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Christos C. Zouboulis

Christos C. Zouboulis
Städtisches Klinikums Dessau, Medizinische Hochschule Brandenburg Theodor Fontane · Hochschulklinik fuer Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum

Prof. Dr. med. Prof. honoraire Dr. h.c.

About

1,178
Publications
225,046
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35,173
Citations
Introduction
Prof. Zouboulis has performed fundamental research on the sebaceous gland and acne, Dermato-Endocrinology and molecular ageing, skin stem cells, hidradenitis suppurativa, Adamantiades-Behçet’s disease and cryosurgery. Major awards: Oskar Gans Prize (1993), EADV Research Fellowship (1997), Felix Wankel Prize (2000), ADK Beauty Care Prize (2000, 2002), Geroulanos Prize (2003), Paul Gerson Unna Prize (2005), Liérac Award (2005), Springer Prize (2007), Germany-Land of Ideas selected location (2009)
Additional affiliations
January 2011 - present
Position
  • Biogen Idec-supported research project “Etiology and treatment of sarcoidosis”
January 2010 - December 2010
Position
  • DFG project „Evaluation of sebocyte effect on melanocyte proliferation and pigment formation“
January 2009 - December 2011
Position
  • BMBF Network “Stem cell research” with the project “iPS cells from healthy and AD somatic cells”
Education
January 1994 - March 1994
Massachusetts General Hospital
Field of study
  • Lasers in Dermatology
November 1993 - December 1993
The Cleveland Clinic Foundation
Field of study
  • Dermatologic Surgery
January 1993 - November 1993
University of Michigan
Field of study
  • Molecular Biology

Publications

Publications (1,178)
Article
Full-text available
Exposome factors that lead to stressed skin can be defined as any disturbance to homeostasis from environmental (meteorological factors, solar radiation, pollution or tobacco smoke) and/or internal exposure (unhealthy diet, hormonal variations, lack of sleep, psychosocial stress). The clinical and biological impact of chronic exposome effects on sk...
Article
Background Behçet’s syndrome, a chronic, multi-system variable vessel vasculitis, is often characterized by painful oral ulcers (OU) affecting quality of life (QoL). Apremilast (APR), an oral PDE4 inhibitor, demonstrated efficacy in OU treatment in the phase 3 multinational RELIEF study. Objectives To evaluate APR efficacy in OU treatment in patie...
Article
Importance Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory skin disease characterized by occlusion of hair follicles as a primary pathogenic factor. There are scarce data regarding the prevalence of HS. Objective To estimate overall HS prevalence. Data Sources This review and meta-regression analysis was conducted using the M...
Article
The benign atrophic papulosis Köhlmeier-Degos (BAP) only involves the skin and exhibits a mild course, unlike its systemic form. The probability of never developing systemic disease increases from 70% at the time cutaneous lesions appear to 97% after a 7-year strict cutaneous course.
Article
Syndromic hidradenitis suppurativa (HS) is a form of symptom constellations, which differs from the familial and genetic form and comprises predominantly osteoarticular manifestations. Many forms include pyoderma gangrenosum and acne (PASH), pyogenic arthritis (PAPASH), spondyloarthritis (PASS) and psoriatic arthritis (PsaPASH) and are categorized...
Article
Full-text available
Epidermal growth factor (EGF) acts as a paracrine and autocrine mediator of cell proliferation and differentiation in various types of epithelial cells, such as sebocytes, which produce the lipid-rich sebum to moisturize the skin. However, sebum lipids via direct contact and by penetrating through the epidermis may have regulatory roles on epiderma...
Article
Full-text available
Some Cutibacterium acnes subgroups dominate on healthy skin while others are frequently acne-associated. Here we provide mechanistic insights into this difference, using an anaerobic keratinocyte-sebocyte-C. acnes co-culture model. An acneic C. acnes strain as well as its porphyrins activate NRLP3 inflammasome assembly, while this was not observed...
Article
Adalimumab is the only approved biological therapy for the debilitating skin condition Hidradenitis suppurativa HS. Although several clinical trials, as well as real‐world studies, support its efficacy at dosages of 40 mg/week or 80 mg/2nd week1‐3, a subgroup of patients may show insufficient disease control or a progressive loss of response with t...
Article
The immunopathogenesis of COVID‐19 remains ill‐defined. Through hyperstimulation of the immune system, SARS‐CoV2 may cause a multi‐facetted inflammatory disease and generate immune‐mediated organ damage even leading to fatal consequences. However, it is still unclear, if a modified course of COVID‐19 occurs in patients with autoimmune and/or autoin...
Article
Full-text available
Proper regulation of sebum production is important for maintaining skin homeostasis in humans. However, little is known about the role of epigenetic regulation in sebocyte lipogenesis. We investigated histone acetylation changes and their role in key lipogenic gene regulation during sebocyte lipogenesis using the human sebaceous gland cell line SZ9...
Article
Background: Auricular keloids belong to the most perplexing medical conditions, which have significant psychosocial impact on the patient's body image and quality of life. Summary: The article is purposed to provide dermatologists and plastic surgeons with the best proven practice using intralesional cryosurgery for the treatment of the differen...
Article
Zusammenfassung Eine Patientin mit androgenetischer Alopezie (female pattern) wurde zunächst mit Minoxidil 2 %-Lösung behandelt, wobei sie innerhalb von 15 Tagen ein juckendes Kopfhauterythem entwickelte. Die Epikutantestung zeigte eine polyvalente Kontaktsensibilisierung, wobei sie auf die Bestandteile der Minoxidil-Präparate Propylenglycol, Butyl...
Article
Full-text available
Importance Standard morphological terminology and definitions are vital for identification of lesion types in the clinical trial setting and communication about the condition. For hidradenitis suppurativa (HS), morphological definitions have been proposed by different groups, representing various regions of the world, but no international consensus...
Article
Zusammenfassung Im Zuge der Neugründung medizinischer Fakultäten in Deutschland muss auch die dermatologische Forschung und Lehre aufgebaut werden. Diese großen Zusatzaufgaben neben der Krankenversorgung stellen eine Herausforderung für die Klinikleitungen dar. In diesem Übersichtsbeitrag beschreiben exemplarisch Chefärztinnen und Chefärzte neuer U...
Article
Zusammenfassung Die Nachfrage nach Studienplätzen der Humanmedizin übersteigt seit vielen Jahren deutlich das Angebot der staatlichen Medizinfakultäten in Deutschland. Durch den zunehmenden Ärztemangel steigt auf der anderen Seite der Bedarf an ausgebildeten Medizinerinnen und Medizinern. Um diese Lücke zu schließen, wurden in den letzten Jahren za...
Article
Hidradenitis suppurativa/acne inversa (HS) is a painful disease.1,2 Pain, drainage and itching are the symptoms, which HS patients consider of playing a central role in the reduction of their quality of life. Pain could be classified in two types, a nociceptive, acute skin pain, which correlates well with the severity of skin lesions,3,4 and a chro...
Article
Adamantiades‐Behçet’s disease (ABD; MIM 109650) is a rare, neutrophilic vascular reaction or vasculitis with a chronic recurrent progressive course leading to systemic inflammatory vascular disease with potentially severe prognosis.¹ Its aetiology remains unknown. A genetic predisposition, triggered by infection/environmental factor(s) leading to h...
Preprint
Full-text available
Activation of Toll-like receptors (TLR) 1/2 and 4 are central in inducing inflammation in sebocytes and in the pathogenesis of acne by regulating the expression of protein coding mRNAs, however the microRNA (miRNA) profile in response to TLR activation and thus the possible role of miRNAs in regulating sebocyte functions has not been elucidated. In...
Article
Background: As the pathogenesis of keloids is poorly understood, there is no sound biological basis of keloid management. Few controlled therapeutic studies have been published, and recurrences are a major reason for treatment failure. Objective: To detect efficacy and safety of cryosurgery regimens on keloids and the occurring biological change...
Article
A 69-year-old man presented with a 12-month history of unilateral eczematous changes of the left nipple and areola without any signs of systemic inflammation. His main complaints were mild, intermittent itching, and occasionally local pain or burning. An external initial treatment with topical corticosteroids combined with disinfectants/antibiotics...
Article
Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated, inflamed lesions in the apocrine gland‐bearing areas of the body, most commonly on the axillary, inguinal and anogenital regions.1 European studies estimate H...
Article
Full-text available
Acne vulgaris is one of the most common skin disorders and affects the pilosebaceous units. Although the exact pathogenesis of acne is still unknown, Cutibacterium acnes (formerly known as Propionibacterium acnes) is considered one of the key contributing factors. In fact, a significant association exists between C. acnes strains belonging to phylo...
Article
Full-text available
Current transcriptome and proteome studies have identified differentially regulated genes and proteins in hidradenitis suppurativa/acne inversa (HS), both in entire involved skin¹ and in involved skin apocrine glands.² Such studies may provide relevant data for identification of druggable molecular targets leading to novel therapeutic compounds or...
Article
Background: Despite their widespread clinical use in both acne vulgaris and rosacea, the effects of tetracyclines on sebocytes have not been investigated until now. Sebaceous glands are central to the pathogenesis of acne and may be important in the development of rosacea. Objective: The aim of this study was to assess the effects of doxycycline...
Article
Full-text available
The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote “Hopefully, this heralds a welcome ne...
Article
Full-text available
Background: Following the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma published in 1983, this technology has received continued use and further recognition for additional earlier as well as refractory forms. After the publication of the first guidelines for this technology i...
Article
Full-text available
Background The macrophage‐activating lipopeptide‐2 (MALP‐2) activates cells carrying a functional Toll‐like receptor (TLR)‐2/6. Human sebocytes express functional TLR‐2, TLR‐4 and CD14. Upregulation of stearoyl‐CoA desaturase (SCD) and fatty acid desaturase‐2 (FADS2) expression inducesin SZ95 sebocytes pro‐inflammatory sebaceous activity. On the ot...
Article
Full-text available
Background: Following the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma published in 1983, this technology has received continued use and further recognition for additional earlier as well as refractory forms. After the publication of the first guidelines for this technology i...
Article
Background: There is growing evidence that (certain) hidradenitis suppurativa (HS) comorbidities comprise syndromes including HS as a key cutaneous manifestation. These apparently autoinflammatory syndromes and their diagnostic delay might have detrimental effects on affected patients. Methods: A systematic review was performed on the databases...
Article
Hidradenitis suppurativa (HS) is a chronic, recurrent cutaneous disease of the terminal hair follicle which manifests with deep-seated, painful nodules, abscesses, and sinus tract formation. The pathophysiology of the disease includes among various factors also dermatoendocrinologic variables: Correlations with metabolic syndrome, obesity, sex ster...
Article
Full-text available
In 2018, Schneider and Zouboulis analyzed the available tools for studying sebaceous gland pathophysiology in vitro. Since then, the interest in this field remains unbroken, as demonstrated by recent reviews on sebaceous gland physiology, endocrinology and neurobiology, the role of sebaceous glands beyond acne, and several original works on differe...
Article
Hyperandrogenism or hyperandrogenemia are medical conditions characterized by excessive levels of androgens in the periphery or systemically. Clinical manifestations of hyperandrogenism include hirsutism, seborrhea, acne, androgenetic alopecia, and virilization. Hirsutism, defined as excessive growth of terminal hair in women in a male-like pattern...
Article
Full-text available
Current experimental research on acne pathophysiology has revealed a more complicated template than the classically reported four factor etiology. Cells of the pilosebaceous unit, which represent the template for the developments of acne lesions seem to be parallelly affected by endocrinological/metabolic factors as well as inflammatory/immunologic...
Article
Full-text available
Cryosurgery, a safe physical regimen with only a few adverse effects and contraindications, provides satisfactory results in the overall frustrating treatment of keloids. Contact cryosurgery has mostly been applied, while intralesional cryosurgery is a relatively new, safe, therapeutic modality with still limited level of evidence (15 evidence‐rele...
Article
Full-text available
The skin exposome is defined as the totality of environmental exposures over the life course that can induce or modify various skin conditions. Here, we review the impact on the skin of solar exposure, air pollution, hormones, nutrition and psychological factors. Photoageing, photocarcinogenesis and pigmentary changes are well‐established consequen...
Article
Background Recent studies about the important roles of autophagy signaling in sebaceous lipogenesis and epidermal differentiation suggest potential benefits of autophagy activation in acne. Objective To investigate the effects of an autophagy activator on acne‐prone skin. Methods Autophagy signaling in human immortalized SZ95 sebocytes, normal hu...
Article
on behalf of the German Central Malignant Melanoma Registry and the European Organisation for Research and Treatment of Cancer abstract PURPOSE Three new therapies have been approved recently for the adjuvant treatment of stage III melanoma, substantially reducing the risk of tumor recurrences. This study evaluates 3 independent data sets to clarif...
Article
PURPOSE Three new therapies have been approved recently for the adjuvant treatment of stage III melanoma, substantially reducing the risk of tumor recurrences. This study evaluates 3 independent data sets to clarify the survival probabilities of patients with stage III melanoma. PATIENTS AND METHODS The Central Malignant Melanoma Registry (CMMR) e...
Article
For the second year in a row the European Academy of Dermatology and Venereology (EADV) School on Hidradenitis suppurativa/acne inversa (HS), which took place on February 3‐4, 2020 in Athens with the participation of 4 specialists and 20 residents (17 female, 7 male; Table 1) systematically assessed its effect on the participants knowledge. The glo...
Article
Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by active caspase-1. It has been reported that overactivation of the NLRP3 inflammasome contributes to the development and pathology of acne vulgaris. Th...
Article
Full-text available
BACKGROUND: Tufted angioma/kaposiform hemangioendothelioma represents a spectrum of rare benign skin vascular neoplasms that differ in the extent and prognosis. Tufted angioma affects primarily children, is localized to skin, shows no tendency for ulceration or tissue invasion and has a favorable prognosis. CASE REPORT: In this case report, tufted...
Article
Guidelines and consensus on the management of patients with acne aim to give evidence‐based, expert‐group recommendations. This review compares current guidelines and consensus articles to provide a compilation of recommendations on the treatment of acne with oral isotretinoin. Ten common, relevant, clinical questions are addressed, based on publis...
Article
Background/objective: Skin diseases, especially those with visible manifestation, are considered to cause a major influence on global mental health. Therefore, we determined the prevalence and severity of anxiety, depression, and suicidal ideation in a large sample of patients with facial dermatoses, namely acne, rosacea, folliculitis, and periora...
Article
Background Autophagy is a catabolic process for eliminating damaged organelles or proteins to maintain cellular homeostasis. Recently, lipids have been demonstrated to be targets for autophagosomal degradation. Therefore, autophagy might be involved in sebaceous gland homeostasis, however, relevant data are lacking. Objectives We investigated the...
Article
Full-text available
Background Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle affecting apocrine glands‐rich areas of the body. The disease usually occurs after puberty leading to painful nodules, abscesses, tunnels and scarring. Although uncommonly, HS can also occur in children and adolescents. Ob...
Article
Full-text available
The authors would like to correct the error in publication which is mentioned below.
Article
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We present a series of three kidney transplant patients developing epidermoid cysts after receiving oral tacrolimus for long‐term prevention of rejection of the allograft. Cyclosporin A has been known to show this cutaneous adverse drug reaction, but this is the first series of patients with epidermoid cysts following tacrolimus to the best of our...
Article
We have shown previously that endocannabinoids promote sebaceous lipogenesis, and sebocytes are involved in the metabolism of the endocannabinoid-like substance oleoylethanolamide (OEA). OEA is an endogenous activator of GPR119, a recently deorphanized receptor, which currently is being investigated as a promising antidiabetic drug target. In this...
Article
Background: Excessive sebum is produced by specialized cells called sebocytes and is considered a cause or consequence of acne, sebaceous cysts, hyperplasia, and sebaceous adenoma. Objective: To report changes in lipid accumulation in human sebocytes under hypoxia, which occurs under conditions of seborrhea. Methods: Sebocytes from the immorta...
Article
Full-text available
Background: Intralesional cryosurgery is effective in the treatment of keloids, however, clinical studies have presented diversified results. Objective: A novel, reproducible model for biophysical studies on intralesional cryosurgery of keloids is presented. Methods: Triplicate studies with a cryosurgical needle on 37°C-heated potatoes, which...
Article
Full-text available
Background: Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS). Objective: Detection of apocrine gland involvement in HS. Methods: Apocrine glands were isolated from skin biopsies of involved and uninvolved skin of HS patients (n=16, females:males 1:1) by laser captu...
Article
Background: Acne, a disease of the sebaceous gland with multifactorial pathogenesis, affects more than 85% of adolescents. A better deepening of the mechanisms underlying the disease is needed to define effective and mechanism-targeted treatments. Objective: To understand whether the sebocyte differentiation process could be involved in the path...
Article
Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher...
Article
Full-text available
Background: The large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy requires the elucidation of disease-driving mechanisms and tissue targeting. Objective: Robust characterization of the underlying HS mechanisms and detection of the involved skin compartments. Methods: HS molecular taxonomy and key signaling pathways were st...
Article
Background: Adalimumab is the only approved compound for the treatment of adult patients with moderate-to-severe hidradenitis suppurativa (HS) who did not respond to a systemic classical treatment. Despite its significant short- and long-term efficacy, a percentage of patients do not respond sufficiently. Moreover, some primary responders experien...
Article
Hidradenitis suppurativa (HS) is a long‐lasting skin disease with flares of painful boils in areas where skin meets skin, such as the armpits and groins. It affects somewhere between 1 and 40 people out of 1000 worldwide. When trying to measure the effect of a treatment in a clinical trial, so‐called ‘outcome measurement instruments’ are used. Thes...
Article
化脓性汗腺炎 (HS) 是一种慢性皮肤病,在皮肤相互接触部位(如腋下和腹股沟)有疼痛性毒疮发作。在全世界,每 1000 人中有约 1 到 40 人受此病影响。当尝试在一项临床试验中测量治疗效果时,会使用所谓的“结局测量量表”。已有一些方法估计存在“多少”疾病。结局测量量表的测量结果应正确且不发生随机变化,显而易见这很重要。之前已证实,HS 试验中使用的结局测量量表缺乏可靠性验证。因此,这项研究旨在明确,在使用 9 种不同的量表时,12 名具有 HS经验的皮肤科医生对 24 名 HS 患者的评分一致性如何。这项研究显示,一种名为 Hurley 分期的量表在评分一致性方面是可接受的量表。但是,Hurley 分期仅适合严重程度分期,以指导各期的最适合治疗。对于指定测量疾病严重程度变化的量表,发现其...
Article
Full-text available
In a recently published research letter Burney et al. demonstrated that isotretinoin (13‐cis‐retinoic acid, 13CRA) induced acnegenic changes in SEB‐1 cultured human sebocytes1. However, Melnik et al., suggested that the observed changes may largely be influenced by the Simian virus (SV)‐40 immortalization of the used cell line, which may inhibit th...
Article
Background: The quality of outcome assessment in acne studies has been either subjective/insufficient or time consuming through the ordinary lesion counting. Objective: To evaluate the application of multimodal clinical imaging (MCI), a combination of imaging technology and computation, in the assessment of acne lesions in a clinical study setti...