About
24
Publications
3,471
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
335
Citations
Introduction
My research centres on modulating and measuring neural activity. I have a particular interest in plasticity and how our brains adapt and develop as part of the ageing process.
Current institution
Additional affiliations
October 2015 - present
Position
- Lecturer
Description
- PSY-212 Development Across the Lifespan: How alterations in brain structure and function influence cognition in later life.
October 2010 - September 2012
Position
- Research Assistant
Description
- Large-scale study designed to investigate the association between changes in cognition and brain structure and function across the lifespan.
Education
October 2012 - July 2016
September 2009 - September 2010
September 2004 - July 2007
Publications
Publications (24)
Background/Objectives: Vulnerability to sound distraction is commonly reported in older adults with dementia and tends to be associated with adverse impacts on daily activity. However, study outcome heterogeneity is increasingly evident, with preserved resistance to distraction also evident. Contributory factors may include individual differences i...
Facilitating communication between generations has become increasingly important. However, individuals often demonstrate a preference for their own age group, which can impact social interactions, and such bias in young adults even extends to inhibitory control. To assess whether older adults also experience this phenomenon, a group of younger and...
Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and bl...
Background/objectives
Obesity affects more than forty percent of adults over the age of sixty. Aberrant eating styles such as disinhibition have been associated with the engagement of brain networks underlying executive functioning, attentional control, and interoception. However, these effects have been exclusively studied in young samples overloo...
Response inhibition is important for adherence to social norms, especially when norms conflict with biases based on one's social identity. While previous studies have shown that in-group bias generally modulates neural activity related to stimulus appraisal, it is unclear whether and how an in-group bias based on age affects neural information proc...
Background
The study of reaction time (RT) and its intraindividual variability (IIV) in aging, cognitive impairment, and dementia typically fails to investigate the processing stages that contribute to an overall response. Applying “mental chronometry” techniques makes it possible to separately assess the role of processing components during enviro...
Regarded as a defining factor in resource management, it is widely accepted that visual attention and related processing will deteriorate, in a global fashion, across the lifespan and produce detrimental consequences for environmental interactions [...]
Age-related decline in information processing can have a substantial impact on activities such as driving. However, the assessment of these changes is often carried out using cognitive tasks that do not adequately represent the dynamic process of updating environmental stimuli. Equally, traditional tests are often static in their approach to task c...
Transcranial direct current stimulation (tDCS) has been shown to support cognition and brain function in older adults. However, there is an absence of research specifically designed to determine optimal stimulation protocols, and much of what is known about subtle distinctions in tDCS parameters is based on young adult data. As the first systematic...
The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 322, aged 18-89 years) using a v...
Slowed behavioral reaction time is associated with pathological brain changes, including white matter lesions, the common clinical characteristic of subcortical ischemic vascular cognitive impairment (SIVCI). In the present study, reaction time (RT) employing Trails B of the Trail Making Test, with responses capped at 300 s, was investigated in SIV...
Objective: Studies of “healthy” cognitive aging often focus on a limited set of measures that decline with age. The current study argues that defining and supporting healthy cognition requires understanding diverse cognitive performance across the lifespan. Method: Data from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) cohort was exami...
In this study, reaction time (RT), intraindividual variability (IIV), and errors, and the effects of practice and processing load upon such function, were compared in patients with subcortical ischemic vascular cognitive impairment (SIVCI) [n = 27] and cognitively healthy older adults (CH) [n = 26]. Compared to CH aging, SIVCI was characterized by...
Age-related somatosensory processing appears to remain intact where tasks engage centrally- as opposed to peripherally-mediated mechanisms. This distinction suggests that insight into alterations in neural plasticity could be derived via metrics of vibrotactile performance. Such an approach could be used to support the early detection of global cha...
In this study we examined attention-related reaction time (RT) and intra-individual variability (IIV) in younger and older adults using an iPad-based visual search test, in which, for each trial, participants were required to sequentially press a series of on-screen stimuli numbered from 1 to 8. Although overall performance RT was significantly slo...
Transcranial direct current stimulation (tDCS) facilitates cognitive enhancement by directly increasing neuroplasticity, and has shown promising results as an external intervention to attenuate age-related cognitive decline. However, stimulation protocols have failed to account for age-associated changes in brain structure and the present literatur...
Background: With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult ages within a contemporary cross-sectional population-based cohort, the Cambridge Centre for Ageing and Neuroscience (Cam-...
Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from 98 healthy participants aged 23-87 years from the population-based Cam-CAN cohort. Participants per...
Memory problems are among the most common complaints as people grow older. Using structural equation modeling of commensurate scores of anterograde memory from a large (N = 315), population-derived sample (www.cam-can.org), we provide evidence for three memory factors that are supported by distinct brain regions and show differential sensitivity to...
Despite the increasing use of transcranial direct current stimulation (tDCS), the physiological mechanisms underlying its effects are still largely unknown. One approach to directly investigate the effects of the neuromodulation technique on the brain is to integrate tDCS with non-invasive neuroimaging in humans. To provide new insight into the neu...
The neuromodulation technique transcranial direct current stimulation (tDCS) is thought to produce its effects on behavior by altering cortical excitability. Although the mechanisms underlying the observed effects are thought to rely on the balance of excitatory and inhibitory neurotransmission, the physiological principles of the technique are not...
Questions
Question (1)
Like most researchers in the tDCS community, I'm looking to induce persistent LTP-like effects.
The current literature is informative insofar as highlighting that multiple sessions of tDCS appear to enhance the strength and prolong the duration of resulting after-effects. The time at which repeat stimulation is administered also appears to be crucial but as yet there is little-to-no consensus on the most optimal parameters to use, including appropriate inter-stimulation-intervals. More recently, there seems to be a suggestion that implementing within-session intervals instead of continuous stimulation could be the way to go, however, the related studies only cover single sessions and don't comment on the frequency at which subsequent sessions of stimulation should be delivered.
Does anyone have any experience of attempting to induce longer lasting modulations - successful or otherwise? I'd appreciate advice on what to trial, what to avoid and whether you've noted differences between target populations (healthy/clinical, young/old etc) with regard to the parameters that show the most potential.
Thanks in advance!
