Claudine Gauthier

Claudine Gauthier
Concordia University Montreal · Department of Physics

PhD

About

37
Publications
5,687
Reads
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1,247
Citations
Citations since 2016
11 Research Items
939 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Additional affiliations
September 2014 - present
Concordia University Montreal
Position
  • Professor (Assistant)
September 2012 - August 2014
Max Planck Institute for Human Cognitive and Brain Sciences
Position
  • PostDoc Position
January 2008 - December 2012
Université de Montréal
Education
September 2007 - December 2012
Université de Montréal
Field of study
  • Physiology/Neurological Sciences
September 2003 - June 2006
McGill University
Field of study
  • Neurology
September 1999 - June 2003
McGill University
Field of study
  • Biochemistry

Publications

Publications (37)
Article
Functional magnetic resonance imaging (fMRI) studies of cognitive aging have generally compared the amplitude and extent of blood oxygen level-dependent (BOLD) signal increases evoked by a task in older and younger groups. BOLD is thus used as a direct index of neuronal activation and it is assumed that the relationship between neuronal activity an...
Article
Calibrated MRI techniques use the changes in cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) signal evoked by a respiratory manipulation to extrapolate the total BOLD signal attributable to deoxyhemoglobin at rest (M). This parameter can then be used to estimate changes in the cerebral metabolic rate of oxygen consumption (CM...
Article
We present a method allowing determination of resting cerebral oxygen metabolism (CMRO₂) from MRI and end-tidal O₂ measurements acquired during a pair of respiratory manipulations producing different combinations of hypercapnia and hyperoxia. The approach is based on a recently introduced generalization of calibrated MRI signal models that is valid...
Article
Background: Physical inactivity significantly increases risk of cardiovascular diseases, which are highly prevalent in aging. Conversely, higher levels of physical activity in aging have been associated with benefits for physical and cognitive health and is hypothesized to prevent and reduce development of cardiovascular risk factors. However, thos...
Article
Full-text available
It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function (EF) tasks. Interestingly, the relationship betwee...
Article
Aging is associated with cognitive decline. Importantly cognition and cerebral health is enhanced with interventions like cognitive (CT) and exercise training (ET). However, effects of CT and ET interventions on brain magnetic resonance imaging outcomes have never been compared systematically. Here, the primary objective was to critically and syste...
Poster
Aging is associated with cerebrovascular impairments in males and females, yet this impairment develops nearly one decade later in females. Although cerebral blood flow (CBF) is consistently reported as higher in females, results on cerebrovascular reactivity (CVR) have not been uniform in studies comparing females to males. Here, given that much l...
Conference Paper
SYNOPSIS: Attenuated heart rate recovery (HRR) and systolic blood pressure recovery (SBPR) after a maximal exercise test (VO 2 peak) are linked to cardiovascular risk factors (CVRF). The relationship between the presence of CVRF and reduced cognition is well established in older adults. Yet the explicit relationship between HRR or SBPR and cognitio...
Article
Full-text available
Arterial stiffness and blood pressure (BP) are contributors to cognitive decline and dementia. Lower global cerebral blood flow (CBF) is one of the earliest manifestations of biological alterations linked to cognitive decline, nevertheless the best cardiovascular predictor of CBF in gray-matter (CBF-GM) remains to be identified. Our objective is to...
Article
Disentangling neural activity at different cortical depths during a functional task has recently generated growing interest, since this would allow to separate feedforward and feedback activity. The majority of layer-dependent studies have, so far, relied on gradient-recalled echo (GRE) blood-oxygenation-level dependent (BOLD) acquisitions, which a...
Article
Full-text available
Many studies have suggested that physical exercise training improves cognition and more selectively executive functions. There is a growing interest to clarify the neurophysiological mechanisms that underlie this effect. The aim of the current study was to evaluate the neurophysiological changes in cerebral oxygenation associated with physical fitn...
Article
Full-text available
Here we present a test-retest dataset of functional magnetic resonance imaging (fMRI) data acquired at rest. 22 participants were scanned during two sessions spaced one week apart. Each session includes two 1.5 mm isotropic whole-brain scans and one 0.75 mm isotropic scan of the prefrontal cortex, giving a total of six time-points. Additionally, th...
Article
Full-text available
Recent works have demonstrated that oxygenation in the brain can be measured via susceptibility shifts between vessels and neighboring regions in magnetic resonance images. To obtain a rich picture of local oxygenation, small venous vessels across the cortex need to be extracted. This work presents a novel vessel filter for the segmentation of vasc...
Article
To compare the performance of pulsed and pseudocontinuous arterial spin-labeling (PASL and pCASL) methods in measuring CO(2) -induced cerebrovascular reactivity (CVR). Subjects were scanned using both ASL sequences during a controlled hypercapnia procedure and visual stimulation. CVR was computed as the percent CO(2) -induced increase in cerebral b...
Article
Carbon dioxide (CO(2)), a potent vasodilator, is known to have a significant impact on the blood-oxygen level dependent (BOLD) signal. With the growing interest in studying synchronized BOLD fluctuations during the resting state, the extent to which the apparent synchrony is due to variations in the end-tidal pressure of CO(2) (PETCO(2)) is an impo...
Article
Breathing a mixture of 10% CO2 with 90% O2 (referred to here as carbogen-10) increases blood flow due to the vasodilatory effect of CO2, and raises blood O2 saturation due to the enriched oxygen level. These effects both tend to reduce the level of deoxygenated hemoglobin in brain tissues, thereby reducing the potential for further increases in BOL...
Article
Functional MRI of the spinal cord is challenging due to the small cross section of the cord and high level of physiological noise. Though blood oxygenation level-dependent (BOLD) contrast has been used to study specific responses of the spinal cord to various stimuli, it has not been demonstrated using a controlled stimulus. In this paper, we use h...
Article
Full-text available
Biophysical models of hemodynamics provide a tool for quantitative multimodal brain imaging by allowing a deeper understanding of the interplay between neural activity and blood oxygenation, volume and flow responses to stimuli. Multicompartment dynamical models that describe the dynamics and interactions of the vascular and metabolic components of...
Article
Full-text available
We present in vivo measurements of baseline physiology from five subjects with a four-wavelength (690, 750, 800, and 850 nm) time-resolved optical system. The measurements were taken at four distances: 10, 15, 25, and 30 mm. All distances were fit simultaneously with a two-layered analytical model for the absorption and reduced scattering coefficie...
Article
Full-text available
Previous studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead to disproportionately large blood oxygenation level...

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