Chun-Chieh Yang

Chi-Mei Medical Center | CHIMEI · intensive care

Methods: We retrospectively analyzed 82 adult patients with MALA admitted to the ICU over 20 years. The association between the clinical parameters and mortality post-MALA was estimated using logistic regression analysis. Results: Patients with MALA admitted to the ICU presented with clinical symptoms mainly associated with the head (40.24%), ch...

We read with interest to the article of invasive pulmonary aspergillosis (IPA) in patients with influenza published in the journal [1]. Huang et al. reported 28% IPA (18/64) of patients with influenza admitted to the intensive care unit (ICU) of the China‐Japan Friendship Hospital in Beijing during the influenza season (2017‐2018). This article is...

Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii is a major cause of mortality and morbidity in immunocompromised patients, especially in HIV-positive persons. Trimethoprim/ sulfamethoxazole (TMP /SMZ) is first choice for drug of standard therapy or prophylaxis for PCP. Caspofungin in combination with TMP/SMZ as salvage therapy for s...

Background/purpose: Aspergillus-associated infection might comprise up to 23-29% of severe influenza patients from the community throughout stay in an intensive care unit (ICU). In Taiwan, cases of severe influenza with aspergillosis are increasingly reported. Therefore, we describe the relative risk of mortality among severe influenza patients wi...

We found significant correlation between incidence of severe influenza and Aspergillus antigenemia among medical intensive care unit patients for 7-month observation (coefficient γ = 0.976, p < 0.001). High-level ambient pollution has been noticed for 2 months before the epidemic, highlighting that influenza patients might co-infect with aspergillo...

Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the peak blood lactate concentration...

Aggressive nature killer (NK)-cell neoplasm includes aggressive NK-cell leukemia (ANKL) and extranodal NK/T-cell lymphoma (ENKTL), nasal type. ANKL is rare and is characterized by a systemic neoplastic proliferation of NK-cells, usually with a leukemic presentation. ENKTL is a predominantly extranodal lymphoma, occurring mainly in the upper aerodig...

Natural killer (NK) cell neoplasms are aggressive tumors and comprise aggressive NK cell leukemia (ANKL) and extranodal nature killer (NK)/T-cell lymphoma (ENKTL), nasal type. Here we report two cases of NK cell neoplasm localized in the bone marrow without peripheral blood involvement. Both patients presented with prolonged fever, anemia, and thro...

Purpose Cytomegalovirus (CMV) infection occurs increasingly in critically ill patients in intensive care units (ICUs). We reported CMV colitis which has rarely been recognized in the ICU patients. Methods CMV DNA was detected by polymerase chain reaction (PCR) for blood and/or stool samples. Definite diagnosis of CMV colitis required histopatholog...

Objectives: Population-based data on the risk of diabetes mellitus onset after acute pancreatitis (AP) are lacking. We assessed the incidence of diabetes in AP survivors compared with matched controls. Methods: The study cohort, drawn from Taiwan National Health Insurance claims data, included 2,966 first-attack AP patients and 11,864 non-AP gen...

Large granular lymphocytes (LGLs) are either cytotoxic T or natural killer (NK) cells exhibiting round nuclei and azurophilic cytoplasmic granules. Morphologically, neoplastic LGLs of T cell lineage (T-LGLLs) are usually indistinguishable from normal LGLs, while there is a wide morphological range of aggressive NK cell leukemia (ANKL). We present 2...

Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma (DLBCL) of the elderly is a recently defined subgroup of DLBCL in the 2008 WHO classification of lymphoid neoplasms. It is characterized by an EBV-positive clonal B cell lymphoproliferation that occurs in patients aged over 50 years without any known immunodeficiency. This disease show...

Listeria monocytogenes meningitis appears to have increased in incidence. Although most reported cases of listeriosis involve the central nervous system, brain computed tomography is usually normal. Hydrocephalus is a common complication of tuberculous meningitis, which has a high prevalence in Taiwan. However, patients with L. monocytogenes mening...