
Claudia I. Gamboa-GómezMexican Institute of Social Security | IMSS · Unidad de Investigación Biomédica
Claudia I. Gamboa-Gómez
About
57
Publications
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Introduction
Claudia I. Gamboa-Gómez currently works at the Unidad de Investigación Biomédica, Mexican Institute of Social Security. Claudia does research in Toxicology, Nutrition and Dietetics and Nutritional Biochemistry. Their current project is 'Biodisponibilidad de compuestos fenólicos de bebidas vegetales fermentadas de hojas de encino y su eficacia sobre marcadores de estrés oxidativo e inflamación en sujetos con dislipidemia'.
Publications
Publications (57)
Background
In vascular tissue, macrophages and inflammatory cells produce the enzyme lipoprotein- associated phospholipase A2 (Lp-PLA2). Treatment with fibrates decreases Lp-PLA2 levels in individuals with obesity and metabolic syndrome; however, these findings have not been fully clarified.
Objective
The goal of this study was to investigate the...
This study aimed to assess the impact of roasting degree on antioxidant and metabolic parameters in vitro and in vivo. In vitro, we evaluated radical scavenging, lipid peroxidation, and the activity of digestive enzymes (α-glucosidase, α-amylase, and lipase). In vivo, we first examined coffee's effect on carbohydrate and lipid absorption in healthy...
769-Retos, número 58, 2024 (septiembre) The effect of concurrent training on glucose, lipid profile, liver enzymes, and lipid peroxidation in young men El efecto del entrenamiento concurrente en la glucosa, perfil lipídico, las enzimas hepáticas y la peroxidación lipídica en hombres jóvenes Abstract. The objective of this study was to determine the...
El objetivo de este estudio fue determinar el efecto del entrenamiento concurrente (EC) en glucosa, función hepática, perfil lipídico y estrés oxidativo en hombres jóvenes. Dieciséis hombres jóvenes moderadamente activos (Edad= 23.11 ± 4.20 años, Altura= 172.44 ± 6.50 cm, Peso= 73.52 ± 15.70 kg, IMC= 24.84 ± 5.85 kg/m2) entrenaron durante doce sema...
The effects of Buddleja scordioides (BsLI) leaf infusions on digestive enzymes and carbohydrate absorption were evaluated. The BsLI yield was 21.64 %. In addition, a chemical characterization was carried out identifying hydroxybenzoic acids, hydroxycinnamic acids, flavonols, flavanones and flavones. In vitro studies were performed to determine the...
Ludwigia octovalvis (Jacq.) P.H. Raven is widely used in traditional medicine for different illnesses, including diabetes and hypertension. However, its impact on lipotoxicity and metabolic syndrome in vivo has not been addressed. Therefore, the aim of this study was to evaluate the effects of this plant on the metabolic syndrome parameters in a C5...
Ludwigia octovalvis (Jacq.) P.H. Raven is widely used in traditional medicine for different illnesses included diabetes and hypertension. However, its impact on lipotoxicity and metabolic syndrome in vivo has not been addressed. Therefore, the aim of this study was to evaluate the effects of this plant on the metabolic syndrome parameters in a C57B...
A nivel mundial hay 537 millones de pacientes diabéticos y 14.1 millones en México. Se ha reportado que el Aloe barbadensis Miller, comúnmente conocido como Aloe vera (AV), presenta propiedades anti-hiperglucemiantes y éste contiene compuestos fenólicos. En el presente estudio se evaluó el contenido fenólico (FC), la capacidad antioxidante (AC) y e...
The objective of this study was to evaluate the effect of roasting coffee degree on inflammatory (NF-kβ F-6 and TNF-α) and stress oxidative markers (malondialdehyde (MDA), nitric oxide (NO) end product concentrations, catalase (CAT), and superoxide dismutase (SOD) in high-fructose and saturated fat (HFSFD)-fed rats. Roasting was performed using hot...
We thank Dr. Scarpati and Dr. Piazza for their interest and comments [...]
Ethnopharmacological relevance
Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed.
Aim of the study
Assess the effect of Mexican oregano (Lippia graveolens Kunth) on carbohydrates and lipids absorption in vivo. The antioxidant activity also was invest...
Purpose
Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent group...
Obesity, type 2 diabetes, arterial hypertension, decrease in immune response, cytokine storm, endothelial dysfunction, and arrhythmias, which are frequent in COVID-19 patients, are associated with hypomagnesemia. Given that cellular influx and efflux of magnesium and calcium involve the same transporters, we aimed to evaluate the association of ser...
Background:
It has been reported that insulin resistance is related to cognitive decline. The triglycerides and glucose (TyG) index, is a reliable and inexpensive surrogate test for detecting insulin resistance.
Aims:
The goal of this study was to evaluate the association between the TyG index and the mild cognitive impairment (MCI) in older adu...
In order to search viable alternatives for detoxifying the castor bean toxic waste, and harnessing for diverse applications, the objective of this study was evaluate the thermal-detoxified method and determinate the castor bean cake nutraceutical potential properties. Autoclaving (15 psi, 15 min, 121 ° C) process in presence of humidity (30 %) was...
Non-alcoholic fatty liver disease is becoming in one of the most prevalent liver diseases that leads to liver transplantation. This health problem is a multisystem disease with a complex pathogenesis that involves liver, adipose tissue, gut, and muscle. Although several pharmacological agents have been investigated to prevent or treat non-alcoholic...
The aim of this study was to evaluate the hypoglycemic and antioxidant potential of green tomato (Physalis ixocarpa Brot.) calyxes’ extracts. Three methods were used to obtain the extracts: maceration (M), ultrasound‐assisted (US), and infusion. Regarding in vitro hypoglycemic evaluation, glucose diffusion assay and enzymatic inhibitory action of α...
Background. Given the numerous gaps in our knowledge about the biological interactions of lipoprotein(a) [Lp(a)], we determined whether Lp(a) was associated with hyperinsulinemia in healthy normal-weight, prepubertal children.
Methods. A total of 131 healthy normal-weight Mexican children aged 6 to 9 years at Tanner stage 1 who were born appropriat...
Objective: To evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to hyperinsulinemia in healthy adolescents.
Methods: Apparently healthy adolescents aged 10 to 15 years that according to sex, age, and percentiles of body fat percent, were included and allocated into the groups with elevated (body fat percent ≥85 percentile) and normal...
The aim of this study was to evaluate the hypoglycemic and antioxidant potential of konjac in vitro and in vivo. Glucose diffusion and enzymatic starch digestion of konjac were assayed using α‐amylase and α‐glucosidase. Oral glucose tolerance test (OGTT) and oral starch tolerance test (OSTT) were performed at dose of 102 mg/Kg of body weight (equiv...
We evaluate the hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa ) supplements: (1) bulk samples, (2) turmeric root from India, (3) curcuma turmeric Pronat®, (4) turmeric & black pepper Swanson®, and (5) C3 complex® turmeric curcumin. Glucose diffusion and enzymatic starch digestion assays, using α‐amylase and α‐gluco...
It has been suggested that the triglyceride and glucose (TyG) index is an early indicator for type 2 diabetes (T2D) in adults. Thus, the aim of this study was to evaluate whether the TyG index is useful in the screening of glucose disorders (GD) in apparently healthy children and adolescents. Eligible participants were apparently healthy children a...
Studies in adults show that family history of diabetes correlates with the increase of serum triglyceride levels (1) and that hypertriglyceridaemia is associated to insulin insensitivity (2). These findings suggest that hypertriglyceridaemia is an early biomarker of inadequate insulin secretion and action; results that highlight the role of triglyc...
It has been known for years that diet is of crucial importance as a risk
factor for cardiovascular diseases. The consumption of foods integrated
into the Mediterranean diet is associated with beneficial effects on health,
since many nutrients and phytochemicals in these foods could be independently
or jointly responsible for the apparent reduction...
Various anthropometric measurements have been used for the screening of individuals at risk of developing metabolic abnormalities. Bioelectrical impedance is a method for measuring body composition that provides a convenient, cheap and non‐radioactive alternative to standard methods such as Dual Energy X‐Ray Absorptiometry (DXA). However, data obta...
Prevalence of elevated blood pressure in pediatric population has been increasing worldwide. Thus, the aim of this study was to examine whether the triglycerides and glucose (TyG) index is associated with the presence of prehypertension or hypertension in children and adolescents. Apparently healthy children aged 6 to 15 years were enrolled in a po...
The effect of dehydrated apple‐based snack supplemented with Agave fructans on short‐chain fatty acids (SCFA) production in mice was evaluated. Animals were randomly divided into three groups (n = 8): Control group (CG), oligofructose (OG), and Agave fructans (AG). After 24 days of treatment (stage 1), AG and OG showed elevated levels of acetate (1...
Objective:
The aim was to evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to glucose metabolic disorders (GMD).
Design:
Cross-sectional population based study.
Methods:
Eligible subjects were healthy men and non-pregnant women with new diagnosis of GMD that were allocated into following groups: 1) Normal Glucose Tolerance (NGT)...
The aim of this study was to evaluate the effect of agave fructans on short chain fatty acid (SCFA) production in mice (C57BL/6). Animals were randomly divided into three groups (n = 8): control group (CG), fructans from Agave tequilana group (FG) (55 g per day/kg of body weight), and oligrofructose group (OG) (55 g per day/kg of body weight). Trea...
In the current era, the customers are very demanding for an innovative nutritious food with enhanced functionality. Diet containing healthy foods and beverages plays a major role in avoiding and healing of chronic dreadful diseases eventually improving human health. Nutraceuticals are part of food ingredient or source from food products/by-products...
The effect of high-intensity pulsed electric fields (HiPEF) has been reported on the microbial resistance of fruit juices and beverages. However, the influence of HiPEF on bioactive compounds in herbal infusions is still limited. The objective of the present work was to evaluate chemical stability of polyphenols of infusions from Buddleja scordioid...
The aim of the study was to evaluate the effect of Buddleja scordioides Kunth leaves infusion on lipid peroxidation in mice with ultraviolet (UV) light-induced oxidative stress. CD-1 mice were allocated into treatment and control groups (n = 8). Mice in the intervention group were treated with B. scordioides leaves infusion (500 µL equivalent to 0....
The objective of the study was to evaluate the efficacy of oral magnesium supplementation in the improvement of metabolic syndrome (MetS) and its components. This is a randomized double-blind, placebo-controlled clinical trial that enrolled 198 individuals with MetS and hypomagnesemia who were randomly allocated to receive either 30 mL of magnesium...
In this chapter, a historical and conceptual review on natural polyphenols is given. The general and classical concepts as well as recent contributions to the fascinating field of chemistry of natural products are presented concisely. Fifty years ago, phenolics were
more known or perceived for their effects rather than for the science behind them a...
Polyphenol compounds are synthesized in plants as secondary metabolites in response to ecological and physiological stresses such as adverse climate, insect attack, UV radiation, and wounding. The basic structural feature of phenolic compounds is an aromatic ring bearing one or more hydroxyl groups. Plant polyphenols are classified as simple phenol...
Among secondary metabolites commonly found in fruits, vegetables, grains, spices, herbs, and their derived foods and beverages, there are polyphenols, which are significant phytochemicals in human diet. These compounds at minor concentrations exert important antioxidant activity as radical scavengers in vitro against radical oxygen species (ROS), w...
The aim of this study was to evaluate the anti-hyperglycemic and antioxidant effects of oak leaves infusions and fermented beverages from Quercus convallata and Q. arizonica in vitro and in vivo. Female C57BL/6 mice fed with high saturated fat and fructose diet-induced obesity were treated with oak leaves beverages (200 μL/per day equivalent to 15....
Black tea infusion is the common substrate for preparing kombucha; however other sources such as oak leaves infusions can be used for the same purpose. Almost any white oak species have been used for medicinal applications by some ethnic groups in Mexico and could be also suitable for preparing kombucha analogues from oak (KAO). The objective of th...
Physicochemical properties, consumer acceptance, antioxidant and angiotensin-converting enzyme (ACE) inhibitory activities of infusions and fermented beverages of Eucalyptus camaldulensis and Litsea glaucescens were compared. Among physicochemical parameters, only the pH of fermented beverages decreased compared with the unfermented infusions. No r...
Processing option such as fungal fermentation (tempeh) improves legume nutraceutical properties. The aim of this work was to evaluate the physicochemical and antioxidant potential of common bean tempeh flour from two varieties: Bayo victoria (BV) and Pinto durango (PD) processed at two different temperature and fermentation times. Results showed di...
Oaks (Quercus spp.) are some of the world's most important and abundant trees in nearly all temperate forests of the northern hemisphere. There are two diversity centers for this genus: one is in Southeast Asia, and the other is in Mexico. Studies on the use of oak have mainly highlighted its timber applications. However, its non-timber value is st...
This study aimed to evaluate the antihypertensive effect of Citrus paradisi and Ocimum sanctum infusions in obese rats, and its association with renal alterations. Both herbal infusions decreased blood pressure. The effect of O.sanctum was related to improved renal vascular remodeling, renin and angiotensinogen gene downregulation, as well as reduc...
Some herbal infusions used in folk medicine in Mexico to treat gastrointestinal disorders were evaluated. Antioxidant activity and phenolic compounds were analyzed on the lyophilized aqueous crude extracts (LACE) of arnica (Aster gymnocephalus), chamomile (Chamaemelum nobile), cumin (Cominum cyminum), desert resurrection plant (DRP) (Selaginella le...
Obesity is the most prevalent nutritional disease and a growing public health problem worldwide. This disease is a causal component of the metabolic syndrome related with abnormalities, including hyperglycemia, dyslipidem-ia, hypertension, inflammation, among others. There are anti-obesity drugs, affecting the fundamental processes of the weight re...
Obesity is the most prevalent nutritional disease and a growing public health problem worldwide. This disease is a causal component of the metabolic syndrome related with abnormalities, including hyperglycemia, dyslipidemia, hypertension, inflammation, among others. There are anti-obesity drugs, affecting the fundamental processes of the weight reg...
Diabetes mellitus affects a significant proportion of the population worldwide. Dietary supplements, such as pomegranate juice (PJ), may contribute to prevent diabetic complications improving antioxidant status. Nowadays, pomegranate is among the most popular fruits due to its numerous health benefits. The composition of the pomegranate is strongly...
A high saturated fat and fructose diet leads to metabolic disorders through dysregulation of genes involved in lipid metabolism. Consumption of plant infusions reduces these obesity alterations, but the precise mechanism remains unclear. In this study, we investigated the effect and the possible mechanism of Ocimum sanctum L. (OS) and Citrus paradi...
Plants that are traditionally used by the Mexican population, including Calendula officinalis Linn., Salvia officinalis and Hypericum perforatum, possess important nutraceutical properties and have been empirically tested as treatments for diverse diseases and inflammation. Infusions prepared with these plants at 1% (w/v) were tested for their phen...