Ciddi Veeresham

Ciddi Veeresham
Kakatiya University · Faculty of Pharmacy

B.Pharm, M.Pharm., Ph.D

About

127
Publications
50,994
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2,083
Citations
Additional affiliations
May 2005 - July 2007
Addis Ababa University
Position
  • Professor (Full)
Description
  • teach master students in Pharmacognosy
November 2002 - July 2004
Addis Ababa University
Position
  • Professor (Associate)
Description
  • toteach master students
April 1991 - present
Kakatiya University
Position
  • Professor (Full)
Description
  • Professor of Pharmacy to teach and guide master and Ph.D students

Publications

Publications (127)
Article
Full-text available
A series of new isatin–mesalamine conjugates (9a–g) were synthesized via conjugation of isatin (3a) and its derivatives (3b–3d, 4, 5, and 6) with mesalamine (7) by using chloroacetyl chloride as a bifunctional linker. Compounds 3a–3d were prepared by employing Sandmeyer reaction. Compounds 4, 5, and 6 were obtained from isatin (3a) via previously r...
Article
Full-text available
Background Aldose reductase (AR) and Advanced glycation end product (AGE) are known to play important roles in the development of diabetic complications. The inhibitors of AR and AGE would be potential agents for the prevention of diabetic complications. Objective The present study was aimed to evaluate the aldose reductase (AR) and advanced glyca...
Article
Full-text available
Inspired by the concept of molecular hybridization, a series of new isatin‐pomalidomide hybrids (9a–9g) were designed, synthesized, characterized, and evaluated for in vitro cytotoxic activity against U266B1 and RPMI 8226 multiple myeloma cell lines. Sandmeyer methodology and N‐halomethylketo alkylation reaction are the two important reactions invo...
Article
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This study was aimed at selecting suitable biocatalysts for the enantioselective conversion of racemic sotalol to R(-)-sotalol and to determine the effect of immobilization on enantiomeric purity of the product. Among the various biocatalysts used, Aspergillus Niger (GUFCC5443), Cunninghamella blakesleeana (CBS133.27), Cunninghamella elegans (NCIM6...
Article
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Objective: The present investigation is aimed to determine the effect of ashwagandha (AG) on pharmacokinetic (PK) and pharmacodynamic (PD) parameters of glimepiride (GP) in diabetic rats. Simultaneously, the effect was also studied in normal rats.Methods: Diabetes in rats was induced by streptozotocin. The PK parameters are calculated in normal and...
Article
Background: Picrorhiza kurroa (PK) belongs to Scrophulariaceae family and is a representative endemic, medicinal herb, widely distributed throughout the higher altitudes of alpine Himalayas from west to east, between 3000 and 4500 m above mean sea level. Objective: The objective of the present study is to assess the production of picroside I and...
Article
A simple, rapid and highly sensitive liquid chromatography-mass spectrometry method was developed and validated for analysis of iloperidone on rat dried blood spots. The chromatographic separation was achieved on an Agilent RP-18 column (250 × 4.6 mm; 5 μm), using 20 mM ammonium acetate (adjusted to pH 5 with TFA) and acetonitrile (60 : 40 v/v) as...
Article
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Objective: The objectives were to study the in-vitro and in-vivo aldose reductase and in-vitro advanced glycation end products formation inhibitory activities of the standardized extracts of Picrorhiza kurroa roots and Hibiscus rosa-sinensis flowers.Methods: In-vitro Aldose reductase inhibitory activity was studied by using isolated rat lens and ki...
Article
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Among the microorganisms employed in the study, Aspergillus niger (GUFCC5443), Escherichia coli (ATCC9637), Streptomyces halstedii (CKM-2), Pseudomonas putida (NCIB9494), Cunninghamella elegans (NCIM689) and Sphingomonas paucimobilis (NCTC11030) were capable for the enantioselective conversion of racemic Carvedilol. Immobilization technique enhance...
Article
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Aim: Abrus precatorius leaves methanolic extract (APME) was evaluated for in vivo antihyperglycemic activity and in vitro insulinotropic effect. Materials and methods: In vivo antihyperglycemic and insulin secretagogue activities were assessed in streptozotocin-induced diabetic rats by oral administration of APME (200 mg/kg body weight [bw]) for...
Article
Full-text available
A series of new isatin-benzoic acid conjugates (9a - n) were synthesized via conjugation of isatin (3a) and its derivatives (3b - d, 4, 5 and 6) with 4-amino-5 chloro-2-ethoxybenzoic acid or 4-amino-5-(ethylsulfonyl)-2- methoxybenzoic acid by using chloroacetyl chloride as a bifunctional linker. Compounds 3a - d were prepared by employing Sandmeyer...
Article
The present retrospective study was aimed to provide information about the prevalence and clinical outcomes of patients living with HIV in Warangal District, in the Northern Telangana region, India. The national AIDS control organization and Kakatiya Medical College (KMC) Institutional Review Board reviewed and approved the study. The study reviewe...
Article
The effect of boswellic acids (BA) and andrographolide (AD) on the pharmacokinetics and pharmacodynamics of glyburide in normal as well as in streptozotocin-induced diabetic rats was studied. In normal and diabetic rats, the combination of glyburide with BA or AD increased significantly (p < 0.01) all the pharmacokinetic parameters, such as Cmax ,...
Article
Objective: A simple, precise, and accurate stability indicating high-performance thin-layer chromatography (HPTLC) method was developed and validated for simultaneous estimation of linagliptin and metformin active pharmaceutical ingredients and fixed dose combination. Methods: Linagliptin and metformin densitograms were developed on silica gel 60 F...
Article
Full-text available
The present study involves the enantioselective resolution of racemic Felodipine by using free and immobilized forms of microbial cultures as well as an enzyme (Lipase AP6). Among the microbial cultures employed in the present study, Aspergillus niger, Sphingomonas paucimobilis, Cunninghamella elegans, Escherichia coli, Pseudomonas putida and Cunni...
Article
Full-text available
Benzophenenathridine alkaloids nitidine and chelerythrine production from callus cultures of Toddalia asiatica was investigated. Callus cultures were initiated on Murashige and Skoogs medium fortified with different hormonal combinations. Nitidine and chelerythrine levels in callus culture extracts was analyzed by high performance liquid chromatogr...
Article
Full-text available
Objective: A simple, precise, and accurate stability indicating high-performance thin-layer chromatography (HPTLC) method was developed and validated for simultaneous estimation of linagliptin and metformin active pharmaceutical ingredients and fixed dose combination. Methods: Linagliptin and metformin densitograms were developed on silica gel 60 F...
Article
Full-text available
Various mechanisms including polyol pathway along with a complex integrating paradigm with oxidative stress and advanced glycation end products (AGE) formation have been implicated in the pathogenesis of diabetic nephropathy. The present study was aimed at investigating a well known antioxidant, pterostilbene for its therapeutic role in streptozoto...
Article
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A rapid, simple, specific and precise high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous estimation of sitagliptin (STG) and metformin (MET) content in a fixed dose pharmaceutical formulation and also in bulk drug. In the developed method, aluminium backed silica gel 60 F254 HPTLC plates were employed as st...
Article
Full-text available
Background: Aldose Reductase (AR) enzyme and advanced glycation end products (AGEs) play an important role in diabetic complications. The AR and AGEs inhibitors are beneficial in prevention of diabetic complications. Objective: Aim of present study was to evaluate the in vitro and in vivo AR and AGEs inhibitory activity of an antidiabetic plant But...
Article
Full-text available
The effect of quercetin on the pharmacokinetics (PK) and pharmacodynamics (PD) of glimepiride was studied in normal and streptozotocin induced diabetic rats. In normal and diabetic rats the combination of glimepiride with quercetin increased significantly (p < 0.01) all the pharmacokinetic parameters, such as C max , AUC 0-n , AUC total , t ½, MRT...
Article
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Abstract: Mesua ferrea flowers have been used in the Indian traditional medicine for treating various diseases. In present study, the Mesua ferrea flowers methanolic extract (MFME, 200 mg/kg bw) was studied for anti diabetic activity and underlying mechanisms for its activity. In Streptozotocin induced diabetes rats model, MFME treatment enhanced p...
Article
Full-text available
The present study was intended to evaluate, highlight and explore the role of four medicinal plant (Morus alba L., Phyllanthus amarus Schum. & Thonn., Punica granatum L., and Stevia rebaudiana Bertoni) standardized extracts and their major constituents (morusin, phyllanthin, punicalagin and stevioside) in the treatment of long-term diabetic complic...
Article
Tissue cultures of the leaves and stems of the indigenous tree Ervatamia heyneana (Wall) T. cooke were established with the aim to investigate the production of camptothecin (CPT) and its analogues such as 9-methoxy camptothecin and 10-hydroxy camptothecin. Unorganized callus tissue was developed from stems on Murashige and Skoog's (MS) medium, whi...
Article
Tissue cultures of the leaves and stems of the indigenous tree Ervatamia heyneana (Wall) T. cooke were established with the aim to investigate the production of camptothecin (CPT) and its analogues such as 9-methoxy camptothecin and 10-hydroxy camptothecin. Unorganized callus tissue was developed from stems on Murashige and Skoog's (MS) medium, whi...
Article
Full-text available
To enhance patient compliance toward treatment in diseases like diabetes, usually a combination of drugs is prescribed. Therefore, an anti-diabetic fixed-dose combination of 2.5 mg of linagliptin 500 mg of metformin was taken for simultaneous estimation of both the drugs by reverse phase-high performance liquid chromatography (RP-HPLC) method. The...
Article
Full-text available
A simple chiral HPLC method was developed and validated for quantification of S(-)-Carvedilol in Active Pharmaceutical Ingredient (API) and marketed tablet formulation of racemic Carvedilol. Chiral resolution of enantiomers of Carvedilol was achieved on Phenomenex Lux-cellulose–4 (250 mm × 4.6 mm; 5 µ particle size) chiral column by using a mobile...
Article
Full-text available
Since ancient times, traditional medicines have been in the usage for the treatment of Diabetes mellitus. An edible fruit from traditional medicinal plant Capparis zeylanica (CZ) was studied for its anti diabetic, insulin secretagogue activities and mechanisms involved in it. In Streptozotocin induced diabetes rats, oral administration of Capparis...
Article
Full-text available
A simple, specific, accurate and precise high performance thin layer chromatographic method (HPTLC) was developed for the quantitative analysis of Saxagliptin in active pharmaceutical in- gredients (APIs) and pharmaceutical dosage forms. The method was achieved using silica gel alu- minum plate 60 F254 (10 × 10 cm) as stationary phase and Methanol:...
Article
Background Various mechanisms with a complex integrating paradigm have been implicated in diabetic complications. The present study was aimed to evaluate the aldose reductase (AR) and advanced glycation end products (AGEs) inhibitory activity of resveratrol (RSV) and its potential in the treatment of diabetic complications such as cataract and neph...
Article
Full-text available
Background: Toddalia asiatica (Rutaceae) is an important medicinal plant in traditional medicinal system of India and China. Nitidine production from callus cultures of the plant had been investigated, but in vitro multiplication and secondary metabolite production from shoot cultures is not reported. Objective: The aim of the present work is to...
Article
Full-text available
Microbial transformation is a complementary tool in the investigation of drug metabolism. In the present investigation, biotransformation of vincamine was studied using microbial cultures. Bacterial, fungal, and yeast cultures were employed to elucidate the metabolism of vincamine. The results indicate that a number of microorganisms metabolized vi...
Article
Full-text available
ABSTRACT: The present investigation was aimed at studying the biotransformation of midazolam, a marker substrate for CYP3A4 metabolic reactions using nine microbial cultures. The study was performed using a two stage fermentation protocol and the results indicate that the microbial cultures produce hydroxylated metabolites of midazolam, based on HP...
Article
Full-text available
Diabetes is a disease, which has assumed vital public health importance because of the complications associated with it. Various mechanisms including polyol pathway along with a complex integrating paradigm have been implicated in glucose-mediated complications. Though polyol pathway was established as a major mechanism, precise pathogenesis of the...
Article
Diabetic complications are attributed to hyperglycaemic condition which is in turn associated with the polyol pathway and advanced glycation end products. Aldose reductase (AR) is the principal enzyme of polyol pathway which plays a vital role in the development of diabetic complications. AR inhibitory activity can be screened by both in vitro and...
Article
Full-text available
Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from lack of insulin secretion or insulin sensitivity or both. Enhancement of insulin levels and insulin sensitivity is the primary target in the treatment of diabetes. Current treatment options, such as dietary modifications, oral hypoglycemic drugs and insulin have...
Article
The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and related diseases, and their principal components for AR inhibitory activity and to...
Article
Oroxylum indicum (Bignoniaceae) also known as Sonapatha is an indigenous medicinal plant widely used in Ayurvedic medicine for over thousands of years. It is an active ingredient of well-known Ayurvedic formulations such as Chyawanprash and Dasamula. Root bark of this plant has tonic and astringent properties and it is also used in rheumatism. The...
Article
Aldose reductase is the first enzyme in the polyol pathway and catalyzes the reduction of glucose to sorbitol by coupling with the oxidation of NADPH to NADP(+) . This sorbitol accumulation leads to various diabetic complications, including neuropathy, nephropathy, cataracts, and retinopathy. In the present study, aldose reductase inhibitory (ARI)...
Article
Full-text available
The effect of piperine on the pharmacokinetics and pharmacodynamics of glimepiride in normal as well as diabetic rats was studied. In normal and streptozotocin induced diabetic rats the combination of glimepiride with piperine increased all the pharmacokinetic parameters, such as Cmax, AUC0-n, AUCtotal, t1/2, and MRT, and decreased the clearance, V...
Article
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Diabetes has become a worldwide problem afflicting humans irrespective of age. Even though a number of synthetic drugs are available for the treatment of diabetes, plant drugs are generally preferred due to the assumption that they have less side effects and low cost. This study reports the hypoglycaemic and antihyperglycaemic actions of the methan...
Article
The aim of this study was to elucidate the effect of elicitors and precursors on the production of forskolin from the hairy root cultures of Coleus forskohlii Briq. Hairy root cultures were established from leaf explants by infecting with Agrobacterium rhizogenes strain A4 on MS basal medium. Suspension cultures of hairy root cultures were initiate...
Article
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Carduus schimperi Sch. Bip. ex A. Rich (Asteraceae) is a perennial herb and its roots are used in some localities in Ethiopia for orofacial inflammation in the form of warm aqueous macerate. In the present study, the in vivo antiinflammatory and antinociceptive effects of the aqueous root extracts of C. schimperi were investigated. The antiinflamma...
Article
Jatropha curcas L. (physic nut) belongs to Euphorbiaceae and is gaining importance for the production of biodiesel. It is considered as a potential source of non-edible fuel producing plant along with its different medicinal properties and grows well in the tropical and subtropical climate in India. A detailed pharmacognosy of the vegetative parts...
Article
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In Ethiopian traditional medicine the aqueous decoction of the leaves of Cineraria abyssinica Sch. Bip. exA. Rich (Asteraceae) is used for the treatment of various ailments including liver diseases, however, to date, there appears to have been no scientific report on the phytochemistry and claimed hepatoprotective activity of the plant. The main pu...
Article
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widely used for the treatment of a variety of diseases including wounds, asthma, rheumatism and cancer. This study reports the antioxidant, 5-lipoxygenase (LOX) inhibitory and anticancer activities of the bark extracts of this plant. For evaluation of in vitro antioxidant activity DPPH (1,1-diphenyl-2-picry1 hydrazy1) and superoxide radical scaveng...
Article
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The common usage of Galium spp. in the Ethiopian traditional medicine, as described in few documentations, are generally related to diseases associated with the nervous system, the immune system, infections and inflammation. Preliminary phytochemical and antimicrobial screening on extracts of the aerial parts of Galium spurium (subspecies africanum...
Article
Full-text available
Aldose reductase (AR) enzyme and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to look into two standardized plant extracts used in Ayurvedic medicine for the treatment of diabetes, and their principal components for AR and AGEs inhibitory activities, and to e...
Article
Hairy root cultures of Catharanthus roseus produce indole alkaloids like ajmalicine, serpentine and catharanthine but the yields are low for economical production. A number of abiotics and biotics (i.e., signal transduction molecules) were therefore tested for enhancing productivity of root cultures. Among metal ions, copper and silver produced mor...
Article
Full-text available
The essential oil from the aerial parts of Plectranthus caninus roth (lamiaceae), obtained by hydro-distillation was analyzed by gas chromatography/mass spectrometry (gc/Ms) and evaluated for antimicrobial, free radical scavenging and anti-inflammatory activities. Thirty-four compounds representing 91.02% of the total oil were identified. the major...
Article
Full-text available
Biotransformation of Silibinin using fungi was performed and parameters viz., effect of incubation period, effect of pH, effect of temperature, effect of glucose concentration and effect of substrate concentration were studied. Of the 29 fungi studied 11 were able to metabolize Silibinin to produce one or two metabolites, which was evidenced from t...
Article
Full-text available
A simple and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method was de-veloped for the determination of glimepiride in rat serum. The assay involves one step liquid-liquid extrac-tion with methanol. Gliclazide was used as an internal standard. Chromatographic separation was performed on a C 18 column using a mobile phas...
Article
The common perception regarding the herbal medicines is that they are natural and safe. Although considered natural, most of the herbal medicine can interact with other drugs causing either potentially dangerous side effects or they can lead to loss or decreased therapeutic benefits of the drugs. Currently, there is growing concern to analyse and u...
Article
Toddalia asiatica(Rutaceae) is a woody liana used traditionally in the treatment of malaria, sprains, cough, fever, neuralgia, epilepsy, dyspepsia and other disease conditions. The extracts of the plant have been reported to have anticancer and anti-HIV activities. These activities are mainly attributed to benzophenanthridine alkaloid i.e., nitidin...
Article
St. John's wort or Hypericum perforatum L. (family: Hypericacae) is one of the leading herbal drug used for the treatment of mild to moderate depression and the high demand for the medicinal constituents like hypericins have necessitated a search for an alternative, biotechnological method for their production. Ethephon and ancymidol are growth ret...
Article
Full-text available
Microbial biotransformations can be used to predict mammalian drug metabolism. The present investigation deals with microbial biotransformation of valdecoxib using microbial cultures. Thirty nine bacterial, fungal and yeast cultures are used to elucidate the biotransformation pathway of valdecoxib. A number of microorganisms metabolized valdecoxib...