Cleiton Augusto Libardi

Cleiton Augusto Libardi
Universidade Federal de São Carlos | UFSCar · Physical Education

PhD

About

112
Publications
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2,833
Citations
Additional affiliations
February 2013 - present
Federal University of São Carlos - UFSCar
Position
  • Professor

Publications

Publications (112)
Article
Full-text available
High-intensity resistance training (HRT) has been recommended to offset age-related loss in muscle strength and mass. However, part of the elderly population is often unable to exercise at high-intensities. Alternatively, low-intensity resistance training with blood flow restriction (LRT-BFR) has emerged. The purpose of the present study was to com...
Article
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Losses in skeletal muscle mass, strength, and metabolic function are harmful in the pathophysiology of serious diseases, including breast cancer. Physical exercise training is an effective non-pharmacological strategy to improve health and quality of life in patients with breast cancer, mainly through positive effects on skeletal muscle mass, stren...
Article
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We aimed to investigate whether muscle fiber cross‐sectional area (fCSA) and associated molecular processes could be differently affected at the group and individual level by manipulating resistance training (RT) variables. Twenty resistance‐trained subjects had each leg randomly allocated to either a standard RT (RT‐CON: without specific variables...
Article
Background: Skeletal muscle adaptations are affected by resistance training (RT)-induced acute and chronic transcriptional responses. An under-explored gene target involved in mechanotransduction is the expression of the G protein-coupled receptor 56 (GPR56). However, studies investigating the acute and chronic effects of RT manipulations on GPR56...
Article
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Background Intensive care unit-acquired atrophy and weakness are associated with high mortality, a reduction in physical function, and quality of life. Passive mobilization (PM) and neuromuscular electrical stimulation were applied in comatose patients; however, evidence is inconclusive regarding atrophy and weakness prevention. Blood flow restrict...
Article
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Context: Low-load resistance training (LL) and neuromuscular electrostimulation (NES), both combined with blood flow restriction (BFR), emerge as effective strategies to maintain or increase muscle mass. It is well established that LL-BFR promotes similar increases in muscle cross-sectional area (CSA) and lower rating of perceived exertion (RPE) a...
Article
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We sought to determine if manipulating resistance training (RT) variables differentially altered the expression of select sarcoplasmic and myofibril proteins as well as myofibrillar spacing in myofibers. Resistance-trained men ( n = 20; 26 ± 3 years old) trained for 8 weeks where a randomized leg performed either a standard (CON) or variable RT pro...
Article
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In aging populations for which the use of high loads is contraindicated, low load resistance training associated with blood flow restriction (RT-BFR) is an alternative strategy to induce muscle mass gains. This study investigates the effects of RT-BFR on muscle mass, muscle function, and quality of life of a 99-year-old patient with knee osteoarthr...
Article
Using a within-subject design we compared the individual responses between drop-set (DS) vs. traditional resistance training (TRAD) (n=16) and crescent pyramid (CP) vs. TRAD (n=15). Muscle cross-sectional area (CSA), leg press and leg extension 1 repetition maximum (1-RM) were assessed pre and post training. At group level, CSA increased from pre t...
Article
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There is emerging evidence that decreased muscle mass and cardiorespiratory fitness (CRF) are associated with increased risk of cancer-related mortality. This paper aimed to present recommendations to prescribe effective and safe exercise protocols to minimize losses, maintain or even improve muscle mass, strength, and CRF of the cancer patients wh...
Article
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Previous research has suggested that concurrent training (CT) may attenuate resistance training (RT)-induced gains in muscle strength and mass, i.e.‚ the interference effect. In 2000, a seminal theoretical model indicated that the interference effect should occur when high-intensity interval training (HIIT) (repeated bouts at 95–100% of the aerobic...
Article
Introduction: Exercise-induced microRNAs (miRNAs) expression has been implicated in the regulation of skeletal muscle plasticity. However, the specificity and acute time course in miRNA expression following divergent exercise modes are unknown. In a randomized cross-over design, we compared the acute expression profile of eight skeletal muscle miR...
Article
The concurrent training led to beneficial effects on aerobic fitness and muscle strength. However, its effects on blood pressure (BP) and autonomic control marks are little studied. This study aimed to evaluate the concurrent training effects on BP, autonomic control, aerobic fi tness and muscle strength of middle-aged men and women. Thirty-two vol...
Article
The aim of this study was to compare the effects of resistance training to muscle failure (RT-F) and non-failure (RT-NF) on muscle mass, strength and activation of trained individuals. We also compared the effects of these protocols on muscle architecture parameters. A within-subjects design was used in which 14 participants had one leg randomly as...
Article
Metabolic stress is a primary mechanism of muscle hypertrophy and is associated with microvascular oxygenation and muscle activation. Considering that drop-set (DS) and crescent pyramid (CP) resistance training systems are recommended to modulate these mechanisms related to muscle hypertrophy, we aimed to investigate if these resistance training sy...
Article
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This study investigated the relationship between repeated-sprint ability, aerobic capacity, and oxygen uptake kinetics during the transition between exercise and recovery (off-transient) in female athletes of an intermittent sport modality. Eighteen professional soccer players completed three tests: 1) a maximal incremental exercise test; 2) a cons...
Article
The purpose was to compare the effects of protein (whey protein) and carbohydrate supplementation and protein alone both combined with resistance training on muscle strength, muscle mass and total training volume progression in untrained young men. Resistance training was performed using the leg press and knee extension until concentric failure (8−...
Article
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PurposeWe compared the effects of suspension training (ST) with traditional resistance training (TRT) on muscle mass, strength and functional performance in older adults.Methods Forty-two untrained older adults were randomized in TRT, ST (both performed 3 sets of whole body exercises to muscle failure) or control group (CON). Muscle thickness (MT)...
Article
Respiratory limitation can be a primary mechanism for exercise cessation in female athletes. This study aimed to assess the effects of IL on intercostal (IM), vastus lateralis (VL) and cerebral (Cox) oxygenation in women soccer players during high-intensity dynamic exercise. Ten female soccer players were randomized to perform in order two constant...
Article
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Background: Patients affected by hepatic cirrhosis show reductions in muscle mass and function, with poor quality of life and functional performance. As such, resistance training with blood flow restriction (BFR-RT) could be a useful therapeutic tool for health promotion. Thus, we aim to verify the effects of this intervention on muscle strength,...
Article
Full-text available
Bergamasco, JGA, Gomes da Silva, D, Bittencourt, DF, Martins de Oliveira, R, Júnior, JCB, Caruso, FC, Godoi, D, Borghi-Silva, A, and Libardi, CA. Low-load resistance training performed to muscle failure or near muscle failure does not promote additional gains on muscle strength, hypertrophy, and functional performance of older adults. J Strength Co...
Article
Full-text available
The aim of this study was to compare the effect of self-selected repetition duration (SELF), with and without volume load (VL) equalized with controlled repetition duration (CON) on muscle strength and hypertrophy in untrained males. We used a within-subjects design in which 20 volunteers (age: 24.7 ± 2.9 years) had one leg randomly assigned to CON...
Article
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Scarpelli, MC, Nóbrega, SR, Santanielo, N, Alvarez, IF, Otoboni, GB, Ugrinowitsch, C, and Libardi, CA. Muscle hypertrophy response is affected by previous resistance training volume in trained individuals. J Strength Cond Res XX(X): 000-000, 2020-The purpose of this study was to compare gains in muscle mass of trained individuals after a resistance...
Article
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The current manuscript sets out a series of guidelines for blood flow restriction exercise, focusing on the methodology, application and safety of this mode of training. With the emergence of this technique and the wide variety of applications within the literature, the aim of this review is to set out a current research informed guide to blood flo...
Article
The manipulation of resistance training (RT) variables is used among athletes, recreational exercisers and compromised populations (e.g., elderly) attempting to potentiate muscle hypertrophy. However, it is unknown whether an individual's inherent predisposition dictates the RT-induced muscle hypertrophic response. Twenty resistance-trained young (...
Article
To optimize/maximize increases on muscle strength and mass in well resistance-trained individuals, the use of resistancetraining (RT) systems have been widely recommended by powerlifters, bodybuilders and coaches. These systems may be characterized as advanced techniques that manipulate specific RT variables emphasizing physiologic mechanisms. Howe...
Article
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Background: The current study examined the acute effects of a lower body resistance training (RT) session on physiological and thermoregulatory measures during a sub-maximal running protocol in the heat in heat-acclimatized men. Ten resistance-untrained men (age 27.4 ± 4.1 years; height 1.78 ± 0.06 m; body mass 76.8 ± 9.9 kg; peak oxygen uptake 48...
Article
The aim of this study was to compare if an acute exercise session of high-load resistance training (HL-RT, e.g. 70% of 1 repetition-maximum, 1RM) induces a higher magnitude of muscle damage compared with a RT protocol with low-loads (e.g. 20% 1RM) associated with partial blood flow restriction (LL-BFR), and investigate the recovery in the days afte...
Article
Full-text available
The current manuscript sets out a position stand for blood flow restriction exercise, focusing on the methodology, application and safety of this mode of training. With the emergence of this technique and the wide variety of applications within the literature, the aim of this position stand is to set out a current research informed guide to blood f...
Article
Full-text available
The metabolic stress induced by blood flow restriction (BFR) during resistance training (RT) might maximize muscle growth. However, it is currently unknown whether metabolic stress are associated with muscle hypertrophy after RT protocols with high- or low load. Therefore, the aim of the study was to compare the effect of high load RT (HL-RT), high...
Article
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The aim of the present study was to investigate if resistance training (RT), performed with individualized recovery between sessions (RT-IND), promotes greater gains in strength and muscle mass and reduces the variability on adaptations compared to RT with fixed recovery intervals (RT-FIX). Twenty young men (age 21.9 ± 3.3 years) were randomized in...
Article
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Background Gene expression is an important process underpinning the acute and chronic adaptive response to resistance exercise (RE) training. PurposeTo investigate the effect of training status on vastus lateralis muscle global transcriptome at rest and following acute RE. Methods Muscle biopsies of nine young men (age: 26(2) years; body mass: 69(9...
Article
Low-intensity resistance exercise with blood-flow restriction (BFR) promotes similar adaptations to high-intensity resistance exercise (HI-RE). Interestingly, BFR has been demonstrated to be effective for a wide range of occlusion pressures. However, the occlusion pressure magnitude may alter the psychophysiological stress related to BFR as measure...
Article
Damas, F, Barcelos, C, Nóbrega, SR, Ugrinowitsch, C, Lixandrão, ME, Santos, LMEd, Conceição, MS, Vechin, FC, and Libardi, CA. Individual muscle hypertrophy and strength responses to high vs. low resistance training frequencies. J Strength Cond Res XX(X): 000-000, 2018-The aim of this short communication was to compare the individual muscle mass and...
Article
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Introduction: Low-intensity endurance training performed with blood flow restriction (ET-BFR) can improve muscle strength, cross-sectional area (CSA) and cardiorespiratory capacity. Whether muscle strength and CSA as well as cardiorespiratory capacity (i.e.:V˙O2max) and underlying molecular processes regulating such respective muscle adaptations a...
Article
Context: Given the comparable muscle hypertrophy constantly observed between blood-flow restriction exercise (BFR-RE) and conventional resistance exercise, understanding their particular rating of perceived exertion (RPE) and pain may help to better prescribe exercise at a low-discomfort level, thus increasing its feasibility. Design: Randomized...
Article
We aimed to investigate the mechanisms underlying muscle growth after 12 weeks of RT-BFR and HRT in older individuals. Participants were allocated into the groups HRT, RT-BFR and control (CG). High-throughput transcriptome sequencing was performed by the Illumina HiSeq2500 platform. HRT and RT-BFR presented similar increases in quadriceps femoris C...
Article
The aim of the study was to compare the effect of resistance training (RT) frequencies of five times (RT5), thrice- (RT3) or twice- (RT2) weekly in muscle strength and hypertrophy in young men. Were used a within-subjects design in which 20 participants had one leg randomly assigned to RT5 and the other to RT3 or to RT2. 1 RM and muscle cross-secti...
Presentation
Full-text available
Verificar se o TF realizado com intervalo de recuperação entre sessões de forma individualizada (TF-IND) promove maior aumento na força e hipertrofia muscular que o TF realizado com intervalos de fixos recuperação (TF-FIX).
Presentation
Full-text available
Verificar se o TF realizado com intervalo de recuperação entre sessões de forma individualizada (TF-IND) promove maior aumento na força e hipertrofia muscular do que o TF realizado com intervalos de recuperação fixos entre as sessões (TF-FIX).
Article
Full-text available
Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process. Despite substantial advances, we are far from understanding exactly how muscle hypertrophy develops during RT. The aim of the present review is to discuss new insights related to the role of skeletal muscle damage and muscle protein synthesis (MPS) in mediat...
Article
Introduction: The myonuclear domain theory postulates that myonuclei are added to muscle fibres when increases in fibre cross-sectional area (i.e. hypertrophy) are ≥26%. However, recent studies have reported increased myonuclear content with lower levels (e.g. 12%) of muscle fibre hypertrophy. Purpose: To determine whether a muscle fibre hypertr...
Article
Full-text available
Background Low-load resistance training (< 50% of one-repetition maximum [1RM]) associated with blood-flow restriction (BFR-RT) has been thought to promote increases in muscle strength and mass. However, it remains unclear if the magnitude of these adaptations is similar to conventional high-load resistance training (> 65% 1RM; HL-RT). Objective To...
Article
The aim of the present study was to compare the effects of self-selected and fixed repetition duration (RD) on resistance exercise (RE) volume, muscle activation, time under tension (TUT) per repetition and per session. Twelve resistance-trained men participated in the study. A randomized cross-over design was utilized and each participant performe...
Article
Full-text available
Satellite cells (SC) are associated with skeletal muscle remodelling after muscle damage and/or extensive hypertrophy resulting from resistance training (RT). We recently reported that early increases in muscle protein synthesis (MPS) during RT appear to be directed toward muscle damage repair, but MPS contributes to hypertrophy with progressive mu...
Article
The aging process is associated with several changes in the elderly such as the decrease in cardiorespiratory fitness, strength and muscle mass, in addition to chronic low-grade inflammation. Concurrent training with blood flow restriction can be an interesting alternative to improve functional capacity with low mechanical stress in the elderly. Th...
Article
The present study aimed to compare the early metabolic response between high-load resistance exercise (HL-RE) and low-load resistance exercise with blood flow restriction (LL-BFR). Nine young well-trained men participated in a randomized crossover design in which each subject completed LL-BFR, HL-RE or condition control (no exercise) with a one-wee...
Article
This study was conducted to determine the effects of inspiratory muscle training (IMT) on respiratory and peripheral muscles oxygenation during a maximal exercise tolerance test and on repeated-sprint ability (RSA) performance in professional women football players. Eighteen athletes were randomly assigned to one of the following groups: SHAM (n =...
Article
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13...
Article
Introduction We investigated acute hemodynamic responses during resistance exercises performed with small and large muscle mass, comparing high intensity resistance exercises and low intensity resistance exercise with blood flow restriction. Summary of facts and results In a randomized crossover design, 15 sedentary men aged 40–60 years performed...
Article
Full-text available
Purpose The aim of this study was to compare the effects of crescent pyramid (CP) and drop-set (DS) systems with traditional resistance training (TRAD) with equalized total training volume (TTV) on maximum dynamic strength (1-RM), muscle cross-sectional area (CSA), pennation angle (PA) and fascicle length (FL). Methods Thirty-two volunteers had th...
Article
Full-text available
Purpose: Autophagy is an intracellular degradative system sensitive to hypoxia and exercise-induced perturbations to cellular bioenergetics. We determined the effects of low-intensity endurance-based exercise performed with blood-flow restriction (BFR) on cell signaling adaptive responses regulating autophagy and substrate metabolism in human skel...
Article
Introduction: Physical inactivity is considered as one of the factors to increase the risk of developing cardiovascular diseases (CVDs) and decrease aerobic fitness mainly in middle-age. Increased habitual physical activity (HPA) is one of the strategies recommended to reduce physical inactivity. However, it is not known whether middle-age individu...
Article
The purpose of the present study was to investigate the effects of resistance training (RT) at high- and low-intensities performed to muscle failure or volitional interruption on muscle strength, cross-sectional area (CSA), pennation angle (PA) and muscle activation. Thirty-two untrained men participated in the study. Each leg was allocated in one...
Article
The aim of the present study was to compare hemodynamic responses between blood flow-restricted resistance exercise (BFR-RE), high-intensity resistance exercise (HI-RE) and low-intensity resistance exercise (LI-RE) performed to muscular failure. 12 men (age: 20±3 years; body mass: 73.5±9 kg; height: 174±6 cm) performed 4 sets of leg press exercises...
Article
Full-text available
Reduction in the volume daily physical activity (VAF – number of steps) and in the intensity of daily physical activity (IAF- average walk velocity) are related with higher incidence of falls and increase of incidence of chronic diseases in elderly. However, the identification of factors which may increase the VAF and the IAF became essential, espe...
Article
BACKGROUND: Female athletes are more susceptible to expiratory flow limitation and arterial hypoxemia during high-intensity exercise compared to men, which might induce to diaphragmatic fatigue with negative consequences to muscle blood flow supply to respiratory and peripheral muscles. AIM: To assess the impact of inspiratory resistive loading (IR...
Article
This study analysed the time course of the global metabolic acute response after resistance exercise (RE), with the use of proton nuclear magnetic resonance ((1)H NMR) spectroscopy. Ten young healthy males performed 4 sets of 10 repetitions at 70% of one-repetition maximum in the leg press and knee extension exercises and had the serum metabolome a...
Article
Full-text available
Introduction Aging has been shown to be associated with decreases in brain and muscle tissues, accompanied by dysfunction in cognition and functionality, respectively. Resistance training (RT) has been widely recommended to mitigate muscle loss but its effects on brain tissue are still unclear. Purpose This study verified the effects of 12 weeks of...
Article
BACKGROUND AND OBJECTIVE: Maximal voluntary isometric contraction (MVIC) is used to determine both peak torque (PT) and rate of torque development (RTD). Familiarization sessions are usually performed to stabilize PT and RTD when performing MVIC. However, it is not clear how many familiarization sessions are required to achieve such stability in di...