Cielito Caneja

Cielito Caneja
Chelsea and Westminster Hospital NHS Foundation Trust

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16
Publications
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253
Citations
Introduction

Publications

Publications (16)
Article
Full-text available
Treatment options for severe asthma are limited, particularly in those patients who do not meet criteria for biologicals. Targeted lung denervation (TLD) is the bronchoscopic ablation of the peribronchial vagal nerve trunks to reduce cholinergic stimulation of airway smooth muscle and submucosal glands. This report describes the experience of the f...
Conference Paper
Introduction: Bronchoscopic visualisation of the lungs, has proved an invaluable aid for many specialities. There has been an exponential increase in interventional therapies. Their safe delivery is crucially dependent on the expertise of skilled endoscopy team. However, structured training for bronchoscopy nurses is limited. An in-house patient e...
Conference Paper
Introduction: Chronic bronchitis (CB) is a phenotype of chronic obstructive pulmonary disease characterised by bronchial epithelial hyperplasia. Metered cryospray (MSC) (RejuvenAir® system) is a novel, bronchoscopic treatment that utilises titrated sprays of liquid nitrogen to enact controlled epithelial ablation, triggering the regeneration of bro...
Article
Background: No currently approved intervention counteracts airway metaplasia and mucus hypersecretion of Chronic Bronchitis (CB) in COPD. Metered Cryospray (MCS) delivering liquid nitrogen (LN2) to the tracheobronchial airways ablates abnormal epithelium and facilitates healthy mucosal regeneration. The objective of this study was to evaluate the f...
Article
Background: Lung volume reduction surgery is a proven treatment for emphysematous patients with hyperinflation, but the precarious health of candidates has prompted development of less invasive approaches. Bronchoscopic implanted endobronchial coils, shape-memory nitinol filaments, shrink emphysematous lung tissue to restore elastic recoil and to...
Article
BackgroundGiant bullae contribute to breathlessness through hyperinflation, airflow obstruction and V/Q mismatch in emphysema. Surgical removal is the optimal treatment but has an associated morbidity.Aims and objectivesThis single arm, open label interventional trial aims to determine the effect of bronchoscopic intrabullous autologous blood insti...
Article
The current standard therapy for patients with giant bullae is surgical bullectomy; however, high operative risk and comorbidities preclude surgical procedures in many patients. Autologous blood instilled directly into bullae can induce an inflammatory reaction, leading to scarring, fibrosis, and ultimately volume loss. We have treated 5 patients w...
Article
ZZ and SK contributed equallyINTRODUCTION: The RePneu Lung Volume Reduction Coils (LVRCs) are nitinol devices implanted bronchoscopically using fluoroscopic guidance, and retake their original coiled shape as they are deployed.Around 10 LVRCs implanted in an emphysematous lobe reduce hyperinflation and gas trapping.METHODS: The RESET trial randomis...
Article
Background: At present, surgical bullectomy is the standard of care for the treatment of patients with giant bullae. However, a significant proportion of patients are not suitable for surgical treatment due to high operative risk and co-morbidities. There is also limited availability to bullectomy, a high cost, and a significant morbidity associate...
Conference Paper
Background The predominant pathophysiology in severe emphysema with gas trapping and hyperinflation is that of dynamic airway collapse on minimal expiratory effort. This limits the benefit from drug therapy. Safer and cheaper alternatives to lung volume reduction surgery (LVRS), which has success in selected patients with low exercise capacity and...
Article
SESSION TYPE: Bronchoscopy and Interventional Procedures PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Current practice in interventional pulmonology (IP) encompasses complex procedures that require a solid teamwork among team members including the IP nurse assistants (IPNA) and IP respiratory therapist assistants...
Article
SESSION TYPE: Late-Breaking AbstractsPRESENTED ON: Tuesday, October 23, 2012 at 04:30 PM - 05:45 PMPURPOSE: Therapeutic options for severe emphysema with gas trapping and hyperinflation are limited. The predominant pathophysiology of dynamic airway collapse with minimal expiratory effort renders drug therapy of little benefit. Lung volume reduction...
Article
Evidence suggests that oxidative stress is a unifying feature underlying the toxic actions of particulate matter (PM). We have investigated whether individual plasma antioxidant concentrations (uric acid and vitamins C, A, and E) and 10 antioxidant genes modify the response to PM with respect to hospital admissions for chronic obstructive pulmonary...
Article
Problem Acute exacerbations of COPD are a major cause of hospital admission and readmission. National surveys have revealed significant differences in patient outcomes which are likely to be due to variations in care. Design A care bundle, comprising a short list of evidence-based practices to be implemented prior to discharge for all patients adm...
Article
Full-text available
National surveys have revealed significant differences in patient outcomes following admission to hospital with acute exacerbation of COPD which are likely to be due to variations in care. We developed a care bundle, comprising a short list of evidence-based practices to be implemented prior to discharge for all patients admitted with this conditio...

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