Christopher Timmermann

Christopher Timmermann
Imperial College London | Imperial · Division of Brain Sciences

PhD cand

About

19
Publications
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105
Citations
Introduction
Christopher Timmermann currently works at the Psychedelic Research Group in Imperial College London. He is currently leading a study involving the effects of DMT in the human brain and experience.

Publications

Publications (19)
Article
Full-text available
A striking feature of psychedelics is their ability to increase attribution of truth and meaningfulness to specific contents and ideas experienced, which may persist long after psychedelic effects have subsided. We propose that processes underlying conferral of meaning and truth in psychedelic experiences may act as a double-edged sword: while thes...
Article
Full-text available
Therapeutic psychedelic administration and contact with nature have been associated with the same psychological mechanisms: decreased rumination and negative affect, enhanced psychological connectedness and mindfulness-related capacities, and heightened states of awe and transcendent experiences, all processes linked to improvements in mental healt...
Preprint
Full-text available
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes such as personality changes. These findings are particularly intriguing given that a decrease of brain entropy is a robust indicator of loss of...
Article
Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by vivid and elaborate visual imagery. Here, we investigated the electrophysiological correlates of the DMT induce...
Preprint
Full-text available
Background N,N-Dimethyltryptamine (DMT) is a short acting psychedelic tryptamine found naturally in many plants and animals. Few studies to date addressed the neural and psychological effects of DMT alone, either administered intravenously or inhaled in freebase form, and none conducted in natural settings. Aims Our primary aim was to study the ac...
Preprint
Full-text available
Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) is a particularly interesting serotonergic psychedelic that can rapidly induce an extremely immersive state of consciousness characterized by vivid and elaborate visual imagery. In the present...
Article
The regulatory role of the serotonergic system on conscious perception can be investigated perturbatorily with psychedelic drugs such as N,N-Dimethyltryptamine. There is increasing evidence that the serotonergic system gates prior (endogenous) and sensory (exogenous) information in the construction of a conscious experience. Using two generative de...
Article
Full-text available
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal div...
Preprint
Full-text available
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N- Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal di...
Article
Full-text available
Responses to psychedelics are notoriously difficult to predict, yet significant work is currently underway to assess their therapeutic potential and the level of interest in psychedelics among the general public appears to be increasing. We aimed to collect prospective data in order to improve our ability to predict acute- and longer-term responses...
Article
Full-text available
Near-death experiences (NDEs) are complex subjective experiences, which have been previously associated with the psychedelic experience and more specifically with the experience induced by the potent serotonergic, N,N-Dimethyltryptamine (DMT). Potential similarities between both subjective states have been noted previously, including the subjective...
Article
Full-text available
Under the predictive coding framework, perceptual learning and inference are dependent on the interaction between top-down predictions and bottom-up sensory signals both between and within regions in a network. However, how such feedback and feedforward connections are modulated in the state induced by lysergic acid diethylamide (LSD) is poorly und...
Article
Full-text available
The medial pFC (mPFC) and ACC have been consistently implicated in learning predictions of future outcomes and signaling prediction errors (i.e., unexpected deviations from such predictions). A computational model of ACC/mPFC posits that these prediction errors should be modulated by outcomes occurring at unexpected times, even if the outcomes them...
Poster
Full-text available
In the literature, the importance of medial prefrontal cortex (mPFC) and its interactions with the dopaminergic system in learning and predicting events is clearly established. Mediofrontal event-related potential (ERP) components originating from mPFC, such as feedback-related negativity (fERN), have been found to code for Feedback Prediction Erro...
Article
Full-text available
The main scope of this review is to expose the main advances regarding recent research of psychedelic substances in the neurociences and their potential psychotherapeutic applications. Psilocybin, a 5-HT2A receptor agonist has been associated with reduced activity in the Default-Mode Network (commonly activated during introspection and self-reflect...
Article
Full-text available
The main scope of this review is to expose the main advances regarding recent research of psychedelic substances in the neurociences and their potential psychotherapeutic applications. Psilocybin, a 5-HT2A receptor agonist has been associated with reduced activity in the Default- Mode Network (commonly activated during introspection and self-reflec...

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Projects

Projects (2)
Project
We argue that the Bayesian predictive processing account of brain function is a useful framework for developing an integrated, multi-level neuroscience of psychedelic drugs, spanning receptor pharmacology, neuroanatomy, computation, cognition, and phenomenology. The paper extends Bayesian interpretations of drug models of clinical psychosis (delusions and hallucinations) to psychedelic neuroscience. Paradigm perceptual and cognitive effects of serotonergic psychedelics (LSD, psilocybin, DMT), dissociative anesthetics (ketamine, PCP, nitrous oxide), and other drugs (salvinorin A, THC) are interpreted within the predictive processing framework. Future research and methodological issues inspired by the framework are considered. We discuss epistemic, recreational, phenomenological, entheogenic, clinical, and psychotherapeutic implications of the Bayesian framework. (Please see outline and references bellow!)