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Introduction
Generalist in clinical trials.
Current institution
Additional affiliations
February 1989 - present
Education
April 2013 - March 2015
September 1986 - July 1989
University Hospital of Ulm for Medical documentation
Field of study
- Medical documentation
Publications
Publications (97)
Background
Perceived safety has received attention in the digital transformation of healthcare. However, the impact of perceived safety on the future of digital transformation has not been fully elucidated.
Aim
To investigate perceived safety in the context of the digital transformation of healthcare while considering relevant needs, influencing f...
Fachverband für Dokumentation und Informationsmanagement in der Medizin (DVMD) e.V. vergeben seit dem Jahr 2000 das Zertifikat Medizinische Dokumentation. Das Zertifikat soll den Absolvent*innen äquivalente Kenntnisse bescheinigen (1,2). Diese werden in der Regel durch eine Ausbildung als Medizinische Dokumentations-assistent*in, mehrjährige Berufs...
Zusammenfassung Klinische Studien können für einzelne Patientinnen und Patienten einen relevanten Nutzen bringen. Welche Herausforderungen und Chancen ergeben sich daraus für das Krankenhaus? Die Herausforderungen für das Krankenhaus liegen in der Auswahl gut durchführbarer Studien, in der zügigen und korrekten Vertragsgestaltung mit dem Pharmaunte...
Hintergrund und Stand der Forschung: Das Gefühl von Sicherheit ist ein Grundbedürfnis für Patient:innen und Leistungserbringende in der Gesundheitsversorgung. Obwohl das Thema der emotionalen und psychologischen Sicherheit im Hinblick auf (digitale) Technologien im Gesundheitswesen bedeutsam ist, ist dieses bisher kaum erforscht.
Fragestellung und...
Hintergrund und Stand der Forschung: Das Thema Sicherheit spiegelt eines der grundlegenden Bedürfnisse von Menschen wider und umfasst nicht nur die physische, funktionale oder soziale Ebene, sondern in Erweiterung bestehender Definitionen auch die emotionale und psychologische Ebene. Insbesondere in der digitalen Transformation des Gesundheitswesen...
Hintergrund und Stand der Forschung: Sich als Patient:in oder Leistungserbringende:r in der Gesundheitsversorgung sicher zu fühlen, stellt ein Grundbedürfnis dar. Trotz der Bedeutung der sogenannten emotionalen und psychologischen Sicherheit im Gesundheitswesen bei digitalen Technologien, ist diese bisher kaum erforscht.
Fragestellung und Zielsetz...
Objective
In active early rheumatoid arthritis (RA), glucocorticoids are often used for bridging, due to the delayed action of methotrexate. This study was undertaken to compare the effect of 3 bridging strategies, including high‐dose and low‐dose prednisolone, on radiographic and clinical outcomes.
Methods
Adult RA patients from 1 rheumatology ho...
BACKGROUND
In patients with coronary artery disease and concomitant asymptomatic severe carotid stenosis, combined simultaneous coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA) has been widely performed despite lack of evidence from randomized trials. We recently showed that the risk of stroke or death within 30 days was high...
Background
We previously reported that modified-release nicotinamide (NAMR) was superior to placebo in reducing serum phosphate concentrations over 12 weeks in a large cohort of haemodialysis patients with hyperphosphataemia. Here, we report outcomes after 52 weeks of treatment.
Methods
NOPHOS was a phase III, international, randomised, controlled...
■ Weiterentwicklungen der Studienrichtungen Medizinische Informatik und Medizinisches
Informationsmanagement
■ Bachelor-Studienprogramme in Deutschland
■ Perspektiven grundständiger Ausbildung in Medizinischer Informatik in Deutschland
Background
Longitudinal hypertension control prevents heart attacks, strokes, and other cardiovascular diseases. However, 49% of patients in German family medicine practices do not reach blood pressure (BP) targets (< 140/90 mmHg). Drawing on successful international approaches, the PIA study introduces the PIA information and communication technol...
Proceedings of the Joint Conference of the 66th Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (gmds)
and the 13th Annual Meeting of the TMF – Technology, Methods, and Infrastructure for Networked Medical Research e.V.
online conference / Kiel / 2021 / all full paper are open access
An amendment to this paper has been published and can be accessed via the original article.
Background
Prednisone is commonly used for initial short-term therapy of episodic cluster headaches before preventive medication such as verapamil becomes effective, but this strategy has not been tested in large randomised trials. We aimed to access the safety and efficacy of this treatment approach.
Methods
This study was a multicentre, randomi...
Attention deficit hyperactivity disorder (ADHD) is associated with sub- stantial personal and social impairments. Besides psychosocial interven- tions, current guidelines recommend a therapy with methylphenidate. This prospective, non-interventional study aims to investigate the effi- cacy and tolerability of methylphenidate treatment of adult ADHD...
5q-Associated spinal muscular atrophy is a hereditary neuromuscular disease leading to progressive muscle weakness in which fatigue occurs and affects quality of life. Treatment with the antisense oligonucleotide nusinersen has been shown to improve motor function. Fatigue can be measured within the Fatigue Severity Scale (FSS). FSS is a self-repor...
Background:
Perceived high chronic stress is twice as prevalent among German general practitioners (GPs) and non-physician medical staff compared to the general population. The reasons are multi-factorial and include patient, practice, healthcare system and societal factors, such as multi-morbidity, the diversity of populations and innovations in...
Background
Nusinersen is approved for the treatment of 5q spinal muscular atrophy of all types and stages in patients of all ages. Although clinical trials have shown improvements in motor function in infants and children treated with the drug, data for adults are scarce. We aimed to assess the safety and efficacy of nusinersen in adults with 5q sp...
Background: Perceived high chronic stress is twice as high prevalent among German general practitioners (GP) and non-physician medical staff compared to the general population. The reasons are multi-factorial and include patient, practice, health-care system and societal factors, such as multi-morbidity, the diversity of populations, and innovation...
Die Efficacy-Guideline der International Conference for Harmonisation (ICH) E6, allgemein auch als sog. ICH-GCP-Leitlinie – und damit als zentrales Regelwerk der Good Clinical Practice – bekannt, wurde 1996 erstmals veröffentlicht. Nach ca. 20 Jahren wurde es Zeit für eine umfassende Aktualisierung und Anpassung an den Stand der Zeit. Die Praxis in...
Objectives:
For early stage non-small cell lung cancer (NSCLC) retrospective data of functionally compromised patients undergoing segmentectomy showed equal outcomes for perioperative complications and quality of life (QoL) compared with lobectomy patients. However no prospectively randomized data comparing patients eligible for both procedures ar...
Standard first-line treatment of aggressive B cell lymphoma comprises six or eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus eight doses of rituximab (R). Whether adding two doses of rituximab to six cycles of R-CHOP is of therapeutic benefit has not been systematically investigated. The Positron Emission Tomo...
Adolescent extreme obesity is associated with somatic and psychiatric comorbidity, low quality of life, and social dysfunction. Nevertheless, few adolescents seek obesity treatment, thus many may elope appropriate care. We examine whether previous treatment seeking relates to disease burden, and whether previously non-treatment seeking adolescents...
Introduction: Treatment results in diffuse large B-cell lymphoma (DLBCL) are heterogeneous. Established risk models like the International Prognostic Index (IPI) and molecular lymphoma features such as MYC translocations and the cell of origin (COO) subtype are prognostic of outcome. A positive iPET scan after 2 cycles of rituximab, cyclophosphamid...
The analysis of adverse events (AEs) is a key component in the assessment of a drug's safety profile. Inappropriate analysis methods may result in misleading conclusions about a therapy's safety and consequently its benefit‐risk ratio. The statistical analysis of AEs is complicated by the fact that the follow‐up times can vary between the patients...
Purpose
Interim positron emission tomography (PET) using the tracer, [ ¹⁸ F]fluorodeoxyglucose, may predict outcomes in patients with aggressive non-Hodgkin lymphomas. We assessed whether PET can guide therapy in patients who are treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP).
Patients and Methods
Newly diagnosed pa...
The analysis of adverse events (AEs) is a key component in the assessment of a drug's safety profile. Inappropriate analysis methods may result in misleading conclusions about a therapy's safety and consequently its benefit-risk ratio. The statistical analysis of AEs is complicated by the fact that the follow-up times can vary between the patients...
Background
An European society growing older sets the need to explore treatment options for elderly patients. Here we aimed to gather evidence on the effectiveness of a modified cognitive behavioural therapy (mCBT) in elderly schizophrenia patients as compared to treatment as usual (TAU).
Methods
43 schizophrenia patients > 55y (mean 60 y), were a...
Einleitung: Das Thema ist die Vorarbeit für ein programmgesteuertes System, welches dem Arzt während der Behandlung passende Studien für den Patienten vorschlägt. Ein häufiges Problem bei klinischen Studien stellt die zeit- und kostenintensive Rekrutierung von Probanden dar [1]. Eine unzureichende Rekrutierung kann neben erhöhten Kosten und zeitlic...
Background and purpose:
The optimal operative strategy in patients with severe carotid artery disease undergoing coronary artery bypass grafting (CABG) is unknown. We sought to investigate the safety and efficacy of synchronous combined carotid endarterectomy and CABG as compared with isolated CABG.
Methods:
Patients with asymptomatic high-grade...
![CONSORT 2010 Flow Diagram [28] for the STEREO trial.¹Note that...](publication/318997908/figure/fig1/AS:11431281079534149@1660734813069/CONSORT-2010-Flow-Diagram-28-for-the-STEREO-trialNote-that-adherence-as-part-of-the_Q320.jpg)
Background:
To compare efficacy and safety of a manual-based low-level psychological intervention with treatment as usual (weight loss treatment).
Methods:
A two-armed randomized controlled trial without blinding and computer-based stratified block randomization included adolescents and young adults (14.0-24.9 years) with a BMI ≥ 30 kg/m2 at fiv...
Introduction: The PETAL trial is a multicenter randomized controlled study for patients with aggressive lymphomas of diverse histologies (EudraCT 2006-001641-33, NCT00554164). In the study population as a whole interim PET (iPET) reliably predicted time to treatment failure (TTTF) and overall survival (OS). Interim PET-based treatment changes, howe...
Introduction: The PETAL trial is a multicenter randomized controlled study for patients with aggressive lymphomas of diverse histologies (EudraCT 2006-001641-33, NCT00554164). In the study population as a whole interim PET (iPET) reliably predicted time to treatment failure (TTTF) and overall survival (OS). Interim PET-based treatment changes, howe...
A national German funding initiative for Medical Informatics focusing at data integration for medicine gives an opportunity to reopen a window to Germany. In the open window appears a best paper selection of the 2015 annual conference of the German Society of Medical Informatics, Biometry and Epidemiology and papers of the German journal GMS Medica...
Oral prednisone is considered the standard first-line therapy of adult immune thrombocytopenia, but its long-term efficacy is limited. We performed a prospective, randomized, multicenter trial comparing daily prednisone (1-2 mg/kg/day for 2-4 weeks with subsequent dose reduction) with six 3-week cycles of pulsed dexamethasone (0.6 mg/kg/day, days 1...
Background
Trigeminal neuralgia is characterized by paroxysmal facial pain attacks. Adequate prophylactic drug therapy is often limited by the lack of efficacy and intolerance due to central nervous system side effects.
Subcutaneous injections of botulinum toxin type A are a promising treatment option for patients with unsatisfactory response to dr...
The demand for evidence-based health informatics and benchmarking of 'good' information systems in health care gives an opportunity to continue reporting on recent papers in the German journal GMS Medical Informatics, Biometry and Epidemiology (MIBE) here. The publications in focus deal with a comparison of benchmarking initiatives in German-speaki...
Einleitung: Die Europäische Verordnung über klinische Prüfungen mit Arzneimitteln (Clinical Trials Regulation) [1] ist am 16. Juni 2014 in Kraft getreten und soll die bisher geltende Richtlinie über klinische Prüfungen (Clinical Trials Directive) 2001/20/EC ersetzen. In Kapitel XIV. der Verordnung wird die zukünftig zu nutzende IT-Struktur – besteh...
Introduction: The predictive value of 18-fluorodeoxyglucose PET performed after a few cycles of chemotherapy has been questioned in aggressive lymphomas. Inconsistent study results, however, may be due to procedural differences rather than an inability of the method to predict outcome. Whether changing treatment in pts. with an unfavorable interim...
The publication of a memorandum on improving medication safety by information technology in both the German journal GMS Medical Informatics, Biometry and Epidemiology (MIBE) and the journal Methods of Information in Medicine (MIM) gives reason to strengthen cooperation of MIBE and MIM and to report on more publications of MIBE here. The publication...
Randomisierte kontrollierte Therapiestudien („randomized controlled trial“; RCT) zum Nachweis der Wirksamkeit von Therapien sind der Goldstandard der klinischen Prüfung. In Abgrenzung zu anderen Studientypen wie Anwendungsbeobachtungen, die oft dazu dienen, die Verschreibungspraxis nach der Zulassung eines Präparates zu dokumentieren, sind RCTs exp...
Introduction
Daily prednisone is considered standard first line therapy in idiopathic thrombocytopenic purpura (ITP). Since its long-term efficacy is limited, other glucocorticosteroids and schedules have also been tested. The most widely used regimen is pulsed dexamethasone. We performed a randomized, prospective, multicentre trial to analyze the...
The aim of this analysis is to describe medication adherence, and treatment persistence, in adults with attention deficit/hyperactivity disorder (ADHD) treated for 24weeks with extended release methylphenidate (MPH-ER). Additionally, patient-, disorder- and treatment-related factors associated with adherence and persistence will be identified.
Post...
Episodic cluster headache (ECH) is a primary headache disorder that severely impairs patient's quality of life. First-line therapy in the initiation of a prophylactic treatment is verapamil. Due to its delayed onset of efficacy and the necessary slow titration of dosage for tolerability reasons prednisone is frequently added by clinicians to the in...
This multi-centre, open-label, non-interventional study evaluates effectiveness, safety and adherence to treatment of a specific extended-release methylphenidate with a 50 % immediate and a 50 % extended-release component (Medikinet® retard) in the clinical routine treatment of 381 adolescents with ADHD and a mean age of 14.0 ± 1.9 years. ADHD and...
The publication of German competencybased learning objectives "Medical Informatics" for undergraduate medical education gives reason to report on more publications of the German journal GMS Medical Informatics, Biometry and Epidemiology ( MIBE ) in Methods. The publications in focus deal with support of medical education by health and biomedical in...
High-grade carotid artery stenosis is present in 6-8% of patients undergoing coronary artery bypass graft surgery. Many cardiovascular surgeons advocate staged or synchronous carotid endarterectomy to reduce the high perioperative and long-term risk of stroke associated with multivessel disease. However, no randomized trial has assessed whether a c...
Background
This open label multi-centre non-interventional study examines the effectiveness and tolerability of a modified-release methylphenidate (MPH) preparation with a 50% immediate-release component (Medikinet® retard) in children and adolescents with attention deficit hyperactivity disorder (ADHD).
Methods
A total of 447 patients aged 6–17 ye...
Background
Early graft dysfunction due to preservation/reperfusion injury represents a dramatic event after liver transplantation. Enhancement of donor organ criteria, in order to cope with the ever increasing donor shortage, further increases graft susceptibility to ischemic alterations.
Major parts of post-preservation injury, however, occur at t...
The comparison of the efficacy of Medikinet(®) retard and Concerta(®) trial was a multisite, randomized, double-blind, crossover trial that aimed at comparing the effects of two different modified release methylphenidate preparations (Medikinet retard: 50% immediate release (IR); Concerta: 22% IR) in a natural setting across the day in 113 randomiz...
This trial was performed to test the efficacy and safety of an extended-release formulation of methylphenidate (MPH ER).
A total of 162 adults with ADHD according to DSM-IV were treated for 8 weeks with either two daily individually body weight-adjusted doses of MPH ER up to 1 mg/kg per day (N = 84) or placebo (N = 78). The primary efficacy outcome...
Pharmacological intervention with methylphenidate (MPH) is very common and helpful in the treatment of attention-deficit/ hyperactivity disorder (ADHD). It ameliorates inattention, impulsivity and hyperactivity and improves psychosocial functioning. The core symptoms of ADHD are problematic mainly in demanding structured situations such as in the c...
Treatment investigations with methylphenidate in adults with ADHD focus preferentially on the classical psychopathology: inattention, hyperactivity and impulsivity. ADHD-associated emotional symptoms, which are frequently present at least in ADHD subpopulations, were studied rarely. The vast majority of the placebo-controlled trials had observation...
Medizinische Dokumentation
Heft 2 - 2010
Seiten: 83 - 84
Introduction
Attention-deficit/hyperactivity disorder (ADHD) affects many adults who had ADHD in childhood. Although stimulants and methylphenidate in particular are a common off-label treatment for adult patients with ADHD in European countries, little is known about their long-term efficacy and safety.
Methods
A randomized, 24-week double-blind,...
Introduction:
Attention-deficit/hyperactivity disorder (ADHD) affects many adults who had ADHD in childhood. Although stimulants and methylphenidate in particular are a common off-label treatment for adult patients with ADHD in European countries, little is known about their long-term efficacy and safety.
Methods:
A randomized, 24-week double-bl...
Aggression is frequently observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to assess the efficacy with regard to oppositional and aggressive behavior of a new long-acting methylphenidate preparation (Medikinet retard, MPH-MR), with equal portions of the immediate-release and the sus...
Background:Does there exist a difference in the outcome of severely injured children and severely injured healthy adults?
Methods:The data of 1,566 severely injured patients, treated between May 1998 and December 2002 in our emergency department of the
University Essen/Germany, were analyzed. Patients with an injury severity score (ISS) > 24 were...
Individual symptoms of patients with varicose veins are not considered in the CEAP-classification. Method: We analysed how far people with CEAP class 1 and 2 differ in their symptoms from people without varicose veins in the Duesseldorf/ Essen civil servants study recruiting 9935 employees. All volunteers were asked to fill out a questionnaire and...
In a prospective randomized trial the effect of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients and was compared with patients ventilated in supine position.
Multiple trauma patients of the intensive care units of two university hospitals were considered eligible if they met the criteria for acu...
To determine the prevalence of varicose veins in the German population and specify possible risk factors the data of the Duesseldorf/Essen civil servants study were analysed.
From December 1989 to July 1993 a total of 9 935 employees were recruited. All volunteers filled out a questionnaire regarding family history and risk factors and were clinica...
Given the dosing limitations of methylphenidate short-acting preparations in treating ADHD, galenics with longer release of the substance were developed mainly to avoid drug intake during school hours.
This investigation was conducted to assess the efficacy and the duration of action of a new extended-release formulation of methylphenidate (Medikin...
Nowadays the planing, conduct and analysis of clinical trials according to ICH-GCP
costs about 1,5 mill. € per trial.
Conducting a clinical trial according to ICH-GCP increases the number of man-days as
well as.financial expenses. Proper use of available ressources however can reduce costs
to a level acceptable even for institutions of the public s...
To investigate changes in the size of the deep and superficial venous systems associated with gender, age, body mass index and varicose veins, changes to the cross-sectional area of the femoral and the long saphenous veins were analysed in the Duesseldorf/Essen civil servant study population. Between December 1989 and July 1993 a total of 9935 empl...
The treatment of acute lung failure, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is still one of the key problems in the treatment of severely ill patients in the intensive care unit (ICU). Sepsis and ARDS leading to multi-organ dysfunction are being reported with mortality rates up to 40%. The treatment of severe oxygena...
The aim of the study was to examine the predictive value of CT for severe intracranial lesions of mild (GCS 15-13) and moderate (12-9) head injuries. Further,we examined the possibility of predicting these lesions by various variables/factors. Data were collected prospectively from the trauma registry of the DGU (Deutsche Gesellschaft für Unfallchi...
The purpose of this study was to evaluate process and outcome quality of severely injured patients admitted during on-call (OC) versus regular trauma service (RS).
This was a prospective and multicentric analysis of the Trauma Registry of the German Trauma Society. Patients were evaluated if directly admitted from the scene of accident with an Inju...
In a randomized trial the effect of a predefined strategy of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients with acute lung injury or acute respiratory distress syndrome. Patients in the prone group (n = 21) were continuously kept prone for at least 8 hours and a maximum of 24 hours per day. Pr...
Prone positioning developed to the most hopeful therapeutical approach in the treatment of severe respiratory failure. Different types of kinetic therapy are practiced, but so far no data are available about the real number of institutions that practice kinetic therapy in the treatment of respiratory failure and which sort of therapy is practiced....
The aim of the study was to examine the predictive value of CT for severe intracranial lesions of mild (GCS 15–13) and moderate (12–9) head injuries.Further,we examined the possibility of predicting these lesions by various variables/factors.Data were collected prospectively from the trauma registry of the DGU (Deutsche Gesellschaft für Unfallchiru...
Objective: The long-acting methylphenidate (MPH, Medikinet® Retard), a preparation with a two-step dynamic to release MPH - step one: acute; step two: prolonged - was tested concerning its efficacy and safety during school-time in children with ADHD. Method: In a multicenter drug treatment study (placebo controlled, randomized-parallel, double-blin...
Zusammenfassung
Fragestellung: Langzeitwirksame Methylphenidatpräparate mit einer zweistufigen Freisetzungsdynamik (Stufe 1: rasch; Stufe 2: verzögert) erlauben eine morgendliche Einmalgabe und werden so der Unterstützung von Schulkindern mit ADHS besser gerecht. Das diesbezüglich erste deutsche Arzneimittel (Medikinet® Retard 20 mg) sollte daher a...
On the basis of the data of a multicenter study, the impact of prehospital intubation and ventilation in the therapy of severe thoracic trauma without manifest respiratory insufficiency was analyzed.
Data were collected prospectively in the Trauma Registry of the German Trauma Society. In a matched-pair analysis, patients with severe thoracic traum...
Aim: Since the clinical relevance of small cutaneous veins (SCV) is still under discussion we analysed its prevalence, individual symptoms, and age dependent changes in the Duesseldorf/Essen civil servants study. Method: This cross-sectional study recruited 9935 employees of which 9100 were finally evaluated. Documentation of clinical findings was...
The clinical relevance of small cutaneous veins (SCV) is still being discussed. In the Duesseldorf/Essen civil servants study, the prevalence of SCV and the individual symptoms and age-dependent changes were analysed.
This cross-sectional study recruited 9935 employees; 9100 could be finally evaluated for this analysis. All volunteers were asked to...
Zusammenfassung
Ziel: Da der Krankheitswert der Besenreiservarikosis (BV) nicht eindeutig definiert ist, analysierten wir in der Düsseldorf-Essener Beamtenstudie die Symptome und ihre altersabhängigen Veränderungen bei den Patienten mit isolierter BV. Methode: Die Querschnittsstudie umfasst 9935 Mitarbeiter der Städte Düsseldorf und Essen, von dene...
Patients with acromegaly have an increased risk of ventricular dysrhythmias and sudden death. Late potentials in a signal-averaged electrocardiogram (SAECG), a predictor of ventricular dysrhythmias, are frequently seen in patients after previous myocardial infarction, but little is known about the prevalence of late potentials in acromegaly. The ai...
Objective: To evaluate process quality and outcome of severely injured patients admitted during on-call (OC) versus regular trauma service (RS). Methods: Prospective and multicentric analysis of the DGU Trauma Registry. Results: 70% of the patients were admitted during OC. This group was significantly younger. No differences were found for Emergenc...
In dem Zeitraum November 1999 bis Mai 2001 wird in 50 niedergelassenen Praxen in Deutschland eine Anwendungsbeobachtung zum Thema “Lansoprazol bei Refluxosophagitis” durchgefuhrt. 9000 Patienten sollen aufgenommen werden.
Systemic blood pressure, stroke volume, systolic time intervals (measured via impedance cardiography), rheological properties of blood (hematocrit, plasma viscosity and erythrocyte aggregation) and peripheral flow conditions (measured via occlusive impedance plethysmography) were assessed longitudinally in 21 nonpregnant women and in 49 patients fr...
In einer prospektiven Studie wurden bei 49 Schwangeren in der 5. bis 14. SSW, 15. bis 30. SSW, 31. bis 36. SSW und 37. bis 41. SSW mit Hilfe der Impedanzkardiographie die systolischen Zeitintervalle und Schlagvolumina bestimmt. Berechnet wurden aus diesen Parametern der Herzindex und der totale periphere Widerstand. Als Vergleichsgruppe dienten 21...
Routine postoperative monitoring of plasma coagulation and fibrinolysis system values after cesarean delivery in 191 women who did not develop thrombosis and 16 who did revealed a preoperative defect in the fibrinolysis (PAI, TAT) and inhibitor (AT III) systems. Significant postoperative correlations in the drop in antithrombin levels could not be...
In 207 consecutive randomized women undergoing cesarean section, of whom 104 received 3 X 5000 IE unfractionated heparin and 103 3 X 500 ml hydroxyethylstarch 6% 0.62, the frequency of deep vein thrombosis was evaluated with a non-invasive diagnostic technique-impedance plethysmography. 5.9% of the patients in the hydroxyethylstarch group and 7.8%...
In 207 consecutive randomized women undergoing cesarean section, of whom 104 received 3 x 5000 IE unfractionated heparin and 103 3 x 500 ml hydroxyethylstarch 6% 0.62, the frequency of deep vein thrombosis was evaluated with a non-invasive diagnostic technique-impedance plethysmography. 5.9% of the patients in the hydroxyethylstarch group and 7.8%...
