Clariss Ann LimsoDuke University Medical Center | DUMC · Department of Biochemistry
Clariss Ann Limso
Master of Science
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4
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Introduction
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Publications
Publications (4)
Cell surface translocation of the chaperone glucose‐regulated protein 78 kDa (GRP78) is a key event that promotes cancer cell survival during endoplasmic reticulum stress. Here, we identify Gα‐Interacting Vesicle‐Associated Protein (GIV) — an enhancer of pro‐survival signaling during ER stress — as a binding partner of GRP78. We show that GIV and G...
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase essential for embryonic development whose overactivation has been implicated in several pathologies including neurodegeneration, cancer cell metastasis and type II diabetes. Therefore, it is important to investigate molecular mechanism(s) that mediate regulation of CDK5 activity. Here we...
Genetic and genomic studies indicate that copper-deficiency triggers changes in the expression of genes encoding key enzymes in various chloroplast-localized lipid/pigment biosynthetic pathways. Among these are CGL78 involved in chlorophyll biosynthesis and HPPD1, encoding 4-hydroxyphenylpyruvate dioxygenase catalyzing the committed step of plastoq...
