Claire Piochon

Claire Piochon
Northwestern University | NU · Department of Physiology

PhD

About

28
Publications
5,016
Reads
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964
Citations
Citations since 2016
10 Research Items
671 Citations
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
Additional affiliations
February 2015 - present
Northwestern University
Position
  • PostDoc Position
April 2014 - January 2015
University of Chicago
Position
  • PostDoc Position
October 2008 - March 2014
University of Chicago
Position
  • PostDoc Position

Publications

Publications (28)
Article
Full-text available
A common feature of autism spectrum disorder (ASD) is the impairment of motor control and learning, occurring in a majority of children with autism, consistent with perturbation in cerebellar function. Here we report alterations in motor behaviour and cerebellar synaptic plasticity in a mouse model (patDp/+) for the human 15q11-13 duplication, one...
Article
Full-text available
A classic view in cerebellar physiology holds that Purkinje cells do not express functional NMDA receptors and that, therefore, postsynaptic NMDA receptors are not involved in the induction of long-term depression (LTD) at parallel fiber (PF) to Purkinje cell synapses. Recently, it has been demonstrated that functional NMDA receptors are postsynapt...
Article
Full-text available
Among integrative neurons displaying long-term synaptic plasticity, adult Purkinje cells seemed to be an exception by lacking functional NMDA receptors (NMDA-Rs). Although numerous anatomical studies have shown both NR1 and NR2 NMDA-R subunits in adult Purkinje cells, patch-clamp studies failed to detect any NMDA currents. Using more recent pharmac...
Article
The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterolog...
Article
Full-text available
Small-conductance Ca(2+)-activated K(+) channels (SK channels) modulate excitability and curtail excitatory postsynaptic potentials (EPSPs) in neuronal dendrites. Here, we demonstrate long-lasting plasticity of intrinsic excitability (IE) in dendrites that results from changes in the gain of this regulatory mechanism. Using dendritic patch-clamp re...
Article
Full-text available
Background Autism spectrum disorder (ASD) patients often show altered responses to sensory stimuli as well as motor deficits, including an impairment of delay eyeblink conditioning (EBC), which involves integration of sensory signals in the cerebellum. Here, we identify abnormalities in parallel fiber (PF) and climbing fiber (CF) signaling in mouse...
Article
Full-text available
Sensory perturbations in visual, auditory and tactile perception are core problems in fragile X syndrome (FXS). In the Fmr1 knockout mouse model of FXS, the maturation of synapses and circuits during critical period (CP) development in the somatosensory cortex is delayed, but it is unclear how this contributes to altered tactile sensory processing...
Data
Supplemental Table 2: Comparison of quantitative proteomic differences of Fmr1 KO and Fmr1 WT mice between Bumetanide and Vehicle treatment groups Table of the data for the categories shown in figure 4D. Data compares the Log2 fold change and Student’s t-test and -Log10 t-test values between Bumetanide and Vehicle treatment groups (fold change and...
Data
Supplementary Figure S1: Effect of furosemide and mannitol on somatosensory cortical synaptic transmission and plasticity (A) AMPA and NMDA EPSCs recorded at −70 mV and +40 mV in furosemide and mannitol treated Fmr1 KO mice at P7. (B) Summary of N:A ratio in furosemide group (n = 9/3) and mannitol group (n = 8/3, p < 0.05 unpaired t-test). Mean and...
Data
Supplemental Table 3: Proteomic identification of FMRP mRNA targets Table identifying the significant proteins in our Vehicle (first tab) and Bumetanide (second tab) datasets that were previously identified as mRNA targets of FMRP 2 (p value < 0.05). Columns are arranged left-to-right as protein accession number, gene name, fold change (KO vs. WT),...
Data
Supplemental Table 1: Fold differences between Fmr1 KO and Fmr1 WT mice in Vehicle and Bumetanide treatment groups Table listing all quantified proteins between Fmr1 KO and Fmr1 WT mice in either vehicle (first tab) or bumetanide (second tab) treatment groups. Columns are arranged left-to-right as protein accession number, gene name, fold change (K...
Article
Significance Instructive signals play an important role in synaptic plasticity and learning. For example, at cerebellar parallel fiber (PF)-Purkinje cell synapses, climbing fiber (CF) coactivation provides an instructive signal that promotes long-term depression (LTD) by amplifying spine calcium transients above a threshold level that, at these syn...
Article
In long-term depression (LTD) at synapses in the adult brain, synaptic strength is reduced in an experience-dependent manner. LTD thus provides a cellular mechanism for information storage in some forms of learning. A similar activity-dependent reduction in synaptic strength also occurs in the developing brain and there provides an essential step i...
Data
Wild-type values for eyeblink conditioning parameters.Last column, results of comparison across all wild-type cohorts. Statistical test indicated.DOI: http://dx.doi.org/10.7554/eLife.06085.004
Article
Full-text available
Spike-timing-dependent plasticity (STDP) provides a cellular implementation of the Hebb postulate, which states that synapses, whose activity repeatedly drives action potential firing in target cells, are potentiated. At glutamatergic synapses onto hippocampal and neocortical pyramidal cells, synaptic activation followed by spike firing in the targ...
Article
Ethanol profoundly influences cerebellar circuit function and motor control. It has recently been demonstrated that functional NMDA receptors are postsynaptically expressed at climbing fiber (CF) to Purkinje cell synapses in the adult cerebellum. Using whole-cell patch-clamp recordings from mouse cerebellar slices, we examined whether ethanol can a...
Article
Full-text available
Basket axon collaterals synapse onto the Purkinje soma/axon initial segment (AIS) area to form specialized structures, the pinceau, which are critical for normal cerebellar function. Mechanistic details of how the pinceau become organized during cerebellar development are poorly understood. Loss of cytoskeletal adaptor protein Ankyrin G (AnkG) resu...
Article
Small-conductance calcium-activated K(+) channels (SK channels) regulate the excitability of neurons and their responsiveness to synaptic input patterns. SK channels contribute to the afterhyperpolarization (AHP) following action potential bursts, and curtail excitatory postsynaptic potentials (EPSPs) in neuronal dendrites. Here we review evidence...
Article
Full-text available
Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using both in vitro and in vivo recordings from the rat cerebellum that tetanization protocols for the induction of LTP at parallel fiber (PF)-to-Purkinje cell synapses can als...
Article
Full-text available
The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term depression (LTD) at parallel fiber-Purkinje cell synapses have become hallmark features of cerebellar phy...
Article
Full-text available
N-methyl-D-aspartate receptors (NMDA-R), that are key players of neuronal function, are widely expressed by most of integrative neurons. Regarding this rule, adult cerebellar Purkinje cells have long been considered as an exception by lacking NMDA-R and were therefore used as peculiar model of plastic integrative neurons. This view has largely emer...
Article
Full-text available
In several regions of the developing nervous system, neurons undergo programmed cell death. In the rat cerebellum, Purkinje cell apoptosis is exacerbated when cerebellar slices are cultured during the first postnatal week. To understand the mechanism of this developmental apoptosis, we took advantage of its inhibition by the steroid analog mifepris...
Article
Full-text available
Le cervelet est une structure cérébrale nécessaire au maintien de la posture, à la coordination motrice ainsi qu'aux apprentissages moteurs. Son implication dans des fonctions cognitives ou émotionnelles, ainsi que dans des pathologies, comme l'autisme ou la schizophrénie, est également de plus en plus avancée. C'est enfin un modèle de choix pour c...

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Projects

Project (1)
Archived project
To decipher the cellular mechanisms of parallel fiber to Purkinje cell synaptic plasticity (LTD and LTP). Our aim is to understand how LTD/LTP takes place and how it changes computation of cerebellar cortex input.