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Christos Iavazzo

Christos Iavazzo
Metaxa Cancer Hospital, Piraeus, Greece · Gynaecological Oncology

MD - MSc - PhD - CCT - ESGO - ESPSO - RCOG

About

284
Publications
26,223
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Introduction
Christos Iavazzo is an ESGO accredited Gynaecologist Oncologist Consultant who currently works at the Gynaecological Oncology Department, Metaxa Cancer Hospital, Piraeus, Greece. Christos does research in Gynaecological Oncology, HIPEC, Robotic and Laparoscopic Surgery.

Publications

Publications (284)
Article
Full-text available
Uterine angiolipoleiomyomas are rare, benign mixed mesenchymal lesions. A manifestation in the gynecological region is quite uncommon, with few cases described in the literature so far. We present an interesting case of a 59-year-old woman diagnosed with uterine angiolipoleiomyoma, and the results of the conducted systematic review of the literatur...
Article
Objective: Optimal management of ovarian cancer patients have been investigated by several centers and have been discussed in a great number of published articles. Aim of this article is the review of current data regarding this lethal malignancy treatment. Moreover, we discuss the ongoing trials regarding primary or interval cytoreductive surgery...
Article
Background: Long operation time remains a disadvantage of robotic-assisted gynaecological procedures. A score that predicts the duration of such surgeries could be useful. Methods: A retrospective analysis of robotic-assisted gynaecological surgeries in our institution were conducted. We assessed preoperative values such as body mass index, uter...
Article
Importance: Extramammary Paget disease (EMPD) is a frequently recurring malignant neoplasm with metastatic potential that presents in older adults on the genital, perianal, and axillary skin. Extramammary Paget disease can precede or occur along with internal malignant neoplasms. Objective: To develop recommendations for the care of adults with...
Article
Full-text available
Crohn’s disease is a multi-systemic chronic inflammatory disease that can affect various organs besides the gastrointestinal tract such as joints, uvea, and the skin. Vulvar Crohn’s disease is a rare entity occurring with vulvar lesions that show typical Crohn’s disease granulomatous inflammation but are not contiguous with the gastrointestinal inv...
Article
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Haemorrhoids are considered among the most frequent proctologi-cal condition at a general practitioner (GP) practice. Acute prolapse of internal haemorrhoids is presented with oedema, inflammation and acute pain. The application of granulated sugar on swollen hae-morrhoids leads to an immediate reduction of their edema and to the patient's relief....
Article
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Purpose As the prevalence of obesity has been rising during the past decades worldwide and especially in Greece, surgeons have faced significant challenges concerning the treatment of morbidly obese women with gynecologic cancer. Panniculectomy is a safe procedure that offers better visualization of pelvic anatomy and prevention of major complicati...
Conference Paper
Objectives Robotic hysterectomy and sentinel lymph node biopsy (SLNB) using Indocyanine green is an effective and safe alternative treatment for patients with endometrial cancer. Methods A single-institutional retrospective study was performed including all patients with intermediate-risk endometrial cancer who underwent robotic hysterectomy plus...
Conference Paper
Objectives Geriatric population, namely people aged 80 or older, is going to see the greatest growth over the next years. The standard treatment cannot be implemented for all the geriatric women with gynecological cancer and it depends on multiple factors such as physiological organ function as well as comorbidities. The aim of this study is to exa...
Article
The purpose of this study is to evaluate the effectiveness and safety of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) approached by minimally invasive surgical (MIS) techniques. We conducted a systematic review of the published relevant studies and evaluated a total of 403 patients, with a median age of 57 years old (20–69). The histology of t...
Conference Paper
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Introduction/Background* Paraaortic lymph node dissection is a challenging surgical procedure. Recent data mentioned that bulky nodal disease in ovarian/fallopian tube cancer patients stage IIB and above should be dissected in fallopian tube cancer patients that optimal primary cytoreduction has been achieved. Methodology A challenging paraaortic...
Conference Paper
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Introduction/Background* All surgeons are in concern for thromboembolic events especially following a major operation for cancer. The aim of this audit is to report the incidence of PE in our oncology department, to identify risk factors and help us design future studies in order to reduce the incidence of PE and provide the best healthcare service...
Conference Paper
Introduction/Background* The standard of treatment for advanced epithelial ovarian cancer (EOC) is primary debulking surgery (PDS) followed by platinum-based systemic chemotherapy. Due to the presence of extensive metastatic disease in most of the cases, primary debulking surgery can be an aggressive procedure associated with high peri-operative mo...
Article
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Background: A sarcomatoid squamous cell carcinoma of the vul-va is a very rare malignancy of the female genital tract . It has been characterized as an aggressive disease typically associated with early development of local recurrences as well as distant metastases. Case: A 77-year old woman presented to our hospital with an aggravated vulvar ma...
Article
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Altered fetal growth, either reduced or exacerbated, is associated with adverse perinatal outcomes. The underlying pathogenetic mechanisms of altered growth remain unclear. Fibroblast growth factor 21 (FGF21) and insulin are both considered to be major regulators of tissue growth and metabolism. The aim of our study was to investigate the associati...
Article
This study aimed to discuss the possible role of morcellation for a giant myoma in the minimal invasive approach. Current literature, including U.S. Food and Drug Administration guidelines, was reviewed. We found that safety of morcellation for a giant myoma is questionable. The risk and benefits of morcellation as well as alternative treatment opt...
Article
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Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical (EDC), is increasingly hypothesized to be a factor contributing to changes in fetal growth velocity. BPA exposure may be environmental, occupational, and/or dietary, with canned foods and plastic bottles contributing significantly. Our systematic review aims to evaluate the current liter...
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Purpose: Peritoneal spread of neoplastic diseases is considered a fatal condition with a dismal prognosis. Few therapeutic options were offered to these patients and surgery had only palliative character. However, advances in surgical techniques and new drugs development, have changed the management of this terminal stage disease. Cytoreductive su...
Article
Aim The aim of the present study was to evaluate the role of metformin in endometrial cancer (EC), focusing on its potential preventive effect in breast cancer and obese patients and its safety and efficacy when added to progesterone monotherapy in EC patients who wish to preserve their fertility. Methods We reviewed the literature and then conduc...
Article
Full-text available
We evaluated the effectiveness, safety and efficacy of robotic interval debulking surgery (IDS) in advanced epithelial ovarian cancer (EOC) treated with neoadjuvant chemotherapy (NACT). We conducted a systematic review of the published relevant studies. Α total of 102 patients were evaluated. Mean operative time ranged from 164 to 312 min (mean ± S...
Article
Full-text available
Aim of the study: Our aim was to analyse the feasibility of white blood cell and platelet counts along with their ratios as a prognostic factor in patients who underwent surgery for ovarian mass. Material and methods: We retrospectively studied the patients admitted in the Department of Gynaecology due to adnexal mass. The potential association...
Article
Ovarian cancer is the leading cause of death among gynecologic malignancies. Combining cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) can benefit patients with advanced ovarian cancer. We evaluate the role of small bowel peritoneal cancer index (sb-PCI) score as a prognostic factor. We retrospectively analyzed character...
Article
Objective. To review the existing studies on single-site robotic myomectomy and test the safety and feasibility of this innovative minimally invasive technique. Data Sources. PubMed, Scopus, Google Scholar (from their inception to October 2019), as well as Clinicaltrials.gov databases up to April 2020. Methods of Study Selection. Clinical trials (p...
Conference Paper
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Introduction/Background Cervical cancer is oftentimes plagued by several urological complications during or post treatment. Early disease is mainly managed with radical hysterectomy, while more advanced disease is usually treated by chemoradiation. Although urological complications of cervical cancer treatment have declined during the past decades,...
Conference Paper
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Introduction/Background Endometrial cancer (EC) is the most commonly diagnosed gynecological malignancy in the developed countries. Obesity, diabetes mellitus and infertility are some of the contributory factors. Some patients with EC wish to preserve their fertility or others have several comorbidities that contraindicate surgery. These groups of...
Conference Paper
Introduction/Background Safety and efficacy of robotic interval debulking surgery (IDS) after treatment with neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian cancer (EOC) was evaluated. Methodology A systematic review of the literature was conducted. Results We evaluated 102 patients in total. Perioperative outcomes were estimated a...
Conference Paper
Introduction Compared to benign disease, gynecologic cancer surgery has 6-fold higher risk for DVT and 14-fold for PE. Estimated DVT risk was reported 15–40% in major gynecologic procedures without thromboprophylaxis. Methods MeTHOS is a prospective observational study aiming to evaluate a possible reduction of VTE risk in High Thrombotic Burden (...
Article
Background Newly diagnosed advanced‐stage ovarian cancer patients are treated with neoadjuvant chemotherapy, primary or intermediate cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this study is to evaluate the optimal timing of cytoreduction plus HIPEC for advanced ovarian cancer patients. Methods Advanced...
Article
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The change in life expectancy affects the clinical presentation and the prognosis of elderly patients with gynecological cancer. The in-crease of life expectancy and increased numbers of elderly patients, the healthcare systems have to deal more frequently with patients who are not simply older adults but have also severe comorbidities and physiolo...
Article
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Purpose: We aimed to evaluate the role of repeat cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of patients with recurrent peritoneal metastatic disease (PM) with special consideration to perioperative outcomes and long-term survival outcomes. Methods: Patients with recurrent PM who underwent...
Article
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Primary peritoneal serous carcinoma (PPSC) is a rare malignancy, the clinical characteristics of which resemble ovarian serous carcinoma. We present a rare case of PPSC detected by an abnormal cervical smear, the first one with an absence of ovarian tissue at the time of the initial diagnosis. A 59-year-old asymptomatic woman presented with glandul...
Article
Objective. To evaluate the contribution of PlasmaJet application in achieving optimal cytoreduction in advanced ovarian cancer. Methods. We systematically searched for articles published up to June 2019 using MEDLINE, Scopus, Google Scholar databases and clinicaltrials.gov along with the references of the articles retrieved in full text. Observatio...
Article
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Background The aim of this survey was to acquire an overview of the current management of ovarian cancer with an emphasis on the utility of hyperthermic intraperitoneal chemotherapy (HIPEC). Methods: An email was sent to Oncologists prior to PSOGI International Symposium on Advanced Ovarian Cancer, Athens 11–13 April 2019. Doctors submitted respons...
Article
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Panniculectomy combined gynaecological surgery constitutes an alternative approach for endometrial cancer (EC) in obese patients. The present study aimed to accumulate the current knowledge on the safety and efficacy of combining panniculectomy in surgical management of EC. A total of 4 electronic databases were systematically searched for articles...
Article
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Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host’s immunological response. We present the case of a 54 years old postmenopausal patie...
Article
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Fibroids are the most common benign tumors affecting fertility and quality of life. Different methods either definitive or fertility sparing are used for their management by using open, laparoscopic and robotic techniques. This is a narrative review presenting the role and the advantages of robotic surgery in fibroids (myomectomies or hysterectomie...
Article
Full-text available
Dermatomyositis (DM) is defined as an autoimmune inflammatory disease that affects the skin, the blood vessels and the muscles. It typically presents with erythema affecting mostly the eyes and the hands as well as proximal muscle weakness. It has been also correlated with various types of cancer, including ovarian cancer. A systematic PubMed and S...
Conference Paper
Full-text available
Introduction/Background Endometrial cancer affects approximately 5% of the female patients. Lately, serum tumor markers such as Ca-125 and HE4 have been suggested as useful prognostic markers of advanced disease. Furthermore ROMA index is used so far to estimate the likelihood of malignancy of an ovarian tumor but its utility in assessing endometri...
Conference Paper
Introduction/Background Para-aortic lymphadenectomy is performed for disease staging to tailor the optimal treatment in a plethora of gynecological malignancies such as in advanced cervical, ovarian and high-risk endometrial cancer. With the advances in minimally invasive procedures, laparoscopic lymphadenectomy approaches have become the gold stan...
Conference Paper
Introduction/Background Pelvic and para-aortic lymphadenectomy has been considered a standard procedure in encountering and treating patients with various gynecological malignancies. On the other hand, formation of lymphoceles are considered the most common early or late lymphadenectomy-related complications. The present study aimed to evaluate the...
Conference Paper
Introduction/Background The prevalence of obesity has been rising during the past decades, Greece´s population is not an exception. The treatment of obese female patients with gynaecologic cancer is a challenging task for surgeons. Panniculectomy is a safe procedure that offers better visualization of pelvic anatomy and thus increased lymph node ex...
Conference Paper
Full-text available
Introduction/Background Endometrial cancer is estimated to be most common female cancer. Among other predictive factors, inflammation biomarkers resulting from white blood cell and platelet counts ratios have been introduced in the assessment of endometrial cancer. Methodology Preoperative NMR, LMR, NPR, LPR and MPR ratios in 154 patients of the g...
Conference Paper
Introduction/Background Ovarian epithelial cancer presents in advanced stages (III/IV) and is typically managed by combination of cytoreductive plus adjuvant chemotherapy. Cytoreduction increases the postoperative sensitivity of adjuvant chemotherapy and longer free-disease interval. Methodology Our case describes an aggressive surgical primary cy...
Conference Paper
Introduction/Background This research sought to understand Gynaecologists Oncologists knowledge of, experience with, and attitudes toward the use of HIPEC in ovarian cancer patients. Methodology A 17-question, self-report survey request was emailed to Gynaecologists Oncologists prior to PSOGI International Symposium on Advanced Ovarian Cancer, Ath...
Conference Paper
Introduction/Background Carcinogenesis and systemic inflammation have been correlated and the ratios of white blood cell and platelet counts have been suggested to have a prognostic significance in ovarian tumor patients. The purpose of our study was to estimate the prognostic value of inflammation biomarkers in ovarian mass patients. Methodology...
Conference Paper
Introduction/Background Muir-Torre Syndrome (MTS) is a rare autosomal dominant inherited disease that appears to be a variation of non polyposis colorectal carcinoma-HNPCC, known as Lynch syndrome. Current criteria for its diagnose include at least one sebaceous malignancy and a visceral cancer, most commonly colonic and genitourinary. Methodology...
Conference Paper
Introduction/Background Microcystic, elongated, fragmented (MELF) pattern of myometrial invasion is a recently introduced histological pattern detected in some specimens from patients with endometrial carcinoma (EC) with debatable prognostic and predictive effect. The aim of the present study is to examine the role of MELF in the prognosis and surv...
Conference Paper
Introduction/Background Endometrial cancer is the most common cancer of the female reproductive tract in developed countries. Peritoneal metastases from endometrial cancer as advanced stage disease or as a recurrence is not rare. The aim of the present study was to evaluate the efficacy of cytoreductive surgery and hyperthermic intraperitoneal chem...
Article
Full-text available
Purpose To present the clinical and laboratory characteristics, as well as the management, of patients with primary peritoneal serous papillary carcinoma (PPSPC). Methods This is a retrospective study of 19 patients with PPSPC who underwent debulking surgery followed by first line chemotherapy and were managed in Metaxa Memorial Cancer Hospital be...
Article
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Objective: To analyse the kind of ovarian cancer relapse by separating residual from recurrent disease and correlating them with patients’ survival. Material and methods: Retrospective study of 200 women with ovarian carcinoma relapse during the period 2005-2017. Results: The main sites of residual disease included great omentum, epiploic appe...
Article
Imiquimod has been demonstrated to be rather effective in patients with anal as well as perianal high-grade squamous intraepithelial lesions (HSILs). Nevertheless, until now the intra-anal use of imiquimod has been considered off-label. The aim of this study is to review the clinical evidence related to the intra-anal use of imiquimod in the treatm...
Article
Full-text available
Purpose Cervical cancer (CC) ranks 2nd for mortality among women of reproductive age in the United States. Abdominal radical trachelectomy (ART) is a fertility sparing approach that has been proposed in women with early stage CC who wish to preserve their fertility. The aim of the present meta-analysis was to evaluate the short- and long-term outco...