Chunying Chen

Chunying Chen
Chinese Academy of Sciences | CAS · Laboratory for Biological Effects of Nanomaterials and Nanosafety

About

520
Publications
138,827
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33,564
Citations
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June 2006 - present

Publications

Publications (520)
Article
Full-text available
The global-scale production of plastics has been instrumental in advancing modern society, while the rising accumulation of plastics in landfills, oceans, and anything in between has become a major stressor on environmental sustainability, climate, and, potentially, human health. While mechanical and chemical forces of man and nature can eventually...
Article
Graphdiyne oxide (GDYO) nanosheets have remarkable electronic, mechanical, and thermal properties, which is hoped to act a better alternative for biomedical applications. Tumor-associated macrophage (TAM) is a promising cell population for nanotechnology application to cancer immunotherapy. In the present study, we found M2-like macrophages can be...
Article
Significance This study analyzed the dynamic protein corona on the surface of nanoparticles as they traversed from blood to cell lysosomes and escaped from lysosomes to cytoplasm in the target cells. We found with proteomic analysis an abundance of chaperone and glycolysis coronal proteins (i.e., heat shock cognate protein 70, heat shock protein 90...
Article
Achieving a complete response to cancer treatment is a severe challenge, and has puzzled humans for a long time. Fortunately, radiotherapy (RT) gives rise to a common clinical treatment method, during which the usage of radiosensitizers is essential. Among preclinical radiosensitizers, bismuth-based nanoparticles (Bi-based NPs) are widely explored...
Article
Multidrug resistance (MDR) has become one of the most intractable problems in clinics as it would cause failure in chemotherapy. In this study, we demonstrated that a nanoscale self-assembled nanomedicine, which almost consisted of a pure chemo-drug, could efficiently overcome MDR. Celastrol (CST) was directly assembled into a discrete nanomedicine...
Article
Full-text available
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous collection of biomolecular species by nanoparticles in living systems. The protein corona is dynamic in composition and may entail improved water suspendability and compromised delivery and targeting to the nanoparticles. How much of this nonspecific protein...
Article
Controllable nano-assembly with stimuli-responsive groups is emerging as a powerful strategy to generate theranostic nanosystems that meet unique requirements in modern medicine. However, this prospective field is still in a proof-of-concept stage due to the gaps in our understanding of complex-(nano-assemblies)-complex-(biosystems) interactions. I...
Article
Full-text available
Viral infections have been proven a severe threat to human beings, and the pandemic of Coronavirus Disease 2019 (COVID-19) has become a societal health concern, including mental distress and morbidity. Therefore, the early diagnosis and differentiation of viral infections are the prerequisite for curbing the local and global spread of viruses. To t...
Article
The antibacterial activity of graphene family materials (GFMs) has been explored since 2010, 6 years after the discovery of graphene in 2004. It is proposed that the antibacterial activity is derived from both physical interaction and chemical reaction between GFMs and bacteria. However, whether the two mechanisms work synergistically or whether th...
Article
Periodontitis places a substantial burden on healthcare worldwide. Due to the complexity of the periodontium, regenerative periodontal therapy in healing periodontal tissue damage caused by periodontitis has long been difficult using traditional tissue engineering techniques. The current clinical treatment, guided tissue regeneration (GTR), has sho...
Article
Improving virus control in HIV-infected individuals without a timely antiretroviral therapy (ART) intervention still remains an important challenge, which is largely due to the lack of a potent means to co-deliver a complex therapeutic system consisting of diverse types of vaccines and drugs to the human body. Here, we used a one-step method to rap...
Article
Alzheimer’s disease (AD) has been an intractable neurodegenerative disease among the elderly in the worldwide. One of the important pathogenic factors in AD is the aggregation of amyloid-β 1- 42 (Aβ42) in AD patients’ brain. Inhibition of Aβ peptide aggregation is considered as one of the effective approaches against AD. Herein, a pulsed laser abla...
Article
Blood brain barrier (BBB) protects homeostasis and sensitive environment of brain from several toxic substances coming from the systemic circulation. This barrier along with those substances also prevents therapeutic chemicals to reach brain tissues for several brain diseases. BBB consists of a number of cell types and junctions that help maintain...
Article
Nanozyme Im Forschungsartikel auf S. 25532 berichten Xin Yu, Jing Liu, Chunying Chen et al. über ein Titannitrid-Nanozym für die pH-responsive und bestrahlungsverstärkte katalytische Tumortherapie.
Article
Parkinson's disease (PD) is becoming prevalent with the increasingly ageing global population. PD is a multi-factorial disease for which there is currently no cure but only mitigative therapies. The development of nanomedicine has broadened opportunities for finding new and effective neuroprotective and neuror-estorative therapies, thereby offering...
Article
The rapid development of nanotechnology has greatly benefited modern science and engineering and also led to an increased environmental exposure to nanoparticles (NPs). While recent research has established a correlation between the exposure of NPs and cardiovascular diseases, the intrinsic mechanisms of such a connection remain unclear. Inhaled NP...
Article
The occurrence and development of tumors depend on the tumor microenvironment (TME), which is made up of various immune cells, activated fibroblasts, basement membrane, capillaries, and extracellular matrix. Tumor associated macrophages (TAMs) and microbes are important components in TME. Tumor cells can recruit and educate TAMs and microbes, and t...
Article
Nanozymes In their Research Article on page 25328, Xin Yu, Jing Liu, Chunying Chen et al. report a titanium nitride nanozyme for pH‐responsive and irradiation‐enhanced cascade‐catalytic tumor therapy.
Article
Manufactured nanomaterials with unique properties have been extensively applied in various industrial, agricultural or medical fields. However, some of the properties have been identified to be closely related to nanomaterial toxicity. The “nano-paradox” has aroused concerns over the use and development of nanotechnology, which makes it difficult f...
Article
Graphdiyne(GDY) is a kind of two-dimensional carbon nanomaterial with specific configurations of sp and sp2 carbon atoms. The key progress in the preparation and application of GDY is bringing carbon materials to a brand-new level. Here, the various properties and structures of GDY are introduced, including the existing strategies for the preparati...
Article
Nanozyme‐based tumor catalytic therapy is an emerging therapeutic method with high reactivity in response to tumor microenvironment (TME). To overcome the current limitations of deficient catalytic activity of nanozymes, we studied the contributing factors of enzymatic activity based on non‐metallic atom doping and irradiation. Except for the chemi...
Article
Nanozyme-based tumor catalytic therapy is an emerging therapeutic method with high reactivity in response to tumor microenvironment (TME). To overcome the current limitations of deficient catalytic activity of nanozymes, we studied the contributing factors of enzymatic activity based on non-metallic atom doping and irradiation. Except for the chemi...
Article
Surgical site infections are the most common and serious concern in health care settings. Currently, systemic administration of prophylactic antibiotics or local disinfection treatment is prescribed after surgical procedures. However, prolonged use of antibiotics may pose adverse side effects, bacterial resistance and hospitalization costs. Recentl...
Article
Full-text available
Graphdiyne oxide (GDYO) is a carbon‐based nanomaterial possessing sp2 and sp-hybridized carbon atoms with many promising applications. However, its biocompatibility and potential biodegradability remain poorly understood. Using human primary monocyte-derived macrophages as a model we show here that GDYO elicited little or no cytotoxicity toward cla...
Article
Full-text available
Radioresistance is an important challenge for clinical treatments. The main causes of radioresistance include hypoxia in the tumor microenvironment, the antioxidant system within cancer cells, and the upregulation of DNA repair proteins. Here, a multiple radiosensitization strategy of high-Z-element-based radiation enhancement is designed, attenuat...
Article
Full-text available
Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding of the fundamental principles of their in vivo behaviour. Here we describe the transport, transformation and bioavailability of MoS2 nanomaterials through a combination of in vivo experiments and molecular dynamics simulations. We show that after intraven...
Article
Nanozymes are next-generation artificial enzymes having distinguished features such as cost-effective, enhanced surface area, and high stability. However, limited selectivity and moderate activity of nanozymes in the biochemical environment hindered their usage and encouraged researchers to seek alternative catalytic materials. Recently, metal-orga...
Article
Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COV...
Article
To keep fast proliferation, tumor cells are exposed to higher oxidative stress than normal cells and they upregulate the amount of some antioxidants such as glutathione (GSH) against reactive oxygen species to maintain the balance. This phenomenon is severe in hypoxic tumor cells. Although researchers have proposed a series of treatment strategies...
Article
Swelling is ubiquitous for traditional as-prepared hydrogels, but is unfavorable in many situations, especially biomedical applications, such as tissue engineering, internal wound closure, soft actuating and bioelectronics, and so forth. As the swelling of a hydrogel usually leads to a volume expansion, which not only deteriorates the mechanical pr...
Article
Full-text available
The widespread occurrence of microplastics (MPLs) and nanoplastics (NPLs), collectively abbreviated as M/NPLs, has markedly affected the ecosystem and has become a global threat to human health. Multiple investigations have shown that the chronic ingestion of M/NPLs negatively affects gut barrier function but the mechanism remains unclear. Herein,...
Preprint
The global emergency caused by the SARS-CoV-2 pandemics can only be solved with adequate preventive and therapeutic strategies, both currently missing. The electropositive Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein with abundant β-sheet structure serves as target for COVID-19 therapeutic drug design. Here, we discovered that ultrathi...
Article
Coronavirus is named for its crown shape. Encoded by the genetic material inherited from the coronavirus itself, this intrinsic well-known “viral corona” can be considered the “inherited corona”. After contact with mucosa or the entrance into the host, bare coronaviruses could become covered by a group of dissolved biomolecules to form one or multi...
Article
Nanosafety evaluation is paramount since it is necessary not only for human health protection and environmental integrity but also as a cornerstone for industrial and regulatory bodies. The current nanometallomics did not cover non-metallic nanomaterials, which is an important part of nanomaterials. In this critical review, the concept of nanometal...
Article
As environmental pollutants and possible carcinogens, carbon nanotubes (CNTs) have recently been found to induce carcinogenesis and tumor metastasis after long-term pulmonary exposure. However, whether CNT-induced carcinogenesis can be inherited and last for generations remains unclear. Herein, postchronic single-walled carbon nanotubes (SWCNTs) ex...
Article
Full-text available
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologie...
Article
Effective vaccines are vital to the fight against the COVID-19 global pandemic. As a critical component of a subunit vaccine, the adjuvant is responsible for strengthening the antigen-induced immune responses. Here, we present a new nanovaccine that comprising the Receptor-Binding Domain (RBD) of spike protein and the manganese nanoadjuvant (MnARK)...
Article
In recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and modulating immunity. Adjuvants have an unshakable position in the battle against the virus. In addition to th...
Article
Nanosafety evaluation is necessary not only for nanomaterials research and development but also as a cornerstone for legal regulation. In this study, we proposed a non-invasive protocol for nanosafety evaluation through feces using metagenomics and metabolomics together with metallomics. Male SD rats were orally exposed to equal amounts of Se (Se⁰N...
Article
Full-text available
Molybdenum (Mo), as a nontoxic and low‐cost transition metal, has been employed for synthesis of various Mo‐based nanomaterials with unique structures and physicochemical features to achieve various properties. Especially, bioinspired Mo‐based nanomaterials show great potential for the construction of novel nanozyme catalysts due to their variable...
Article
Full-text available
Ferroptosis is an iron-dependent cell death caused by excessive peroxidation of polyunsaturated fatty acids. It can be activated by iron-based nanoparticles as a potential cancer therapeutic target. However, the intracellular transformation of iron-based nanoparticles is still ambiguous and the subsequent ferroptosis mechanism is also obscure. Here...
Article
Full-text available
Interleukin 12 (IL12) is a potent pro‐inflammatory chemokine with multifunction, including promoting cytotoxic T‐cell‐mediated killing of cancer cells. IL12‐based cancer gene therapy can overcome IL12's life‐threatening adverse effects, but its clinical translation has been limited by the lack of systemic gene‐delivery vectors capable of efficientl...
Article
Full-text available
Hypoxia is a common phenomenon among most solid tumors that significantly influences tumor response toward chemo- and radiotherapy. Understanding the distribution and extent of tumor hypoxia in patients will be very important to provide personalized therapies in the clinic. Without sufficient vessels, however, traditional contrast agents for clinic...
Article
Mercury (Hg) is one of the chemicals that bring serious adverse effects to the environment and human beings. Methylmercury (MeHg) is a neurotoxin while inorganic Hg (IHg) is not. Early screening of the neurotoxicity of chemicals may help reduce the occurrence of neurological disorders by minimizing chemical exposure. This work proposed the combined...
Chapter
Cancer is the most threatening disease for humans worldwide. While conventional treatment modalities have limitations and result in adverse side effects, nanotechnology offers a new avenue in the development of cancer nanomedicine. Herein, we discuss the state-of-the-art principles in the design and discovery of nanomaterials for clinical use in th...
Chapter
Nanotechnology provides enormous momentum for the growth of various fields and contributes a huge number of nanoscale substances either as products or by-products to human society and the environment. However, exposure to various nanomaterials has been reported to elicit toxic effects on diverse organisms, which provokes worries about nanosafety is...
Article
The development of three-dimensional (3D) single-cell imaging and protein quantitative methods can provide more comprehensive information for diagnoses. We report the design and synthesis of a multisignal nanoprobe (AuGdNC@BSA-CV) for single-cell 3D imaging and quantifying the integrin αIIbβ3 using correlated synchrotron radiation soft X-ray tomogr...
Article
The increasing emergence of nano-cosmetics in the marketplace provokes safety concerns with respect to percutaneous permeation and toxicity of nanomaterials inside the human body. In this study, in vivo percutaneous permeation and dermal safety of cosmetic cream containing Au nanosheets and extracted Au nanosheets from cosmetic creams are investiga...
Article
The coronavirus disease 2019 (COVID-19) pandemic represents a severe global health threat. Selenium (Se), as one of the essential trace elements in human body, is well known for its antioxidant and immunity-boosting capabilities that induce a strong antiviral effect. In response to the global pandemic, we highlight here the current status of Se in...
Article
Full-text available
Nanomaterials with intrinsic enzyme‐like activities, namely “nanozymes,” are showing increasing potential as a new type of broad‐spectrum antibiotics. However, their feasibility is still far from satisfactory, due to their low catalytic activity, poor bacterial capturing capacity, and complicated material design. Herein, a facile synthesis of a def...
Article
The 20S proteasome, the catalytic core particle of 26S proteasome, degrades a wide range of intracellular proteins, which is essential for many cellular processes. Herein, we have found that the 20S proteasome activity is either up- or down-regulated by introducing gold nanoclusters (AuNCs) coated with nine peptide tails in two different forms, AuN...
Article
With the increased aging population and economic climate, people's demand for healthcare has changed from seeking medical treatment after illness to maintaining active health into later years. Flexible electronic technological advancements have now given us the potential to develop wearable, next-generation implantable medical devices. However, bef...
Article
Nanotherapeutics exhibit unique advantages in clinical outcomes compared with conventional small molecular drugs. The past three decades have seen intensive research in the field of nanomedicine, leading to a large number of nanomedical products commercialized globally as well as a pipeline of candidates being translated. However, the development o...
Article
Mercury (Hg) is one of the chemicals that bring serious adverse effects to the environment and human beings. Methylmercury (MeHg) is a neurotoxin while inorganic Hg (IHg) is not. Early screening of the neurotoxicity of chemicals may help reduce the occurrence of neurological disorders by minimizing chemical exposure. This work proposed the combined...
Article
Recent clinical and pathological evidence have implicated the gut microbiota as a nexus for modulating the homeostasis of the human body, impacting conditions from cancer and dementia to obesity and social behavior. The connections between microbiota and human diseases offer numerous opportunities in medicine, most of which have limited or no thera...
Article
As a conceptually attractive strategy, the use of immune checkpoint blockade antibodies to treat cancer is limited due to the restrained tumor-infiltrating lymphocytes (TILs), poor accumulation and penetration of antibodies, and deficient checkpoint blockade in malignancies. In this study, we describe a pH and mild photothermal sequentially trigger...
Article
Nanocatalysts have attracted many concerns in biomedical fields because their catalytic performance is robust and remains efficient even at a harsh condition compared to biological enzymes. However, the stability for both physical forms and the catalytic activity are the main challenges during biomedical applications. Here, we described a strategy...
Article
Hypoxia, a common feature of most solid tumors, plays an important role in tumor proliferation, metastasis, and invasion, leading to drug, radiation, and photodynamic therapy resistance, and resulting in a sharp reduction in the disease-free survival rate of tumor patients. The lack of sufficient blood supply to the interior regions of tumors hinde...
Article
Cardiovascular disease is a leading cause of death and one of the effective therapeutic strategies is to provide a controlled, constant supply of nitric oxide (NO) in a mild manner, but this has proved challenging in the clinic. To address this problem, we built nitric oxide synthase (NOS)-like nanoplatform (NanoNOS) that consists of a noble metal...