
Cintia GalliNational Technological University | utn · Facultad Regional Buenos Aires
Cintia Galli
Doctor of Medicine
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61
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Introduction
Investigación en área médica con aplicación de desarrollos tecnológicos del GIBIO.
MECÁNICA VASCULAR
HTA
ERC
Publications
Publications (61)
Background:
Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showe...
Aims:
To analyze the early vascular aging (EVA) in end-stage renal disease (ESRD) patients, attempting to determine a potential association between EVA and the etiology of ESRD, and to investigate the association of hemodialysis and EVA in ESRD patients during a 5-year follow-up period.
Methods:
Carotid-femoral pulse wave velocity (cfPWV) was ob...
Introduction:
The etiology of the end-stage renal disease (ESRD) and the hydration status may be involved in the arterial stiffening process observed in hemodialyzed patients. The ratio between carotid-femoral and carotid-radial pulse wave velocity (PWV ratio) was recently proposed to characterize the patient-specific stiffening process.
Aims:
t...
Objective: Pulse Pressure (PP) and pulse wave velocity (PWV) are related to cardiovascular risk (CVR). We evaluated in patients with arterial hypertension (HT), as unique risk factor, the impact of arterial hypertension on PP and PWV, the mean and age related PWV values, the relationship between PP and PWV and the rate of changes with aging.
Design...
Objectives: Changes in arterial stiffness in hemodialysis patients occur both, in elastic and muscular vessels but only the aortic Pulse Wave Velocity (PWV) has demonstrated to be a high prognostic value index, however, muscular arteries are not involved in the aortic PWV measurement. The purpose of this research was: a) to evaluate the aortic and...
Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (P...
Aortic stiffness evaluated through pulse wave velocity (PWV) measurement is nowadays accepted as a reliable parameter to estimate cardiovascular risk. However the data about arterial stiffness in South America come from urban populations.
To determine the relationship between PWV changes and ageing and to identify the rate of change in each decade...
The increase of arterial stiffness has been to have a significant impact on predicting mortality in end-stage renal disease patients. Pulse wave velocity (PWV) is a noninvasive, reliable parameter of regional arterial stiffness that integrates the vascular geometry and arterial wall intrinsic elasticity and is capable of predicting cardiovascular m...
Aortic stiffness is a prognostic parameter associated with patient mortality. Vascular access creation has been shown to have effects on arterial stiffness both in the aorta and in the upper limb arteries in chronically hemodialyzed patients (CHPs). However, no longitudinal studies have been conducted in order to characterize the evolution of arter...
In medical practice the reference values of arterial stiffness came from multicenter registries obtained in Asia, USA, Australia and Europe. Pulse wave velocity (PWV) is the gold standard method for arterial stiffness quantification; however, in South America, there are few population-based studies. In this research PWV was measured in healthy asym...
The goal of the present study was to evaluate the clinical characteristics and postoperative seizure outcome of epileptogenic tumors associated with focal cortical dysplasias (FCDs) compared to both solitary FCD type I and solitary tumors. Particular attention is given to FCD type IIIb (tumors associated with FCD type I), which have been recently c...
The aims of this work were (1) to analyze the viscoelastic behavior of different venous segments and their differences, considering the structural characteristics (elastin, collagen, and smooth muscle content) of the venous wall; (2) to analyze the venous biomechanical behavior by means of the histological characteristics of the veins. Nine healthy...
Purpose. To evaluate in chronically haemodialysed patients (CHPs), if: (1) the vascular access (VA) position (upper arm or forearm) is associated with differential changes in upper limb arterial stiffness; (2) differences in arterial stiffness exist between genders associated with the VA; (3) the vascular substitute (VS) of choice, in biomechanical...
This study aimed to characterize the following: (i) in chronically hemodialyzed subjects (CHDSs), with and without diabetic nephropathy (DN), and in healthy subjects (non-CHDSs) different arterial pathways stiffness to determine potential pathology-dependent, etiology- and/or pathway-dependent differences; and (ii) the biomechanical mismatch (BM) b...
Background
Vascular access (VA) dysfunction is a common cause of hospitalization in chronically hemodialyzed patients (CHP) limiting the improvement in health and has been largely studied in order to decrease the morbidity events that involves both the artery and the vein used in the construction of the fistula. In parallel, patients in end-stage r...
Arterial stiffening is a common finding in patients on chronical hemodialysis (CHID) impairing the prognosis. The aim of this work was to characterize aortic stiffness through pulse wave velocity (PWV) determinations in a population of patients on CHID. For this purpose PWV, arterial pressure and biochemical and antropometric parameters were measur...
Despite the availability of detailed electroclinical and imaging data, only a few neuropathological studies of nodular heterotopia have been published. The aim of this study was to describe the neuropathological features of various types of nodular heterotopia obtained from patients undergoing surgery for intractable epilepsy.
Specimens of heteroto...
Arterial stiffening is a common finding in patients on chronical hemodialysis (CHD) impairing the prognosis. The aim of this work was to characterize aortic stiffness through pulse wave velocity (PWV) determinations in a population of patients on CHD. For this purpose PWV, arterial pressure and biochemical and antropometric parameters were measured...
To retrospectively analyze the results on seizures of surgery in children with drug-resistant focal epilepsy. To identify the factors predicting seizure control among several presurgical, surgical, and postsurgical variables.
One hundred thirteen patients (67 male, 46 female), younger than 16 years, operated on from 1996 to 2004 and followed-up for...
Summary High-resolution imaging techniques can demonstrate anatomic alterations in most patients identified as candidates for surgical treatment of their partial epilepsy. The demonstration of an anatomic lesion is only one step in the presurgical diagnostic procedure, which includes video-EEG and, when necessary, video-stereo-EEG recordings of sei...
Long-term vascular accesses are usu- ally performed in patients submitted to renal re- placement therapy using autologous vessels. When arterio-venous fistula creation is impossible, animal conduits have been used in order to obtain high patency rates. Bovine vessel heterograft has been introduced as a substitute for the construction of arterio-ven...
Intimal hyperplasia development is largely the most important cause of vascular access failure in patients submitted to hemodialysis. Differences in the biomechanical properties between the vascular substitutes and the native vessels have been related to the development of intimal hyperplasia. This work aim was to characterize the biomechanical beh...
The aim of this study was to assess efficacy and toxicity of temozolomide given alone or in combination with thalidomide, an anti-angiogenetic drug, in patients with newly diagnosed glioblastoma multiforme (GBM).
46 patients with histologically proven GBM were eligible for inclusion. Twenty-three patients (15 males and 8 females) received temozolom...
Of the cases with nocturnal frontal lobe epilepsy (NFLE) approximately 30% are refractory to antiepileptic medication, with several patients suffering from the effects of both ongoing seizures and disrupted sleep. From a consecutive series of 522 patients operated on for drug-resistant focal epilepsy, 21 cases (4%), whose frontal lobe seizures occu...
Sexual function disturbances are common findings in chronic kidney disease populations. Factors such as uremia, anemia, physical limitations, malnutrition, hypertension, diabetes, depression, aged and others, are usually associated to this dysfunction. Some of them, begun long before dialysis therapy was instituted. Prolonged survival in patients w...
The prosthesis nowadays used in the vascular access for haemodialysis have low patency rates, mainly due to the luminal obstruction, determined by the intimal hyperplasia. Several factors have been related to de development of intimal hyperplasia and graft failure. Among them are the differences in the biomechanical properties between the prosthesi...
Intimal hyperplasia development is recognized as the most important cause of vascular access failure in patients submitted renal function replacement therapy. An important factor that affects the development of intimal hyperplasia is elastic mismatch between native vessel and among vein, arteries and the synthetic graft. In this work, a biomechanic...
Epilepsy-associated malformations of cortical development (MCDs) comprise a variety of dysplastic and neoplastic lesions of yet undetermined molecular pathology. Histopathologic similarities between MCDs and dysplastic brain lesions in the autosomal inherited neurocutaneous phacomatosis tuberous sclerosis (TSC), which affects the TSC1 and/or TSC2 g...
A 62-year-old woman developed dysphasia, signs of intracranial hypertension and seizures. An MRI scan evidenced extra-axial contrast enhancement in the absence of mass lesions. CSF analysis was negative for malignant cytology and viral or bacterial microbiology. In the absence of other evidence, considering the acute clinical onset and MRI picture,...
We compared the blood pressure determinations taken by technical and nurse personnel with that obtained by medical doctors specialized in arterial hypertension in a group of 61 patients in hemodialysis. We also evaluated the usual procedure of measurement performed by nurses taking as parameters the most frequent mistakes made not fulfilling presen...
We present the results of a retrospective study on 10 patients operated on for intractable epilepsy associated with nodular heterotopia as identified by high resolution MRI. Seven patients had unilateral heterotopia, one patient had symmetric bilateral heterotopia and two patients had asymmetric bilateral heterotopia. By stereo-electroencephalogram...
A reduced quality and length of the patient's survival is the reason why the appearance of a brain metastasis (BM) is generally regarded as an ominous event in the progression of many solid tumors. It is important to study the biology of the brain metastatic process because present treatments are principally palliative. Brain metastases are the mos...
During the dialysis procedure, arterial hypotension is one of the most common problems and it has been object of many studies. In hemodialysis, changes are produced in body volume through ultrafiltration that generate an increase in the production of thermic energy, which is removed during the treatment. The hypovolemia resulting from the removal o...
Focal cortical dysplasia is a well‐known cause of intractable epilepsy with early onset of seizures, and is potentially amenable to surgical therapy.
It was first described by Taylor in 1971 as a peculiar malformative disorganisation of the neocortex characterised at histology by loss of cortical lamination and accompanied by giant, dysmorphic neur...
Focal cortical dysplasia are a frequent histological finding in epilepsy surgery series. Among the different types of focal cortical dysplasia, distinctive anatomical, electrical and clinical details have been identified for Taylor's focal cortical dysplasia, and in a recent article we reported a better post‐surgical outcome in Taylor's focal corti...
The authors performed an MRI, stereo-EEG, and pathology study on a woman with subcortical band heterotopia and partial epilepsy. Clinical manifestations of seizures always started when ictal discharges were present in outer and heterotopic cortices. Simultaneous activation of both cortices and presence of differentiated neurons in the white matter...
Focal cortical dysplasia (FCD) covers a spectrum of conditions in which the neuropathologic and electroclinic presentations and the surgical outcomes vary. The aim of this study was to identify the MR features of histologic subtypes of FCD that would be useful for differential diagnosis.
We reviewed the MR data of 49 patients treated surgically for...
Temporal lobe epilepsy (TLE) is the commonest form of focal epilepsy syndrome. Starting from the fifties and the en bloc anterior temporal lobectomy, hippocampal sclerosis (HS) has been recognized as the most frequent pathological finding in TLE surgical series. In recent years, MRI techniques allowed HS to be reliably recognized in vivo, reinforci...
Since the original description by Taylor, the term focal cortical dysplasia has been used to refer to a wide range of alterations of the cortical mantle. More recently, these conditions have been described from neuroimaging, neuropathological and genetic standpoints, generating several classifications. It is widely recognized that these classificat...
Brain metastases (BrM) are tumours that originate in tissues outside the central nervous system and spread secondarily to involve mainly the brain. The management of patients with cerebral metastases is complex, costly, and in some instances controversial. Furthermore, even in patients with widespread systemic cancer, the symptoms of the disease ar...
High-resolution imaging techniques can demonstrate anatomic alterations in most patients identified as candidates for surgical treatment of their partial epilepsy. The demonstration of an anatomic lesion is only one step in the presurgical diagnostic procedure, which includes video-EEG and, when necessary, video-stereo-EEG recordings of seizures. A...
Different types of epilepsies and seizures depend on the nature and location of the primary disturbance and are presumably mediated by different physiopathological mechanisms. We immunocytochemically investigated possible changes in the inhibitory-aminobutyric acid (GABA)ergic system in specimens taken from four patients who underwent surgery for i...
Introduction. Rarely, a primary cardiac tumor may be the cause of a cerebrovascular ischemic event. Objective. To show the importance of transesophageal echocardiography (TEE) to detect the etiology of transient ischemic attacks (TIA) and ischemic stroke in young patients. Material and methods. A 47-year-old man with non-insulin-dependent diabetes...
In the present report we describe the neuropathological characteristics of tissue surgically resected from three patients affected by intractable epilepsy secondary to cortical dysplasia. Common features, suggestive of a focal cortical dysplasia of Taylor, were observed in all specimens. Immunocytochemical procedures were performed using neuronal a...
MR imaging is considered the neuroradiological procedure of choice for the study of intractable partial epileptic patients. The role of CT-scan is limited to the demonstration of calcific components of the lesion and of bony abnormalities of the adjacent skull. In this chapter we describe an MR protocol for the evaluation of temporal lobe epilepsy...
Arterial stiffening is a common finding in patients on chronical hemodialysis (CHD) impairing the progno- sis. The aim of this work was to characterize aortic stiffness through pulse wave velocity (PWV) determi- nations in a population of patients on CHD. For this purpose PWV, arterial pressure and biochemical and antropometric parameters were meas...
Los estudios epidemiol ógicos y los seguimientos de pacientes son necesarios para determinar el valor predictivo, tanto de los parámetros arteriales estructurales como de los dinámicos. La velocidad de la onda del pulso constituye un método simple, confiable y reproducible, que puede ser determinado en forma no invasiva en pacientes ambulatorios. E...