
Christos IavazzoMetaxa Cancer Hospital, Piraeus, Greece · Gynaecological Oncology
Christos Iavazzo
MD - MSc - PhD - CCT - ESGO - ESPSO - RCOG
About
359
Publications
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Introduction
Christos Iavazzo is an ESGO accredited Gynaecologist Oncologist Consultant who currently works at the Gynaecological Oncology Department, Metaxa Cancer Hospital, Piraeus, Greece. Christos does research in Gynaecological Oncology, HIPEC, Robotic and Laparoscopic Surgery.
Publications
Publications (359)
Background:
Isolated mediastinal metastases from ovarian carcinoma are considered exceptional. Since such metastases are considered advanced stage disease, systemic therapy is the indicated therapeutic approach; however, some articles report that surgical excision is also feasible.
Methods:
We reviewed the English-language literature to detect c...
The article “Comparison of operative and fertility outcomes of single-incision robotic myomectomy: a retrospective single-center analysis of 286 cases” by Kim et al. compares the effectiveness of robotic single-port myomectomy against the traditional multiport approach. The study finds similar operating outcomes, complication rates, and pregnancy r...
Introduction/Background
Vulvar cancer represents only 4% of gynecological malignancies. Vacuum-assisted closure (VAC) is a non-pharmacologic/non-surgical means, which use negative pressure for spontaneous healing of the wound. It is reported that the use of VAC after vulvectomy helps cicatrization. We report one case of 82 years old woman, who was...
Introduction/Background
GI neuroendocrine tumors (NETs) are rare neoplasms and are most frequently encountered in the pancreas. Only 3% of these neoplasms are found in the small intestine (SI). We present a case of synchronous SI NET and an ovarian cystadenofibroma.
Methodology
A 63-year-old woman was referred to our department for a multilocular...
Introduction/Background
Struma ovarii is a germ cell tumor of the ovary, which consists of >50% thyroid tissue. Malignant struma ovarii is a very rare type of gynecologic cancer, accounting 5–10 % of these tumors. The most common type is papillary carcinoma, followed by typical follicular carcinoma.
Methodology
A 54-year-old woman, was referred to...
Introduction/Background
Borderline ovarian tumours represent a rather challenging entity requiring a balance between oncological outcomes and the preservation of fertility in younger patients desiring pregnancy. Numerous retrospective studies have explored the outcomes of fertility-sparing surgery (FSS), emphasising its potential advantages in pres...
Introduction/Background
Smooth muscle tumor of uncertain malignant potential (STUMP) is a rare subtype of mesenchymal tumor in the gynecologic tract, which affects approximately 0.01% of patients treated by myomectomy or hysterectomy. These neoplasms may represent a ’transition’ tumor between leiomyoma to leiomyosarcoma. We report on a case of a 46...
Paraovarian tumors of borderline malignancy (PTBM) are exceedingly rare, with only slightly over 60 cases reported worldwide. This report presents the case of a 22-year-old nulliparous patient who incidentally discovered a left paraovarian mass during a routine abdominal ultrasound. Subsequent MRI revealed a 2.5×2.1 cm cystic lesion located in clos...
Background: Despite the considerable progress made in recent years in fetal assessment, the etiology of fetal growth disturbances is not as yet well understood. In an effort to enhance our knowledge in this area, we investigated the associations of the amniotic fluid angiotensinogen of the renin–angiotensin system with fetal growth abnormalities. M...
Objective:
To investigate whether uterine artery embolisation (UAE) offers better quality of life (QoL) compared to myomectomy in premenopausal women diagnosed with leiomyomas of the uterus.
Data sources:
We searched the electronic databases PubMed and Cochrane Central Register of Controlled trials to January 2023.
Study eligibility criteria:
We...
Müllerian duct anomalies (MDAs) concurrent with endometrial cancer are exceptionally rare, with only a few documented cases. Here, we present a case of endometrial cancer in both horns of a didelphys uterus in a 54-year-old woman with a history of renal cancer, who underwent left radical nephrectomy and left salpingo-oophorectomy. The patient sough...
Post-partum bleeding or post-partum hemorrhage (PPH) is often defined as the loss of more than 500 mL of blood after vaginal delivery or 1000 mL of blood after cesarean section following the delivery of a child [...]
Introduction/Background
The rectovaginal septum is a rare location for gastrointestinal stromal tumors (GIST) to occur. The aim of this study is presentation of a patient with solitary liver metastasis and local recurrence from low-risk extra gastrointestinal tumor (e-GIST) in rectovaginal space.
Methodology
A 55-year-old woman with a medical hist...
Background:
Abnormal fetal growth is associated with adverse perinatal and long-term outcomes. The pathophysiological mechanisms underlying these conditions are still to be clarified. Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are two neurotrophins that are mainly involved in the neuroprotection process, namely promotion of growth and dif...
Endometriosis is a chronic gynecologic condition that affects around 6–10% of reproductive age women. This clinical entity is characterized with pelvic pain, dysmenorrhea, dyspareunia, and infertility which are the most often presenting symptoms. Aromatase P450 is the key enzyme for ovarian estrogen biosynthesis and there is evidence that endometri...
Background and Objectives: Fetal growth abnormalities increase the risk of negative perinatal and long-term outcomes. Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical to which humans may be exposed in a number of ways, such as from the environment, via various consumer products, and through the individual’s diet. Since the compound p...
Background/aim:
Ovarian cancer remains one of the most lethal malignancies in women. Optimal surgical cytoreduction is the most important prognostic factor of survival in patients with advanced ovarian cancer. The helium gas plasma device (J-Plasma) has recently been introduced into surgical treatment of these patients with some promising results....
Introduction:
During the past decade, the theory that high-grade extrauterine pelvic tumors originate from the fallopian tube has been strongly suggested. Our study aims to illuminate the possible role of tubal cytology as an accessory identification tool for gynecologic extrauterine malignancies, allowing in the long term the implementation of po...
Introduction:
Fetal growth disturbances place fetuses at increased risk for perinatal morbidity and mortality. As yet, little is known about the basic pathogenetic mechanisms underlying deranged fetal growth. Apelin is an adipokine with several biological activities. Over the past decade, it has been investigated for its possible role in fetal gro...
Objectives:
To analyze the published evidence for the use of fallopian tube brush cytology for the early detection of extrauterine serous gynecological cancer.
Methods:
We systematically searched the literature and, additionally, cross checked on the bibliographies of selected articles. The inclusion criteria involved studies assessing the utili...
Sentinel lymph node biopsy for the management of endometrial cancer patients has been introduced into surgical staging of these patients. Several articles and guidelines have evaluated and found sentinel lymph node biopsy as an efficient and oncological safe procedure. The aim of this article is to highlight the most important tips and tricks in or...
Background
A recent theory supports that high-grade serous epithelial ovarian cancer derives from the fimbrial end of the fallopian tube and during the last decade, a few studies have examined the fallopian tube cytology. Our study aims to determine the cytomorphological characteristics of both benign and non-benign salpingeal samples, in order to...
Introduction: Obesity is a worldwide problem that considered to be a challenge in optimal surgical management. A breakthrough in the technologies of minimal invasive surgery over the last ten years has turned robotic approach into the widespread method for surgical management of obese population. Aim: In this study we emphasize the benefits of the...
Introduction:
Crypts are small anatomical structures situated between the anal papillae, which do not cause any symptoms unless they become inflamed. Cryptitis is a localized infection of one or more of the anal crypts.
Case presentation:
A 42-year-old woman presented to our practice, complaining intermittently of anal pain and pruritus ani over...
Background:
Splenosis is the presence of ectopic autotransplantation of splenic tissue in various compartments of the human body, occurring after rupture of the splenic parenchyma.
Methods:
A systematic PubMed and Scopus search was conducted.
Results:
The mean age of the patients was 51.7 years. The majority of patients were of female gender....
The management of the advanced peritoneal disease is demanding especially in cases of extensive bowel infiltration and the obstruction of the gastrointestinal tract in different sites. Patients with bowel obstruction due to peritoneal carcinomatosis have an overall survival that ranges from three to eight months to four to five weeks based on the o...
We aim to assess the available evidence concerning the robot-assisted repair of cesarean scar defect. A systematic PubMed and Scopus search was conducted. All databases were assessed up to May 23, 2022. Studies reporting data on robot-assisted repair of cesarean scar defect were included in this review. Data of 34 patients are presented. The mean a...
Background:
Extrapelvic manifestations of endometriosis can be identified in nearly every part of the female body, and the true prevalence of extrapelvic locations is unknown. Pancreatic endometriosis may manifest in several ways, ranging from emergency presentations to asymptomatic cysts.
Method:
A systematic PubMed and Scopus search was conduc...
Vaginal cuff dehiscence (VCD) is an extremely rare complication after a hysterectomy, with possible life-threatening consequences. Multiple cases of pelvic organ evisceration through the vaginal cuff have been reported, most frequently precipitated by sexual intercourse. Surgeons should be suspicious of clinical signs of VCD postoperatively, as any...
Background
Clinical practice recommendations for the management of acute appendicitis in pregnancy are lacking.
Objective
To develop an evidence-informed, trustworthy guideline on the management of appendicitis in pregnancy. We aimed to address the questions of conservative or surgical management, and laparoscopic or open surgery for acute appendi...
Introduction/Background
Ovarian cancer is the most lethal gynecological malignancy.The high mortality rate is a consequence of delayed diagnosis due to the lack of screening and early diagnostic methods. Based on the recent theory that the majority of the gynecological extrauterine high grade serous carcinomas originate from the fallopian tube, we...
Introduction/Background
Gynecologic cancer surgery has 6-fold higher risk for DVT and 14-fold for PE, compared to benign disease. Two meta-analyses (Rasmussen2009, Faragesanu2016) show residual VTE rates 5.3% and 14.3% in patients following standard thromboprophylaxis approach. Despite increased awareness, improved surgical techniques and more exte...
Introduction/Background
Epithelial Ovarian Cancer (EOC) is still the most lethal gynecological malignancy, with approximately 21,410 new cases and 13,770 deaths in the USA in 2021. Many theories have been proposed in terms of clarifying the etiology and the carcinogenesis -mechanism of EOC. Based on the latest trends, ovarian, fallopian tube, and p...
Introduction/Background
In the last decades the rate of robotic-assisted gynecological surgeries has increased exponentially. The main reason for this increase is the less postoperative pain, the immediate patients’ mobilization, and the evidence-based safety of these procedures. However, the prolongation of robotic-assisted gynecological surgeries...
Introduction/Background
Endometrial stromal tumors (EST) represent less than 1% of all uterine malignant neoplasms. Those include endometrial stromal nodule (ESN), low-grade stromal sarcoma (LGESS), high-grade stromal sarcoma (HGESS), undifferentiated uterine sarcoma (UUS), uterine adenosarcoma (ADENOSA) and uterine tumor resembling ovarian sex cor...
Introduction/Background
Peritoneal carcinomatosis with/without lymph node involvement is a particularly common clinical scenario in gynaecological oncology. However, unexpected diagnoses may occur following an exploratory laparotomy. We present three exceptional cases of patients that were finally diagnosed with cancer of hepatobilliary origin.
Me...
Introduction/Background
Neuroendocrine tumors (NETs) of the female genital tract are a very unusual clinical entity, with most known cases involving the uterine cervix. Those tumors include small and large-cell neuroendocrine carcinomas and carcinoid tumors. Interestingly small cell cervical cancer is a non-pulmonary variation of small-cell lung ca...
Objective: To investigate whether neoadjuvant chemotherapy (NACT) confers superior outcomes compared to primary debulking surgery (PDS) in patients with stage III and IV epithelial ovarian, tubal or peritoneal cancer as well as in patients with high tumour load.
Methods: We searched the electronic databases PubMed, Cochrane Central Register of Cont...
We read with great interest the article entitled “Indocyanine green fluorescent image-guided inguinal sentinel lymph node biopsy in vulvar cancer.” by Kwak et al. [1]. We would like to congratulate the authors for their excellent surgical technique. The method was applied in a patient with a 3 cm sized palpable vulval mass, and the final histology...
Uterine angiolipoleiomyomas are rare, benign mixed mesenchymal lesions. A manifestation in the gynecological region is quite uncommon, with few cases described in the literature so far. We present an interesting case of a 59-year-old woman diagnosed with uterine angiolipoleiomyoma, and the results of the conducted systematic review of the literatur...
Objective
Optimal management of ovarian cancer patients have been investigated by several centers and have been discussed in a great number of published articles. Aim of this article is the review of current data regarding this lethal malignancy treatment. Moreover, we discuss the ongoing trials regarding primary or interval cytoreductive surgery a...
Background:
Long operation time remains a disadvantage of robotic-assisted gynaecological procedures. A score that predicts the duration of such surgeries could be useful.
Methods:
A retrospective analysis of robotic-assisted gynaecological surgeries in our institution were conducted. We assessed preoperative values such as body mass index, uter...
Eileithyia was the goddess of birth in Ancient Greek mythology. Daughter of Zeus and Hera, she was considered to be a pre-Hellenic goddess as her name was mentioned in several Linear B tablets from ancient Crete. Eileithyia was initially considered to have two functions, either to further childbirth or to protract and delay the labour. Sanctuaries...
Importance:
Extramammary Paget disease (EMPD) is a frequently recurring malignant neoplasm with metastatic potential that presents in older adults on the genital, perianal, and axillary skin. Extramammary Paget disease can precede or occur along with internal malignant neoplasms.
Objective:
To develop recommendations for the care of adults with...
Crohn’s disease is a multi-systemic chronic inflammatory disease that can affect various organs besides the gastrointestinal tract such as joints, uvea, and the skin. Vulvar Crohn’s disease is a rare entity occurring with vulvar lesions that show typical Crohn’s disease granulomatous inflammation but are not contiguous with the gastrointestinal inv...