Cindy Xu

Cindy Xu
Massachusetts General Hospital | MGH · Center for Regenerative Medicine

Doctor of Philosophy

About

8
Publications
1,111
Reads
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55
Citations
Citations since 2017
8 Research Items
55 Citations
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201720182019202020212022202305101520

Publications

Publications (8)
Article
Full-text available
Species with multimodal communication integrate information from social cues in different modalities into behavioral responses that are mediated by changes in gene expression in the brain. Differences in patterns of gene expression between signal modalities may shed light on the neuromolecular mechanisms underlying multisensory processing. Here, we...
Article
Full-text available
Abstract Reptiles are the only amniotes that maintain the capacity to regenerate appendages. This study presents the first anatomical and histological evidence of tail repair with regrowth in an archosaur, the American alligator. The regrown alligator tails constituted approximately 6–18% of the total body length and were morphologically distinct f...
Article
Full-text available
The immune system of ectotherms, particularly non-avian reptiles, remains poorly characterized regarding the genes involved in immune function, and their function in wild populations. We used RNA-Seq to explore the systemic response of Mojave desert tortoise (Gopherus agassizii) gene expression to three levels of Mycoplasma infection to better unde...
Presentation
Social information can lead to changes in brain gene expression that underlie and modulate behavioral responses. However, the molecular basis of behavior remains poorly understood. Here, we use RNA-Seq to analyze brain transcriptome profiles in response to either chemical or visual signals in a territorial lizard with multimodal communication. We e...
Article
While tail regeneration is observed in a number of vertebrate groups, including teleost fish such as the zebrafish, urodeles such as the axolotl, and anurans such as Xenopus tadpoles, mammalian and avian amniote vertebrates have lost this capacity. Among the amniotes, squamate reptiles such as lizards retain the ability to regrow their tails and al...
Article
Peripheral nerves exhibit robust regenerative capabilities in response to selective injury among amniotes, but the regeneration of entire muscle groups following volumetric muscle loss is limited in birds and mammals. In contrast, lizards possess the remarkable ability to regenerate extensive de novo muscle after tail loss. However, the mechanisms...
Chapter
Full-text available
Among amniote vertebrates, reptiles display the greatest variation in axial skeleton morphology. Only recently have they been used in gene expression studies of somitogenesis, challenging previous assumptions about the segmentation clock and axial patterning. An increasing number of reptile genomes and transcriptomes are becoming available as next-...

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