Constantinos Pitsios

Constantinos Pitsios
University of Cyprus · Medical School

MD, PhD

About

61
Publications
18,469
Reads
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1,863
Citations
Introduction
Constantinos Pitsios is currently teaching Physiology and Immunology at the Medical School, University of Cyprus. His main research field is Allergology & Clinical Immunology.
Additional affiliations
September 2009 - May 2016
Harokopio University
Position
  • Assoc. Teaching Faculty Member
February 2001 - February 2004
Laiko Hospital
Position
  • Fellow
December 1997 - December 1999
Penteli Children's Hospital
Position
  • Fellow
Education
January 1997 - February 2008
March 1987 - October 1992
Sapienza University of Rome
Field of study
  • Medicina e Chirurgia

Publications

Publications (61)
Article
Introduction and objectives: Profilin is a panallergen contained in pollen, plant foods and latex. Although cross-reactivity is expected while performing skin prick tests (SPT) with allergens that contain profilin, this is not always noticed. The purpose of this study was to detect if profilin is contained in the commercial SPT extracts of pollen a...
Article
Full-text available
Clinical trials for allergen immunotherapy products’ development and approval are conducted, aiming to monitor safety and efficacy of them. Symptom scores and the use of rescue medication are the primary clinical endpoints used in the conducted clinical trials, while Quality of Life scores and symptom-free days are measurements also used as seconda...
Article
Full-text available
Allergen Immunotherapy (AIT) is a well-established, efficient, and safe way to treat respiratory and insect-venom allergies. After determining the diagnosis of the clinically relevant culprit allergen, AIT can be prescribed. However, not all patients are eligible for AIT, since some diseases/conditions represent contraindications to AIT use, as des...
Article
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Introduction and objectives: In order to investigate food allergy's prevalence, risk factors and eating behavior of children with relevant anamnesis, a study was performed in Cypriot primary schools. Patients: A specially composed questionnaire for self-reported adverse reactions to food, created in the context of the EuroPrevall study, was dist...
Article
Objective; Although systemic reactions (SRs) due to allergen immunotherapy (AIT) are rare, preventing them is a major concern for allergologists. Natural exposure during pollen season is a controversial risk factor, so some centers reduce AIT's maintenance dose in-season. The aim of this study was to examine whether administering the maintenance do...
Conference Paper
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus. EoE’s main symptoms in infants are vomiting, failure to thrive and food refusal, in school-age children difficulty in swallowing, vomiting and food impaction, while heartburn and chest pain are the main symptoms in puberty and adulthood1. The clinical experience has...
Article
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The continuous advancement of biomedical sciences has offered an extreme boost in improving the diagnosis and therapy of allergic diseases [...]
Article
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It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. We present two cases of COVID-19 vaccine-induced pityriasis rosea. Skin lesions appeared in a 49...
Article
Full-text available
Background Guidelines for management of patients with allergic conditions are available, but the added value of nurses, allied health care professionals (AHPs) and general practitioners (GPs), in the management of allergic disease has not been fully clarified. The European Academy of Allergy and Clinical Immunology (EAACI) appointed a task force to...
Article
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Background: School nurses play an important role in coping with food allergy (FA) in schoolchildren, but in schools with no school nurse, the school personnel should be prepared to manage health emergencies. This study aimed to evaluate allergy management competences in primary schools in Cyprus. Methods: The study was conducted September 2016 t...
Article
Purpose Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease. Most EoE patients have atopic comorbidities and they test positive when allergy tests are performed. Our aim is to critically assess the relation of allergens detected by allergy tests with clinically confirmed triggers of EoE. Methods A systemic review and meta...
Article
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Mobile Health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health‐related services, data flow and information, patient self‐management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunol...
Article
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Community pharmacists can play an important role by supplying EAI, offering instructions on its correct use and storage, and assisting patients who are experiencing anaphylaxis (4,5). However, it has been reported that there are gaps in pharmacists' knowledge on anaphylaxis and on EAI use (6-9). Therefore, it has been proposed that they should be a...
Article
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Background: Recommendations on contraindications to allergen immunotherapy (AIT) have been independently developed by National and International Societies/Academies. AIT contraindications are mainly based on case reports, case-series, or experts' opinion, while evidence-based information is limited. The aim of the present review was to describe ex...
Article
Adherence to allergen immunotherapy (AIT) is crucial for its efficacy. Subcutaneous AIT requires monthly visits (or more extended in the case of venom immunotherapy), while sublingual is performed with a daily intake of allergen drops. Non-adherence to an AIT schedule and premature discontinuation are common problems. Results from various studies h...
Article
Background: The long-term protection provided by venom immunotherapy (VIT) is related to the dose administered and to its long duration; the latter, however, becomes inconvenient for patients in countries like Greece, with many islanders or inhabitants of distant mountainous areas. Maintenance interval prolongation reduces the number of office vis...
Article
Full-text available
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we sought to critically assess the systematic review evidence on the effectiveness, safety and cost-effectiveness of AIT for ARC....
Article
Background: Profilin is a panallergen often responsible for cross-reactivity between pollen and plant foods. Oral allergy syndrome (OAS) consists a clinical expression of this cross-reaction, in some profilin-sensitized patients. The aim of this study was to determine the prevalence of sensitization to profilin in Greece and to examine the correlat...
Article
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis. To inform the development of clinical recommendations, we undertook a systematic review to assess the effectiveness, cost-effectiveness, and safety of AIT in the man...
Article
Full-text available
Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-e...
Article
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Background: Itraconazole can be used in the treatment of allergic bronchopulmonary aspergillosis (ABPA), as add-on therapy to antiasthmatic medications. Description of the case: The case of an 83-year-old male with asthma, newly diagnosed with ABPA, is presented. A daily itraconazole dose of 100 mg managed to efficiently control eosinophilia and r...
Article
Full-text available
Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee, vespid or ant sting. Systemic allergic sting reactions have been reported in up to 7.5% of adults and up to 3.4% of children. They can be mild and restricted to the skin or moderate-to-severe with a risk of life-threatening anaphylaxis. Patients shou...
Article
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis. In order to inform the development of clinical recommendations, we undertook a systematic review to assess the effectiveness, cost-effectiveness and safety of AIT i...
Article
Background: Allergen immunotherapy (AIT) is the only disease-modifying treatment in allergy but several contraindications limit its use. Objective: To collect the outcome of using AIT in theoretically contraindicated situations in real patients in the Contraindications to Specific ImmunoTherapy (CONSIT) survey. Methods: The CONSIT is an electr...
Article
Full-text available
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of allergic rhinoconjunctivitis....
Article
Full-text available
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy. ME...
Article
Full-text available
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy....
Article
Full-text available
Erythema multiforme is mainly caused by drug allergy and infections. This is the case of a HIV-positive, 49-year-old male, recently cured for syphilis, that presented erythema multiforme minor, five days after taking sildenafil. He had a fast recovery, only with the use of antihistamines. Cell-mediated allergy to sildenafil was confirmed six months...
Article
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Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Insect Venom Allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy. Methods: We w...
Article
Full-text available
Adherence to allergen immunotherapy is important for its effectiveness. There is currently limited data available on allergen immunotherapy adherence outside of clinical trials i.e. in real-life clinical practice. As part of a European Academy of Allergy and Clinical Immunology Immunotherapy Interest group initiative, we endeavoured to design a sur...
Article
Clinical indications for allergen immunotherapy (AIT) in respiratory and Hymenoptera venom allergy are well established; however, clinical contraindications to AIT are not always well documented. There are some discrepancies when classifying clinical contraindications for different forms of AIT as 'absolute' or 'relative'. EAACI Task Force on 'Cont...
Article
BackgroundA combination of PPIs and corticosteroids is the pharmacotherapy mostly used to treat eosinophilic esophagitis (EoE), while dietetic manipulations consist also an efficient option. The aim of this study was to compare the efficacy of allergy-test-driven elimination diet in children with mild symptoms of EoE to a group of children with mod...
Article
Full-text available
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on th...
Article
Full-text available
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on th...
Article
Full-text available
The aims of this study were to evaluate the implication of food allergy as a cause of paediatric constipation and to determine the diet period needed to tolerate the constipation-causing foods. Fifty-four children aged 6 months to 14 years (median, 42 months) suffering from chronic constipation (without anatomic abnormalities, cοeliac disease or hy...
Article
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The aim of this study is to evaluate the usefulness of Free Running Asthma Screening Test (FRAST) as a method that may help the diagnosis of exercise-induced bronchospasm (EIB) in children from a rural area and to compare the results with their history of asthma. A FRAST challenge took place at 9 schools. It lasted for 6 minutes and pupils performe...
Article
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Respiratory type-IV hypersensitivity reactions due to corticosteroids is a rare phenomenon. We describe two such cases. The first is a 37- year-old atopic woman who developed labial angioedema and nasal itching after the use of budesonide nasal spray. A month later, after the first puffs of a formoterol/budesonide spray prescribed for asthma, she n...
Article
Skin testing is the diagnostic cornerstone for allergies and is considered extremely safe. It is usually performed with the prick and the prick-to-prick method. The aim of this study is to report the first two pediatric cases of systemic allergic reactions during skin prick tests (SPT) with commercial food allergens. Both patients had a history of...
Article
Full-text available
Skin testing is a reliable and safe way to diagnose IgE-mediated allergies, with rare side-effects. Two cases of systemic allergic reactions during skin testing to food allergens are hereby reported. A 28-year-old male reported allergic reactions, mild to moderate in severity, each time he tasted fish in the frame of his professional duties. During...
Article
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CD69 is the earliest activation marker newly synthesized and expressed during T lymphocyte activation. In this study, a whole-blood flow-cytometry-based assay was used to assess expression of the activation antigen CD69 on CD4 and CD8 T lymphocytes, and the co-expression of CD69 and CD28 on T cells. The expression of CD69 was studied in both unstim...
Article
Full-text available
Pollen, glandular glycoproteins and honeybee’s body constituents are the main substances included in honey which are considered to be responsible for honey allergy. In this paper two cases of atopic patients who developed systemic reactions upon eating honey are described. The first case is that of a male patient who reported rhinitis, conjunctivi...
Article
Physicians who practice alternative medicine often prescribe bee pollen as a food supplement and a treatment for various ailments. To determine the qualitative and quantitative composition of bee pollen and to investigate the cutaneous reactivity of atopic patients to bee pollen extracts. The absolute number of pollen grains per gram of bee pollen...
Article
An IgE-mediated allergic reaction to an antihistamine sounds like a paradox and is rare. To describe 2 patients with anaphylaxis caused by mizolastine. In one patient, differential diagnosis from food allergy was necessary, whereas in the other patient, the history was clear. History and in vivo skin testing were used for diagnosis. A challenge tes...
Article
The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). Sixty-one patients were recruited from 3 referral allergy centers....
Article
Full-text available
In summary, in patients with deep vein thrombosis not associated with classic predisposing factors, the diagnostic work up should include a duplex sonography, an abdominal MRI, or CT scan to exclude developmental abnormalities of the IVC.
Article
Full-text available
The appearance of more than one physical urticaria (PU) in the same patient has been documented; cold urticaria or dermatographism in association with some other type of PU are encountered more frequently. Three female patients exhibiting multiple PUs simultaneously are presented. In one female patient four different forms of PU could be shown with...

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Project (1)
Project
To prepare guidelines on allergen immunotherapy based on the metaanalysis of literature research. I am involved by EAACI on the insect venom immunotherapy.