Claudia Mazzuca

Claudia Mazzuca
University of Rome Tor Vergata | UNIROMA2 · Dipartimento di Scienze e Tecnologie Chimiche

Professor

About

92
Publications
12,036
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,357
Citations
Introduction
Claudia Mazzuca was born in 1976. In 2001 she got her Master Degree of Science in Chemistry cum laude at the University of Rome "Sapienza". In 2005 she got her PhD degree in Chemical Science at the University of Rome "Tor Vergata". Since 2007 she is assistant professor in Physical Chemistry at the Department of Chemical Science and Technologies of the University of Rome "Tor Vergata". From 2009 she has been teacher of "Physical Chemistry" in this University at the degree course of “Conservation
Additional affiliations
November 2007 - present
University of Rome Tor Vergata
Position
  • Researcher

Publications

Publications (92)
Preprint
Among hydrocolloids, gellan is one of the most used anionic polysaccharides, because of its capability of forming mechanically stable gels at relatively low concentrations. Despite its long-standing use and importance, the gellan aggregation mechanism is still not presently understood at the microscopic level due to the lack of atomistic informatio...
Article
There has been increasing interest in using nanosized fillers in cement-based construction materials to upgrade mechanical properties, durability, and multi-functionality. In this context, graphene oxide (GO) is proved to be an effective candidate, and its interaction with cement can lead to remarkable enhancement in its macro-properties. To guaran...
Article
In this work, the application of nanodiamond (ND)‐composites and dispersions as consolidating agents for parchment substrates has been studied. Different nanocomposites and ND‐based dispersions have been tested showing very promising results and making ND a potential high‐performance additive in the field of restoration. The effect of ND treatment...
Article
The application of cleaning treatments for the restoration of nineteenth–twentieth-century photographs represents an innovative and still little explored aspect. In this work, in order to remove the degradation products, two cleaning methods were used for two different photographic techniques: poly(vinyl alcohol)-based hydrogels were applied to cle...
Article
We report a non-invasive and multi-analytical physico-chemical method for the characterization of paper artworks, able to identify sizing, inks, and glues and to quantify oxidative degradation by-products. The proposed methodology is mostly carried out in situ by using easy-to-use and cheap portable instrumentation for the acquisition of multispect...
Article
Full-text available
The impact of extra-low dosage (0.01% by weight of cement) Graphene Oxide (GO) on the properties of fresh and hardened nanocomposites was assessed. The use of a minimum amount of 2-D nanofiller would minimize costs and sustainability issues, therefore encouraging the market uptake of nanoengineered cement-based materials. GO was characterized by X-...
Article
Full-text available
An innovative consolidation strategy for degraded paper is presented based on the reversible application of cellulose nanocrystals as sustainable fillers to reinforce mechanical properties and resistance to further degradation. The compatibility and efficacy of the proposed consolidation treatment are assessed first on pure cellulose paper, used as...
Article
Full-text available
In this study, the employment of the X-ray irradiation as bioremediation method to treat parchment has been deeply investigated. In particular, the effect of the irradiation doses on the structural stability of collagen, the main constituent of parchment, has been evaluated on a series of modern parchment samples by means of different opto-thermal...
Article
The quantitative evaluation of chemical elements from X-ray Fluorescence (XRF) analysis still remains a strong hurdle in X-ray Spectrometry, mainly due to significant matrix effects involved in the processes. The Fundamental Parameter Method (FPM) is a valid tool for the calculation of analyte concentration unless the primary source comes from a Sy...
Article
Full-text available
In this work, we shed new light on ultrasound contrast agents applied to the field of cultural heritage as an invaluable fine-tune cleaning tool for paper artworks. In this context, one of the primary and challenging issues is the removal of modern adhesives from paper artifacts. Modern adhesives are synthetic polymers whose presence enhances paper...
Article
Aqueous cleaning of works of art on paper is one of the most important and delicate steps in a conservation process. It allows the removal of inorganic (metals) and organic substances, such as degradation products and other contaminants. These substances are responsible for yellowing, weakening, and loss of mechanical properties of paper. In this a...
Article
Full-text available
This paper reports atomic force microscopy results and molecular dynamics simulations of the striking differences of long-term self-organization structures of negatively charged (AcA4)2KD (double tail) and AcA4D (single tail) peptides, respectively, forming micrometer-long, linearly ordered ribbon-like structures and nanometer-sized, unstructured,...
Article
Full-text available
The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway diseases. C-GMs of Carpinus betul...
Article
A sustainable approach for the green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of hyperpigmented tomato (Solanum lycopersicum L) skins (HTS) was described. AgNPs characterization and catalytic activity in the degradation of methylene blue were reported. The influence of some experimental parameters on synthesis, such as gre...
Article
Microgel particles have emerged in the last few years as a favourite model system for fundamental science and for innovative applications ranging from industrial to biomedical fields. Despite their potentialities, no works so far have focused on the application of microgels for cultural heritage preservation. Here we show their first use for this p...
Article
Full-text available
Microorganisms often cause significant damage on historical objects. The archive or library materials as well as textile or leather artifacts suffer serious attacks that need appropriate care treatments. Several biocide processes have been implemented but often their application does not preserve the material of the good. The objective of this work...
Article
The conservation and restoration of paper artworks play a fundamental role in the field of our Cultural Heritage. In this contest, the characterization of paper composition as well as degradation state is fundamental to determine the suitable restoration and conservation processes for paper artworks. In this work, we present an interdisciplinary st...
Article
Wet cleaning of paper artworks by using hydrogels is a recently proposed process in the cultural heritage field. In this contest, on one side, research has focused on more effective and tuned cleaning hydrogels; on the other, the cleaning performances of the proposed hydrogels have been studied on ancient paper and very little on modern paper. This...
Article
Hydrogel-based cleaning of paper artworks is an increasingly widespread process in the cultural heritage field. However, the search for tuned (compatible, highly retentive and not perishable) hydrogels is a challenging open question. In this paper, a complete characterization of chemical hydrogels based on polyvinyl alcohol (PVA) crosslinked with t...
Article
Trichogin GA IV is a short peptaibol with antimicrobial activity. This uncharged but amphipathic sequence is aligned at the membrane interface and undergoes a transition to an aggregated state that inserts more deeply into the membrane, an assembly which predominates at P/L 1/20. Here, the natural trichogin sequence was prepared and reconstituted i...
Article
Full-text available
Nanostructures can strongly interact with cells or other biological structures; furthermore when they are functionalized with targeting units, they are of great interest for a variety of applications in the biotechnology field like those for efficient imaging, diagnosis and therapy and in particular for cancer theranostic. Obtaining targeting with...
Article
The cyclic change of structure, thickness and density, with pH switching from acid (pH=3) to basic (pH=11) condition, has been revealed for chemisorbed monolayers of the peptide Lipo-Aib-Lys-Leu-Aib-Lys-Lys-Leu-Aib-Lys-Ile-Lol, a Trichogin GA IV-analog carrying Lys residues instead of Gly ones at positions 2, 5, 6, 9, while a homologous peptide non...
Article
A work of chemical engineering has been realized on gold surfaces. Three building blocks have been designed, in order to chemically link the surface and vertically self assemble in an ordered manner in 3D, through thymine‐adenine hydrogen bonds. Starting from these building blocks, we have engineered two different films on gold surface. In film 1,...
Article
A work of chemical engineering has been realized on gold surfaces. Three building blocks have been designed, in order to chemically link the surface and vertically self assemble in an ordered manner in 3D, through thymine‐adenine hydrogen bonds. Starting from these building blocks, we have engineered two different films on gold surface. In film 1,...
Article
Irradiation with γ rays is widely used in the sterilization of a large variety of products and materials in the field of medical supplies, pharmaceuticals, cosmetics, food industry and cultural heritage. It is also applied on wood materials, with the purpose of improving their shelf-life, by lowering the microbial charge and hence the microbial-rel...
Article
Full-text available
A simple, eco-friendly, cost-effective and rapid microwave-assisted method has been developed to synthetize dendritic silver nanostructures, composed of silver nanoparticles (AgNPs), using white grape pomace aqueous extract (WGPE) as both reducing and capping agent. With this aim, WGPE and AgNO3 (1mM) were mixed at different ratio, and microwave ir...
Article
Trichogin GA IV (TrGA) is an antimicrobial peptide isolated from Trichoderma longibrachiatum. The amino acid sequence of TrGA is rather peculiar, because it is characterized by three Aib and four Gly residues, which confer unique dynamic and structural properties. In a previous study, we found that TrGA shows excellent binding properties to Ca(II)...
Article
Peptide self-assembly is ubiquitous in nature. It governs the organization of proteins, controlling their folding kinetics and preserving their structure stability and bioactivity. In this connection, model oligopeptides may give important insights on the molecular mechanisms and elementary forces driving the formation of supramolecular structures....
Article
Disposable non-invasive and compatible real time monitoring tool was developed in order to follow the cleaning process of paper artwork directly in situ. This tool was based on a biocompatible cleaning hydrogel coupled with flow electrochemical diagnostic tool, suitable to verify in situ and in a simple way the assessment of degradation of artwork...
Article
Experimental and theoretical reports have shown that nanostructured surfaces have a dramatic effect on protein adsorbed amount and conformational state and, in turn, on the performances of the related devices in tissue engineering strategies. Here we report an innovative method to prepare silica-based nanostructured surfaces with a reproducible, we...
Article
A detailed characterization of the behavior of the amphiphilic antimicrobial peptide Trichogin GA IV (TRIC) at the air/water interface during a Langmuir-Blodgett (LB) isotherm is reported. By means of molecular dynamics simulations, experimental data are explained in terms of the conformational changes and aggregate features adopted by TRIC. We sho...
Article
The gellan hydrogel is used as a cleaning agent for paper artworks. The purposes of this work were to give the gellan hydrogel both a microbial resistance and a cytocidal action against the biodeteriogens using hydrolates. Broth microdilution assays were performed to identify the fungicidal action of 16 hydrolates vs 3 fungal strains. The study con...
Article
Full-text available
During the Middle Ages in Europe, a different post-mortem funerary custom came to be used in order to transport and solemnly dispose of the bodies of high-status individuals. Because of their high degree of mobility, most medieval kings and queens rarely died where they had planned to be buried; thus, they had to be moved to the place of burial. An...
Article
Hypothesis: Due to their highly retentive properties, innovative recently developed, semi-interpenetrated hydrogels made up of poly(vinyl pyrrolidone) (PVP) chains embedded in a poly(2-hydroxyethyl methacrylate) (p(HEMA)) network should be efficiently used as cleaning material for fragile and degraded paper artworks. In restoration practice, indee...
Article
Full-text available
The effects that an increase of environmental pH has on the triple helix of scleroglucan (Sclg) and on the Sclg/borax hydrogel are reported. Rheological experiments show that the hydrogel is less sensitive to pH increase than Sclg alone, while at pH = 14 a dramatic viscosity decrease takes place for both systems. This effect is evidenced also by th...
Article
Chiral mesoscopic structures were obtained by Langmuir–Blodgett (LB) deposition of two tetrasteroid-porphyrins differing by the number of hydroxy groups functionalizing the steroid rings. The morphology of the porphyrin aggregates was characterized by spectroscopy (UV-Vis absorption, steady-state fluorescence, circular dichroism) and microscopy (fl...
Article
Paper has been used as writing and drawing support for thousands of years. The conservation of paper artworks plays a fundamental role in the field of our cultural heritage. Moreover, restoration of paper artworks is difficult due to their inherent fragility, the presence of many components and their degradation state. Among the factors that may co...
Article
Full-text available
Mono and bis ethynyl and ethynylphenyl β-substituted porphyrins have been synthesized and characterized. Their conformational properties have been analyzed through a combination of NMR experiments and molecular mechanic calculations, while UV-Vis absorption and fluorescence measurements together with electrochemical studies allows us to probe the e...
Article
Scleroglucan (Sclg) is a polysaccharide that exhibits a triple helix conformation (triplex), both in aqueous solution and in the solid state, which is lost in DMSO solution, at high temperature and at high pH values. The triplex conformation is characterized by a high rigidity, responsible of Sclg peculiar properties. Although the relative stabilit...
Article
The interest towards natural rubber (NR) is progressively increasing due to its sustainable production and remarkable mechanical properties, presenting a wide application range in the automotive industry and civil engineering. In this paper we report, for the first time, the use of electrospinning technique to produce neat and graphene nanoplatelet...
Article
Full-text available
Wet cleaning of ancient papers is one of the most delicate and important steps in a restoration process. It allows to improve the optical quality of a graphic work as the removal of pollution and of organic substances resulting from cellulose degradation. Nevertheless, washing by immersion – the traditional process – usually involves a substantial...
Article
Paper manuscripts are among the most valuable historical artifacts, but they are also very fragile. Furthermore, they were often strengthened by gluing external materials (like wooden or cardboard lining paper) to the original piece. The glues induced structural transformations that accelerate the degradation processes of the artwork itself. In thi...
Conference Paper
Full-text available
The technological application of the  rays is used in various fields: the sterilization of materials and equipment for medical use pharmaceutical and cosmetics, but also for wooden musical instruments. The purpose of irradiating the wood is to improve the "shelf-life", lowering the microbial charge of deterioration. In general, the sterilization b...
Article
The removal of old glue from paper artworks is of paramount importance for the preservation of its integrity during the restoration process. Wet cleaning is one of the traditional methods, although, it may cause damages on artworks. In this work, an advantageous alternative method, based on the use of a rigid hydrogel, for a simple and localized re...
Article
Full-text available
In this work an outlook on the design and application, in the cultural heritage field, of new tools for diagnostic and cleaning use, based on biocompatible hydrogels and electrochemical sensors, is reported. The use of hydrogels is intriguing because it does not require liquid treatment that could induce damage on artworks, while electrochemical bi...
Article
Amyloid fibrils are formed by a model surfactant-like peptide (Ala)10-(His)6 containing a hexa-histidine tag. This peptide undergoes a remarkable two-step self-assembly process with two distinct critical aggregation concentrations (cacs), probed by fluorescence techniques. A micromolar range cac is ascribed to the formation of pre-fibrillar structu...
Article
Interactions between peptides are relevant from a biomedical point of view, in particular for the role played by their aggregates in different important pathologies, and also because peptide aggregates represent promising scaffolds for innovative materials.In the present article, the aggregation properties of the homo-peptides formed by α-aminoisob...
Article
Full-text available
The aggregation of a steroid-functionalised porphyrin derivative occurs with the formation of J-type chiral species. Spectroscopic and SEM studies indicate that the initial concentration of the macrocycle strongly influences the morphology of the final mesoscopic structures, as a consequence of a change in the mechanistic course of the self-assembl...
Article
Full-text available
Paper based artworks are probably ones of the most difficult materials to restore, because of their complexity and fragile structure. Cleaning of paper artifacts, one of the process commonly carried out during restoration, usually involves the use of solvents (organic or not), that may cause several troubles, like swelling and dissolution of some c...
Article
In this work we present innovative materials able to remove in a single, simple and not invasive treatment, different contaminants like starch paste from paper artworks. The materials, based on biocompatible hydrogels, overcome many of the problems usually faced by restorers during the cleaning of paper samples.
Article
The application of UV irradiation processes are successfully proposed for the first time in the fabrication of both of the two plastic electrodes in flexible dye solar cells (DSCs) and modules. For the realization of the photo‐electrode, a customized TiO2 paste formulation and UV processing method was developed which yields 134% (48%) performance e...
Article
In this paper we describe in detail a general and efficient methodology, based on the perturbed matrix method and molecular dynamics simulations, to model UV-Vis absorption and emission spectra including vibrational and conformational effects. The basic approximation used is to consider all the chromophore atomic coordinates as semiclassical degree...
Article
Full-text available
We carried out a systematic study on the effect of nanocrystalline TiO2 paste formulations and temperature treatment on the performance of dye solar cells (DSCs) over a large temperature range, to provide useful information for the fabrication of both plastic and metal flexible devices. We compared conventional screen-printable and binder-free TiO2...
Article
The aggregation propensity of helical oligopeptides formed exclusively by the conformationally constrained α-aminoisobutyric acid (Aib or U in a three- or single-letter code, respectively) was studied in methanol and methanol/water solutions by spectroscopic methods (UV-Vis absorption, steady-state and time-resolved fluorescence, FT-IR absorption)...
Article
Full-text available
Guar Gum is a natural polysaccharide that, due to its physicochemical properties, is extensively investigated for biomedical applications as a matrix for modified drug delivery, but it is also used in the food industry as well as in cosmetics. A commercial sample of Guar Gum was sonicated for different periods of time, and the reduction in the aver...
Article
Full-text available
Paper-based artworks are among the most valuable assets for transmission of knowledge. Historical paper is composed of different polysaccharides (e.g. cellulose), binders, and glues. During aging all of these components undergo several degradation processes, as a result of external and intrinsic causes, and these can compromise the state of conserv...
Article
Full-text available
Since their initial discovery, 30 years ago, antimicrobial peptides (AMPs) have been intensely investigated as a possible solution to the increasing problem of drug-resistant bacteria. The interaction of antimicrobial peptides with the cellular membrane of bacteria is the key step of their mechanism of action. Fluorescence spectroscopy can provide...
Article
The assembly of multifunctional nanostructures bearing G-quadruplex motifs broadens the prospects of using G-quadruplexes as therapeutic carriers. Herein, we report the synthesis and characterization of an oligodeoxyguanosine, G15-mer polymer conjugate. We demonstrate that G15-mer oligonucleotides grafted to a polymer chain preserve the ability to...