Conor Kerley

Phytaphix

Male gender, age over 40 years, cancer, diabetes mellitus, and chronic respiratory and cardiovascular disease have each been associated with increased severity of disease, including ARDS, after SARS-CoV-2 infection.1,2 We hypothesize that nutrition might also play a role. Vitamin D (25OHD) deficiency has previously been linked to a greater suscepti...

Background Randomised controlled trials (RCTs) exploring the potential of vitamin D to prevent acute respiratory infections have yielded mixed results. Individual participant data (IPD) meta-analysis has the potential to identify factors that may explain this heterogeneity. Objectives To assess the overall effect of vitamin D supplementation on th...

Introduction: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD) prevention and treatment. It is likely that the serum response to vitamin D supplementation contributes to its effectiveness. Multiple factors affect serum vitamin D 25(OH)D response to supplementation. Methods: We conducted post-hoc analysis of two double-b...

Dietary nitrate may improve exercise tolerance in some healthy and clinical populations. Existing data regarding dietary nitrate in COPD is inconsistent. We conducted a 14d double-blind, randomised, placebo-controlled, crossover trial of daily nitrate-rich beetroot juice (BRJ; 12.9 mmol) versus nitrate-depleted BRJ (PL; 0.5 mmol). At baseline and a...

Growing evidence has emerged about the role of dietary patterns and components in heart failure (HF) incidence and severity. The objective here is to provide a comprehensive summary of the current evidence regarding dietary patterns/components and HF. A comprehensive search of online databases was conducted using multiple relevant keywords to ident...

Background. Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate the association between 2 VDR polymorphisms and uncontrolled paediatric asthma. Methods. 44 asthmatic children and 57 health...

Evidence supporting the role of nutrition in heart failure (HF) incidence and severity is growing. A comprehensive search of online databases was conducted using relevant keywords to identify human studies including diet and HF. Several plant-based diets have consistently been associated with decreased HF incidence and severity, notably the Dietary...

Purpose of review: There is a growing body of evidence that nutritional factors influence the incidence of heart failure (HF). The current manuscript aims to collate evidence relating to nutritional intervention in the treatment of HF as well as to provide context regarding challenges and opportunities in the field. Recent findings: Despite the...

Dietary nitrate has been shown to increase nitrate/nitrite levels and decrease blood pressure (BP) in multiple populations. There are few reports among hypertensives and these reports have provided conflicting evidence. We aimed to assess the effect of daily nitrate compared with placebo in subjects with uncontrolled hypertension (HTN). On day 0, h...

Background: A previous aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Whether this effect is restricted to patients with low baseline vitamin D status is unknown. Methods: For this systematic review and...

Purpose of review: Early interventional trials reported improvements in cardiac and exercise outcomes with inorganic nitrate ingestion. The current review aims to provide a brief update of recent evidence regarding ergogenic and cardiovascular effects of dietary nitrate and practical recommendations. Recent findings: Recent evidence has been inc...

Objectives Data suggest a potential role for vitamin D in autism spectrum disorder (ASD). We wanted to assess the effect of vitamin D3 supplementation compared with placebo in children with ASD. Design This was a double-blind, randomised, placebo-controlled trial. Setting A paediatric outpatient centre at high latitude over the winter season in D...

Background: Dietary nitrate has been shown to increase nitrate/nitrite levels in multiple populations, with potential blood pressure lowering effects. However, there are few reports among hypertensives. Aims: We aimed to assess the effect of daily nitrate in subjects with controlled hypertension vs. uncontrolled hypertension. Methods: On day 0...

Vitamin D Receptors TaqI Gene Variant in Exon 9 and ApaI in Intron 8 in uncontrolled paediatric asthma. Hutchinson K1,4, Kerley CP3,Cormican L2, Faul J2,Greally P3,Coghlan D3, Louw M1, Elnazir B3 , Rochev Y4. 1. Biomnis Ireland, Sandyford, Dublin 18, Ireland. 2. Asthma Research Centre, Connolly Hospital, Dublin 15, Ireland. 3. Adelaide and Meath...

Study objectives: Our group and others have reported a high rate of vitamin D deficiency in obstructive sleep apnoea syndrome (OSAS), where vitamin D levels (25(OH)D) correlate negatively with OSAS severity and some of its associated metabolic alterations. Data regarding vitamin D supplementation in OSAS are lacking. We wanted to evaluate the effe...

Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ing...

Since Vitamin D has anti-inflammatory effects we wondered whether the association between low serum 25OHD and airway obstruction in moderate persistent asthma might be explained by inflammatory pathways that worsen asthma. All subjects examined were Irish Caucasians with moderate persistent asthma and none took systemic steroid therapy. In addition...

Background: Observational and mechanistic data suggest a role for vitamin D in childhood asthma. However, subsequent interventional trials have been inconsistent. We aimed to assess the effect of 15 weeks of vitamin D3 supplementation compared to placebo in Irish asthmatic children. Methods: We conducted a double-blind, randomized, placebo-contr...

div class="title">The prevalance of iron deficiency anaemia in heart failure and non-heart failure controls - Volume 75 Issue OCE3 - C.P. Kerley, N. Glezeva, C.J. Watson, K. McDonald, M. Ledwidge

Study objectives: To evaluate vitamin D (25(OH)D) levels in obstructive sleep apnea syndrome (OSAS) and possible relationships to OSAS severity, sleepiness, lung function, nocturnal heart rate (HR), and body composition. We also aimed to compare the 25(OH)D status of a subset of OSAS patients compared to controls matched for important determinants...

We and others have recently demonstrated that acute consumption of dietary nitrate can improve exercise capacity in COPD subjects. These studies are limited by their acute nature. In this uncontrolled, pilot study we wanted to asses the chronic effect of dietary nitrate supplementation in COPD. At baseline we assessed exercise tolerance with the in...

Introduction Non ischaemic dilated cardiomyopathy (NIDCM) and resistant hypertension (HTN) are common, chronic diseases. Blood nitrate/nitrite indicate nitric oxide (NO) bioavailability and levels are typically lower in NIDCM and HTN compared to controls indicating perturbed nitric oxide (NO) metabolism. In addition to the well-characterised L-argi...

Vitamin D deficiency (VDD) is highly prevlalent worldwide, with adverse effects on bone health but also potentially other unfavourable consequences. VDD and asthma-incidence/severity share many common risk factors, including winter season, industrialization, poor diet, obesity, dark skin pigmentation, and high latitude. Multiple anatomical areas re...

Vitamin D deficiency (VDD) is highly prevlalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D...

The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity. We hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in COPD subjects. Eleven COPD s...

Vitamin D deficiency is highly prevalent during winter in Northern European countries. Diet and lack of sun exposure are known to be the cause of vitamin D deficiency in Ireland, but its link with airway obstruction in asthma is unclear.

Supplemental dietary nitrate for chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled, crossover trial - Volume 72 Issue OCE3 - C. P. Kerley, K. Cahill, K. Bolger, K. Fennell, A. O'Brien, A. McGowan, C. Burke, J. L. Faul, L. J. Cormican

Serum vitamin D and its association with lung function and inflammation in subjects with respiratory symptoms - Volume 71 Issue OCE2 - C. P. Kerley, K. Hutchinson, K. Bolger, L. J. Cormican, C. M. Burke, J. L. Faul