Clare Elizabeth Honor Craig

In 2021 we presented an interim analysis of reported deaths associated with Covid-19 using data from the Vaccine Adverse Events Reporting System (VAERS). This work applies the same analytical approach used on the original 250 reports from the December 2020 to March 2021 VAERS dataset, to a larger collection containing 1012 reports from the December...

The latest ONS vaccine mortality surveillance report for England (for the period 1 Jan 2021 to 31 May 2022) fails to take account various confounding factors in the 'headline' results and can thus be easily misinterpreted. Those seeking evidence that the vaccines are unsafe might point to the overall all-cause mortality rate in the vaccinated (1,36...

The accuracy of any data purporting to show covid 19 vaccine effectiveness or safety is critically dependent on the accuracy of four measurements: (1) people classified as having the disease; (2) vaccination status; (3) reported deaths; and (4) the population of vaccinated and unvaccinated (the so called 'denominators'). Errors in any of these coul...

The risk/benefit of Covid vaccines is arguably most accurately measured by comparing the all-cause mortality rate of vaccinated against unvaccinated, since it not only avoids most confounders relating to case definition but also fulfils the WHO/CDC definition of "vaccine effectiveness" for mortality. We examine two of the most recent UK ONS vaccine...

This paper has been updated and the new version can be found here: Official mortality data for England suggest systematic miscategorisation of vaccine status and uncertain effectiveness of Covid-19 vaccination UPDATED WITH ONS DECEMBER DATA RELEASE & HEALTHY VACCINEE/MORIBUND ANALYSIS http://dx.doi.org/10.13140/RG.2.2.28055.09124 https://www.re...

Background:: After submitting our review report on Corman et al. (referred hereinafter as CD-report) and republishing it on a scientific preprint server (http://doi.org/10.5281/zenodo.4298004) and Researchgate.net we offered the report for public discussion at cormandrostenreview.com on 27th November 2020. The scientific community provided addition...

After submitting our review report on Corman et al. (referred hereinafter as CD-report) andrepublishing it on a scientific preprint server [50] and Researchgate.net [51] we offered thereport for public discussion at cormandrostenreview.com on 27th November 2020. Thescientific community provided additional literature, references, and analyses concer...

This extensive review report has been officially submitted to Eurosurveillance editorial board on 27th November 2020 via their submission-portal, enclosed to this review report is a retraction request letter, signed by all the main & co-authors. First and last listed names are the first and second main authors. All names in between are co-authors....

Purpose: Lamins are the major component of nuclear lamina, maintaining structural integrity of the nucleus. Lamin A/C variants are well established to cause a spectrum of disorders ranging from myopathies to progeria, termed laminopathies. Phenotypes resulting from variants in LMNB1 and LMNB2 have been much less clearly defined. Methods: We inve...

Accurate massively parallel sequencing (MPS) of genetic variants is key to many areas of science and medicine, such as cataloging population genetic variation and diagnosing genetic diseases. Certain genomic positions can be prone to higher rates of systematic sequencing and alignment bias that limit accuracy, resulting in false positive variant ca...

Rationale: The Xpert (GeneXpert) MTB/RIF, an integrated polymerase chain reaction assay, has not been systematically studied in extrapulmonary and in particular mediastinal tuberculosis (TB). Objectives: To investigate the performance of Xpert MTB/RIF in the diagnosis of intrathoracic nodal TB in a large tertiary urban medical center in the UK....

Progress in Pathology reviews many aspects of pathology, describing issues of everyday diagnostic relevance and the mechanisms underlying some of these processes. Each volume in the series reviews a wide range of topics and recent advances in pathology of relevance to daily practice, keeping consultants, trainees, laboratory staff and researchers a...

This chapter provides an extensive but not completely exhaustive overview of drug induced liver injury, with key concepts illustrated by examples of individual drugs. It also considers the problems associated with making a diagnosis of drug induced liver injury (DILI). Our society has a massive desire for the consumption of active compounds; the dr...

To determine the frequency of extramedullary haematopoiesis (EMH) in massive hepatic necrosis (MHN). Explanted livers of 11 adult patients transplanted consecutively for MHN were examined histologically and immunohistochemically for the presence of EMH. The aetiology of the liver damage was unknown in seven cases and drug induced in four. The prese...

Massive hepatic necrosis (MHN) is a condition that offers an opportunity to study the remarkable ability of the liver to become repopulated with hepatocytes. A maximal regenerative stimulus is expected in cases of MHN (Roskams et al. APMIS Suppl 1991;23:32-39). Sequential chronological observations, after a severe degree of liver cell loss, permit...

A 75 year old woman was treated for over three years with the somatostatin analogue, octreotide for an insulinoma. She had presented in a hypoglycaemic coma. C-peptide and insulin concentrations were both raised and an area of increased vascularity within the pancreas was shown by angiography. No lesion was found at laparotomy and no resection was...