Cláudio Mendes Pannuti

• Professor (Associate) at University of São Paulo

Objectives To identify changes in immunological, microbiological, and histological biomarkers that may indicate resistance during the induction phase and resilience during the resolution phase of experimental peri‐implant mucositis (PiM). Materials and Methods The search was performed in MEDLINE, EMBASE, Web of Science, SCOPUS, Cochrane Library, a...

Objectives This meta-research assessed methodologies used for evaluating peri-implant marginal bone levels on digital periapical radiographs in randomised clinical trials published between 2019 and 2023. Methods Articles were searched in four databases. Data on methods for assessing peri-implant marginal bone levels were extracted. Risk of bias as...

Background Gingivitis, a widely prevalent oral health condition, affects up to 80% of the population. Traditional assessment methods for gingivitis rely heavily on subjective clinical evaluation. This study seeks to explore the efficacy of interpreting the color metrics from intraoral scans to objectively differentiate between healthy and inflamed...

Introduction. Selective Outcome Reporting (SOR) is a type of bias that potentially manifests in Randomized Controlled Trials (RCTs) and is defined as the change or omission of the primary outcome in the publication compared to the protocol. Researchers may alter outcomes to emphasize statistical significant results. We aimed to assess the prevalenc...

There is scarcity of information on the determinants of periodontitis in Latin America and Caribbean countries. We conducted a comprehensive review of studies examining the association of smoking and diabetes with periodontitis outcomes in this region. We searched for population-based, cross-sectional and prospective cohort studies from Latin Ameri...

Purpose: To evaluate the additional benefits of the adjunctive use of systemic antibiotics in the non-surgical and surgical treatment of peri-implantitis. Materials and methods: A systematic search following the population, intervention, comparison, outcome and study design framework was conducted across the MEDLINE (via PubMed), Embase and Web...

Background To assess how the diagnostic reproducibility of the 2018 Classification of Gingival Recession Defects (GRD) could be applied when comparing in‐person chairside measurements with photographic measurements. Methods Thirty‐four GRD were photographed and evaluated by 4 masked operators. For each case, the operators measured twice recession...

This study aimed to estimate the prevalence and extent of bleeding on probing and calculus in 12-year-old schoolchildren of Quito, Ecuador, and evaluate the associated factors. We conducted an epidemiological survey with a representative sample of 1,100 12-year-old schoolchildren from public schools in the urban area of Quito, Ecuador. We assessed...

Internet amplio la posibilidad de las personas para que administren su propia salud en un contexto de autogestión y facilidad de acceso. La observación del comportamiento de las búsquedas relacionadas a salud puede reflejar las necesidades de la población acerca de la salud bucal. Este estudio retrospectivo longitudinal ecológico está dirigido a pr...

Background and Objective As elsewhere in the world, the prevalence of periodontitis in stages I–II is high in the Latin American population, this scenario emphasizes the need for identification of urgent needs for allocating adequate resources to provide diagnosis, prevention, and treatment of these diseases. The aim of this Delphi study was to pre...

The Internet is a growing source of knowledge and can provide information about oral health. This ecological study aimed to characterize the interests in toothpaste among Google users from different countries. Our hypothesis was that there would be an increase in Google users' interest in information about toothpaste. This retrospective longitudina...

Objective To analyze bibliometrics, characteristics, and the risk of bias of randomized controlled trials (RCTs) on dental implants published in six high‐impact factor journals and to identify factors contributing to citation number. Materials and Methods A systematic electronic search was conducted in four databases (PubMed, Scopus, Web of Scienc...

Objectives The primary aim of this study was to evaluate if children's oral health and oral health‐related quality of life (OHRQoL) were associated with school performance. Moreover, the study aimed to examine whether school environment factors influenced this association. Methods This cross‐sectional study was based on a population‐based sample o...

Background The comprehension of the interests of Internet users regarding their health‐related searches may reveal the community's demands about oral health. The study aimed to characterize the interests of Google users related to mouthwash in Australia, Brazil, Chile, Japan, Mexico, Russia, the United Kingdom, the United States, Saudi Arabia and S...

About half of the cases of gingival recession are associated with the noncarious cervical lesion (NCCL), resulting in combined defects (CDs). NCCL negatively affects the root coverage outcomes. In addition, considering the morbidity associated with graft harvesting, soft-tissue substitutes (STSs) appeared as a suitable option for connective tissue...

Abstract Accumulated evidence has shown that the oral cavity may be an important reservoir for SARS-CoV-2. Some authors have suggested that the use of mouthrinses could reduce SARS-CoV-2 viral load in the saliva. Thus, the aim of this review was to synthesize evidence about the efficacy of mouthrinses in reducing the salivary viral load of SARS-CoV...

Objective: This pilot, prospective interventional study aimed to analyze the influence of supracrestal tissue height (STH) when using the one abutment-one time concept (OAOT) at the time of implant placement, on peri-implant hard and soft tissue remodeling in esthetic areas. The definitive crown was placed seven days later. Method and materials:...

The aim of this systematic review was to evaluate the methodological quality and the consistency of recommendations of clinical practice guidelines (CPGs) in Periodontology. An electronic search was conducted in two databases, MEDLINE and EMBASE, eight CPGs databases, and home pages of scientific societies in Periodontology up to April 2022. Three...

Objective: The aim of this study is to systematically analyze the influence of smoking on the incidence of peri-implantitis. Materials and methods: The search was performed in the National Library of Medicine (MEDLINE-PubMed), SCOPUS, EMBASE, and ISI Web of Science databases (finished on November 30th , 2022). Systematic review and meta-analysis...

The purpose of this study was to compare the outcomes of a modified gingival graft technique, in which the released flap is positioned and sutured over the graft, with the conventional free gingival graft (FGG) procedure, when both are used for gingival augmentation. A 12-month, multicenter parallel randomized controlled trial was conducted. Subjec...

Purpose: Evaluate the impact of gingivitis on oral health-related quality of life (OHRQoL) amongst 12-year-old schoolchildren from Quito, Ecuador. Methods: We evaluated 998 school children using the Community Periodontal Index for gingival bleeding and calculus. OHRQoL was assessed with the Child Perceptions Questionnaire 11-14 (CPQ11-14) questi...

This prospective longitudinal study evaluated the peri-implant soft tissue remodeling, marginal bone levels, and implant success rate of immediately placed single implants-which received a definitive zirconia abutment and provisional restoration at implant placement-in the maxillary esthetic zone. The final crown was delivered 7 days later. Patient...

This study aimed to evaluate how quarantine affected final-year dental students' self-perceptions of preparation and assess how online training affected clinical students' education at SEGi University. Year 3 to 5 students (n=140) were asked to fill up an online questionnaire. The first part included the effects of online education experience betwe...

Background: Plaque quantification indices are frequently used to evaluate personal oral hygiene. Education in self-care and self-diagnosis is effective in prevention and control of both dental and periodontal disease. Mobile technology has become a ubiquitous technology and can be particularly useful in the self-monitoring of health promotion. To e...

Selective outcome reporting (SOR) is a type of bias that can compromise the validity of results and affect evidence‐based practice. SOR can overestimate the effect of an intervention and lead to conclusions that a treatment is effective when it is not. This study aimed to investigate the prevalence of SOR in publications of RCTs on nonsurgical peri...

Background: The aim of this study was to investigate the inter- and intra-examiner agreement among international experts on the diagnosis of gingival recession defects (GRDs) using the 2018 Classification of Gingival Recession Defects and Gingival Phenotype as proposed in the 2017 World Workshop. Materials and methods: Standardized intraoral pho...

Background The Internet is a growing source of knowledge and can provide information about oral health. This ecological study aimed to characterize the interests of Google users on toothpaste in different countries. Methods This longitudinal retrospective study analyzed the toothpaste-related interest of Google users from ten distinct countries be...

Objectives: This review aimed to assess the impact of mouthwashes on the composition of the human oral microbiome. Method: An electronic search algorithm was adapted to MEDLINE- PubMed, Scopus, Embase, and ISI Web of Science, and reference lists of relevant sources were manually searched. Inclusion criteria were controlled clinical trials publis...

Objectives This randomized controlled trial aimed to evaluate different protocols for dentin hypersensitivity treatment with low-power lasers and desensitizing agents, and the association between low-power lasers and desensitizing agents. Materials and methods Fifty-four patients (303 teeth) were randomly allocated to three groups: G1, 3% nitrate...

The aim of this cross-sectional study was to assess whether favorable factors related to school characteristics have a positive effect on the impact of traumatic dental injury (TDI) on oral health-related quality of life (OHRQoL). An epidemiological survey of oral health was conducted with 12-year-old schoolchildren from Quito, Ecuador. Children we...

Background: Selective outcome reporting (SOR) is a bias that occurs when the primary outcome of a randomised clinical trial (RCT) is omitted or changed. Aim: We evaluated the prevalence of SOR in RCTs on restorative treatment in primary teeth. Design: We conducted an electronic search on ClinicalTrials.gov and the World Health Organisation pla...

Aim: To evaluate the frequency of side effects associated with intake of metronidazole (MTZ) + amoxicillin (AMX) in periodontal treatment, and to explore associations between these events and patients' features. Materials and methods: Data of five randomized clinical trials testing MTZ + AMX adjunctive to mechanical therapy were evaluated. Volun...

Objectives: This study aimed to investigate the prevalence of a type of bias named Selective Outcome Reporting (SOR) in publications of RCTs on non-surgical periodontal therapy (NSPT) and verify its associated factors. Materials and Methods: The protocols were searched and selected on the www.clinicaltrials.gov platform up to January 16, 2022. Corr...

Objective: This study assessed the efficacy of two adjunct therapies (antibiotic and probiotic) for periodontal treatment based on clinical and immunological parameters in patients with Stage II and III Grade B periodontitis. Methodology: 45 patients were randomly allocated into three groups: control group (CG); antibiotic group (GAtb), in which...

Introduction Evidence-based dental practice provides patient-centered, compatible, and efficient interventions and forms the basis for health profession education. So far, there is a paucity of data about Malaysian undergraduate dental education and the role of evidence-based dentistry in it. The current research aimed to study the level of knowled...

This study aimed to simultaneously assess hard and soft tissues alterations and their proportions after alveolar ridge preservation (ARP). Participants (n = 65) who were previously enrolled in a clinical trial investigating ARP healing were selected. The CBCT DICOM (Digital Imaging and Communications in Medicine) and the cast STL (stereolithographi...

Background Smokers present a higher prevalence and severity of periodontitis and, consequently, higher prevalence of tooth loss. Smoking cessation improves the response to periodontal treatment and reduces tooth loss. So, the aim of this study was to evaluate the efficiency in resources allocation when implementing smoking cessation therapy vs. its...

Background Selective outcome reporting (SOR) is a type of bias that occurs when the primary outcome of a randomized clinical trial (RCT) is omitted or changed prospectively. We evaluated the prevalence of SOR in RCTs on restorative caries treatment in primary teeth. Methods We conducted an electronic search on ClinicalTrials.gov and the World Healt...

Aim To compare tissue changes at implant sites previously treated with two biomaterials for alveolar ridge preservation (ARP) in the esthetic zone, one year after restoration. Materials and Methods Sixty-six participants were treated with ARP using demineralized bovine bone mineral (DBBM) or DBBM + 10% of collagen (DBBM-C) both covered with a coll...

Background The aim of this study was to adapt, translate and validate the Rapid Estimate of Adult Literacy in Dentistry (MREALD-30) instrument for the Orang Asli population in Malaysia. Methods After translation and cross-cultural adaptation, interviews were conducted with 326 participants of the Temuan tribe from village Kampung Tering in Johol,...

Randomized clinical trials (RCTs) are human studies carried out to compare different treatments or interventions, and their results are used to support clinical decision-making and improve patient care. Herein, the aim of this study was to review the selection process of study outcomes in periodontology. Primary outcomes should draw the main conclu...

Background: Dental students endure the pressures of an academically challenging degree combined with high contact hours, making them vulnerable to burnout. Moreover, the effect of lockdown on their psychological well-being has been profound. The aim of this study was to address this issue by incorporating an app-based meditation into the timetable...

Objectives The purpose of this study was to estimate the prevalence of thin and thick gingival phenotype (GPh) in a sample of Dominican subjects and correlate it with clinical parameters. Materials and methods One-hundred seven periodontal healthy volunteers in the range of 18–73 years were enrolled in the study. GPh was defined by the transparenc...

A peri-implantite é caracterizada pela inflamação da mucosa peri-implantar associada à perda progressiva do osso que circunda o implante dentário. Apesar de ser uma condição clínica prevalente, ainda não há consenso na literatura sobre um protocolo de tratamento ideal. O presente relato de caso tem como objetivo apresentar uma terapia aplicada a um...

Background: The social diversity, heterogeneous culture and inherent economic inequality factors in Latin America (LA) justify conducting a comprehensive analysis on the current status and future trends of peri-implant diseases and conditions. Thus, the aim of this Delphi study was to predict the future trends in the diagnosis and treatment of per...

OBJECTIVE: The purpose of the present clinical retrospective study was to evaluate the influence of the peri-implant keratinized mucosa (KM) on clinical parameters: mean plaque index, bleeding on probing, mean probing depth, and exposure of implant threads. MATERIAL AND METHODS: Patients were recruited during their routine maintenance visit from 20...

The aim of this online cross-sectional study is to identify the sources of scientific information used by Brazilian dentists in clinical decision-making and the barriers that they perceive as important to the incorporation of scientific evidence into clinical practice. A pretested questionnaire created in Google Forms which was made available to pa...

Background Outcome discrepancies between protocols and respective publications represent a concerning bias. The purpose of this study was to assess the prevalence of selective outcome reporting (SOR) in root coverage randomized clinical trials (RCTs). Methods Published root coverage RCTs (July 2005 to March 2020) were included if a corresponding p...

Purpose: To assess whether favourable factors related to school characteristics have a positive effect on the impact on OHRQoL related to occurrence TDI. Methods: An epidemiological survey of oral health was conducted with 12-year-old scholars from Quito, Ecuador. Children were examined regarding TDI, dental caries, and malocclusion. Individual soc...

Background: Smokers present a higher prevalence and severity of periodontitis and, consequently, higher prevalence of tooth loss. Smoking cessation improves the response to periodontal treatment and reduces tooth loss. So, the aim of this study was evaluated the efficiency in resources allocation when implementing smoking cessation therapy vs. its...

Background: Translocation of periodontal pathogens into the respiratory tract could either cause pneumonia or disrupt local defense mechanisms, predisposing the host to infection by respiratory pathogens. The objective of this pilot study was to evaluate the levels of periodontopathogenic bacteria in subglottic samples of intubated and mechanicall...

There is cumulative evidence supporting the negative effects of smoking on periodontal tissues. Smoking cessation can be successfully accomplished through specific programs, including behaviour modification and medications, and has been suggested as a suitable way to reduce the risk of several diseases, including periodontitis. The aim of this revi...

In this study, we describe a method for reaching a target population (i.e., dentists practicing in Brazil) to engage in survey research using traditional e-mail invites and recruitment campaigns created on Instagram. This study addresses methodological aspects and compares respondents reached by different methods. A pre-tested questionnaire was use...

Background: Periodontitis may be associated with the development of head and neck cancer (HNC). A literature review was conducted to understand the possible association between them. Material and methods: Articles published in the PubMed database from January 1999 and May 2020 were retrieved. Limitations of the studies and biological mechanisms...

Dental professionals work closely with patients and present an increased risk of person-to-person transmission of SARS-CoV-2. Moreover, the use of ultrasonic scalers, air–water syringes, and slow and high-speed handpieces, which are common in the dental office, generate spatter and aerosol. The use of preprocedural mouthrinses has been proposed to...

Randomised clinical trial (RCT) is the best study design to evaluate the effect of the treatment and preventive health care procedures. The effects of the tested treatments on patient's' health are compared in terms of outcomes, which are used to evaluate the participants' health changes. However, these outcomes should be relevant for the target po...

Randomised clinical trial (RCT) is the best study design to evaluate the effect of the treatment and preventive health care procedures. The effects of the tested treatments on patient's' health are compared in terms of outcomes, which are used to evaluate the participants' health changes. However, these outcomes should be relevant for the target po...

In this study, we describe and evaluate a method for reaching a target population (i.e., dentists practicing in Brazil) to engage in survey research using traditional e-mail invites compared with recruitment campaigns created on Instagram. A pre-tested questionnaire was used and participants were recruited for 10 days via a source list of email add...

The impact of clinical trials on patient care depends on the outcomes that they evaluate. In Dentistry, many trials use outcomes that are important to clinicians, but not to the patients. Thus, the aim of the present manuscript is to present an overview of the limitations, challenges, and proposals on the use of clinically relevant outcomes (CRO) i...

Background Visual inspection (VIS) with radiographic examination (RAD) is the recommended diagnostic strategy for detecting caries in children; however, this recommendation is based on accuracy studies. The authors conducted a clinical trial to compare the detection and subsequent treatment of carious lesions in primary molars performed with VIS al...

Objectives to radiographically evaluate the effect of the adjunctive use of tenting screws (TS) for primary horizontal guided bone regeneration (GBR). Materials & Methods 28 patients in need of staged bone augmentation were consecutively treated in a private practice. A xenogenic particulate bone substitute material (DBBM) and a resorbable collage...

Objectives This research aimed to longitudinally evaluate the optical density of peri-implant alveolar bone. The data acquired from study participants previously treated with thirty-seven osseointegrated implants were analyzed utilizing the radiographic subtraction technique. Methods and materials The radiographic follow-ups were performed five ti...

The aim of this systematic review was to assess in patients with gingival recessions and noncarious cervical lesions (NCCLs) whether restoration of NCCLs may influence the percentage of root coverage following surgical root coverage procedures compared to surgical root coverage procedures without subsequent restoration. Four studies (randomized con...

The epidemiological data on gingivitis and periodontitis in Latin America are scarce, as the majority of the Latin American studies have analyzed probing depth instead of clinical attachment loss. Reported data have shown high variations in results between different Latin American countries, with the main causes of these differences being the clini...

Background/Aim Since children spend most of their time in school, some environmental characteristics of the schools may influence the occurrence of traumatic dental injuries (TDI). Therefore, the aim of this cross‐sectional study was to assess the prevalence of TDI in 12 years old children in Quito, Ecuador, and its association with some school env...

Root coverage surgery can be performed in patients with gingival recession to cover the exposed root aiming to control hypersensitivity and promotes better aesthetic. Optical magnification has been proposed as a refinement in this surgical technique to increase root coverage. This approach may lead to enhanced soft tissue stability, less post-opera...

Photobiomodulation therapy (PBMT) with low-power laser is used for pain relief in several clinical conditions, including temporomandibular disorders (TMD). As musculoskeletal pain often produces changes in motor behavior, it is common for patients with TMD to present limited mandibular movements. To the date, there is no consensus about the optimal...

Objectives: To test the non-inferiority of demineralized bovine bone mineral (DBBM) compared to demineralized bovine bone mineral with 10% collagen (DBBM-C) for the maintenance of the soft tissue contour after tooth extraction in the esthetic zone. Material and methods: Sixty-five patients randomly received ridge preservation at a single site in...

Background: The authors of this systematic review aimed to evaluate the efficacy of preprocedural mouthrinses in reducing the number of microorganisms disseminated by means of the aerosol generated via dental procedures when compared with a placebo, water, or no mouthrinse. Types of studies reviewed: The authors included only randomized clinical...

Background: Smoking is a major risk factor for periodontitis and tooth loss. Smoking cessation has a positive impact in periodontal treatment. However, so far, no systematic review has evaluated the effect of smoking cessation on tooth loss. Therefore, this review aimed to evaluate if smoking cessation reduces the risk of tooth loss. Methods: Ob...

Background: Smoking is a major risk factor for periodontitis and tooth loss. Smoking cessation has a positive impact in periodontal treatment. However, so far, no systematic reviewhas evaluatedthe effect of smoking cessation on tooth loss. Therefore, this review aimed to evaluate if smoking cessation reduces the risk of tooth loss. Methods: Observa...

Background: There is a paucity of population-based surveys on oral health conditions in Ecuador. Thus, the aim of this study was to conduct an epidemiological survey with a representative sample of children aged 12 years from public schools of Quito, Ecuador. The aim of this initial report was to describe the methodology used in the survey, as wel...

Aim This double-blind, placebo-controlled, randomized clinical trial evaluated the effectiveness of Nd:YAG laser and a calcium sodium phosphosilicate–containing paste (NovaMin®) in the treatment of cervical dentin hypersensitivity (CDH). Materials and methods Seventy patients were randomly allocated into the following experimental groups: control-...

Objectives: This review aimed at evaluating changes in alveolar bone thickness after completion of orthodontic treatment. Methods: Only prospective clinical studies that reported bone thickness in adult patients undergoing non-surgical orthodontic treatment were considered eligible. MEDLINE, EMBASE and LILACS databases were searched for articles...

Objective The aim of this study was to compare the anesthetic efficacy of two volumes of articaine in conventional inferior alveolar nerve block (IANB) of mandibular molars with irreversible pulpitis, and in cases of anesthetic failure, its complementation with periodontal ligament injection (PDL). Methods Ninety patients with irreversible pulpiti...

Aim Selective outcome reporting (SOR) is a type of bias that occurs when the primary outcome of a trial protocol is changed or omitted in the paper. The purpose of this study was to evaluate the prevalence of SOR in publications of randomized clinical trials (RCT) concerning dental implants. Materials and Methods Two reviewers independently screen...

Test the non-inferiority of demineralized bovine bone mineral (DBBM) compared with demineralized bovine bone mineral with 10% collagen (DBBM-C) in the maintenance of soft tissue contour after tooth extraction in upper anterior region. Full text on the website: https://box.osteology.org/Symposia/PublicSymposium?symposiaId=25#poster_clinical_1863

BACKGROUND: The local and systemic immunological profiles of important inflammatory mediators in the localized (LAgP) and generalized (GAgP) forms of aggressive periodontitis are still unknown, as well as the effect of periodontal therapy on these parameters. The aim of this prospective study was to evaluate clinical and immune responses of patient...

The aim of this study was to investigate the effects of the use of an occlusal splint on postural balance considering the occlusal splint as a device for treating temporomandibular joint disorder. A randomized, controlled, prospective clinical trial was conducted. The research group consisted of 49 patients (36 as test group and 13 as control group...

Objective To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans. Materials and Methods Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/Medline. Human observational and interventional studies that evaluated t...

Aim To test the non‐inferiority of demineralized bovine bone mineral (DBBM) compared to DBBM with 10% collagen (DBBM‐C) for maintenance of bone volume after tooth extraction in the anterior maxilla. Materials and Methods Sixty‐six patients were randomly treated with DBBM or DBBM‐C, both of which were covered with a collagen matrix for ridge preser...

The aim of this study was to evaluate the effect of a lower dose of parathyroid hormone- PTH (1-34) on osteogenic potential of bone healing around titanium implants inserted into the tibia of rats. A blind parallel study was conducted in 45 adult male Wistar rats. Each rat received one titanium implant (4.5 x 2.2 mm) and was randomly assigned to re...

Aim The aim of this study is to report root coverage outcomes in single deep gingival recessions (GR) following a proposed decision-making algorithm. Materials and Methods A retrospective, practice-based study included single deep (≥5 mm) Miller Class II and III defects. The step-by-step decision-making algorithm led to a choice among three differ...

The objective of this study was to determine whether collagen matrix (CM) is an alternative to connective tissue graft technique (CTG) in the treatment of multiple gingival recessions (GR). The indication of CM for the treatment of multiple GR is not yet clear. More studies are needed to better understand this treatment modality, as an alternative...

Objetivo: Avaliar a saúde bucal de pacientes com cirrose hepática em fi la de transplante. Materiais e Método: Foram avaliados 103 pacientes cirróticos quanto às características sócio-demográfi cas e histórico médico da cirrose hepática (etiologia, tempo de inclusão na fi la de transplante, valor do MELD - Model for End-Stage Liver Disease, complic...

The objective of the present study was to analyze individual, contextual and social support factors associated with periodontal condition among 2332 dentate elderly Brazilian participants from the São Paulo State Oral Health Survey 2015 (SBSP-15). Methods: This study used the database compiled by the SBSP-15, conducted from January to December in 2...

Objectives: To assess the oral health of patients waiting for a liver transplantation. Material and Methods: A total of 103 cirrhotic patients were evaluated for socio-demographic characteristics and medical history of liver cirrhosis (etiology, time of inclusion in the transplant list, MELD - Model for End Liver Disease - value, complications of c...