Cleber Ferraresi

Cleber Ferraresi
Universidade Federal de São Carlos | UFSCar · Departamento de Fisioterapia (DFisio)

PT, MS, PhD

About

68
Publications
34,594
Reads
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1,402
Citations
Introduction
Graduated in Physical Therapy at Federal University of Sao Carlos (UFSCar), Specialist in Exercise Physiology, master degree and PhD in Biotechnology with partial time at Wellman Center for Photomedicine, MGH-Harvard and University of Waterloo. Dr Cleber Ferraresi was a Postdoctoral Research Fellow at MGH-Harvard. Currently he is a Professor and Principal Investigator at UFSCar. He has experience with photobiomodulation therapy (lasers and LEDs), physical exercise, fatigue, muscle damage, sports
Additional affiliations
August 2018 - December 2020
Brasil University
Position
  • Professor (Full)
June 2016 - December 2018
Universidade do Sagrado Coração
Position
  • Professor (Assistant)
February 2015 - December 2015
Wellman Center for Photomedicine - Massachusetts General Hospital - Harvard Medical School
Position
  • PostDoc Position
Education
May 2014 - August 2014
December 2012 - July 2013
Harvard Medical School
Field of study
  • Light-therapy applied to physical exercise
September 2010 - December 2014
Universidade Federal de São Carlos
Field of study
  • Light-therapy applied to physical exercise

Publications

Publications (68)
Article
Background: Insulin resistance (IR) is the main risk factor for the development of type 2 diabetes mellitus (DM2). Noninvasive and nonpharmacological therapies, such as exercise and diet are effective in treating IR and DM2; however, adherence to them generally is low and diminishes positive effects in the long term. Photobiomodulation therapy (PBM...
Article
Full-text available
Background Insulin resistance (IR) is the main risk factor for developing type 2 diabetes. Both strength training (ST) and photobiomodulation therapy (PBMt) reduce IR, but the effect of combining different volumes of ST with PBMt is unknown. Methods Overweight/obese individuals will be assigned to 4 groups (n = 12/group): ST with volume following...
Article
Full-text available
This study verifies the acute dose response effect of photobiomodulation (PBM) by light emitting diodes (LEDs) on hemodynamic and metabolic responses in individuals with type 2 diabetes mellitus (T2DM). Thirteen participants with T2DM (age 52 ± 7 years) received PBM by a light-emitting diode array (50 GaAIAs LEDs, 850 ± 20 nm, 75 mW per diode) on t...
Article
Full-text available
Chitosan-based glycerol-plasticized membranes were prepared aiming to develop low-cost and biocompatible material for wound dressing. They were produced by casting/solvent evaporation, and their formation mechanisms were attributed to intra- and inter-hydrogen bonds between materials. The results show that the glycerol acted as plasticizer and chan...
Article
Full-text available
Purpose The aim of the current study was to investigate the effects of photobiomodulation therapy (PBMT) applied 30 min or 6 h prior to cycling on blood flow velocity and plasma nitrite concentrations at rest, time to exhaustion, cardiorespiratory responses, blood acid-base balance, and K ⁺ and lactate concentrations during exercise. Methods In a...
Article
Objective: To investigate the recovery of male water polo athletes applying full body photobiomodulation therapy (PBMT) regarding inflammation and muscle damage markers, testosterone and cortisol hormonal responses, heart rate variability (HRV), maximal voluntary contraction, and squat jump (SJ) after official water polo matches. Background: PBMT...
Article
Background: Photobiomodulation therapy (PBMT) by lasers or light-emitting diodes (LEDs) has been used in the last two decades to increase muscle performance in humans. The main findings of PBMT on muscle performance are increment in torque and number of muscle contractions, and fatigue resistance in high-intensity exercises. Although there are sugg...
Article
Full-text available
The aim was to analyze the effect of neuromuscular electrical stimulation (NMES) and photobiomodulation (PBMT) on cardiovascular parameters, hemodynamic function, arterial baroreflex sensitivity (BRS), and autonomic balance (ANS) of rats with heart failure (HF). Male Wistar rats (220-290g) were organized into five groups: Sham (n=6), Control-HF (n=...
Article
Objective: To evaluate the influence of two different photobiomodulation therapy (PBMT) protocols (red 660 nm vs. infrared 830 nm) combined with a blood flow restriction (BFR) training protocol in wrist extensor muscles on handgrip, wrist extension force, and electromyographic behavior [root mean square (RMS)]. Background: PBMT has been widely used...
Article
Full-text available
To investigate the effects of photobiomodulation applied to respiratory muscles on lung function, thoracoabdominal mobility, respiratory muscle strength, and functional capacity in COPD patients. This is a randomized double-blind crossover clinical trial. Twelve male COPD patients participated in the study. Participants were randomly allocated to r...
Article
Purpose: The purpose of the present study was to investigate the ergogenic effects of two doses of photobiomodulation therapy (PBMT) in comparison to placebo on markers of respiratory and muscle activity, blood acid-base, ion and lactate concentrations, indicators of muscle fatigue (global, central, and peripheral), and time to exhaustion in sever...
Article
Full-text available
Exposure of biological tissue to photobiomodulation therapy (PBMT) seems to increase the oxygen availability and mitochondrial electrochemical activity. With the advancement of new technologies, such as near-infrared spectroscopy (NIRS), information can be obtained about the balance between oxygen utilization and delivery by assessing local oxy- ([...
Article
Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm², PBMT 30...
Article
This systematic review analyzed the light parameters and effects of photobiomodulation therapy (PBMT) through low‐level laser therapy (LLLT) and/or LED (light‐emitting diode) on tendon repair of rats submitted to calcaneal injury. This study was conducted in accordance with the guidelines of the Preferred Reporting Items for Meta‐Analysis, and PubM...
Article
Full-text available
To evaluate the photobiomodulation (PBM) effect on the cardiovascular autonomic control, analyzed by baroreflex sensitivity (sequence method), during constant load exercise and recovery in diabetic men, we evaluated 11 men with type 2 diabetes (DM2) (40–64 years). The constant workload exercise protocol (TECC) was performed on two different days, 1...
Article
ABSTRACT Background: Photobiomodulation therapy (PBMT) and Creatine (Cr) intake have been used in conjunction with heavy training, but little is known about their possible effects during a long-term training program. Objective: We wanted to assess long-term use of PBMT and Cr in an exercise training program. Methods: Twenty-five male Wistar rats w...
Article
Full-text available
Photobiomodulation therapy (PBMT) in the infrared spectrum exerts positive effects on glucose metabolism, but the use of PBMT at the red spectrum has not been assessed. Male Swiss albino mice were divided into low‐fat control (LFC) and high‐fat diet (HFD) for 12 weeks and were treated with red (630 nm) PBMT or no treatment (Sham) during weeks 9‐12....
Article
Full-text available
RESUMO Lesões de nervos periféricos levam a perda funcional elevada no tecido muscular. Assim, muitas pesquisas têm investigado técnicas cirúrgicas, como neurorrafias, e recursos terapêuticos, como eletroestimulação, para melhorar a funcionalidade de um músculo reinervado após lesão periférica. Este estudo tem como objetivo investigar os efeitos da...
Article
The aim of this study was to evaluate the acute effects of light-emitting diode therapy (LEDT) on cardiopulmonary adjustments and muscle oxygenation dynamics during transition to moderate exercise, as well as in glucose and lactate levels in patients with type 2 diabetes mellitus (T2DM). Sixteen individuals with T2DM (age 55.1±5.4 years) performed...
Article
Full-text available
Light-emitting diodes (LEDs) might have a beneficial impact on cytochrome-c oxidase enzyme activity. Thus, it was hypothesized that photobiomodulation by light-emitting diode therapy (LEDT) could influence aerobic metabolism dynamics. Possible LEDT-mediated aerobic improvements were investigated mainly by a precise characterization of the pulmonary...
Article
Full-text available
This study investigated the effects of photobiomodulation by low-laser laser therapy (LLLT) on the activities of citrate synthase (CS) and lactate dehydrogenase (LDH) and the anaerobic threshold (AT) in rats submitted to treadmill exercise. Fifty-four rats were allocated into four groups: rest control (RCG), rest laser (RLG), exercise control (ECG)...
Article
Full-text available
Obesity represents a continuously growing global epidemic and is associated with the development of type 2 diabetes mellitus. The etiology of type 2 diabetes is related to the resistance of insulin-sensitive tissues to its action leading to impaired blood glucose regulation. Photobiomodulation (PBM) therapy might be a non-pharmacological, non-invas...
Article
Photobiomodulation (PBM) is a simple, efficient and cost-effective treatment for both acute and chronic pain. We previously showed that PBM applied to the mouse head inhibited nociception in the foot. Nevertheless, the optimum parameters, location for irradiation, duration of the effect, and the mechanisms of action remain unclear. In the present s...
Article
Full-text available
Photobiomodulation (PBM) describes the use of red or near-infrared (NIR) light to stimulate, heal, and regenerate damaged tissue. Both preconditioning (light delivered to muscles before exercise) and PBM applied after exercise can increase sports performance in athletes. This review covers the effects of PBM on human muscle tissue in clinical trial...
Article
Background and objective: Over the last decade we have seen an increased interest in the use of Low-Level Laser Therapy (LLLT) in diseases that involve increased oxidative stress. It is well established that hyperglycemia in diabetes elicits a rise in reactive oxygen species (ROS) production but the effect of LLLT remains unclear. This study aimed...
Article
Full-text available
The syndrome of heart failure (HF) promotes central and peripheral dysfunctions that result in functional capacity decrease, leading to fatigue, dyspnea, and exercise intolerance. The use of light-emitting diode therapy (LEDT) has shown good results reducing fatigue and exercise intolerance, when applied on skeletal muscles before or after exercise...
Article
In the article by C. Ferraresi et al. (DOI: http://dx.doi.org/10.1002/jbio.201400087), published in J. Biophotonics 8, 740-754 (2015), a statement regarding the approval of some data the authors used is incorrect. This erratum is published to rectify this.
Article
Species of the fungal genus Candida, can cause oral candidiasis especially in immunosuppressed patients. Many studies have investigated the use of photodynamic therapy (PDT) to kill fungi in vitro, but this approach has seldom been reported in animal models of infection. This study investigated the effects of PDT on Candida albicans as biofilms gro...
Article
Full-text available
Objective: The aim of this study was to verify how a pair of monozygotic twins would respond to light-emitting diode therapy (LEDT) or placebo combined with a strength-training program during 12 weeks. Design: This case-control study enrolled a pair of male monozygotic twins, allocated randomly to LEDT or placebo therapies. Light-emitting diode...
Article
Photobiomodulation or low-level light therapy has been shown to attenuate both acute and chronic pain, but the mechanism of action is not well understood. In most cases, the light is applied to the painful area, but in the present study we applied light to the head. We found that transcranial laser therapy (TLT) applied to mouse head with specific...
Book
Before thinking about which exercises, frequency and intensity should be used in strength training programs to achieve muscle strength, promote a healthy lifestyle, hypertrophy or improve athletic performance, we should understand firstly how a muscle contraction happens. The aim of this book is to provide you with a basic to advanced understanding...
Article
Full-text available
Background: Type 2 diabetes mellitus (DM) is responsible for a significant reduction in the quality of life due to its negative impact on functional capacity. Cardiopulmonary fitness impairment in DM patients has been associated with limited tissue oxygenation. Phototherapy is widely utilized to treat several disorders due to expected light-tissue...
Conference Paper
Full-text available
Low-level laser (light) therapy (LLLT) can be emitted by diode lasers or light-emitting diodes (LEDs). LLLT at red and near-infrared spectra increase mitochondrial membrane potential and adenosine tri-phosphate (ATP) synthesis that in turn provide part of the energy necessary for muscle contraction. Recently LLLT has been applied before, during or...
Article
Full-text available
Recently, low-level laser (light) therapy (LLLT) has been used to improve muscle performance. This study aimed to evaluate the effectiveness of near-infrared light-emitting diode therapy (LEDT) and its mechanisms of action to improve muscle performance in an elite athlete. The kinetics of oxygen uptake (VO2), blood and urine markers of muscle damag...
Article
Low-level laser (light) therapy (LLLT) has been applied over skeletal muscles before intense exercise (muscular pre-conditioning) in order to reduce fatigue and muscle damage (measured by creatine kinase, CK) in clinical trials. However, previous exercise protocols do not exactly simulate the real muscle demand required in sports. For this reason,...
Article
Recently, low-level laser (light) therapy has been used to increase muscle performance in intense exercises. However, there is a lack of understanding of the time response of muscles to light therapy. The first purpose of this study was to determine the time response for light-emitting diode therapy (LEDT)-mediated increase in adenosine triphosphat...
Chapter
Lower levels or lack of daily physical activity lead to poor aerobic fitness that is associated with chronic diseases. On the other hand, increased levels of physical activity result in many health improvements, including aerobic fitness. The understanding of aerobic fitness is fundamental, but it is also very complex in nature and comprises the st...
Book
When people think about physical exercise, they imagine athletic competitions and sculpted bodies. More than simply a way to achieve the best performance or a beautiful shape, physical exercise can promote and reestablish health. Physical therapy is a specific area of the health sciences specialized in treating and recovering the human body impaire...
Article
Full-text available
Low level laser (light) therapy has been used before exercise to increase muscle performance in both experimental animals and in humans. However uncertainty exists concerning the optimum time to apply the light before exercise. The mechanism of action is thought to be stimulation of mitochondrial respiration in muscles, and to increase adenosine tr...
Article
Full-text available
Objective: The purpose of this study was to investigate whether low-level laser (light) therapy (LLLT) can provide fatigue resistance via maximum repetitions (RM) with an isokinetic dynamometer, and decrease electromyography fatigue index (EFI). Background data: LLLT has been used to increase muscle performance when applied before or after intense...
Article
Full-text available
Light-emitting diode therapy (LEDT) applied over the leg, gluteus and lower-back muscles of mice using a LED cluster (630 nm and 850 nm, 80 mW/cm(2) , 7.2 J/cm(2) ) increased muscle performance (repetitive climbing of a ladder carrying a water-filled tube attached to the tail), ATP and mitochondrial metabolism; oxidative stress and proliferative my...
Article
Full-text available
A von Frey filament (vFF) is a type of aesthesiometer usually made of nylon perpendicularly held in a base. It can be used in paw withdrawal pain threshold assessment, one of the most popular tests for pain evaluation using animal models. For this test, a set of filaments, each able to exert a different force, is applied to the animal paw, from the...
Article
Full-text available
Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination of viruses, bacteria, spores, fungi or toxins. Dissemination may be airborne, waterborne, or by contamination of food or surf...
Article
Full-text available
The aim of this randomized double-blind placebo-controlled study was to investigate the effect of low-level laser therapy (LLLT) on markers of muscle damage (creatine kinase (CK) and strength performance) in the biceps brachii. Twenty-two physically active men were randomized into two groups: placebo and laser. All volunteers were submitted to an e...
Article
The most typical maximum tests for measuring leg muscle performance are the one-repetition maximum leg press test (1RMleg) and the isokinetic knee extension/flexion (IKEF) test. Nevertheless, their inter-correlations have not been well documented, mainly the predicted values of these evaluations. This correlational and regression analysis study inv...
Book
Muscle function has been used to measure the healthy and functional capacity of patients, sportsmen and athletes. The knowledge about muscle function and how to properly evaluate it can be determinant factors for the success of therapies during the treatment of many diseases, as well as improving muscle performance. Handgrip strength is a measure...
Article
Full-text available
The use of low level laser (light) therapy (LLLT) has recently expanded to cover areas of medicine that were not previously thought of as the usual applications such as wound healing and inflammatory orthopedic conditions. One of these novel application areas is LLLT for muscle fatigue and muscle injury. Since it is becoming agreed that mitochondri...