Claudio Brozzoli

Claudio Brozzoli
French Institute of Health and Medical Research | Inserm · Centre de Recherche en Neurosciences de Lyon U1028

PhD

About

62
Publications
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2,510
Citations

Publications

Publications (62)
Preprint
From observations in rodents, it has been suggested that the cellular basis of learning-dependent changes, detected using structural magnetic resonance imaging (MRI), may be increased dendritic spine density, alterations in astrocyte volume, and adaptations within intracortical myelin. Myelin plasticity is crucial for neurological function and acti...
Article
Common basis for language and tool use Tool use and language are hallmarks of human evolution. Because of the similarity between the motor processes for tool use and those supporting language, it has been hypothesized that syntax and tool use may share brain resources. Using functional magnetic resonance imaging and multivariate pattern analysis, T...
Article
Full-text available
Space coding affects perception of stimuli associated to negative valence: threatening stimuli presented within the peripersonal space (PPS) speed up behavioral responses compared to non-threatening events. However, it remains unclear whether the association between stimuli and their negative valence is acquired in a body-part centered reference sy...
Article
Full-text available
Peripersonal space (PPS) is a multisensory representation of the space near body parts facilitating interactions with the close environment. Studies on non-human and human primates agree in showing that PPS is a body part-centered representation that guides actions. Because of these characteristics, growing confusion surrounds peripersonal and arm-...
Chapter
The neuroscientific approach to peripersonal space (PPS) stems directly from electrophysiological studies assessing the response properties of multisensory neurons in behaving non-human primates. This multisensory context fostered frameworks which i) stress the PPS role in actions (including defensive reactions) and affordances, which are optimally...
Article
Full-text available
Peripersonal space (PPS) is a spatial representation that codes objects close to one’s own and to someone else’s body in a multisensory-motor frame of reference to support appropriate motor behavior. Recent theories framed PPS beyond its original sensorimotor aspects and proposed to relate it to social aspects of the self. Here, we manipulated the...
Preprint
Full-text available
Peripersonal space (PPS) is a multisensory representation of the space near body parts facilitating interactions with the close environment. Studies on non-human and human primates converge in showing that PPS is a body-part-centred representation that guides actions. Because of these characteristics, growing confusion conflates peripersonal and ar...
Article
Full-text available
Different disciplines converge to trace language evolution from motor skills. The human ability to use tools has been advocated as a fundamental step toward the emergence of linguistic processes in the brain. Neuropsychological and neuroimaging research has established that linguistic functions and tool-use are mediated by partially overlapping bra...
Article
Full-text available
Successful interaction with objects in the peripersonal space requires that the information relative to current and upcoming positions of our body is continuously monitored and updated with respect to the location of target objects. Voluntary actions, for example, are known to induce an anticipatory remapping of the peri-hand space (PHS, i.e., the...
Article
Full-text available
Peripersonal space is a multisensory representation relying on the processing of tactile and visual stimuli presented on and close to different body parts. The most studied peripersonal space representation is perihand space (PHS), a highly plastic representation modulated following tool use and by the rapid approach of visual objects. Given these...
Article
Research on human brain changes during skill acquisition has revealed brain volume expansion in task-relevant areas. However, the large number of skills that humans acquire during ontogeny militates against plasticity as a perpetual process of volume growth. Building on animal models and available theories, we promote the expansion–renormalization...
Article
Full-text available
The ability of using a large variety of tools is important in our daily life. Behind human tool-use abilities lays the brain capacity to incorporate tools into the body representation for action (Body Schema, BS), thought to rely mainly on proprioceptive information. Here we tested whether tool incorporation is possible in absence of proprioception...
Data
Comparison between patient D.C. velocity profile and a group of healthy controls. Mean and distribution of velocity peak amplitude (upper panel) and latency (lower panel) for a group of control healthy participants (N = 16) performing free-hand grasping movements before (blue curve) and after (green curve) tool use. Bars show the same values for pa...
Data
Tool movements kinematic profile changed from the first (dark red) to the last (light red) block of tool use. Error bars represent SD.
Data
Free-hand pointing movements were not affected after tool use in sessions 2 and 3. No significant difference was present for the pointing movements kinematic parameters when comparing between before (blue bars) and after (green bars) tool use. Error bars represent SD.
Article
Full-text available
When interacting with objects and other people, the brain needs to locate our limbs and the relevant visual information surrounding them. Studies on monkeys showed that information from different sensory modalities converge at the single cell level within a set of interconnected multisensory frontoparietal areas. It is largely accepted that this ne...
Article
Full-text available
Interactions between people require shared high-level cognitive representations of action goals, intentions [1], and mental states [2], but do people also share their repre-sentation of space? The human ventral premotor (PMv) and parietal cortices contain neuronal populations coding for the execution and observation of actions [1, 3–5], analo-gous...
Article
Full-text available
The perception of our limbs in space is built upon the integration of visual, tactile, and proprioceptive signals. Accumulating evidence suggests that these signals are combined in areas of premotor, parietal, and cerebellar cortices. However, it remains to be determined whether neuronal populations in these areas integrate hand signals according t...
Chapter
Full-text available
The binding of visual information available outside the body with tactile information arising, by denition, on the body, allows the representation of the space lying in between, which is often the theater of our interactions with objects. The representation of this intermediate space has become known as "peripersonal space" (Rizzolatti et al. 1981b...
Article
Full-text available
The ability to identify and localize our own limbs is crucial for survival. Indeed, the majority of our interactions with objects occur within the space surrounding the hands. In non-human primates, neurons in the posterior parietal and premotor cortices dynamically represent the space near the upper limbs in hand-centered coordinates. Neuronal pop...
Article
The existence of hand-centred visual processing has long been established in the macaque premotor cortex. These hand-centred mechanisms have been thought to play some general role in the sensory guidance of movements towards objects, or, more recently, in the sensory guidance of object avoidance movements. We suggest that these hand-centred mechani...
Article
Along the evolutionary history, humans have reached a high level of sophistication in the way they inter-act with the environment. One important step in this process has been the introduction of tools, enabling humans to go beyond the boundaries of their physical possibilities. Here, we focus on some "low level" aspects of sensorimotor pro-cessing...
Chapter
Full-text available
The binding of visual information available outside the body with tactile information arising, by definition, on the body, allows the representation of the space lying in between, which is often the theater of our interactions with objects. The representation of this intermediate space has become known as “peripersonal space” (Rizzolatti et al. 198...
Chapter
This chapter examines the link between number and the spatial biases observed in spatial neglect. Right-brain-damaged patients affected by left unilateral neglect are characterized by a pathological attentional bias to the right side of space. This left-sided deficit encompasses eye and head deviations, visual, somatosensory and auditory sensory pr...
Book
Behind the complex phenomenon of the phylogenetic development of tool use and its potential causal implication for higher forms of cognition, there are important 'lower level' aspects of cognition that highlight how tool use plays a causal role in shaping both spatial and bodily representations, and this is the focus of this chapter. First, it offe...
Article
Behavioral studies in humans and electrophysiological recordings in nonhuman primates have suggested the existence of a specific representation of the space immediately surrounding the body. In macaques, neurons that have visual receptive fields limited to a region of space close around a body part have been found in premotor and parietal areas. Th...
Article
Full-text available
The study of crossmodal extinction has brought a considerable contribution to our understanding of how the integration of stimuli perceived in multiple sensory modalities is used by the nervous system to build coherent representations of the space that directly surrounds us. Indeed, by revealing interferences between stimuli in a disturbed system,...
Article
The portion of space that closely surrounds our body parts is termed peripersonal space, and it has been shown to be represented in the brain through multisensory processing systems. Here, we tested whether voluntary actions, such as grasping an object, may remap such multisensory spatial representation. Participants discriminated touches on the ha...
Article
While avoidance movements might be rapid and relatively automatic (like Indiana Jones rolling under a closing barrier), target directed movements require planning (Jones grasping his hat at the last second). A wealth of studies has been devoted to reveal the neural basis of visuo-motor transformation in target-directed movements. However, less is k...
Article
Neuropsychologia j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / n e u r o p s y c h o l o g i a a b s t r a c t Peripersonal space processing in monkeys' brain relies on visuo-tactile neurons activated by objects near, not touching, the animal's skin. Multisensory interplay in peripersonal space is now well document...
Article
Full-text available
Our ability to interact with the environment requires the integration of multisensory information for the construction of spatial representations. The peripersonal space (i.e., the sector of space closely surrounding one's body) and the integrative processes between visual and tactile inputs originating from this sector of space have been at the ce...
Article
Defensive behaviors, such as withdrawing your hand to avoid potentially harmful approaching objects, rely on rapid sensorimotor transformations between visual and motor coordinates. We examined the reference frame for coding visual information about objects approaching the hand during motor preparation. Subjects performed a simple visuomanual task...
Article
To control bodily movements the human brain relies on a somatosensory representation referred to as the body schema [1]. The almost century-old hypothesis that tool-use induces plastic changes resulting in the tool being incorporated in the body schema is nowadays widely accepted. Whether this somatosensory representation is truly modified remains...
Article
Full-text available
To sensibly interact with the environment, like when grasping objects and navigating through space, the brain needs to compute not only target-and environment-related inputs, but also the size and spatial location of the entire body as well as of its parts. The neuronal construc-tion and dynamic updating throughout the entire life of this bodily re...
Article
Full-text available
We learn counting on our fingers, and the digital representation of numbers we develop is still present in adulthood [Andres M, et al. (2007) J Cognit Neurosci 19:563–576]. Such an anatomy–magnitude association establishes tight functional correspondences between fingers and numbers [Di Luca S, et al. (2006) Q J Exp Psychol 59:1648–1663]. However,...
Article
We learn counting on our fingers, and the digital representation of numbers we develop is still present in adulthood [Andres M, et a. (2007) J Cognit Neurosci 19:563-576]. Such an anatomy-magnitude association establishes tight functional correspondences between fingers and numbers [Di Luca S, et al. (2006) Q J Exp Psychol 59:16481663]. However, it...
Chapter
Full-text available
The study of pathologic behavioral phenomena following damage to the central nervous system has substantially contributed to our understanding of the normal organization of cognitive brain functions. The investigation of clinical extinction in neurological patients, for example, revealed that events occurring in the immediate proximity to the body...
Article
Philosophical considerations as well as several recent studies from neurophysiology, neuropsychology, and psychophys-ics converged in showing that the peripersonal space (i.e. closely surrounding the body-parts) is structured in a body-cen-tred manner and represented through integrated sensory inputs. Multisensory representations may deserve the fu...
Article
Full-text available
A visual analogue, two-route model of somatosensory processing is advanced in this commentary. Touch for perception is seen as separate from, although interconnected with, touch for action. Separate modules are additionally proposed for internal (body) and external (object-related) somatosensation. Here we ask whether dissociation (divide) guarante...
Article
Full-text available
The interest in human conscious awareness has increasingly propelled the study of neglect, the most striking occurrence of an acquired lack of conscious experience of space. Neglect syndromes commonly arise after unilateral brain damage that spares primary sensory areas nonetheless leading to a lack of conscious stimulus perception. Because of the...

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