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Introduction
Current institution
Additional affiliations
March 2017 - present
University Clinics Jena
Position
- Head & Coordinator
August 1987 - July 1989
September 1989 - January 1991
Education
December 1990 - January 1996
University of Freiburg, Dept. Pneumology
Field of study
- Asthma, Eosinophils, Th2-T cells
June 1989 - November 1990
Johns Hopkins University, Asthma and Allergy Center
Field of study
- Asthma and Eosinophils
July 1987 - July 1989
University of London, Department of Thoracic Medicine, National Heart & Lung Institute, London, England
Field of study
- Eosinophils and Signaltransduction
Publications
Publications (369)
Objectives
Inflammatory rheumatic diseases (IRD) are often associated with interstitial lung disease (ILD). The aim of the present study was to establish a correlation between the findings on HRCT and the immunological bronchoalveolar lavage (BAL).
Methods
The study included 74 patients with newly diagnosed IRD and evidence of ILD on HRCT with the...
Background
Lung involvement is the most common organ involvement in inflammatory rheumatic disease (IRD). The current state of the art is to perform a high-resolution computed tomography (HRCT) for evaluation and diagnosis. The main pattern in HRCT in IRD included pure ground glass opacity (GGO) as primary inflammatory pattern and non-specific inte...
Objectives
Inflammatory rheumatic diseases (IRD) are often associated with interstitial lung disease (ILD). The aim of the present study was to establish a correlation between the findings on HRCT and the immunological immunological bronchoalveolar lavage (BAL).
Methods
The study included 74 patients with newly diagnosed IRD and evidence of ILD on...
Zusammenfassung
Ein 69-jähriger Patient mit einer seropositiven erosiven rheumatoiden Arthritis (RA) stellte sich aufgrund einer progredienten Dyspnoe in unserer Klinik vor. Im Rahmen der Diagnostik wurden mittels einer hochauflösenden Computertomographie (HRCT) und einer immunologischen bronchoalveolären Lavage Milchglastrübungen als auch eine lym...
Lung involvement is the most common and serious organ manifestation in patients with inflammatory rheumatic disease (IRD). The type of pulmonary involvement can differ, but the most frequent is interstitial lung disease (ILD). The clinical manifestations of IRD-ILD and severity can vary from subclinical abnormality to dyspnea, respiratory failure,...
Background
Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity and mortality. That is why ILD screening at a very early stage, at the onset of IRD, is essential. The objective of the present study was to evaluate the diagnostic value and ut...
Background:
Inflammatory rheumatic diseases (IRD) are often associated with the involvement of various organs. However, data regarding organ manifestation and organ spread are rare. To close this knowledge gap, this cross-sectional study was initiated to evaluate the extent of solid organ manifestations in newly diagnosed IRD patients, and to pres...
Introduction
La granulomatose éosinophilique avec polyangéite (GEPA) (Churg–Strauss) est une vascularite nécrosante des vaisseaux de petit calibre caractérisée par une éosinophilie sanguine et tissulaire associée à un asthme. Les glucocorticoïdes contrôlent efficacement la maladie, mais les rechutes de la vascularite et la corticodépendance sont fr...
Objectives: Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with a significantly increased morbidity and mortality. Therefore, ILD screening in patients with IRD is essential. The objective of the present study was to determine the diagnostic value of pulmonary function test...
Objectives: Only a third of patients with eosinophilic granulomatosis with polyangiitis (EGPA) are ANCA-positive, mainly directed against MPO. ANCA directed against PR3 are rarely found in EGPA. We aimed to examine the significance of PR3-ANCA in EGPA.
Methods: We set up a retrospective European multicentre cohort including 845 patients. Baseline...
Introduction
La granulomatose éosinophilique avec polyangéite (GEPA) (Churg-Strauss) est une vascularite nécrosante des vaisseaux de petit calibre caractérisée par une éosinophilie sanguine et tissulaire associée à un asthme.En dépit des traitements actuels, la cortico-dépendance est fréquente chez les patients présentant une GEPA, de même que les...
Introduction
La granulomatose éosinophilique avec polyangéite (GEPA) (Churg-Strauss) est une vascularite nécrosante des vaisseaux de petit calibre caractérisée par une éosinophilie sanguine et tissulaire associée à un asthme. Les ANCA sont positifs dans seulement un tiers des cas, le plus souvent dirigés contre la myélopéroxydase (MPO). Les patient...
Background
Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss) is a small-vessel necrotizing vasculitis characterized by blood and tissue eosinophilia and asthma. Glucocorticoids (GCs) control the disease, but GC-dependence is frequent. Evolving concepts distinguish vasculitis-related symptoms from asthma and/or ENT manifestations....
Background
Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss) is a small-vessel necrotizing vasculitis characterized by blood and tissue eosinophilia and asthma. Glucocorticoids (GCs) represent the treatment cornerstone. So far, EGPA management has been based on conventional immunosuppressants, but GC-dependence remains frequent....
Eosinophile Granulozyten bilden von Th2-Lymphozyten dirigierte periphere Effektorzellen, die über die Freisetzung von zytotoxischen basischen Proteinen und Sauerstoffradikalen eine lokale Zell‑, Gewebe- und Funktionsstörung infiltrierter Organe verursachen. Zu den Eosinophilen-assoziierten Erkrankungen der Lunge gehört die eosinophile Granulomatose...
We conducted a large global survey, Still Fighting for Breath, in patients with severe persistent asthma, 10 years after the Fighting for Breath survey to assess the impact of disease on patients' lives and to determine if control and management have changed in recent years.
Data were collected from 1333 adults (aged >18 years) and caregivers of ch...
Eosinophile Granulozyten bilden von Th2-Lymphozyten dirigierte periphere Effektorzellen, die über die Freisetzung von zytotoxischen basischen Proteinen und Sauerstoffradikalen eine lokale Zell‑, Gewebe- und Funktionsstörung infiltrierter Organe verursachen. Zu den Eosinophilen-assoziierten Erkrankungen der Lunge gehört die eosinophile Granulomatose...
Seit seiner Entdeckung im Jahr 1879 durch Paul Ehrlich fasziniert und inspiriert der eosinophile Granulozyt Ärzte wie Wissenschaftler. In den letzten Jahren ist mit der Verfügbarkeit von Interleukin-5-Blockern das Interesse noch weiter gestiegen. Während die Zelle bei physiologischen Prozessen keine Rolle spielt, kommt ihr im Rahmen bestimmter infe...
Bei der eosinophilen Granulomatose mit Polyangiitis (EGPA; früher Churg-Strauss-Syndrom) handelt es sich um eine systemische Angiitis der kleinen Gefäße mit extravaskulären Granulomen und Hypereosinophilie. Klinisch stehen eine chronische Rhinosinusitis und ein progressiv fortschreitendes, kortisonabhängiges Asthma im Vordergrund. Zusätzlich können...
Background
The diagnostic workup of ANCA-associated vasculitis (AAV) is a challenge due to the possible multi-organ involvement and the wide range of differential diagnosis. Before classification, vasculitis needs to be proofed by clinical or histopathologic signs.
Objectives
We aimed to evaluate specific histopathologic features of organ biopsies...
Eosinophile Granulozyten bilden von Th2-Lymphozyten dirigierte periphere Effektorzellen, die über die Freisetzung von zytotoxischen basischen Proteinen und Sauerstoffradikalen eine lokale Zell‑, Gewebe- und Funktionsstörung infiltrierter Organe verursachen. Zu den Eosinophilen-assoziierten Erkrankungen der Lunge gehört die eosinophile Granulomatose...
A variety of different inhaler devices used to deliver various medications (e.g. betaagonists, anticholinergics, glucocorticoids) for respiratory therapy in asthma and COPD are available to date. There are four types of inhaler devices available: the pressurized metered dose inhaler (MDI), the dry powder inhaler (DPI), the soft mist inhaler (SMI),...
Objective:
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by frequent relapses following induction therapy. Interferon-α (IFN-α) can reverse the underlying Th2-driven immune response and has successfully induced remission in previous reports. We undertook this study to investigate its efficacy and safety in patients with EGP...
Asthma is defined as chronic inflammatory airway disease characterized by a reversible airflow limitation, a bronchial hyperreactivity underlying a Th2-associated eosinophilic bronchitis as well as remodelling oft the airways. The disease covers a broad clinical spectrum, ranging from asymptomatic up to a severe persistent manifestations uncontroll...
A 33-year-old Indonesian woman presented for follow-up after a recent history of papillary thyroid carcinoma treated with total thyroidectomy and radioiodine therapy. A I whole-body scintigraphy showed an elongated iodine accumulation in the right hemithorax. On suspicion of pulmonary metastasis, further diagnostics with I PET/CT showed thickening...
Abstract Raman spectroscopy as a technique has high potential for biological applications, e.g. cell and tissue analysis. In these applications, large data sets are normally recorded which require automated analysis. Unfortunately, a lot of disturbing external influences exist, which negatively affect the analysis of Raman spectra. A problematic co...
Das Kapitel fasst die anatomischen Grundlagen, die Klassifikation, die Bildgebung und die klinische Präsentation der Erkrankungen der kleinen Atemwege zusammen. Der Terminus „Bronchiolitis“ bezeichnet eine große Gruppe von primären oder sekundären Erkrankungen der kleinen Atemwege unterschiedlichster Ätiologie, Histopathologie, Klinik und Prognose....
Bei den eosinophilen Pneumonien sind die Lungen durch eosinophile Granulozyten infiltriert. Meistens findet sich eine Bluteosinophilie und sehr konstant eine BAL-Eosinophilie. Die Klassifikation dieser heterogenen Krankheitsgruppe unterscheidet zwischen unbekannten Ursachen (idiopathische chronische eosinophile Pneumonie und akute eosinophile Pneum...
Ulcerative colitis can be associated with numerous extraintestinal organ manifestations. Pulmonary disease in inflammatory bowel disease (IBD) is supposed to be a rare entity and has to be distinguished from infectious complications and side-effects of medications used in the treatment of IBD. We present the case of a 20-year-old male patient with...
Background: OMA is an effective treatment option in SAA. However, little data are available on the long-term-efficacy oft the drug.
Objective: To determine the long-term efficacy of OMA in respect to clinical parameters and IgE serum levels.
Methods: This was a retrospective, open-label, uncontrolled, multi-center observational study according to t...
Spirometry is a highly standardized method which allows to measure the forced vital capacity (FVC) with high precision and reproducibility. In patients with IPF FVC is directly linked to the disease process which is characterized by scaring of alveoli and shrinkage of the lungs. Consequently, there is ample evidence form clinical studies that the d...
Immunoglobulin E (IgE) plays a key role in the induction and maintenance of allergic disorders, making the molecule, and its pathways, an obvious target for a novel treatment approach. Omalizumab, a recombinant humanized monoclonal antibody (mAb), is the first therapeutic agent that specifically targets IgE. Monoclonal anti-IgE omalizumab (recombin...
Background Results from descriptive studies on eosinophilic granulomatosis with polyangiitis (EGPA) hint at distinct clinical subclasses, which might notably be determined by ANCA status.
Objectives This study explored the possibility of subclassifying EGPA using hierarchical cluster analysis.
Methods A standardized retrospective dataset from a coh...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small vessel vasculitis associated with asthma and eosinophilia. Optimal therapy for maintenance of remission is yet to be defined. We present a case-series of three patients with EGPA in whom IFN-α, an immunomodulatory cytokine induced remission, which was maintained even after dis...
Idiopathic pulmonary fibrosis is a fatal lung disease with a variable and unpredictable natural history and limited treatment options. Since publication of the ATS-ERS statement on IPF in the year 2000 diagnostic standards have improved and a considerable number of randomized controlled treatment trials have been published necessitating a revision....
Background:
The aim of this prospective, multicenter study was to define the accuracy of lung ultrasound (LUS) in the diagnosis of community-acquired pneumonia (CAP).
Methods:
Three hundred sixty-two patients with suspected CAP were enrolled in 14 European centers. At baseline, history, clinical examination, laboratory testing, and LUS were perf...
This paper describes the possibility of targeting the small airways. In addition to aiding in the therapy for chronic obstructive lung diseases this may prove to be invaluable in the development of treatment strategies for diseases of the bronchioli. Essential factors in peripheral lung deposition include extra-fine particles, a slow and controlled...
In the recent years growing interest has focused on the involvement of the distal airways (internal diameter < 2 mm) in obstructive lung diseases and other pulmonary conditions. Inflammation in the small airways seems to play a major role in severe and uncontrolled asthma as a major determinant of airflow obstruction. Thus, small airways represent...
Due to the variability in respect to aetiology, histopathology, lung function, imaging and clinical presentation, as well as overlapping parenchymal processes, bronchiolar disorders are generally difficult to diagnose. Thus, diseases of the small airways should generally be considered in the differential diagnostic approach to respiratory condition...
The term "bronchiolitis" refers to a broad spectrum of common conditions related to the small airways associated with a miscellaneous aetiology, histology, clinical features and course. Due to their variability, bronchiolar disorders are generally difficult to diagnose. History (smoking, collagen vascular disease, inhalational injury, medication us...
A 74-year old woman suffering from increasing dyspnea was admitted to the university clinic hospital. She had been diagnosed with asthma for a period of ten years prior to admission. Fiberoptic bronchoscopy revealed a circumscript tumour occluding the left main bronchus immediately above the left upper lobe. The diagnosis of endobronchial hamartoma...
Background and Aims: Although the efficacy and safety of omalizumab (OMA) in uncontrolled severe allergic asthma has been demonstrated in several randomised controlled trials (RCTs), information on the treatment in a practice-related setting is limited. Thus, the purpose of this prospective multi-centre study (XCLUSIVE) was to investigate the effic...
Tracheobronchial complications following lung transplantation are defined as local structural or infectious alterations of the airways, which occur early or several months after lung transplantation (LTx). They preferentially develop in the region of the bronchial anastomosis. The most frequently reported complications are bronchial stenosis, bronc...
Chest sonography has gained clinical significance in the diagnosis of various pulmonary, pleural, cardiac, and mediastinal emergency conditions. Therefore, the current role of emergency ultrasound are assessed.
A systematic literature search of MEDLINE database was performed to identify all studies dealing with transthoracic sonography/chest ultras...
Hintergrund: Ziel der Studie war die Erfassung der prämortal vermuteten Lungenarterienembolien (LE) sowie der durchgeführten Diagnostik und Therapie.
Methoden: Es wurden alle Patienten mit einer autoptisch bestätigten LE einbezogen. Es erfolgte eine Auswertung der Autopsie- und Krankenunterlagen hinsichtlich der Histologie, Begleiterkrankungen, Sym...
The study was conducted to assess the rate of suspected pulmonary embolism (PE) prior to death and the diagnostic and therapeutic procedures performed.
Patients with autopsy-confirmed PE between 1998 and 2002 were included. Autopsy register and medical records were reviewed for history, diagnosis and therapy of PE. Patients were categorised into fa...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The aim of the study was to compare transthoracic sonography (TS) with multislice computed tomography (MSCT) in the detection of peripheral pulmonary embolism (PE). In addition, the study verified peripheral parenchymal findings visualized by TS and MSCT. A total of 33 patients (16 females, 17 males; mean age = 65.4 years) with symptoms of suspecte...
The purpose of this study was to evaluate the long-term safety and therapeutic effects of IFN-alpha in patients with severe persistent uncontrolled asthma on long-term oral glucocorticoid (GC) treatment.
The study included 16 patients (2 male, 14 female; age 39 years [range: 24 - 63]) with severe persistent asthma. Diagnosis and severity classifica...
Cardiac disease is a major contributor to disease-related death in Churg-Strauss syndrome (CSS). We conducted the current study to determine the prevalence and clinical impact of cardiac involvement in CSS patients. We performed a multicenter, cross-sectional analysis of patients diagnosed with CSS. Cardiac workup included electrocardiography, echo...
Hintergrund: Die Studie untersucht die therapeutische Wirkung einer immunmodulatorischen Therapie mit IFN-alpha (IFN-α) bei Patienten mit kortikosteroidabhängigem, schwergradig persistierendem, unkontrolliertem Asthma bronchiale.
Patienten und Methodik: 16 Pat. (14 w/2 m, Alter 39 Jahre [24 – 63]) erfüllten die Kriterien der Deutschen Atemwegsliga...
The Global Initiative for Asthma (GINA), founded in 1993, embodies a network of public health organizations and medical societies, as well as other individuals concerned with asthma. Its first report, published in 1995 and entitled 'A Global Strategy for Asthma Management and Prevention', has been widely adopted, providing the foundation for asthma...
Pulmonary embolism (PE) and pneumonia can be detected by transthoracic sonography (TS), if they extend up to the pleura. In about 70–80% central PE is accompanied by peripheral PE, which is detectable by TS. In patients with suspected PE, all intercostal spaces have to be investigated, especially those in the region of thoracic pain. Typical...
The Global Initiative on Asthma (GINA) was launched in 1993 in collaboration with the National Heart, Lung, and Blood Institute, the National Institutes of Health (USA) and the WHO. Its first effort was the production of a consensus report on asthma treatment, which aimed to bridge the gap between the various treatment options and the incorporation...
IntroductionThe Biology of the IgE MoleculeIgE ReceptorsCell Distribution of IgEPhysiologic and Pathophysiologic Signifi cance of IgEThe Concept of Anti-IgE-Based TreatmentConstruction of the Monoclonal Anti-IgE MoleculeAnti-Infl ammatory Effects of OmalizumabPharmacological Properties of OmalizumabAdverse EffectsIndicationsContraindicationsPrepara...
Asthma hat viele Gesichter. Hierzu zählt zunächst die Häufigkeit der Erkrankung, die Asthma im wahrsten Sinne des Wortes zu
einer »Volkskrankheit« macht. Hierher gehört die Einschränkung der Lebensqualität ebenso wie die Beeinträchtigung des sozialen
Umfelds. Asthma bedingt aber auch Behinderungen im Berufsleben, sei es in Form einer verminderten k...
Bronchial biopsy specimens from chronic obstructive pulmonary disease (COPD) patients demonstrate increased numbers of CD8+ T-lymphocytes, macrophages and, in some studies, neutrophils and eosinophils. Smoking cessation affects the rate of forced expiratory volume in one second (FEV 1 ) decline in COPD, but the effect on inflammation is uncertain....
