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Citations since 2017
6 Research Items
Clayton Mansel currently works at the Department of Biology, William Jewell College. Clayton does research in Biochemistry and Molecular Biology. His current project is 'Determining the Mechanisms of Neurodegeneration from Tributyltin (TBT) in Embryonic Mice ENS Neurons.'
Golgi fragmentation and loss of Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2) are the early key features of many neurodegenerative disorders. We investigated the link between NMNAT2 loss, Golgi fragmentation and axon degeneration. Golgi fragmentation in the cultured dorsal root ganglion (DRG) neurons resulted in caspase dependent axon...
Lead (Pb) is a teratogen that poses health risks after acute and chronic exposure. Lead is deposited in the bones of adults and is continuously leached into the blood for decades. While this chronic lead exposure can have detrimental eﬀects on adults such as high blood pressure and kidney damage, developing fetuses and young children are particular...
Tributyltin (TBT) remains a global health concern. The primary route of human exposure to TBT is either through ingestion or skin absorption, but TBT’s effects on the peripheral nervous system have still not been investigated. Therefore, we exposed in vitro sensory dorsal root ganglion (DRG) neurons to TBT at a concentration of 50-200nM, which is s...
Model organisms have proven to be instrumental in studying molecular mechanisms, the development of diagnostic tests and treatments, and providing researchers with experimental advantages such inexpensive maintenance and short generation times. Breast cancer will affect more than 1 in 8 women in the United States in the coming years. 10% of all bre...
Presented at William Jewell College’s Duke Colloquium undergraduate research symposium in April 2017
The nematode Caenorhabditis elegans will be examined as a model organism for the study of human breast cancer. C. elegans will be evaluated based on its genetic malleability and capability, observability in the lab, and phenotypic expression.
To determine the specific mechanisms of degeneration in embryonic enteric neurons in mice due to the previously observed neurotoxicity of TBT in terms of the apoptotic, calpain, and axonal pathways. Neuroserpin's ability to protect the neuron will also be explored in mice DRG neurons.
We are performing experiments to understand the role of cytoskeleton proteins, lysosomal activity, and ATP availability in the phagocytic process. We are also planning to investigate whether certain environmental toxins can interfere in the process of membrane recycling. Our data are going to provide an insight into the role of above-mentioned factors in endocytosis and shed light on endocytic mechanisms in human disease conditions.