Claire Labbe

Claire Labbe
Seenel Imaging · R&D

Doctor (PhD) in Medical Imaging

About

26
Publications
1,309
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1,269
Citations
Introduction
PhD in Medical Imaging with over 20 years of experience in project management, assurance quality, software and brain image processing for innovating medical devices. I have joined Thomas FONTAINE from SEENEL IMAGING in order to launch together a breakthrough multimodal neuroimaging device combining both Electroencephalography and Near InfraRed Spectroscopy (EEG/NIRS).
Additional affiliations
December 2018 - April 2020
Seenel Imaging
Position
  • Chief Technology Officer - CTO

Publications

Publications (26)
Data
MEDELOPT® - Systèmes diagnostiques de l’activité cérébrale issus des recherches hospitalo-universitaires amiénoises Mieux comprendre l’épilepsie, ou les Accidents Vasculaires Cérébraux est l’ambition de Medelopt®, premier casque d’imagerie cérébrale ambulatoire créé, au bout de 15 années de recherche en neurodéveloppement, au sein du Service d’Exp...
Article
Full-text available
We present a region template and a protocol for transforming that template to define anatomical volumes of interest (VOIs) in the human brain without operator intervention, based on software contained in the SPM99 package (Statistical Parametric Mapping, Wellcome Department of Cognitive Neurology, London, UK). We used an MRI of a reference brain to...
Article
Full-text available
We calculated [(11)C]flumazenil volume of distribution ([(11)C]FMZ-V(d)) after correction for partial volume effect in 10 patients with malformations of cortical development (MCDs) and partial seizures, to quantify the GABA(A)-central benzodiazepine receptor complex. Abnormal grey matter and adjacent or overlying cortex were outlined individually a...
Article
To characterize abnormalities in neocortical central benzodiazepine receptor (cBZR) binding in patients with mesial temporal lobe epilepsy (mTLE) with unilateral hippocampal sclerosis (HS) using [(11)C]-flumazenil-(FMZ) PET and complementary voxel-based and quantitative volume-of-interest (VOI) methods. The authors studied 13 control subjects and 1...
Article
Full-text available
Regional cerebral phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) was performed in 10 non- demented Parkinson's disease patients and nine age-matched control subjects. Five of the patients undergoing (31)P-MRS and four additional Parkinson's disease patients had cerebral 2-[(18)F]fluoro-2-deoxy-D-glucose PET ((18)FDG-PET), the results of...
Article
Using 11C-flumazenil (FMZ) PET with correction for partial-volume effect, reductions of central benzodiazepine receptor (cBZR) binding can be detected reliably in vivo on remaining neurons in sclerotic hippocampi of patients with mesial temporal lobe epilepsy (TLE). To delineate abnormalities of 11C-FMZ binding in patients with medically refractory...
Article
A 3D OSEM and Median Root Prior (3D OSEM-MRP) algorithm has been evaluated for the reconstruction of 3D PET studies. The algorithm was implemented using the software package developed during the EU project PARAPET. Evaluation was performed using experimental phantom data simulating in terms of shape and size PET brain studies. For each phantom, hig...
Article
Full-text available
this paper is to present the development of a library of object-oriented building blocks for the implementation of both analytical and iterative reconstruction algorithms in 3D PET.
Article
Full-text available
We present a object-oriented library of C++ features for 3D PET reconstruction. This library has been designed so that it can be used for many algorithms and scanner geometries. Its flexibility, portability and modular design have helped greatly to (a) develop new iterative algorithms, (b) compare iterative and analytic methods using simulated, pha...
Conference Paper
The linear least-squares (LLS) method introduced in the chapter allows accurate positron emission tomography (PET) quantification in multiple small cerebral structures such as the hippocampus. The method was validated using both computer simulation and an anthropomorphic model. Cjflumazenil (FMZ) PET images coregistered with high-quality MR images...
Article
Full-text available
This paper describes the implementation of the Eidolon Monte Carlo program designed to simulate fully three-dimensional (3-D) cylindrical positron tomographs on a MIMD parallel architecture. The original code was written in Objective-C and developed under the NeXTSTEP development environment. Different steps involved in porting the software on a pa...
Article
By using [11C]flumazenil-positron emission tomography ([11C]FMZ-PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS). Receptor autoradiographic studies on resected hippocampal specimens from...
Article
Full-text available
Using statistical parametric mapping and [11C]flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis. However, bilateral hippocampal pathology can be present in up to 50% of patients with mesial t...
Article
Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS). The limited spatial resolution of PET, however, results in partial-volume averaging that affec...
Article
Ten nondepressed patients with obsessive-compulsive disorder (OCD) who were characterized by predominant checking rituals were compared with 10 age- and sex-matched control subjects. Hemispheric and regional cerebral blood flow levels (rCBF) were measured with positron emission tomography (H2 15O) across four conditions: rest, auditory stimulation...
Article
The correct interpretation of clinical positron emission tomography (PET) data depends largely on the physical limits of the PET scanner. The partial volume effect (PVE) is related to the size of the studied object compared to the spatial resolution. It represents one of the most important limiting factors in quantitative data analysis. This effect...
Thesis
The use of anatomical images obtained from Magnetic Resonance Imaging (MRI) and functional images from Positron Emission Tomography (PET) provides complementary and quantitative information respectively on cerebral structures volume and cellular metabolism. But PET images observation arises some problems on identification from their origin between...

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Question
How to add the co-authors publications and correct some mispelling in my publication title ?

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Projects (3)