Chrysanthos Zamboulis

Chrysanthos Zamboulis
Aristotle University of Thessaloniki | AUTH · Department of Internal Medicine

MD, PhD

About

102
Publications
9,124
Reads
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2,120
Citations
Citations since 2016
4 Research Items
838 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
Additional affiliations
January 1996 - December 2011
January 1994 - December 2012
Aristotle University of Thessaloniki
July 1976 - present
Royal Postgraduate Medical School, Hammersmith Hospital
Position
  • Research Associate

Publications

Publications (102)
Article
Objective: Quantitative evaluation of the retinal vasculature using the non-mydriatic fundus camera is gaining increasing attention as an early, subclinical indicator of cardiovascular risk. Subtle alterations of the retinal vessels have been consistently observed in populations with cardiovascular diseases. However, it has not been investigated wh...
Article
Cardiotrophin 1 (CT-1) is an interleukin 6-related cytokine recently implicated in cardiac hypertrophy and vascular damage in essential hypertension (EH). We aimed first to determine CT-1 levels in naive, untreated patients with grade I EH (UH) as compared with normotensive (NT) individuals and, second, to investigate a possible association of CT-1...
Article
Full-text available
A system for the assessment of hypertension through the measurement of retinal vessels in fundoscopy images, is presented. The proposed approach employs multiple image analysis methods, in an integrated system that is used in clinical practice. Automating the measurement process enables the conduct of a clinical study that, for the first time, show...
Article
Full-text available
Several imaging tests and biomarkers have been proposed for the identification of patients with unstable angina among those presenting to the emergency department with acute chest pain. Preliminary data suggest that ischemia-modified albumin (IMA) may represent a potentially useful biomarker in these patients. To compare IMA and echocardiography in...
Article
Traditional cardiovascular risk factors have been acknowledged as major contributors to sexual dysfunction in the general population. The purpose of this study was to explore their impact on sexual function in rheumatologic patients. A total of 557 consecutive rheumatologic patients, 449 females and 108 males, had their sexual function evaluated wi...
Article
Full-text available
BACKGROUND Hypertensive patients with retinal arteriolar abnormalities are at increased risk for cardiovascular events. However, the extent of retinal microvascular changes in naïve, never-treated patients with hypertension of short duration has not been established. In addition to this, the lack of relevant data about other phenotypes of hypertens...
Article
We report the case of a 43-year-old woman who presented with mild left-sided abdominal pain. Computed tomography and MRI findings revealed a 10.7 × 8.5 × 12 cm left-sided soft tissue mass on the renal vessels pushing away the left kidney. The combination of the patient's medical history (episodes of paroxysmal hypertension accompanied with dizzines...
Article
This study was carried out to assess the efficacy and safety of combined therapy with pravastatin and gemfibrozil in patients with severe refractory familial combined hyperlipidaemia. 26 patients (18 men and 8 women) with a mean age of 50 years (range 32 to 65 years) were included in the study. Patients with secondary forms of dyslipoproteinaemia w...
Article
Primary aldosteronism (PA) is a syndrome which includes a group of clinical entities in which aldosterone production is inappropriately high and nonsupressible by sodium loading. The most frequent causes of PA are adrenal adenoma and unilateral or bilateral primary hyperplasia. We report a case of a 55-year-old man with a 10-year history of hyperte...
Article
Full-text available
Interventional activation of the carotid baroreflex has been an appealing idea for the management of resistant hypertension for several decades, yet its clinical application remained elusive and a goal for the future. It is only recently that the profound understanding of the complex anatomy and pathophysiology of the circuit, combined with the acc...
Article
We conducted a pH-monitoring study to determine the prevalence of pathologic gastroesophageal reflux (GER+) and laryngopharyngeal reflux (LPR+) in patients with resected benign true vocal fold lesions (TVFLs) and positive reflux finding score (RFS). We compared our findings with those of patients with typical GER disease (GERD) symptoms and normal...
Article
Patients with clinical signs of vasculopathy were screened with capillaroscopy for microangiopathy, and its presence was evaluated in the diagnosis of antiphospholipid syndrome (APS). For this purpose, autoantibody profiles in high risk patients with microhaemorrhages were correlated with thrombotic events. 738 patients from a Rheumatology Outpatie...
Conference Paper
Full-text available
This paper presents a framework for the detection and measurement of retinal vessels in fundoscopy images. The proposed method segments retinal vessels, enabling the actual measurement of the vessel diameter. A Graphical User Interface (GUI) further supports a number of methods for the automatic and interactive measurement of vessel diameters at an...
Article
Full-text available
Resistant hypertension is commonly found in everyday clinical practice. However, the risks of resistant hypertension, as well as the benefits of treatment and control of blood pressure in patients with resistant hypertension remain vaguely clarified. Data from small clinical studies and observational cohorts suggest that patients with resistant hyp...
Conference Paper
Full-text available
The HeartCycle EU research project aims to provide disease management solutions for cardiac patients. Developed within HeartCycle, IMAGE is a wearable device capable of acquiring ECG, bioimpedance, and acceleration measurements. The acquired signals are stored in onboard memory and processed, while the results are wirelessly transmitted in real tim...
Article
Hypertension is a major public health problem and its prevalence increases with age. Despite an aging population, only a limited number of population-based studies, and fewer Greek studies, have focused exclusively on the elderly. The objective of this study was to investigate the prevalence, awareness, treatment and control of hypertension in the...
Article
Full-text available
Essential hypertension is associated with increased risk of arterial thrombotic disease. Among other factors, enhanced platelet activity contributes significantly to this phenomenon. An increased level of circulating monocyte-platelet aggregates (MPAs) represents one of the most robust markers of platelet activation; furthermore, these aggregates a...
Article
Both endothelial and platelet-derived nitric oxide have important vasculoprotective properties. Increasing evidence suggests a dysfunctional platelet nitric oxide synthase type 3 (NOS3) pathway in essential hypertension, whereas for endothelial-derived nitric oxide the picture is more complicated, with many studies suggesting an impairment of endot...
Article
Full-text available
The aim of this study was to determine the effect of blood pressure (BP) on platelet nitric oxide (NO) signalling and on formation of circulating monocyte-platelet aggregates (MPA), as well as the role of platelet NO in modulating MPA in hypertension. We first examined platelet NO signalling in 23 untreated hypertensive (UH) and 23 normotensive (NT...
Article
NF 1 is a genetic disorder with an autosomal dominant pattern of inheritence. It is associated with neoplastic disorders mainly derived from the neural seath. However, the co-existence of NF1 with the full spectrum of MEN 2A has rarely been reported. The aim of the study was to investigate the presence of secondary neoplasias in a patient with diag...
Article
Full-text available
Continuous Subcutaneous Insulin Infusion (CSII) and Multiple Daily insulin Injections (MDI) are both strategies aiming to achieve a tight glycemic and metabolic control. However, the choice between them remains controversial. The aim of the present study was to compare the efficacy of MDI (three or more injections daily) with CSII on glycemic contr...
Article
Intracerebral hemorrhage (ICH) in young persons is usually caused by arteriovenous mal-formations, cavernous angiomas, or hypertension. Less common causes include cerebral venous thrombosis, eclampsia, and sympathomimetic drugs.(1) Pheochromocytoma represents a very rare cause of ICH in young adults, and very few cases have been reported. Specifica...
Article
Obesity and hypertension frequently coexist and both represent important risk factors for cardiovascular disease. The mechanisms implicated in the regulation of food intake have not been completely elucidated. Recent data suggests that peripheral and central neuropeptides play an important role in the maintenance of energy balance. More specificall...
Article
Parvovirus B19 infection has been associated with a variety of rheumatic manifestations/diseases, mainly rheumatoid arthritis, vasculitis and systemic lupus erythematosus (SLE). B19 infection may simulate both clinical and laboratory features of SLE, presenting either as a potential first time diagnosis of SLE or as an exacerbation of previously es...
Article
Results of several studies published since 1999 suggest that primary hyperaldosteronism (also known as Conn's syndrome) affects more than 10% of people with hypertension; however, such a high prevalence has also been disputed. Experts generally agree that resistant hypertension has the highest prevalence of primary hyperaldosteronism, on the basis...
Article
Pheochromocytoma is a rare form of secondary hypertension and may be potentially lethal if left untreated. The classical symptoms are paroxysmal hypertension, headaches, palpitations and sweating. They are caused by sudden catecholamine release. Hyperglycemia is reported in some patients with pheochromocytoma but diabetic ketoacidosis is an extreme...
Article
Several epidemiological studies have reported that an elevated heart rate is associated with coronary atherosclerosis independently of other risk factors. In this review we explore the pathophysiologic mechanisms involved in the pro-atherosclerotic effect of elevated heart rate, apart from its association with sympathetic tone. An elevated heart ra...
Article
Coronary artery disease (CAD) constitutes the most common cause of morbidity and mortality in developed countries. Statins effectively reduce low-density lipoprotein cholesterol, an important risk factor for CAD and related acute coronary syndromes. They are an extensively studied group of drugs with versatile properties. Overall, they are safe and...
Article
Pheochromocytoma is a tumor of the adrenal medulla that secretes catecholamines (noradrenaline and adrenaline). The clinical presentation is characterized by paroxysmal hypertension, tachycardia, headache, and sweating. Pheochromocytoma is associated with neurofibromatosis type 1. We report the case of a woman with neurofibromatosis type 1 and bila...
Article
Full-text available
Diabetes mellitus and arterial hypertension are two common diseases that often coexist. Patients with diabetes have much higher rate of hypertension than that in general population. The co-existence of these disorders appears to accelerate microvascular and macrovascular complications and greatly increases the cardiovascular risk, risk of stroke an...
Article
We assessed the effect of the addition of pioglitazone on metabolic control and heart function of patients with type 2 diabetes already receiving sulfonylurea plus metformin. Forty-four patients were given 30 mg of pioglitazone for 3 months. Physical examination, laboratory tests including N-terminal pro-brain natriuretic peptide (NT-proBNP), and e...
Article
Full-text available
Acute vigorous exercise, associated with increased release of plasma catecholamines, transiently increases the risk of primary cardiac arrest. We tested the effect of acute submaximal exercise on vasoactive substances and their combined result on platelet function. Healthy volunteers, hypertensive patients and patients with coronary artery disease...
Article
Although conventional linear 3-dimensional (3D) reconstruction of coronary arteries by intravascular ultrasound has been widely used for the assessment of plaque volume and progression; the volumetric error (VE) that is produced has not been adequately studied. Linear and geometrically correct 3D reconstruction was applied in 16 coronary arterial s...
Article
Skin involvement in dermatomyositis does not always parallel muscle disease and can be the most active or severe component of the disease, failing to respond to therapeutic interventions that are adequate for myositis and other systemic involvement. This case refers to a resistant paraneoplastic amyopathic dermatomyositis rash which readily resolve...
Article
Full-text available
Chronic infections, such as hepatitis C, in the setting of rheumatic disorders pose a potential hindrance to optimal management because of possible complications linked to the institution of immune suppression, as well as the high incidence of hepatotoxicity associated with many of the disease-modifying antirheumatic drugs included in the conventio...
Article
Primary aldosteronism accompanied by hypokalemia is a cause of secondary hypertension. Diagnosis of primary aldosteronism has increased dramatically in recent years with the wider availability of aldosterone and plasma renin activity measurements. The authors present the case of a patient with resistant hypertension and severe hypokalemia that evad...
Article
Full-text available
Sexual dysfunction represents a major quality-of-life-related health problem, and available data indicate that essential hypertension is a risk factor for sexual dysfunction in both men and women. Male and female sexual dysfunc-tion is more prevalent in hypertensive than normotensive individuals, and several mechanisms have been implicated in the p...
Article
Tumor necrosis alpha blockade has proved to be very effective in the treatment of several autoimmune disorders, including rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases and psoriatic arthritis/ psoriasis. Skin abnormalities represent a significant proportion of the adverse events linked to the use of anti TNF-α agents, ma...
Article
Vascular endothelial growth factor (VEGF) is a specific mitogen for endothelial cells and an inducer of the angiogenic procedure. Endothelial nitric oxide (NO) is a potent vasodilator. Because both are implicated in vascular function, it is possible that they would be significantly affected in arterial hypertension. The aim of the study was the inv...
Article
Because of its antifibrotic and anti-inflammatory effects, colchicine has been proposed as a treatment for liver disease. The results from clinical trials have however been inconsistent. The aim of the present study was to evaluate the effect of colchicine in the treatment of patients with hepatic fibrosis of various etiologies. Thirty-eight patien...
Article
Full-text available
Sir, The close association between diabetes mellitus and cardiovascular disease is well known, the risk of cardiovascular disease being 2–5 times greater in diabetics than in the background population.1 Renal arteries seem to be widely involved in the macrovascular disease of diabetes, and primary aldosteronism is also a well-recognized cause of s...
Article
Several studies have indicated the presence of significant interarm blood pressure (BP) differences; this could result in misclassification of BP status. Nevertheless, the findings of these studies were not consistent. This prospective, observational study investigated the presence and magnitude of interarm BP differences and determined the influen...
Article
Full-text available
Am J Hypertens (2005) 18, 167A–167A; doi:10.1016/j.amjhyper.2005.03.462 P-444: Uric acid as a prognostic risk factor in patients with acute stroke Asterios Karagiannis1, Konstantinos Tziomalos1, Anna Kakafika1, Maria Sileli1, Napoleon Krikis1, Euthimia Moschou1, Michael Xohellis1 and Chrysanthos Zamboulis11Second Propedeutic Department of Internal...
Article
Patients with long-standing arterial hypertension are at significantly increased risk to suffer sustained thromboembolic complications, such as ischemic stroke and myocardial infarctions. In addition, hypertension has been associated with impaired fibrinolysis and the fibrinolytic system has been recognized as playing a crucial role in the pathogen...
Article
The aim of this study was to investigate: 1) the effects of treadmill exercise on plasma catecholamines and endothelin-1 (ET-1, a potent vasoconstrictor) levels in hypertensive patients; and 2) the impact of 1-month therapy with losartan as compared with moxonidine on catecholamine and ET-1 changes during exercise. Twenty-eight patients with essent...
Article
Full-text available
Numerous factors have been reported to influence the pathogenesis of atherosclerosis. The angiotensin I converting enzyme (ACE) gene is a candidate gene for atherosclerotic-related disease. In the present study, the association between the polymorphism of the ACE gene and peripheral arterial occlusive disease (PAOD) was investigated. Using polymera...
Article
Numerous factors have been reported to influence the pathogenesis of stroke. The angiotensin I-converting enzyme (ACE) gene is a candidate gene for atherosclerotic-related diseases. In the present study, the association between the polymorphism of the ACE gene and ischaemic stroke was investigated. Using polymerase chain reaction techniques, 100 pa...
Article
Primary aldosteronism (PA) is a rare cause of secondary hypertension and hypokalemia is traditionally considered its main finding. Recently it has been appreciated that hypokalemia may be transient and certainly less common.The use of ratio of Aldosterone/PRA (>30: indicative of PA) has been proposed as the initial screening test. The purpose of ou...
Article
Patients with essential hypertension are characterized as dippers or non-dippers, according to the fall or not of blood pressure during night hours. Non-dippers are at increased risk of cardiovascular complications. Increased activity of the Renin-Angiotensin-Aldosterone system (RAAS) and the Sympathetic Nervous System (SNS) also predispose to incr...
Article
In a 10-week double-blind randomised placebo-controlled trial, the efficacy, safety and effect on renal function of a single dose of fosinopril 20mg once daily were studied in 23 patients with mild to moderate essential hypertension. After discontinuation of previous antihypertensive treatment and a 4-week washout period, all patients received plac...
Article
Studies in various ethnic groups have shown contradictory evidence on the association of the angiotensin converting enzyme (ACE) insertion/ deletion (I/D) polymorphism with essential hypertension. In addition, mistyping of the insertion allele in heterozygotes has been reported. We analyzed the ACE genotype of 98 hypertensive and 84 normotensive su...
Article
Five patients with adrenal insufficiency and large adrenal glands at presentation are reported. Addison's disease was due to adrenal tuberculosis in three patients, with important changes in adrenal configuration on CT reflecting the natural history of the disease. Adrenal infiltration by non-Hodgkin lymphoma and metastatic carcinoma of the lung wa...
Article
This study evaluated the long-term effects of percutaneous transluminal renal angioplasty (PTRA) on blood pressure and renal function in patients with renovascular hypertension. Seventy-eight patients with hypertension and unilateral or bilateral stenoses of the renal arteries (16 with fibromuscular dysplasia and 62 with atherosclerosis) were studi...
Article
The effects of a single dose regimen of lisinopril (10mg daily) and quinapril (10mg daily) were studied in 47 patients with mild to moderate essential hypertension. After discontinuation of previous antihypertensive treatment and a 2-week washout period, all patients received placebo for the next 2 weeks. Patients were then randomly assigned, in a...
Article
This study was carried out to assess the efficacy and safety of combined therapy with pravastatin and gemfibrozil in patients with severe refractory familial combined hyperlipidaemia. 26 patients (18 men and 8 women) with a mean age of 50 years (range 32 to 65 years) were included in the study. Patients with secondary forms of dyslipoproteinaemia w...
Article
Ninety-two patients (51 men and 41 women; mean age, 48 ± 7 years) were enrolled in a study to assess the effect of pravastatin on the 10-year probability of myocardial infarction (MI). All patients had primary hypercholesterolemia but were free of coronary heart disease (CHD) at baseline. They were placed on a hypolipidemic diet and received a plac...