Clariss Ann Limso

• Master of Science
• PhD Student at Duke University Medical Center

Cell surface translocation of the chaperone glucose‐regulated protein 78 kDa (GRP78) is a key event that promotes cancer cell survival during endoplasmic reticulum stress. Here, we identify Gα‐Interacting Vesicle‐Associated Protein (GIV) — an enhancer of pro‐survival signaling during ER stress — as a binding partner of GRP78. We show that GIV and G...

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase essential for embryonic development whose overactivation has been implicated in several pathologies including neurodegeneration, cancer cell metastasis and type II diabetes. Therefore, it is important to investigate molecular mechanism(s) that mediate regulation of CDK5 activity. Here we...

Endoplasmic Reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. Cells facing ER stress initially attempt to restore cellular homeostasis, but if the stress becomes chronic and homeostasis is not achieved within a reasonable timeframe, cells initiate programmed cell death. Cancer cells are able to withstand and survive ER stre...

Genetic and genomic studies indicate that copper-deficiency triggers changes in the expression of genes encoding key enzymes in various chloroplast-localized lipid/pigment biosynthetic pathways. Among these are CGL78 involved in chlorophyll biosynthesis and HPPD1, encoding 4-hydroxyphenylpyruvate dioxygenase catalyzing the committed step of plastoq...