Citra Indriani

Universitas Gadjah Mada | UGM · Faculty of Medicine

Release of Aedes aegypti mosquitoes infected with Wolbachia pipientis (wMel strain) is a biocontrol approach against Ae. aegypti-transmitted arboviruses. The Applying Wolbachia to Eliminate Dengue (AWED) cluster-randomised trial was conducted in Yogyakarta, Indonesia in 2018–2020 and provided pivotal evidence for the efficacy of wMel-Ae. aegypti mo...

The intention-to-treat (ITT) analysis of the Applying Wolbachia to Eliminate Dengue (AWED) trial estimated a protective efficacy of 77.1% for participants resident in areas randomised to receive releases of wMel-infected Aedes aegypti mosquitoes, an emerging dengue preventive intervention. The limiting assumptions of ITT analyses in cluster randomi...

Global COVID-19 booster vaccination uptake has been low, particularly in low-middle-income countries (LMICs). However, studies on the determinants of COVID-19 booster vaccination remain limited, especially in LMIC settings. This study aims to describe the determinants of COVID-19 booster vaccination uptake in an LMIC context. We analyzed data from...

Introduction Field trials and modelling studies suggest that elimination of dengue transmission may be possible through widespread release of Aedes aegypti mosquitoes infected with the insect bacterium Wolbachia pipientis (wMel strain), in conjunction with routine dengue control activities. This study aimed to develop a modelling framework to guide...

Background: Good decisions in policy-making rely on acquiring the best possible understanding at the fast pace of what is happening and what might happen next in the population. Immediate measurements and predictions of disease spread would help authorities take necessary action to mitigate the rapid geographical spread of potential emerging infect...

Dengue prevention efforts are limited to the control strategies of its vector and the management of breeding sites. New alternatives for dengue vector control that are sustainable and more environmentally friendly are needed to complement the government’s current efforts. Research on Wolbachia-infected Aedes aegypti Linnaeus mosquitoes as an altern...

The intention-to-treat analysis of a cluster randomized trial of Wolbachia (wMel strain) mosquito releases for control of dengue (the Applying Wolbachia to Eliminate Dengue [AWED] trial) estimated a protective efficacy of 77.1% for participants resident in areas randomized to receive releases of wMel-infected Aedes aegypti mosquitoes. The limiting...

Introduction Field trials and mathematical modelling studies suggest that elimination of dengue transmission may be possible through widespread release of Aedes aegypti mosquitoes infected with the insect bacterium Wolbachia pipientis (wMel strain), in conjunction with routine dengue control activities. This study aimed to develop a modelling frame...

Background Releases of Wolbachia (wMel)-infected Aedes aegypti mosquitoes significantly reduced the incidence of virologically confirmed dengue in a previous cluster randomised trial in Yogyakarta City, Indonesia. Following the trial, wMel releases were extended to the untreated control areas, to achieve city-wide coverage of Wolbachia. Objective...

Dengue exhibits focal clustering in households and neighborhoods, driven by local mosquito population dynamics, human population immunity, and fine scale human and mosquito movement. We tested the hypothesis that spatiotemporal clustering of homotypic dengue cases is disrupted by introduction of the arbovirus-blocking bacterium Wolbachia (wMel-stra...

COVID-19 case counts in Indonesia inevitably underestimate the true cumulative incidence of infection due to limited barriers to testing accessibility and asymptomatic infections. Therefore, community-based serological data are essential for understanding the true prevalence of infections. This study aims to estimate the seroprevalence of SARS-CoV-...

The restrictions imposed to curb the COVID-19 pandemic affect many aspects of life. This research was conducted to understand the mobility and social interaction pattern of DKI Jakarta residents, Indonesia, to face and adapt to the new normal situation. An e-questionnaire was generated using Google Form, and the link was shared through social med...

Dengue is an important communicable disease in Indonesia with an escalating annual incidence. Between 2016 and 2017, a new dengue control method using Wolbachia-infected Aedes aegypti was implemented in Yogyakarta Municipality. This study aimed to assess community awareness and perception about Wolbachia-infected Ae. aegypti release as a method of...

Dengue has been endemic in Yogyakarta, Indonesia for decades. Here, we report the dengue epidemiology, entomology, and virology in Yogyakarta in 2016–2017, prior to the commencement of the Applying Wolbachia to Eliminate Dengue (AWED) randomized trial. Dengue epidemiological data were compiled and blood samples from dengue-suspected patients were t...

The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative abundance of Ae. aegypti and Ae. albopictus before, during and after wMe...

A bstract Dengue exhibits focal clustering in households and neighborhoods, driven by local mosquito population dynamics, human population immunity, and fine scale human and mosquito movement. We tested the hypothesis that spatiotemporal clustering of homotypic dengue cases is disrupted by introduction of the arbovirus-blocking bacterium Wolbachia...

Background Aedes aegypti mosquitoes infected with Wolbachia pipientis (wMel strain) have reduced potential to transmit dengue viruses. Methods We conducted a cluster randomised trial of deployments of wMel-infected Ae. aegypti for control of dengue in Yogyakarta City, Indonesia. Twenty-four geographic clusters were randomly allocated to receive wM...

Background: The AWED (Applying Wolbachia to Eliminate Dengue) trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Yogyakarta, Indonesia, with the aim of measuring the efficacy of Wolbachia-infected Aedes aegypti deployments in reducing dengue incidence in an endemic setting. Enrolment began in January...

Background:Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachiapipientis ( w Mel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries. Field releases in northern Australia have previously demonstrated near elimination of local dengue transmission from Wolbachia -tre...

Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachia pipientis (wMel strain) have been deployed for the biocontrol of dengue and related arboviral diseases in multiple countries. Field releases in northern Australia have previously demonstrated near elimination of local dengue transmission from Wolbachia-...

Background: On May 4th, 2016, at 12:30 district surveillance officer of Magelang Health Department received reports from Public Health Center of Bandongan about 21 students of SDN 1 Trasan who suffered from the same food-poisoning symptoms. Objective: Investigation was carried out to identify the source, how it spread and how to control it. Methods...

Indonesia is one of the countries where dengue infection is prevalent. In this study we measure the prevalence and distribution of dengue virus (DENV) DENV-infected Aedes aegypti in Yogyakarta City, Indonesia, during the wet season when high dengue transmission period occurred, as baseline data before implementation of a Wolbachia-infected Aedes ae...

Flood disaster in Bima Town, West Nusa Tenggara Province, Indonesia at the end of 2016 affected 105,753 people. For the period of the disaster, water flooding whole area of the town. Universitas Gadjah Mada (UGM) represented by Faculty of Medicine, Public Health, and Nursing supported by the Faculty of Medicine Alumni Association (KAGAMADOK) sent t...

Magelang Regency received malaria elimination certificate in April 2014, however, the epidemic signal was received back in April 2015. Malaria epidemic had occurred for two months and until the end of December, indigenous cases could still be found. The purpose of this study was to find out description of situation regarding malaria, malaria contro...

Dengue is endemic in Indonesia. Here, we describe the epidemiology of dengue in the city of Yogyakarta, Central Java, as a prelude to implementation of a cluster-randomized trial of Wolbachia for the biocontrol of arboviral transmission. Surveillance records from 2006 to 2016 demonstrate seasonal oscillations of dengue incidence with varying magnit...

Background: Dengue and other arboviruses transmitted by Aedes aegypti mosquitoes, including Zika and chikungunya, present an increasing public health challenge in tropical regions. Current vector control strategies have failed to curb disease transmission, but continue to be employed despite the absence of robust evidence for their effectiveness o...

Cluster randomized trials are the gold standard for assessing efficacy of community-level interventions, such as vector control strategies against dengue. We describe a novel cluster randomized trial methodology with a test-negative design, which offers advantages over traditional approaches. It utilizes outcome-based sampling of patients presentin...

Purpose: The purpose of this study is to understand burden of foodborne outbreak in Indonesia during 2000 -2015. Method: Systematic review conducted based on publish and unpublished (grey literature) data during 2000 -2015. Publish data from search engine such as Google scholar, open access, repository online university in Indonesia. Grey literatur...

AFB positive detection cases increase in 2011 until 2013 at Sukoharjo District, but TB CDR is still below national and local targets. Nguter PHC has highest CDR among other subdistrict, that is 84.6% in 2012 and 68.9% in 2013. The objective of this study is screening pulmonary TB patients in Nguter PHC region. Target population screening was ≥ 15 y...

Background and purpose: National strategy to increase the coverage of prevention of mother to child transmission (PMTCT) program in Indonesia is integrating the service into public health centres (puskesmas). In Bali, the integration has been started since 2014. After one year of program implementation, an evaluation was conducted in order to provi...

Background: On March 25, 2016, 20 individuals with gastrointestinal manifestation were hospitalized. The food served had been donated from student’s parent when visit to the boarding school. An investigation was conducted to confirm the outbreak, identify the source of infection, and control measure. Method: Investigation was conducted in March 26-...

Background and purpose: National strategy to increase the coverage of prevention of mother to child transmission (PMTCT) program in Indonesia is integrating the service into public health centres (puskesmas). In Bali, the integration has been started since 2014. After one year of program implementation, an evaluation was conducted in order to provi...

Seroprevalence of human toxoplasmosis in Gianyar Bali provincePurposeThe present study was designed to determine the seroprevalence and risk factors of human toxoplasmosis.Methods The research used a cross-sectional design and was conducted in Gianyar District, Bali Province. A total of 240 sera samples were collected and examined by indirect ELISA...

The prevalence of risk factors in adults who have subjective coronary heart disease symptoms in Gunung KidulPurposeThis study aimed to identify the risk factors of smoking, passive smoking, physical activity, and consumption of fruits and vegetables in adults who have subjective coronary heart disease symptoms.Methods This study used secondary data...

The implications of husband's education on expectant mother's delivery planning in SalatigaPurposeThe purpose of this paper was to determine the implications of husband’s education on expectant mother’s delivery planning. Methods The research was a survey study with a cross-sectional design. The samples were 267 pregnant woman in the third trimeste...

Dinas Kesehatan Kabupaten Sleman melaporkan terjadi peningkatan jumlah kasus hepatitis A di Kabupaten Sleman dan sebagian besar adalah mahasiswa. Tujuannya untuk mengetahui faktor perilaku berisiko dengan kejadian hepatitis A di Sleman. Penelitian observasional dengan rancangan kasus kontrol. Teknik pengambilan sampel adalah consecutive sampling (n...

Kabupaten Gunungkidul adalah daerah endemis DBD di Provinsi Yogyakarta. Salah satu alternatif dalam pengendalian vektor DBD adalah dengan memasang autocidal ovitrap dengan menambahkan zat atraktan berupa air rendaman jerami. Penelitian ini bertujuan mengetahui pengaruh pemasangan autocidal ovitrap dengan atrak- tan air rendaman jerami terhadap juml...