Christopher Tabone

Christopher Tabone
Harvard University | Harvard · Center for Brain Science

Ph.D.

About

17
Publications
2,276
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,578
Citations
Citations since 2017
6 Research Items
1448 Citations
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Additional affiliations
February 2011 - present
Trinity College Dublin
September 2005 - May 2011
University of Nevada, Las Vegas
Education
September 2005 - May 2011
University of Nevada, Las Vegas
Field of study
  • Biology, Cellular & Molecular
September 2001 - May 2005
Fordham University
Field of study
  • Biology

Publications

Publications (17)
Article
Full-text available
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computationa...
Article
Full-text available
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computationa...
Article
Full-text available
FlyBase (flybase.org) is an essential online database for researchers using Drosophila melanogaster as a model organism, facilitating access to a diverse array of information that includes genetic, molecular, genomic and reagent resources. Here, we describe the introduction of several new features at FlyBase, including Pathway Reports, paralog info...
Article
Full-text available
The Alliance of Genome Resources (Alliance) is a consortium of the major model organism databases and the Gene Ontology that is guided by the vision of facilitating exploration of related genes in human and well-studied model organisms by providing a highly integrated and comprehensive platform that enables researchers to leverage the extensive bod...
Article
Odor perception allows animals to distinguish odors, recognize the same odor across concentrations, and determine concentration changes. How the activity patterns of primary olfactory receptor neurons (ORNs), at the individual and population levels, facilitate distinguishing these functions remains poorly understood. Here, we interrogate the comple...
Preprint
Full-text available
Animals can identify an odorant type across a wide range of concentrations, as well as detect changes in concentration for individual odorant type. How olfactory representations are structured to support these functions remains poorly understood. Here, we studied how a full complement of ORNs in the Drosophila larva encodes a broad input space of o...
Article
Full-text available
Since 1992, FlyBase (flybase.org) has been an essential online resource for the Drosophila research community. Concentrating on the most extensively studied species, Drosophila melanogaster, FlyBase includes information on genes (molecular and genetic), transgenic constructs, phenotypes, genetic and physical interactions, and reagents such as stock...
Preprint
Full-text available
The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neuro...
Article
Full-text available
Significance A full understanding of sensorimotor transformation during complex behaviors requires quantifying brainwide dynamics of behaving animals. Here, we characterize brainwide dynamics of individual nematodes exposed to a defined thermosensory input. We show that it is possible to uncover representations of sensory input and motor output in...
Article
Full-text available
Significance A previously unidentified set of thermosensory neurons embedded in the olfactory organ of the Drosophila larva is shown to be required to drive the animal up temperature gradients toward preferred environments. Optogenetics and optical neurophysiology reveal efficient sensory encoding of both favorable (warming) and unfavorable (coolin...
Article
Introduction Olfactory learning and memory are widely investigated in Drosophila neuroscience. Assays can serve as simple measurements of behavioral plasticity in whole animals by harnessing the innate importance of olfactory cues for the fly (Lebreton et al., 2012). A successful fly learning assay needs to do only one thing well: Ask a simple ques...
Article
The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory.
Article
Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including learning, but the neurotransmitters...
Article
Full-text available
Associative conditioning in Drosophila melanogaster has been well documented for several decades. However, most studies report only simple associations of conditioned stimuli (CS, e.g., odor) with unconditioned stimuli (US, e.g., electric shock) to measure learning or establish memory. Here we describe a straightforward second-order conditioning (S...
Article
The family of Eph and ephrin receptors is involved in a variety of functions in normal cells, and the alterations in their expression profiles have been observed in several cancers. We have compared the transcripts for Eph receptors and ephrin ligands in cell lines established from normal prostate epithelium and several carcinoma cell lines isolate...
Article
Full-text available
There are more than 50 genes for autosomal dominant and autosomal recessive nonsyndromic hereditary deafness that are yet to be cloned. The human genome sequence and expression profiles of transcripts in the inner ear have aided positional cloning approaches. The knowledge of protein interactions offers additional advantages in selecting candidate...

Network

Cited By