Chrysostomos Dimitriou

• MBChB(Hons) FEBOphth FRCOphth FEBOS(Glaucoma) PGCertMedEd(Healthcare)
• Consultant at The Colchester University Hospital / East Suffolk & North Essex NHS Foundation Trust / The OAKS Private Hospital / Moorfields Eye Hospital NHS Foundation Trust

Background/Objectives: The aim of this study is to evaluate the long-term efficacy and safety of the MINIject supraciliary device in patients with medically uncontrolled primary open-angle glaucoma (POAG) with up to 2 years of follow-up. Methods: A retrospective study was conducted using electronic medical records. Patients with medically uncontrol...

Purpose:This study evaluates the efficacy and safety of the MINIject (iStar Medical, Wavre, Belgium) supraciliary implant. Methods:Patients with medically uncontrolled primary open angle glaucoma, primary angle closure glaucoma and normal tension glaucoma. This first in the UK, restrospective, single-centre, interventional study evaluated the impla...

At the present time, as newer techniques and minimally invasive procedures gain popularity among anterior segment surgeons for regulating intraocular pressure, trabeculectomy still has a leading role in glaucoma surgery. Trabeculectomy retains a highly successful and safe profile; however, one of the major complications includes bleb-related infect...

Objectives To investigate the safety and efficacy of glaucoma XEN stent implantation and examine the effect of undergoing combined phacoemulsification and XEN versus XEN implant alone.MethodsA retrospective case note review of patients who underwent XEN implantation by a single surgeon over a 24-month period was performed. Outcomes included changes...

We present a previously undescribed case of a persistent hypotony maculopathy secondary to an iatrogenic cyclodialysis cleft created during XEN-45 gel stent insertion. We present this case as a further analysis of the Karimi et al case of cyclopexy by the corresponding surgeon. Following right XEN-45 implantation, our patient developed immediate an...

Purpose To develop and validate a deep learning (DL) system for predicting each point on visual fields (VF) from disc and optical coherence tomography (OCT) imaging and derive a structure-function mapping. Design Retrospective, cross-sectional database study Participants 6437 patients undergoing routine care for glaucoma in three clinical sites i...

Aims: To assess the efficacy of Xen in reducing intraocular pressure (IOP) in varying glaucoma subtypes. To assess the effect of combined phacoemulsification. To determine the frequency of complications and explore further bleb management needed. Methods: Retrospective case note review of all patients undergoing Xen implantation across four cent...

Four patients developed choroidal detachment within three months after trabeculectomy, documented with b-scan ultrasonography (BUS) and ultrasound biomicroscopy (UBM). Intraocular pressure (IOP) of the patients ranged from 3 to 5 mm Hg. Patients were treated with cycloplegia and steroids without complete resolution of detachment. Twelve months late...

Biological membranes play an essential role in the drug action. They constitute the first barrier for drugs to exert their biological action. AT1 antagonists are amphiphilic molecules and are hypothesized to act on AT1 receptor through incorporation (first step) and lateral diffusion through membrane bilayers (second step). Various biophysical meth...

Differential Scanning Calorimetry (DSC) has been applied to study the thermal properties of the membrane perturbing antibacterial octyl-and dodecyl-bromide salts of quaternary dimethylamino adamantanol (ADM8 and ADM-12 correspondingly) incorporated in free or complexed form with P-cyclodextrin (P-CD) into dipalmitoylphosphatidylcholine (DPPC) conta...

This study of angiotensin II (ANG II) membrane interactions uses a combination of31P NMR spectroscopy and differential scanning calorimetry (DSC), two valuable and complementary techniques which can provide useful information about the thermotropic and dynamic properties of peptide hormones in membranes. The major conclusion from the calorimetric e...

We have studied the effects of VPI-68 in model DPPC bilayers and erythrocyte ghost membranes using a combination of Differential Scanning Calorimetry (DSC) and 31P-NMR spectroscopy. VPI-68 has been shown to exert antineoplastic properties (IC70 = 5.6 μg/ml) in four out of six xenografts of human cancers. Its mechanism of action is still unknown but...