C., et al. Mol Psychiatry 28, 1201–1209 (2023). https://doi.org/10.1038/s41380-022-01897-w]

This file provides supplementary tables as being referred to in the linked article [Constantinides C., et al. Disability and Rehabilitation, 44:21, 6166-6178 (2022), DOI: 10.1080/09638288.2021.1963853]

Purpose Achondroplasia (ACH) is the most common form of skeletal dysplasia, resulting in disproportionate short stature and medical complications. We review the literature on physical functioning, psychosocial function, and quality of life (QoL) in ACH individuals compared to average stature individuals or other short stature conditions. Studies th...

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-methyl-D-aspartate receptors (NMDAR) play a central role in synaptic plasticity and cognition, and are implicated in the pathophysi...