Connor Brenna

Connor Brenna
University of Toronto | U of T · Department of Anesthesiology & Pain Medicine

MD

About

40
Publications
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90
Citations

Publications

Publications (40)
Article
Full-text available
Background The expectation of pandemic-induced severe resource shortages has prompted authorities to draft and update frameworks to guide clinical decision-making and patient triage. While these documents differ in scope, they share a utilitarian focus on the maximization of benefit. This utilitarian view necessarily marginalizes certain groups, in...
Article
Objective : To examine the role of explainability in machine learning for healthcare (MLHC), and its necessity and significance with respect to effective and ethical MLHC application. Study Design and Setting : This commentary engages with the growing and dynamic corpus of literature on the use of MLHC and artificial intelligence (AI) in medicine,...
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Full-text available
Unique reports of suicide and euthanasia date back more than 2 millennia, reflecting evolving philosophies of death and dying as expressions of the mores dominating a given era. One longstanding theme in the history of decisions to die has been staunch opposition founded in religious claims that one’s body is a trust from the divine (and therefore...
Article
Emerging evidence, based on the synthesis of reports from past infectious disease-related public health emergencies, supports an association between previous pandemics and a heightened risk of suicide or suicide-related behaviours and outcomes. Anxiety associated with pandemic media reporting appears to be one critical contributing factor. Social i...
Article
Objective: The purpose of this systematic review and meta-analysis is to examine the effect of DEX on delayed dNCR (cognitive dysfunction ≥ 1 week postoperative) after cardiac surgery. Background: DEX has salutary effects on cognitive outcomes following cardiac surgery, however, studies are limited by inconsistent assessment tools, timing, and d...
Article
Purpose of Review Perioperative neurocognitive disorders are common following surgery and have serious socioeconomic impacts. Despite this, these disorders remain under recognized and underdiagnosed. To facilitate detection and direct patients towards appropriate preventative interventions, assessment of cognition during the perioperative period is...
Article
Objective: Mechanical endovascular thrombectomy (EVT) is an increasingly relied-on treatment for clot retrieval in the context of ischemic strokes, which otherwise are associated with significant morbidity and mortality. Despite several known risks associated with this procedure, there is a high degree of technical heterogeneity across both center...
Article
Full-text available
Preexisting cognitive impairment is an important, but underrecognized, predictor of postoperative neurocognitive dysfunction, a common and important sequela of surgery. We have applied computerized neuropsychological testing as an efficient and reliable means of detecting preexisting cognitive impairment in two studies of cardiac and noncardiac sur...
Article
Animal model research is insufficient to guide the application of novel therapies in human patients, but the same objections should apply to human trials which do not representatively sample sexes in the population. Female participants have historically been excluded from anaesthesia research due to concerns of potential teratogenicity and unfounde...
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Full-text available
Carotid-cavernous fistulas (CCFs) are abnormal connections between the carotid arterial system and the cavernous sinus. These acquired vascular malformations may result in severe orbital congestion and sight-threatening complications. The authors present their experience in gaining access to the superior ophthalmic vein to embolize indirect CCFs in...
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The four-principle approach to medical ethics, balancing prima facie obligations to beneficence, nonmaleficence, autonomy, and justice, has supplied a common language for the application of ethical analysis to medical practice for the last four decades. The frayed edges of this edifice are made visible, however, by the ongoing COVID-19 pandemic (an...
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Full-text available
Anatomical dissection is almost ubiquitous in modern medical education, masking a complex history of its practice. Dissection with the express purpose of understanding human anatomy began more than two millennia ago with Herophilus, but was soon after disavowed in the third century BCE. Historical evidence suggests that this position was based on c...
Article
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy of the adrenal cortex. This study characterizes a single-institution cohort of children treated for ACC, and explores the relationship between clinical outcomes of ACC and germline TP53 mutation status. We performed a retrospective chart review of 23 consecutive pediatric patients with...
Article
Background: Carotid-cavernous fistulas (CCFs) are abnormal communications between the arterial and venous circulation within the cavernous sinus, manifesting in myriad neurological and ophthalmological sequalae. In rare circumstances patients' unique vascular anatomies preclude standard endovascular treatment for this pathology, warranting combined...
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Full-text available
Spinal hemangioblastomas represent unique operative challenges given their exquisite vascularity and rare incidence. Herein, we present a case of a 50-year-old gentleman with progressive cauda equina syndrome secondary to a lumbosacral sHGB. The lesion exhibited vascular shunting and dilation of veins tracking the entire spinal cord. We performed a...
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Full-text available
Background: The number of unmatched Canadian Medical Graduates (CMGs) has risen dramatically over the last decade. To identify long-term solutions to this problem, an understanding of the factors contributing to these rising unmatched rates is critical. Methods: Using match and electives data from 2009-2019, we employed machine learning algorith...
Article
Objective To compare different methods for investigation of stable, low-risk chest pain and identify the best first-line test for patients at low or intermediate risk of coronary artery disease (CAD). Sources of information The MEDLINE database was searched for articles on chest pain investigation from 1978 to 2019 using the following key terms: ch...

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