Christopher Sinke

Christopher Sinke
Hannover Medical School | MHH · Clinic for Psychiatry Social Psychiatry and Psychotherapy

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59
Publications
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618
Citations

Publications

Publications (59)
Article
Full-text available
Morphological differences in the auditory brain of musicians compared to nonmusicians are often associated with life‐long musical activity. Cross‐sectional studies, however, do not allow for any causal inferences, and most experimental studies testing music‐driven adaptations investigated children. Although the importance of the age at which musica...
Article
Full-text available
While aging is characterized by neurodegeneration, musical training is associated with experience-driven brain plasticity and protection against age-related cognitive decline. However, evidence for the positive effects of musical training mostly comes from cross-sectional studies while randomized controlled trials with larger sample sizes are rare....
Article
Full-text available
While aging is characterized by neurodegeneration, musical training is associated with experience-driven brain plasticity and protection against age-related cognitive decline. However, evidence for the positive effects of musical training mostly comes from cross-sectional studies while randomized controlled trials with larger sample sizes are rare....
Article
Background: Inhibition of frowning via injections of botulinum toxin A (BTX) into the glabellar region has shown beneficial effects in the treatment of major depression. Preliminary research suggests that improvements in the affective domain are not depression-specific, but may also translate to other psychiatric disorders. Aim: This 16-week, singl...
Article
Synaesthesia is a phenomenon in which the stimulation of one sensory modality automatically and consistently over time evokes a sensation in the same or a different modality in an idiosyncratic manner. In addition to pure sensory coupling, synaesthetes are characterized by cognitive peculiarities, such as abnormalities in perception, creativity, ad...
Article
Numerous studies have shown associations between anomalies of the serotonergic system and impulsive behavior, depression, or traumatic life events. However, it is currently unknown, whether pedophilia or child sexual offending (CSO) is also related to alterations of the serotonergic system. Using a two by two factorial paradigm within a multisite c...
Article
Deficits in audiovisual speech perception have consistently been detected in patients with Autism Spectrum Disorder (ASD). Especially for patients with a highly functional subtype of ASD, it remains uncertain whether these deficits and underlying neural mechanisms persist into adulthood. Research indicates differences in audiovisual speech processi...
Article
Full-text available
Understanding speech in background noise poses a challenge in daily communication, which is a particular problem among the elderly. Although musical expertise has often been suggested to be a contributor to speech intelligibility, the associations are mostly correlative. In the present multisite study conducted in Germany and Switzerland, 156 healt...
Article
Deficits in cognitive empathy (CE) have been associated with a child sexual offense (CSO) history in paedophilia. However, these results have been obtained in cross-sectional comparison. There are no longitudinal studies yet. We performed a longitudinal study with a 3-year interval and investigated CE and emotional empathy (EE) using the Multifacet...
Article
Background A widened temporal window of integration (TWI) in audiovisual processing has been detected for children with autism spectrum disorder. However, research indicates a narrowing of this TWI and an associated change in audiovisual integration in the course of development. Methods To further elucidate audiovisual integration processes in adu...
Article
Synaesthesia is a multimodal phenomenon in which the activation of one sensory modality leads to an involuntary additional experience in another sensory modality. To date, normal multisensory processing has hardly been investigated in synaesthetes. In the present study we examine processes of audiovisual separation in synaesthesia by using a simult...
Article
Botulinum toxin (BTX) treatment of glabellar frown lines is one of the most common procedures in aesthetic medicine. In addition to its cosmetic effect, the neurotoxin has been shown to have a positive influence on mood and affect. Several randomized clinical trials (RCTs) have examined the effect of botulinum toxin on the treatment of depression....
Article
Full-text available
Background Recent data suggest that musical practice prevents age-related cognitive decline. But experimental evidence remains sparse and no concise information on the neurophysiological bases exists, although cognitive decline represents a major impediment to healthy aging. A challenge in the field of aging is developing training regimens that sti...
Article
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Pornography has been repeatedly at the centre of public attention and has been controversially discussed for a long time. However, little is known about the connection between pornographic stimuli and individual (neuronal) processing of attention and memory. Here, the impact and neural underpinnings of pornographic pictures on working memory proces...
Article
Full-text available
Background Attentional control has been observed to play an important role in affective disorders by impacting information processing, the ability to exert top–down control in response to distracting stimuli, and by affecting emotional regulation. Prior studies demonstrated an association between attentional control and response to psychotherapy, t...
Article
Full-text available
Our ability to integrate multiple sensory-based representations of our surrounding supplies us with a more holistic view of our world. There are many complex algorithms our nervous system uses to construct a coherent perception. An indicator to solve this ‘binding problem’ are the temporal characteristics with the specificity that environmental inf...
Article
Full-text available
Audiovisual (AV) integration deficits have been proposed to underlie difficulties in speech perception in Asperger’s syndrome (AS). It is not known, if the AV deficits are related to alterations in sensory processing at the level of unisensory processing or at levels of conjoint multisensory processing. Functional Magnetic-resonance images (MRI) wa...
Article
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Background: Several lines of evidence support the hypothesis of an autoimmune origin of Gilles de la Tourette-Syndrome (GTS). Accordingly, in a recent study we detected positive oligoclonal bands (OCB) in cerebrospinal fluid (CSF) in >30% of adult patients indicating an intrathecal antibody synthesis. However, until today no corresponding antibodie...
Article
Full-text available
High prevalence of child sexual offending stand in contradiction to low conviction rates (one-tenth at most) of child sexual offenders (CSOs). Little is known about possible differences between convicted and non-convicted pedophilic CSOs and why only some become known to the judicial system. This investigation takes a closer look at the two sides o...
Article
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Background and aims: Despite the high prevalence of perceived problems relating to symptoms of hypersexual disorder (HD), important aspects remain underinvestigated. This study examines symptoms of depression, symptoms of problematic cybersex, and coercive sexual behavior in a large online sample from a German-speaking population. Methods: In an...
Article
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The affiliations. Originally, Kolja Schilz was named last in the affiliations, implying that he is the senior author. This has been corrected; Kolja Schilz is now mentioned after Martin Walter in both the html and PDF versions of the article.
Article
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Problems arising from hypersexual behavior are often seen in clinical settings. We aimed to extend the knowledge about the clinical characteristics of individuals with hypersexual disorder (HD). A group of people who fulfilled the proposed diagnostic criteria for HD (men with HD, n = 50) was compared to a group of healthy controls (n = 40). We inve...
Article
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Background: The Attention Training Technique (ATT) as part of Metacognitive Therapy (MCT) has shown to be a promising treatment element for several psychiatric disorders such as depression and anxiety. ATT predicts improvements of the ability to shift attention away from internal and non-relevant stimuli (e.g., ruminative thoughts) toward the relev...
Article
Full-text available
Child sexual offending (CSO) places a serious burden on society and medicine and pedophilia (P) is considered a major risk factor for CSO. The androgen system is closely linked to sexual development and behavior. This study assessed markers of prenatal brain androgenization, genetic parameters of androgen receptor function, epigenetic regulation, a...
Conference Paper
Background: Child sexual abuse and neglect have been related to an increased risk of the victims to develop of a wide range of behavioral, psychological and sexual problems and increased rates of suicidal behavior. Contrary to the large amount of research focusing on the negative mental health consequences of child sexual abuse, very little is know...
Article
Background Child sexual abuse and neglect have been related to an increased risk for the development of a wide range of behavioral, psychological, and sexual problems and increased rates of suicidal behavior. Contrary to the large amount of research focusing on the negative mental health consequences of child sexual abuse, very little is known abou...
Article
Borderline personality disorder (BPD) is characterized by difficulties in emotional regulation and impulse control. In this study, we presented a novel picture-based emotional go/no-go task with distracting emotional faces in the background, which was administered to 16 patients with BPD and 16 age-matched healthy controls. The faces displayed diff...
Conference Paper
Full-text available
Introduction & objectives: Despite all efforts child sexual offending is still a worldwide concern. Child sexual abuse and neglect has been related to an increased risk for the development of a wide range of behavioral, psychological and sexual problems and increased rates of suicidal behavior. Contrary to the large amount of research focusing on t...
Article
Introduction: In the present study we were interested in the processing of audio-visual integration in schizophrenia compared to healthy controls. The amount of sound-induced double-flash illusions served as an indicator of audio-visual integration. We expected an altered integration as well as a different window of temporal integration for patien...
Article
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We describe a patient LS, profoundly deaf in both ears from birth, with underdeveloped superior temporal gyri. Without hearing aids, LS displays no ability to detect sounds below a fixed threshold of 60 dBs, which classifies him as clinically deaf. Under these no-hearing-aid conditions, when presented with a forced-choice paradigm in which he is as...
Article
Background Expectations can dramatically influence the perception of pain, as has been shown in placebo analgesia or nocebo hyperalgesia. Here, we investigated the role of expectation on the interruptive function of pain - the negative consequences of pain on cognitive task performance - in 42 healthy human subjects. Methods Verbal and written inst...
Article
Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity...
Article
Over the recent years, neuroimaging studies have investigated the neural mechanisms underlying the influence of expectations on perception. However, it seems equally reasonable to assume that expectations impact cognitive functions. Here we used fMRI to explore the role of expectations on task performance and its underlying neural mechanisms. 43 he...
Article
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The interruptive effect of painful experimental stimulation on cognitive processes is a well-known phenomenon. This study investigated the influence of pain duration on the negative effects of pain on cognition. Thirty-four healthy volunteers performed a rapid serial visual presentation task (RSVP) in which subjects had to detect (visual detection...
Article
Full-text available
Neurobiological aspects of synaesthesia are discussed from the perspective of the broader philosophical topic of “syn-aisthesis” and the basic fundamentals of a neuropsychological understanding of perceptual inter-modal integration. Herein, the predominance of conceptualization processes in regard to top-down functions of the brain appears as a pre...
Article
Recent research suggests synesthesia as a result of a hypersensitive multimodal binding mechanism. To address the question whether multimodal integration is altered in synesthetes in general, grapheme-colour and auditory-visual synesthetes were investigated using speech-related stimulation in two behavioural experiments. First, we used the McGurk i...
Article
Full-text available
Synesthesia entails a special kind of sensory perception, where stimulation in one sensory modality leads to an internally generated perceptual experience of another, not stimulated sensory modality. This phenomenon can be viewed as an abnormal multisensory integration process as here the synesthetic percept is aberrantly fused with the stimulated...
Article
Full-text available
There is increasing evidence from case reports that synesthesia is more common in individuals with autism spectrum conditions (ASC). Further, genes related to synesthesia have also been found to be linked to ASC and, similar to synaesthetes, individuals with ASC show altered brain connectivity and unusual brain activation during sensory processing....
Article
Neurobiological aspects of synaesthesia are discussed from the perspective of the broader philosophical topic of “syn-aisthesis” and the basic fundamentals of a neuropsychological understanding of perceptual inter-modal integration. Herein, the predominance of conceptualization processes in regard to top-down functions of the brain appears as a pre...
Article
Grapheme-color synesthesia is a condition in which letters are perceived with an additional color dimension. To identify brain regions involved in this type of synesthesia and to analyze functional connectivity of these areas, 18 grapheme-color synesthetes and 18 matched controls were stimulated with letters and pseudo-letters presented in black an...
Article
It has been suggested that synaesthesia is the result of a hyper-sensitive multimodal binding-mechanism. To address the question whether multi-modal integration is altered in synaesthetes in general, grapheme-colour and auditory-visual synaesthetes were studied using the double-flash illusion. This illusion is induced by a single light flash presen...
Article
Despite some principal similarities, there is no systematic comparison between the different types of synesthesia (genuine, acquired and drug-induced). This comprehensive review compares the three principal types of synesthesia and focuses on their phenomenological features and their relation to different etiological models. Implications of this co...
Article
In synesthesia, certain stimuli to one sensory modality lead to sensory perception in another unstimulated modality. In addition to other models, a two-stage model is discussed to explain this phenomenon, which combines two previously formulated hypotheses regarding synesthesia: direct cross-activation and hyperbinding. The direct cross-activation...
Article
Full-text available
Synesthesia is a condition in which stimulation in one processing stream (e.g., letters or music) leads to perception in an unstimulated processing stream (e.g., colors). Behavioral differences in mutisensory processing have been shown for multimodal illusions, but the differences in neural processing are still unclear. In the present study, we exa...
Article
Full-text available
In synaesthesia certain external stimuli (e.g., music) trigger automatically internally generated sensations (e.g., colour). Results of behavioural investigations indicate that multisensory processing works differently in synaesthetes. However, the reasons for these differences and the underlying neural correlates remain unclear. The aim of the cur...
Article
In auditory-visual synaesthesia, all kinds of sound can induce additional visual experiences. To identify the brain regions mainly involved in this form of synaesthesia, functional magnetic resonance imaging (fMRI) has been used during non-linguistic sound perception (chords and pure tones) in synaesthetes and non-synaesthetes. Synaesthetes showed...
Article
Color percept induction in synaesthetes by hearing words was previously shown to involve activation of visual and specifically color processing cortex areas. While this provides a rationale for the origin of the anomalous color percept the question of mechanism of this crossmodal activation remains unclear. We pursued this question with fMRI in col...
Conference Paper
Full-text available
In this paper we present a reliable approach for real-time outdoor trail following and obstacle avoidance. The trail classification is done using an off-the-shelf webcam and a pitched 2D laser scanner on a KURT2 robot equipped with an Intel Centrino laptop. This simple setup enables us to follow given pathways of different kinds using a GPS receive...

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