Christy Mancuso

Christy Mancuso
University of New Mexico | UNM · Department of Biology

PhD (Biology)

About

18
Publications
4,760
Reads
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420
Citations
Citations since 2016
7 Research Items
294 Citations
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201620172018201920202021202201020304050
Education
August 2012 - August 2018
University of Utah
Field of study
  • Biology
August 2007 - May 2009
Boston University
Field of study
  • Biomedical Forensic Sciences
August 2003 - May 2007

Publications

Publications (18)
Article
Rationale: Hydrogen isotope (δ2 H) analysis of keratinaceous bulk tissues have been wildly used in forensic sciences to reconstruct an individual's travel history or determine their region-of-origin. Here, we use a compound-specific approach to examine patterns of individual amino acid δ2 H values in relation to that of local tap water, bulk scalp...
Article
Full-text available
Concern about adolescent diets, obesity, and the associated health risks have been growing in the United States. This inspired former First Lady Michelle Obama to spearhead the Healthy Hunger-Free Kids Act (HHFKA), which made changes to the national school lunch program by increasing servings of whole grains, fruits, and vegetables. Our study exami...
Article
Rationale Strontium isotope ratios (⁸⁷Sr/⁸⁶Sr) in human fingernail keratin tissues have been underexplored for region of origin and travel history reconstruction studies. Here we investigated ⁸⁷Sr/⁸⁶Sr ratios in fingernail keratin to establish baseline measurements in a resident group and to examine how ⁸⁷Sr/⁸⁶Sr ratios changed with relocation. Me...
Article
Global travel has increased, and having a diagnostic tool to distinguish residents from visitors would be valuable. This study examined stable isotope biomarkers of fingernail tissues of resident (n = 26) and nonresident (n = 22) participants in Salt Lake City (SLC), UT, from 2015 to 2016. The purpose of this research was to determine whether finge...
Article
This study focuses on the examination of stable isotope biomarkers in human fingernails of travelers who ventured away from Salt Lake City, UT and subsequently returned. Here, we describe three case studies examining: individual travelers (n = 4), paired travelers (n = 2), and a traveler (n = 1) who repeatedly left and returned. Our case studies ex...
Article
Water availability and sustainability in the Western United States is a major flashpoint among expanding communities, growing industries, and productive agricultural lands. This issue came to a head in 2015 in the State of California, when the State mandated a 25% reduction in urban water use following a multi-year drought that significantly deplet...
Article
Full-text available
Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, newborns fail to respond optimally to most vaccines. Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of human newborn leukocytes to most candidate adjuvants,...
Article
Full-text available
Hematopoietic cell transplant (HCT) is a life-saving therapy for many malignant and non-malignant bone marrow diseases. Associated morbidities are often due to transplant-related toxicities and infections, exacerbated by regimen-induced immune suppression and systemic incursion of bacterial products. Patients undergoing myeloablative conditioning f...
Article
Full-text available
Staphylococcus epidermidis (SE) causes late onset sepsis and significant morbidity in catheterized preterm newborns. Animal models of SE infection are useful in characterizing disease mechanisms and are an important approach to developing improved diagnostics and therapeutics. Current murine models of neonatal bacterial infection employ intraperito...
Data
Full-text available
Summary of gene products used in the mouse TLR signaling array. (PDF)
Data
Full-text available
Comparison of bacterial burden in solid organs of female and male mice. Neonatal pups were injected with 108 CFU of SE and euthanized at 2 h for harvest of spleen and liver. Organ homogenates were plated for bacterial CFU. Pup tissue was genotyped using real time PCR. Mean CFUs were similar for female and male pups (N = 3–7, Mann-Whitney t-test). (...
Data
Intra-jugular injection in newborn mice. Video illustrates the necessary steps for performing accurate intra-jugular injection in newborn mice (injection sore 4). These steps are further described in table 1. (M4V)
Article
Full-text available
Background: Tracheal aspirates (TAs) from critically ill neonates accumulate bacterial endotoxin and demonstrate mobilization of endotoxin-binding proteins, but the potential bioactivity of endotoxin in TAs is unknown. We characterized innate immune activation in TAs of mechanically ventilated neonates. Methods: Innate immune activation in TAs of...
Article
Full-text available
Identification of safe, effective treatments to mitigate toxicity after extensive radiation exposure has proven challenging. Only a limited number of candidate approaches have emerged, and the U.S. Food and Drug Administration has yet to approve any agent for a mass-casualty radiation disaster. Because patients undergoing hematopoietic stem cell tr...
Article
Full-text available
Detection and clearance of bacterial infection require balanced effector and resolution signals to avoid chronic inflammation. Detection of GNB LPS by TLR4 on m induces inflammatory responses, contributing to chronic inflammation and tissue injury. LXs and Rvs are endogenous lipid mediators that enhance resolution of inflammation, and their actions...
Data
Analysis for age-dependent evolution of cytokine responses to TLR agonists. 100 µl of whole blood was cultured overnight with Pam3CSK4 (TLR1/2), Poly (I:C) (TLR3), LPS (TLR4), Flagellin (TLR), FSL-1 (TLR6/2), Gardiquimod™ (TLR7), ssRNA (TLR8) and CL075 (TLR7/8) or ODN M362 (TLR9) at birth (cord), 1, 2, 3, 4, 6, 9 and 12 months of age. IFNγ, TNFα,IL...
Article
Full-text available
The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there are specific limitations to inducing effective immunity in early life, including impaired neonatal leukocyte production of Th1...

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