Chunpeng Wan

Jiangxi Agricultural University

Cancer remains a global health challenge, with drug resistance and disease recurrence posing significant obstacles despite advances in immunotherapy and targeted treatments. This has driven interest in natural products as sources of novel anticancer agents. Withania somnifera (Ashwagandha), a well-regarded plant in Ayurvedic medicine, is noted for...

Diabetes mellitus (DM), a major global health concern, is a chronic metabolic disorder. Bioactive compounds sourced from numerous marine natural products recently have drawn attention as novel therapeutic approaches. Considering these chemicals and their role in cellular redox modulation by involving the nuclear factor erythroid 2-related factor 2...

Phytochemicals are richest source of medicines since human history. Cirsium japonicum (Asteraceae), along with other members in the genus are a rich source of flavonoids, polyacetylenes, acetylenes, phenolic acids, phenylpropanoids, sterols, terpenoids and numerous other compounds. Current study aimed to describe an updated review of the literature...

Foliar calcium (Ca) treatment exhibits strong potential for enhancing yield and quality in some fruit crops. This study aimed to assess the impact of foliar application of Ca-organomineral (Ca-OM) suspension on total soluble solids (TSS) and Ca dynamics in leaves and berries across five red currant cultivars during the vegetation and storage. A ran...

Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However, its clinical application is limited due to severe side effects such as cardiotoxicity. In recent years, numerous studies have demonstrated that cellular aging has become a therapeutic target for DOX-induced cardiomyopathy. However, the underlying mechanism and...

The regulatory mechanisms underlying the salicylic acid (SA)-mediated inhibition of senescence in pummelo fruit, the largest known citrus variety, remain unclear. Herein, postharvest 0.3% SA treatment was demonstrated to delay postharvest 'Jinshayou' pummelo senescence, as evidenced by the inhibitions in firmness loss, electrolyte leakage increase,...

In recent years, there is a growing interest in nutraceutical-rich functional foods for promoting human health. Wild fruits and berries are excellent sources of phytochemicals even though the most deeply studied are the polyphenolic compounds, among them, the major ones such as flavonoids, anthocyanins, or tannins. This review aimed to comprehensiv...

Using network pharmacology, we aimed to examine the underlying mechanisms of FA in treating COVID-19. GeneCards and OMIM were queried for information on FA treatment and COVID-19 targets. The PPI network was obtained using the software Cytoscape. GO and KEGG enrichment analyses were used to identify biological pathways associated with the target pr...

Telomeres are unique structures located at the ends of linear chromosomes, responsible for stabilizing chromosomal structures. They are synthesized by telomerase, a reverse transcriptase ribonucleoprotein complex. Telomerase activity is generally absent in human somatic cells, except in stem cells and germ cells. Every time a cell divides, the telo...

Melatonin treatment was investigated for the sensory quality and senescence in postharvest cattails (Typha latifolia L.) during cold storage. The 0.75 mM melatonin treatment reduced surface browning and delaying lignification of Cattails stored at 4 °C. The results showed that melatonin treatment slowed weight loss and firmness, maintained sensory...

In 2021, the Leaf brown spot of the Japanese privet (Ligustrum japonicum) was observed in Changxi Avenue, Nanchang City, Jiangxi Province, China. 16 isolates from diseased leaves were obtained, and their pathogenicity was confirmed. The pathogen was identified as Phyllosticta capitalensis based on morphological characteristics, cultural appearance,...

The human genetic structure undergoes continuous wear and tear process due to the mere presence of extrinsic as well as intrinsic factors. In normal physiological cells, DNA damage initiates various checkpoints that may activate the repair system or induce apoptosis that helps maintain cellular integrity. While in cancerous cells, due to alteration...

Background: Anticoagulants are the main drugs used for the prevention and treatment of thrombosis. Currently, anticoagulant drugs are primarily multitarget heparin drugs, single-target FXa inhibitors and FIIa inhibitors. In addition, some traditional Chinese drugs also have anticoagulant effects, but they are not the main direction of treatment at...

Introduction This study aimed to examine the anti-biofilm activity and mechanism of gallic acid (GA), kaempferol-7-O-glucoside (K7G) and apigenin-7-O-glucoside (A7G) against Staphylococcus aureus and Escherichia coli. Methods The antibacterial activity of the natural compounds was determined by serial dilution method. The inhibitory activity of na...

ABSTACT Pu-erh tea theabrownins (TBs) exert beneficial effect on egg quality and antioxidant properties of eggs, but the underlying mechanisms behind this response are unclear. In this study, we investigate the effect of TBs on egg antioxidative activity, amino acid and fatty acid profiles, and the underlying relationship between the TBs and oxidan...

Background: The conserved sirtuin protein sirtuin 3 (SIRT3) is a vital protective protein for cardiac hypertrophy. Inhibition of SIRT3 accelerated the development of heart hypertrophy. On the other hand, myocardial hypertrophy was prevented by overexpressing SIRT3. SIRT3 has been proposed as a potential therapeutic target for managing or averting...

Phytochemicals or natural products have been studied extensively for their potential in the treatment of neurodegenerative diseases (NDs) like Parkinson’s disease, Alzheimer’s disease, etc. The neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In spite of impressive and thorough knowledge of neurode...

Purpose: To screen the main active components of Citrus aurantium through a network pharmacology approach, construct a component-disease target network, explore its molecular mechanism for the treatment of non-small-cell lung cancer (NSCLC), and validate it experimentally. Methods: The active ingredients in Citrus aurantium and the targets of Ci...

Cucumber fruit is very sensitive to chilling injury, which rapidly depreciates their commodity value. Herein, the effect of fucoidan treatment on cucumber under cold stress were investigated. Fucoidan treatment of cold-stored cucumber alleviated the occurrence of chilling injury, delayed weight loss, lowered electrolyte leakage and respiration rate...

Penicillium italicum is the causal agent of citrus blue mold, which is a major threat to the global citrus fruit industry. Antofine, a natural phenanthroindolizidine alkaloid, is water-soluble and exhibits a broad range of biological activities. However, whether it can inhibit P. italicum growth and the potential inhibitory mechanism remain to be e...

Biofilm is a complex community of microorganisms with a more stable form compared to planktonic bacteria. Probiotic strains in biofilms have been found to have beneficial effects in numerous studies. The formation process and the regulatory mechanisms of biofilm were introduced. Strategies to promote biofilm growth were reviewed in categories. And...

Diabetes mellitus is one of the major non-communicable diseases accounting for millions of death annually and increasing economic burden. Hyperglycemic condition in diabetes creates oxidative stress that plays a pivotal role in developing diabetes complications affecting multiple organs such as the heart, liver, kidney, retina, and brain. Green tea...

Background: Lung cancer is characterized by high-risk and high mortality, among which non-small cell lung cancer (NSCLC) conquers a dominant position. Previous studies have reported that corylin has anti-inflammatory, anti-oxidant, and anti-tumor effects; however, its role in NSCLC cells remains unclear. Hypothesis: Corylin inhibits the progress...

Inducing natural resistance against pathogen infection in postharvest citrus by exogenous elicitor is a promising alternative to reduce postharvest losses. Here, the potential induced resistance mechanism of blended cinna-maldehyde, carvacrol and eugenol nano-emulsion against P. digitatum in 'Newhall' navel orange (Citrus sinensis (L.) Osbeck) was...

The present study aimed to recognize the recent literature to highlight the pharmacological impacts and highlight the therapeutic potential of the active molecule eriocitrin. Citrus limon are a good resource of the flavanone eriocitrin (eriodictyol 7-O-β-D-rutinoside). Eriocitrin has potent biological actions due to its strong antioxidant, antitumo...

CRISPR/Cas technology originated from the immune mechanism of archaea and bacteria and was awarded the Nobel Prize in Chemistry in 2020 for its success in gene editing. Molecular diagnostics is highly valued globally for its development as a new generation of diagnostic technology. An increasing number of studies have shown that CRISPR/Cas technolo...

Naringin is a dihydroflavone which was found in citrus fruits. Previous studies have indicated the antiapoptotic, antioxidative stress, and anti-inflammatory effects of naringin. It can improve many common diseases, including fibrosis or hepatotoxicity, cardiovascular disease, and diabetes. Acetaminophen (APAP) is a frequently used painkiller, and...

Fruits are among the most important elements of human diet. It is also well known and scientifically confirmed that fruit-based diet helps to protect human health and prevent many human diseases, mainly because of the high contents of vitamins, minerals, and phytochemicals. Since the human population on the earth is increasing, the need for fruits...

Ficus tikoua Bureau (F. tikoua Bur.) is a perennial woody vine in the Moraceae family that has been used as a traditional folk medicine for centuries to treat many diseases such as chronic bronchitis, diarrhea, dysentery, rheumatism, and other inflammation-related diseases in certain parts of China, India, Vietnam, and Laos. This medicinal plant co...

The sea is a vast ecosystem that has remained primarily unexploited and untapped, resulting in numerous organisms. Consequently, marine organisms have piqued the interest of scientists as an abundant source of natural resources with unique structural features and fascinating biological activities. Marine macrolide is a top-class natural product wit...

Mycotoxins can accumulate in various feeds and thus may get in duck meat, which may have severe food safety and public health implications. This study examined mycotoxins and veterinary medications in duck meat marketed in eight marketplaces around China. For the determination of mycotoxins, including the mycotoxins aflatoxin B1 (AFB1), aflatoxin B...

Eugenol (EUG), cinnamaldehyde (CA), and carvacrol (CAR) have been used to prevent fungal invasion due to their potent inhibitory activity. However, nanoemulsion can overcome these limitations because essential oils are hydrophobic, volatile, and have limited bioavailability. The previous study has shown that cytomembrane lipids play an essential ro...

Background Acute kidney injury (AKI) is a common complication in clinical inpatients, and it continues a high morbidity and mortality rate despite many clinical treatment measures. AKI is triggered by infections, surgery, heavy metal exposure and drug side effects, but current chemical drugs often fall short of expectations for AKI treatment and ha...

7-Demethoxytylophorine (DEM), a natural water-soluble phenanthroindolizidine alkaloid, has a great potential for in vitro suppression of Penicillium italicum growth. In the present study, we investigated the ability of DEM to confer resistance against P. italicum in harvested "Newhall" navel orange and the underlying mechanism. Results from the in...

The upregulation telomerase activity is observed in over 85-90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G-quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT promoter could stabilize the G4s and inhibit hTERT...

The present study was designed to investigate the preventive effect of loquat leaf (LL) based green extract combined with alginate-based composite against fungal infection in Nanfeng tangerine fruit. The sensory quality, physiological, and biochemical characteristics of postharvest citrus were estimated after the treatment. Results showed that LL e...

To explore the effect of bagging on the nutritional quality and color of kiwifruit (Actinidia spp.), the fruits of yellow-fleshed kiwifruit cultivars were analyzed after bagging treatment. Bagging treatment promoted the degreening of mesocarp and increased brightness. Bagging significantly reduced the accumulation of dry matter, titratable acids, s...

This review article depicts the possible replacement of staple cereal sources with some pseudocereals like Chia, Quinoa, Buckwheat, and Amaranth, which not only provide recommended daily allowance of all nutrients but also help to reduce the chances of many non-communicable infections owing to the presence of several bioactive compounds. These pseu...

This review article depicts the possible replacement of staple cereal sources with some pseudocereals like Chia, Quinoa, Buckwheat, and Amaranth, which not only provide recommended daily allowance of all nutrients but also help to reduce the chances of many non-communicable infections owing to the presence of several bioactive compounds. These pseu...

Hydrothermal treatments are long known curing methods for the improvement of fruits resistance against storage conditions and for controlling fungal pathogens. The optimal conditions of the hydrothermal treatments significantly vary among species and varieties/cultivars. Present research was conducted to measure the storability effect of hot water...

Epigallocatechin-3-gallate (EGCG), a frequently studied catechin in green tea, has been shown involved in the anti-proliferation and apoptosis of human nasopharyngeal carcinoma (NPC) cells. However, the underlying molecular mechanism of the apoptotic effects of EGCG has not been fully investigated. Recent literature emphasized the importance of Sir...

The present study investigated the antifungal activity of pinocembrin-7-glucoside (P7G), a natural flavanone compound against citrus blue mold caused by Penicillium italicum. The in vitro inhibitory effects of P7G on mycelial biomass, energy status, morphology, and ultrastructure of P. italicum were determined. Moreover, the inhibitory effect of P7...

Postharvest fungal infection can accelerate the quality deterioration of Ponkan fruit and reduce its commodity value. Penicillium italicum is the causal pathogen of blue mold in harvested citrus fruits, not only causing huge fungal decay but also leading to quality deterioration. In our preliminary study, antofine (ATF) was found to have a great po...

BACKGROUND Acute kidney injury (AKI), a common multidisciplinary diagnostic clinical critical illness, eventually causes end-stage renal disease (ESRD). Although many clinical measures have been taken to prevent or treat AKI, high morbidity and death rates were recorded. Therefore, in-depth pathogenesis study and search for new therapeutic targets...

The current research was carried out to test the effects of edible coatings (EC) enriched with laurel essential oil (EC+LEO) on the storability of strawberry ‘Camarosa’ fruits. Freshly harvested strawberry fruits were randomly separated into three groups and each group was treated with a different treatment, including EC, EC+LEO and control. Fruits...

Background Potassium (K) is important in the regulation of plant growth and development. It is the most abundant mineral element in kiwifruit, and its content increases during fruit ripening. However, how K ⁺ transporter works in kiwifruit postharvest maturation is not yet clear. Results Here, 12 K ⁺ transporter KT/HAK/KUP genes, AcKUP1 ~ AcKUP12...

Salinization of soils and freshwater resources by natural processes and/or human activities has become an increasing issue that affects environmental services and socioeconomic relations. In addition, salinization jeopardizes agroecosystems, inducing salt stress in most cultivated plants (nutrient deficiency, pH and oxidative stress, biomass reduct...

Nitric oxide (NO), as an important messenger in eukaryotes, is a novel chemical elicitor capable of inducing defense responses in fruit and vegetables. In this study, exogenous NO fumigation at a concentration of 15 μl L⁻¹ remarkably alleviated the disease symptoms of postharvest kiwifruit inoculated with Botryosphaeria dothidea. The disease incide...

The effects of storage temperature on postharvest storability, quality attributes and antioxidant enzyme activities of harvested Ponkan mandarins were investigated. Fresh fruits were randomly divided into four groups and stored at different temperatures [5 ± 1 °C (S5), 10 ± 1 °C (S10), 15 ± 1 °C (S15), and 20 ± 1 °C (S20 or control)] for 120 days....

BACKGROUND Phomopsis stem‐end rot caused by Diaporthe citri, causes significant commercial postharvest losses of pummelo fruit during storage. Carvacrol (CVR) is a known generally recognized as safe and has the ability to prolong the preservation of harvested fruits. In the present study, the inhibitory effects of CVR treatment at the appropriate c...

Huge epidemiological and clinical studies have confirmed that black tea is a rich source of health-promoting ingredients, such as catechins and theaflavins (TFs). Furthermore, TF derivatives mainly include theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3'-gallate (TF2B), and theaflavin-3,3'-digallate (TF3). All of these TFs exhibit exten...

The storability recession during storage limits the postharvest storage life of Ponkan (Citrus reticulata Blanco cv. Ponkan) fruit and its nutritional value, which potentially lead to huge losses. To develop an effective technique to reduce Ponkan fruit postharvest decay and to maintain the nutritional quality, the preservation effect of 9, 12, and...

Penicillium digitatum is the most severe pathogen that infects citrus fruits during storage. It can cause fruit rot and bring significant economic losses. The continuous use of fungicides has resulted in the emergence of drug-resistant strains. Consequently, there is a need to develop naturally and efficiently antifungal fungicides. Natural antimic...

Pummelo fruit rapidly depreciate in commodity value due to postharvest fungal decay and fruit quality deterioration. Here, we used carvacrol (CVR) to control Phomopsis stem-end rot (SER) caused by Diaporthe citri in pummelo fruit stored at 25 °C. Antifungal activity of CVR inhibited D. citri growth and Phomopsis SER development. Harvested pummelo f...

Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF). It is a tremendous challenge with ever-increasing drug application in the medication system for huge populations. Drug-induced acute liver injury can lead to diverse pathol...