Christopher Weir

Christopher Weir
The University of Sydney · NBRC

PHD

About

21
Publications
3,746
Reads
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300
Citations
Citations since 2016
11 Research Items
118 Citations
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201620172018201920202021202205101520
201620172018201920202021202205101520
Introduction
Christopher Weir currently works at the NBRC, University of Sydney. Christopher does research into cancer immunotherapy.
Skills and Expertise
Additional affiliations
April 2006 - present
Kolling Institute of Medical Research
Position
  • Research Associate
April 2005 - present
Royal North Shore Hospital
Position
  • Research Associate

Publications

Publications (21)
Article
Full-text available
Background The lymphocyte transformation test (LTT) is an in vitro assay used to diagnose drug induced hypersensitivity reactions by detecting the activation and expansion of drug-specific memory T cells to the suspected implicated drug. Traditionally radiolabelled thymidine (3H-thymidine) has been used but requires the handling and disposal of rad...
Article
Full-text available
Canine cancer rates are similar to humans, though the therapeutic options might be limited. Inducing a patient’s own immune system to have an anti-tumor response is an attractive approach to cancer therapy. In this safety study, autologous tumor vaccines produced specifically for each canine patient were combined with Advax™, a novel non-inflammato...
Article
Full-text available
Malignant pleural mesothelioma is an aggressive cancer with poor prognosis. Here we have investigated in vitro efficacy of BAMLET and BLAGLET complexes (anti-cancer complexes consisting of oleic acid and bovine α-lactalbumin or β-lactoglobulin respectively) in killing mesothelioma cells, determined BAMLET and BLAGLET structures, and investigated po...
Data
Supporting information file. (DOC)
Data
Data and code files for qPCR experiments. (GZ)
Data
Data and code files for human and rat cell viability assays. (TGZ)
Article
Full-text available
The enormous upsurge of interest in immune-based treatments for cancer such as vaccines and immune checkpoint inhibitors, and increased understanding of the role of the tumor microenvironment in treatment response, collectively point to the need for immune-competent orthotopic models for pre-clinical testing of these new therapies. This paper demon...
Article
Full-text available
Mesothelioma is inherently chemo-resistant with only 50% of patients responding to the standard of care treatments, and consequently it has a very grim prognosis. The aim of this study was to establish a panel of chemo-resistant mesothelioma models with clinically relevant levels of resistance as tools for investigating chemo-resistance and identif...
Article
Full-text available
Induction of antitumor immunity using autologous tumor proteins is an attractive approach to cancer therapy. However, better methods and stimulants to present these autologous proteins back to the immune system are needed. Here, we identify streptavidin as a novel carrier protein and stimulant, and test the efficacy of both syngeneic (rat) and auto...
Article
Full-text available
Cell therapies have been used to regenerate the heart by direct myocardial delivery, by coronary infusion and by surface attached scaffolds. Multipotent mesenchymal stem cells (MSC) with capacity to differentiate into cardiomyocytes and other cell lines have been predominantly trialled in rodents. However, large animal models are increasingly neede...
Article
An internal positive control for Cryptosporidium and Giardia monitoring was evaluated for use in routine water monitoring quality control. The control, known as ColorSeed C&G (BTF Pty Ltd, Sydney, Australia), is a suspension containing exactly 100 Cryptosporidium oocysts and 100 Giardia cysts that have been modified by attachment of Texas Red to th...
Article
Full-text available
The detection of Cryptosporidium oocysts in drinking water is critically dependent on the quality of immunofluorescent reagents. Experiments were performed to develop a method for producing highly specific antibodies to Cryptosporidium oocysts that can be used for water testing. BALB/c mice were immunized with six different antigen preparations and...
Article
Routine detection of Cryptosporidium oocysts and Giardia cysts depend on immunofluorescence assays (IFA) employing fluorescently labeled monoclonal antibodies. Commercially available mAbs used for the detection of Cryptosporidium oocysts are of the IgM or IgG3 subclass, whilst those used for Giardia analysis are of IgM and IgG classes including IgG...
Article
A simple method is described for the evaluation and quality control of Cryptosporidium-specific antibodies used in monitoring environmental water samples. Purified oocysts were fluorescently labelled with a test antibody at the appropriate concentration. Labelled oocysts were analysed using flow cytometry and a region was defined on a bivariate dot...

Questions

Question (1)
Question
Hi All...can anyone give us a hand to work how to make a 60uM H0CL solution from standard bleach.  I think our stock sodium hypochlorite is 12.5%.
Cheers
Chris

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