Christos Fryganas

Christos Fryganas
Wageningen University & Research | WUR · Department of Food Sciences and Agrotechnology

PhD

About

25
Publications
5,461
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760
Citations
Additional affiliations
January 2014 - April 2014
French National Institute for Agriculture, Food, and Environment (INRAE)
Position
  • Fellow
February 2013 - March 2013
University of Turku
Position
  • Fellow
May 2012 - April 2015
University of Reading
Position
  • PhD Student

Publications

Publications (25)
Article
Acrylamide (AA) is formed by Maillard Reaction (MR), during high-temperature and low moisture processes in several food categories, including bakery products. AA is classified as a toxic and carcinogenic compound and therefore, mitigation strategies are necessary to control its concentration in foods. Selecting ingredients with a reduced amount of...
Article
Full-text available
Condensed tannins (CTs) account for up to 20% of the dry matter in forage legumes used as ruminant feeds. Beneficial animal responses to CTs have included improved growth, milk and wool production, fertility, and reduced methane emissions and ammonia volatilization from dung or urine. Most important is the ability of such forages to combat the effe...
Article
Full-text available
Unambiguous investigation of condensed tannin (CT) structure-activity relationships in biological systems requires well-characterized, high-purity CTs. Sephadex LH-20 and Toyopearl HW-50F resins were compared for separating CTs from acetone/water extracts and column fractions analyzed for flavan-3-ol subunits, mean degree of polymerization (mDP) an...
Article
Full-text available
Interactions between dendritic cells (DCs) and environmental, dietary and pathogen antigens play a key role in immune homeostasis and regulation of inflammation. Dietary polyphenols such as proanthocyanidins (PAC) may reduce inflammation, and we therefore hypothesised that PAC may suppress lipopolysaccharide (LPS)-induced responses in human DCs and...
Article
SUMMARY An in vitro study was conducted to investigate the effects of condensed tannin (CT) structural properties, i.e. average polymer size (or mean degree of polymerization), percentage of cis flavan-3-ols and percentage of prodelphinidins in CT extracts on methane (CH 4 ) production and fermentation characteristics. Condensed tannins were extrac...
Article
Proanthocyanidins (PAC) are a class of plant secondary metabolites commonly found in the diet that have shown potential to control gastrointestinal nematode infections. The anti-parasitic mechanism(s) of PAC remain obscure, however the protein-binding properties of PAC suggest that disturbance of key enzyme functions may be a potential mode of acti...
Article
Full-text available
Plants containing condensed tannins (CT) may have potential to control gastrointestinal nematodes (GIN) of cattle. The aim was to investigate the anthelmintic activities of four flavan-3-ols, two galloyl derivatives and 14 purified CT fractions, and to define which structural features of CT determine the anti-parasitic effects against the main catt...
Article
Plant-derived proanthocyanidins (PAC) have been promoted as a natural method of improving health and immune function in livestock. It has previously been shown that PAC are effective agonists for activating ruminant γδ T-cells in vitro, however effects on other livestock species are not yet clear. Moreover, the fine structural characteristics of th...
Article
Proanthocyanidins (PAs) in sainfoin (Onobrychis viciifolia Scop.) are of interest to ameliorate the sustainability of livestock production. However, sainfoin forage yield and PA concentrations, as well as their composition, require optimization. Individual plants of 27 sainfoin accessions from four continents were analyzed with LC-ESI-QqQ-MS/MS for...
Article
Full-text available
Tannin-containing legumes have attracted much interest due to their animal health and nutritional benefits. Although several tannins are anti-nutritional, a few can generate valuable benefits for controlling parasitic nematodes that are resistant to anthelmintic drugs, for improving protein utilization by ruminants and fatty acid profiles in meat a...
Article
Plants containing condensed tannins (CTs) may hold promise as alternatives to synthetic anthelmintic (AH) drugs for controlling gastrointestinal nematodes (GINs). However, the structural features that contribute to the AH activities of CTs remain elusive. This study probed the relationships between CT structures and their AH activities. Eighteen pl...
Article
Studies with a diverse array of 22 purified condensed tannin (CT) samples from nine plant species demonstrated that procyanidin/prodelphinidin (PC/PD) and cis/trans-flavan-3-ol ratios can be appraised by 1H-13C HSQC NMR spectroscopy. The method was developed from samples containing 44 to ~100% CT, PC/PD ratios ranging from 0/100 to 99/1, and cis/tr...
Article
Full-text available
Background Plant-derived condensed tannins (CT) show promise as a complementary option to treat gastrointestinal helminth infections, thus reducing reliance on synthetic anthelmintic drugs. Most studies on the anthelmintic effects of CT have been conducted on parasites of ruminant livestock. Oesophagostomum dentatum is an economically important par...
Article
Natural anti-parasitic compounds in plants such as condensed tannins (CT) have anthelmintic properties against a range of gastrointestinal nematodes, but for other helminths such effects are unexplored. The aim of this study was to assess the effects of CT from three different plant extracts in a model system employing the rat tapeworm, Hymenolepis...
Article
Full-text available
Ascaris suum is one of the most prevalent nematode parasites in pigs and causes significant economic losses, and also serves as a good model for A. lumbricoides, the large roundworm of humans that is ubiquitous in developing countries and causes malnutrition, stunted growth and compromises immunity to other pathogens. New treatment options for Asca...
Article
We developed a rapid method with ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) for the qualitative and quantitative analysis of plant proanthocyanidins (PAs) directly from crude plant extracts. The method utilizes a range of cone voltages to achieve the depolymerization step of both smaller oligomers and larger pol...
Article
For the analysis of thyroid transporter ligands, a triple bioaffinity mass spectrometry (BioMS) concept was developed, with the aim at three different analytical objectives: rapid screening of any ligand, confirmation of known ligands in accordance with legislative requirements, and identification of emerging yet unknown ligands. These three purpos...

Projects

Project (1)
Archived project
Fodder legumes have two advantages over other forage plants. They are high in protein and require little or no nitrogen fertilizer. There are other benefits which legumes can offer. Some, like sainfoin and birdsfoot trefoil, contain ‘bioactive’ constituents that optimize protein use in ruminant nutrition, reduce methane gas emissions, control parasitic worms and improve food quality. LegumePlus aims to carry out research in these areas. Visit the project page: http://legumeplus.eu