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Christos C. Zouboulis

Christos C. Zouboulis
Städtisches Klinikums Dessau, Medizinische Hochschule Brandenburg Theodor Fontane · Hochschulklinik fuer Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum

Professor

About

1,270
Publications
296,850
Reads
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45,111
Citations
Introduction
Prof. Zouboulis has performed fundamental research on the sebaceous gland, acne, hidradenitis suppurativa, Adamantiades-Behçet’s disease, Dermato-Endocrinology, molecular ageing, skin stem cells, cryosurgery. Major awards: Prof hon (Franche-Comté), Dr hc (Athens), Oskar Gans Prize, Paul Gerson Unna Prize, Nékám Prize, EADV Research Award, Felix Wankel Prize, ADK Beauty Care Prize (2x), Geroulanos Prize, Liérac Award, Springer Prize, Zoltán Fekete Prize, Germany-Land of Ideas selected location.
Additional affiliations
January 2009 - December 2011
Position
  • BMBF Network “Stem cell research” with the project “iPS cells from healthy and AD somatic cells”
January 2007 - December 2009
Position
  • IWT-KMO innovation project (Flandres, Belgium) “Development of new acne drugs”
September 2005 - January 2015
Städtisches Klinikums Dessau
Position
  • Managing Director
Education
January 1994 - March 1994
Massachusetts General Hospital
Field of study
  • Lasers in Dermatology
November 1993 - December 1993
The Cleveland Clinic Foundation
Field of study
  • Dermatologic Surgery
January 1993 - November 1993
University of Michigan
Field of study
  • Molecular Biology

Publications

Publications (1,270)
Article
A direct contact co-culture of skin explants to SZ95 sebocytes (3D-SeboSkin) has been shown to preserve the integrity of epidermal keratinocytes and dermis. In this study, the properties of epidermal melanocytes were evaluated in the same 3D SeboSkin ex vivo model. Skin explants (n = 6) were maintained in the 3D-SeboSkin model, in direct contact to...
Article
Full-text available
Acne vulgaris has a pathogenesis that involves increased sebum production and perifollicular inflammation. Sterol regulatory element-binding protein-1 (SREBP-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are transcription factors that regulate numerous genes involved in lipid biosynthesis. To improve a new therapeutic approach, we de...
Article
Background: Health-related quality of life (HRQoL) assessment in patients with acne is recommended by several national guidelines. There are several acne-specific HRQoL instruments. Objectives: Participants of the European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on QoL and Patient Oriented Outcomes (PO) and Acne, Rosacea,...
Article
Sebaceous glands play an important role in maintaining the skin barrier function by producing lipids. Dysregulated lipid production in these glands may contribute to the pathogenesis of human skin diseases. Galectin-12, a member of the β-galactoside-binding lectin family, is preferentially expressed in adipocytes, where it regulates adipogenesis an...
Article
Background: A disruption of sebocyte differentiation and lipogenesis has fatal consequences and can cause a wide spectrum of skin diseases, from acne vulgaris to sebaceous carcinoma, however, the relevant molecular mechanisms have not been fully clarified. Objectives: The induction of autophagy and apoptosis in human sebocytes in response to bio...
Article
Full-text available
This review presents several aspects of the innovative concept of sebaceous immunobiology, which summarizes the numerous activities of the sebaceous gland including its classical physiological and pathophysiological tasks, namely sebum production and the development of seborrhea and acne. Sebaceous lipids, which represent 90% of the skin surface li...
Article
Zusammenfassung Es wird über einen 58-jährigen Mann mit therapieresistenten makulopapulösen Effloreszenzen an den Unterschenkeln sowie multiplen, krustig belegten Papeln im Gesichts- und Rückenbereich berichtet. Auffällig waren zudem eine B-Symptomatik und eine chronische Anämie ohne bekannte Malignomerkrankung. Diese Hinweise ließen eine Paraneopl...
Article
Background: Validated, inclusive, and easy-to-use outcomes for HS are essential both in the clinical trial setting and clinical practice. The continuous IHS4 is a validated tool that dynamically assesses nodules/abscesses/draining tunnels and classifies disease severity as mild/moderate/severe. However, dichotomous outcomes are often required for...
Article
Full-text available
Since 2021, adalimumab biosimilar ABP 501 can be used alternatively to adalimumab originator (ADAO) in the treatment of hidradenitis suppurativa (HS). Effectiveness and safety data remain scarce. We investigated the impact of switching from ADAO to ABP 501 on disease severity and the occurrence of adverse events (AEs) in patients with HS. We analyz...
Article
Full-text available
Acne tarda is defined as acne that develops (late-onset acne) or continues (persistent acne) after 25 years of age. The disease is more common in women. The etiology of acne tarda is still controversial, and a variety of factors such as endocrinological disorders including hyperandrogenism and hyperandrogenemia, stress, modern western diet, ultravi...
Article
Full-text available
Hidradenitis suppurativa is a chronic disease that disrupts patients' physical and psychological well-being. A disease-specific measure was developed and validated for assessing health-related quality of life in hidradenitis suppurativa. After qualitative item development, the quality of life in hidradenitis suppurativa instrument was tested in 101...
Article
Zusammenfassung In diesem Beitrag werden Kommensalen und relevante Infektionserreger des dermatologischen Patienten wie auch seiner Umgebung systematisch dargestellt und im Hinblick auf die krankenhaushygienische Bedeutung eingeordnet. Auf der antimikrobiellen Behandlung sowie Hygiene-Maßnahmen ausgewählter dermatologischer Erkrankungen liegt ein w...
Article
Zusammenfassung Dermatologie-typische Abläufe in der Patientenversorgung werden in dieser Arbeit im Hinblick auf mögliche Hygienerisiken dargestellt. Das potenziell kontaminierte Oberflächenorgan Haut und seine Umgebung stellen in der medizinischen Versorgung in Bezug auf den intensiven, längeren und großflächigen Kontakt, der mit hautärztlichen un...
Article
Zusammenfassung Auch im Lichte aktueller, infektionsimmunologischer Erkenntnisse über Entstehung und Behandlung spielen im Zeitalter der modernen Therapien einschließlich Antisepsis und Antibiotika sexuell übertragbare Erkrankungen nach wie vor, und speziell für bestimmte Risikogruppen, eine bedeutende Rolle. Die grundsätzliche Behandelbarkeit lang...
Article
Full-text available
Sebaceous glands (SGs) originate from hair follicular stem cells and secrete lipids to lubricate the skin. The coordinated effects of intrinsic and extrinsic aging factors generate degradation of SGs at a late age. Senescence of SGs could be a mirror of the late aging of both the human body and skin. The procedure of SG aging goes over an initial S...
Article
Zusammenfassung Die COVID-19-Pandemie hat weltweit erhebliche Beeinträchtigungen des Lebens und Arbeitens mit sich gebracht. Mit dem Beginn der Impfungen steigt die Hoffnung auf eine Kehrtwende. Dennoch sind COVID- und Intensivstationen in den Kliniken nach wie vor erheblich belastet. Häufig muss in den Kliniken aus Kapazitätsgründen auch dermatolo...
Article
Full-text available
Background: Nearly half of patients with hidradenitis suppurativa (HS) report dissatisfaction with their treatment. However, factors related to treatment satisfaction have not been explored. Objectives: To measure associations between treatment satisfaction and clinical and treatment-related characteristics among patients with HS. Methods: Tre...
Article
Full-text available
Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory disease of the pilosebaceous unit leading to formation of painful, inflammatory nodules, abscesses and tunnels in apocrine gland-bearing areas of the skin. Pain and drainage are the most important symptoms associated with reduction of quality of life in HS. On the other hand, an o...
Article
PURPOSE The first randomized trial of adjuvant treatment with checkpoint inhibitor in stage II melanoma reported a significant reduction in risk of tumor recurrence. This study evaluates two independent data sets to further document survival probabilities for patients with primary stage I and II melanoma. PATIENTS AND METHODS The Central Malignant...
Article
Full-text available
PURPOSE The first randomized trial of adjuvant treatment with checkpoint inhibitor in stage II melanoma reported a significant reduction in risk of tumor recurrence. This study evaluates two independent data sets to further document survival probabilities for patients with primary stage I and II melanoma. PATIENTS AND METHODS The Central Malignant...
Article
Zusammenfassung Der Methicillin-resistente Staphylococcus aureus ist ein im täglichen Alltag insbesondere für den Bereich der Dermatologie relevanter multiresistenter gram-positiver bakterieller Erreger. Chronische Wunden und atopische Dermatitis sowie der Typ II-Diabetes mellitus spielen hier als Risikofaktoren eine wichtige Rolle. Dieser Übersich...
Article
Zusammenfassung Bakterielle Besiedlungen von Haut und Wunden sowie Infektionen mit Problemkeimen spielen in der Dermatologie eine wichtige Rolle. Neben Methicillin-resistenter Staphylococcus aureus (MRSA) finden sich auch zunehmend MRGN und VRE bei Wund- und Weichteilinfektionen. Da sowohl für multiresistente gram-negative Stäbchen (MRGN) als auch...
Article
Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like metabolic syndrome, reduced quality of life, sexual dysfunction, working disability, inflammatory bowel disease, axial spondyloarthritis, depression and anxiety. Like psoriasis, HS patients have been found to have higher...
Article
Background: Although the merely cutaneous, benign form of the extremely rare disease atrophic papulosis (Köhlmeier-Degos disease) may occasionally develop into the systemic, malignant form with time, it is unclear whether it itself exhibits any systemic characteristics. Objective: To determine whether benign atrophic papulosis exhibits inflammat...
Article
Full-text available
Background: Preliminary in vitro and in vivo studies have supported the efficacy of the peroxisome proliferator-activated receptor-γ (PPARγ) modulator N-Acetyl-GED-0507-34-LEVO (NAC-GED) for the treatment of acne inducing sebocyte differentiation, improving sebum composition and controlling the inflammatory process. Objective: Evaluation of the...
Article
Full-text available
Research interest in Hidradenitis Suppurativa (HS) has grown exponentially over the past decades. Several groups have worked to develop novel scores that address the drawbacks of existing investigator assessed and patient reported outcome measures currently used in HS trials, clinical practice and research. In clinical trial settings, the drawbacks...
Article
The European Hidradenitis Suppurativa Foundation (EHSF) e.V. has taken several initiatives to collaborative studies. They result from the data of the European Registry of Hidradenitis Suppurativa (ERHS) based on the knowledge obtained from the regional Northern countries (HISREG) and Italian (IRHIS) registries and the real‐world data generated from...
Article
Background: Atrophic papulosis is a very rare vascular disease of unknown pathogenesis, mostly described by case reports. Objective: To assess demographic data and prognosis in patients with atrophic papulosis. Methods: Single-centre study on a series of 105 patients with atrophic papulosis, diagnosed 2000-2021. Patients referred and diagnosed...
Article
Full-text available
The skin is an endocrine organ and a major target of hormones such as estrogens, androgens and cortisol. Besides vasomotor symptoms (VMS), skin and hair symptoms often receive less attention than other menopausal symptoms despite having a significant negative effect on quality of life. Skin and mucosal menopausal symptoms include dryness and prurit...
Chapter
The application of high and low temperatures for therapeutic purposes is included in the procedures of physical medicine. This approach belongs to the oldest medical treatments and is used in the most diverse medical systems, in the past and at present, in conventional Western medicine as well as in alternative and Chinese medicine. In dermatology,...
Article
Full-text available
Acne vulgaris is the most common disease of the pilosebaceous unit. The pathogenesis of this disease is complex, involving increased sebum production and perifollicular inflammation. Understanding the factors that regulate sebum production is important in identifying novel therapeutic targets for the treatment of acne. Bee Venom (BV) and melittin h...
Article
Background: Minocycline is a second-generation tetracycline drug, which is widely used to treat diverse infectious and inflammatory diseases such as acne vulgaris. The effects of minocycline on acne vulgaris have been mainly attributed to its anti-inflammatory effect; however, its sebum-regulating effect and the relevance to epigenetic regulation...
Article
Full-text available
Human skin functions as a physical barrier, preventing the entry of foreign pathogens while also accommodating a myriad of commensal microorganisms. A key contributor to the skin landscape is the sebaceous gland. Mice devoid of sebocytes are prone to skin infection, yet our understanding of how sebocytes function in host defense is incomplete. Here...
Article
Dear Editor, Hidradenitis suppurativa (HS) is a chronic recurrent immune‐mediated skin disease usually observed during the second and third decades of life, but it can also occur in children and adolescents. HS has an unpredictable course and is challenging to treat due to the limited therapeutic options and long diagnostic delay.¹ It is not surpri...
Article
Full-text available
Melasma is a hyper-pigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet A (UVA) radiatio...
Chapter
Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle affecting apocrine gland-rich areas of the body. The disease usually occurs after puberty leading to painful nodules, abscesses, tunnels, and scarring. Although uncommonly, HS can also occur in children and adolescents. Genetic suscep...
Article
Full-text available
Chronic inflammation and dysregulated epithelial differentiation, especially of hair follicle keratinocytes, have been suggested as the major pathogenetic pathways of hidradenitis suppurativa/acne inversa (HS). On the other hand, obesity and metabolic syndrome have additionally been considered as an important risk factor. With adalimumab, a drug ha...
Article
Full-text available
Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes...
Article
Full-text available
Activation of Toll-like receptors (TLR) 1/2 and 4 are central in inducing inflammation in sebocytes by regulating the expression of protein coding mRNAs, however the microRNA (miRNA) profile in response to TLR activation and thus the possible role of miRNAs in modulating sebocyte functions has not been elucidated. In this work we identified miR-146...
Article
Full-text available
Background Hidradenitis suppurativa (HS) is a chronic, inflammatory disease of the apocrine gland-rich (AGR) skin region. The initial steps of disease development are not fully understood, despite intense investigations into immune alterations in lesional HS skin. Objectives We aimed to systematically investigate the inflammatory molecules involve...
Article
Enhanced sebocyte proliferation is associated with the pathogenesis of human skin diseases related to sebaceous gland hyperfunction and androgens, which are known to induce sebocyte proliferation, are key mediators of this process. Galectin-12, a member of the β-galactoside-binding lectin family that is preferentially expressed by adipocytes and fu...
Article
Significance Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 13% of adults and 10% of children worldwide. The inflammation seen in AD is driven by type 2 cytokines, including IL-4 and IL-13. We have an incomplete understanding about how these cytokines impact the epithelial barrier and drive AD pathology. Our study demonst...
Conference Paper
Introduction: Adamantiades-Behçet’s disease (ABD) is a rare chronic, multisystem, inflammatory disease, characterized by chronic vasculitis and a relapsing-remitting course of mucocutaneous and ocular lesions. Oral ulcers are the most common manifestations and significantly impair quality of life [1]. Current epidemiological data on ABD in Germany...
Article
Cutaneous leishmaniasis is an infectious disease caused by several Leishmania species. It is transmitted to humans by the bite of the infected female phlebotomus sandfly. Today, more than 1 billion people in leishmaniasis endemic areas are at risk of infection. More than 1.5 million new cases of cutaneous leishmaniasis occur every year. On the basi...
Chapter
During the last 25 years, we have reached an impressive increment of knowledge about the pathophysiology of acne. However, the progress of developing effective and tolerable new drugs for the topical or systemic route is far behind modern understanding of acne management. Only a few major efforts have been undertaken to introduce new therapeutic re...
Article
Full-text available
Importance Hidradenitis suppurativa (HS) is a chronic inflammatory disease with a high burden for patients and limited existing therapeutic options. Objective To evaluate the efficacy and safety of bimekizumab, a monoclonal IgG1 antibody that selectively inhibits interleukin 17A and 17F in individuals with moderate to severe HS. Design, Setting,...
Article
Full-text available
Importance Surgery is a mainstay in the management of hidradenitis suppurativa (HS). Adalimumab is the first drug approved for HS. Objective To investigate the efficacy and safety of adalimumab in combination with wide-excision surgery followed by secondary intention healing. Design, Setting, and Participants The Safety and Efficacy of Adalimumab...
Article
Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial re...
Preprint
Full-text available
Although several energy devices targeting sebaceous glands have been developed, an effective and safe therapeutic tool for hyperseborrhea is needed. Non-thermal atmospheric-pressure plasma (NTAPP) induces microscopic tissue reactions in sebaceous glands of rat skin in vivo. Fifteen healthy volunteers with oily facial skin underwent three sessions o...
Article
Full-text available
Syndromic hidradenitis suppurativa (HS) is a form of symptom constellations, which differs from the familial and genetic form and comprises predominantly osteoarticular manifestations. Many forms include pyoderma gangrenosum and acne (PASH), pyogenic arthritis (PAPASH), spondyloarthritis (PASS) and psoriatic arthritis (PsAPASH) and are categorized...
Article
Full-text available
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor expressed in all skin cell types, plays a key role in physiological and pathological processes. Several studies have shown that this receptor is involved in the prevention of inflammatory skin diseases, e.g., psoriasis, atopic dermatitis, representing a potential therapeut...
Article
Hidradenitis suppurativa/acne inversa (HS) has a multifactorial pathogenesis. In addition to a sporadic form, a familial form is reported in around 40% of patients, for whom an autosomal dominant (AD) inheritance with reduced gene penetrance is assumed. The phenotype of the disease with inflammatory nodules, abscesses and secreting sinus tracts sug...
Article
Publication of real world data on the results of treatment with (approved) drugs is important to allow for a reasonable judgement about the efficacy of a medication, especially since due to the nature of controlled clinical studies certain patient groups, who in daily clinical routine would best benefit from such new treatments, are excluded from s...
Article
Hidradenitis suppurativa/acne inversa (HS) is associated with numerous and relevant restrictions on the quality of life for those affected and their relatives. The exact prevalence of HS varies significantly across studies, but it is likely to be higher than suggested in previous publications. HS care is associated with high costs for the healthcar...
Article
Hidradenitis suppurativa/acne inversa is a scarring disease of the intertrigines that is now intensively researched. Improved pathogenetic understanding has led to the introduction of tumor necrosis factor alpha (TNF‑α) inhibition, which represents a major advance over traditional broad immunosuppression and antibiotic administration. In addition,...
Article
Linked article: C. Kursawe Larsen et al. J Eur Acad Dermatol Venereol 2021; 35: 1577–1581. https://doi.org/10.1111/jdv.17148.
Article
antibiotics represent the first-line hidradenitis suppurativa (HS) treatment, although HS is not an infectious disease¹. Prolonged antibiotic courses exhibit an anti-inflammatory effect, utilized for treating follicular/inflammatory skin diseases, e.g. acne and rosacea. Clindamycin/rifampicin or tetracyclines are usually administered for 10 to 12 w...
Article
Background Acne vulgaris is a prevalent skin disease lacking effective and well-tolerated treatment. An earlier study indicated that resveratrol (RVT) has therapeutic effects in acne patients through unknown mechanisms. Objectives To evaluate the effects of RVT on linoleic acid (LA)-induced lipogenesis and peptidoglycan (PGN)-induced inflammation...
Article
Full-text available
Knowledge on hidradenitis suppurativa/acne inversa (HS) is rapidly increasing. HS has a profound impact on patients and their family life. Several factors, such as comorbidities, unemployment and HS severity, make this impact even more severe. The most widely used instrument to measure this impact is the dermatology-specific DLQI. We also identifie...
Article
Full-text available
Exposome factors that lead to stressed skin can be defined as any disturbance to homeostasis from environmental (meteorological factors, solar radiation, pollution or tobacco smoke) and/or internal exposure (unhealthy diet, hormonal variations, lack of sleep, psychosocial stress). The clinical and biological impact of chronic exposome effects on sk...
Article
Background: Hidradenitis suppurativa/acne inversa (HS) is a chronic, recurrent inflammatory skin disease. Its pivotal pathogenetic event is believed to be the occlusion of the hair follicle generating a perifollicular lympho-histiocytic inflammation. However, knowledge of the exact HS pathogenesis requires further research. Objective: To develop...
Article
Full-text available
Background Behçet’s syndrome, a chronic, multi-system variable vessel vasculitis, is often characterized by painful oral ulcers (OU) affecting quality of life (QoL). Apremilast (APR), an oral PDE4 inhibitor, demonstrated efficacy in OU treatment in the phase 3 multinational RELIEF study. Objectives To evaluate APR efficacy in OU treatment in patie...
Article
Ferredoxin reductase (FDXR), a mitochondrial membrane-associated flavoprotein, is essential for electron transfer and modulates p53-dependent apoptosis in cancer cells.FDXR may be implicated in epidermal and sebocytic differentiation, but its explicit function in sebocytes remains to be elucidated. In the present study, immunohistochemistry reveale...
Article
Full-text available
The registration of the tumour necrosis factor‐α inhibitor adalimumab in 2015 was a major step forward in the treatment of hidradenitis suppurativa/acne inversa (HS). However, it soon became evident that the effectiveness of adalimumab in daily practice was highly variable. A significant unmet medical need of HS patients remained, and the search fo...