Christopher J Patrick

Florida State University | FSU · Department of Psychology

Prior studies have found an association between reduced P3 brain responses—a neural marker of task engagement—and increased depressive symptoms during adolescence. However, it is unclear whether P3 correlates with depression globally, or with certain facets. Existing depression studies have also typically quantified P3 as a cross-trial average, neg...

Understanding the neurobiological mechanisms involved in psychopathology has been hindered by the limitations of categorical nosologies. The Hierarchical Taxonomy of Psychopathology (HiTOP) is an alternative dimensional system for characterizing psychopathology, derived from quantitative studies of covariation among diagnoses and symptoms. HiTOP pr...

Psychophysiology can help elucidate the structure and developmental mechanisms of psychopathology, consistent with the Research Domain Criteria initiative. Cross-sectional research using categorical diagnoses indicates that P300 is an electrocortical endophenotype indexing genetic vulnerability to externalizing problems. However, current diagnostic...

Background Neuropsychiatric symptoms are common after traumatic brain injury (TBI) and often resolve within 3 months post-injury. However, the degree to which individual patients follow this course is unknown. We characterized trajectories of neuropsychiatric symptoms over 12 months post-TBI. We hypothesized that a substantial proportion of individ...

In the DSM-5 Alternative Model of Personality Disorders (AMPD), psychopathy is marked by the presence of attention seeking, low anxiousness, and lack of social withdrawal, along with traits from the domains of Antagonism and Disinhibition. The triarchic model of psychopathy (TriPM) posits three biobehaviorally based traits underlying it: disinhibit...

The triarchic model posits that distinct trait constructs of boldness, meanness, and disinhibition underlie psychopathy. The triarchic model traits are conceptualized as biobehavioral dimensions that can be assessed using different sets of indicators from alternative measurement modalities; as such, the triarchic model would hypothesize that these...

Considerable research has linked relative reduction in the amplitude of the P3 event-related potential (ERP) during cognitive task performance (i.e., Target-P3) with increased risk of alcohol-related problems. A separate literature indicates that a relative increase in the amplitude of the P3 elicited by cues signaling alcohol availability (i.e., A...

Psychopathy is a topic that has long been fascinating to the public at large as well as to scientists and clinical practitioners. However, it has also been subject to considerable confusion and scholarly debate over the years. This chapter describes alternative conceptions of psychopathy that have been proposed historically, and reviews major instr...

Background Lower autonomic arousal is a well-known correlate of criminal offending and other risk-taking behaviors in men, but few studies have investigated this association in women. Aim To test associations between autonomic arousal and criminal offending as well as unintentional injuries among female conscripts. Methods All women born 1958–199...

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a dimensional framework for psychopathology advanced by a consortium of nosologists. In the HiTOP system, psychopathology is grouped hierarchically from super-spectra, spectra, and subfactors at the upper levels to homogeneous symptom components and maladaptive traits and their constituent sym...

Attention-deficit/hyperactivity disorder (ADHD) symptoms are associated with myriad adverse outcomes, including interpersonal difficulties, but factors that moderate the developmental course and functional impact of ADHD over time are not well understood. The present study evaluated developmental contributions of the triarchic neurobehavioral trait...

Concerns about physical appearance are a salient feature of several psychiatric conditions, and various self-report-based measures of appearance concerns have been developed for different disorders. An important question, with implications for understanding comorbidity and processes underlying it, is whether these different measures may in fact be...

Intimate partner violence (IPV) is a serious and recurrent phenomenon in many societies with severe physical and psychological consequences. In the present study, we aimed to explore the role of triarchic dimensions of psychopathy (disinhibition, boldness, and meanness) across gender in this occurrence. A questionnaire on inflicted (self) and exper...

The two broad aims of this study were to (a) investigate how the three traits of the triarchic model-boldness, meanness, and disinhibition-relate to compliance with public health measures, as well as to internalizing and externalizing psychopathology, during a public health crisis, and (b) test for associations between psychopathology and complianc...

This study links different-modality indicators of RDoC constructs (self-reports, behavior, and error-related brain activity) to explore their association with internalizing and externalizing dimensions of psychopathology. Participants (N = 182; 54% female) completed a questionnaire assessing clinical problems along with self-report scales and EEG t...

The organization of the Hierarchical Taxonomy of Psychopathology (HiTOP) model provides unique opportunities to evaluate whether neural risk measures operate as indicators of broader latent liabilities (e.g., externalizing proneness) or narrower expressions (e.g., antisociality and alcohol abuse). Following this approach, the current study recruite...

Historically, researchers have proposed higher-order factors to explicate the structure of psychopathology, including Externalizing, Internalizing, Fear, Distress, Thought Disorder, and a general factor. Despite extensive research in this domain, the underlying structure of psychopathology remains unresolved. Here, we examine several issues in adju...

Initiation of alcohol use at younger ages is prognostic of later drinking problems. Reward system dysfunction is theorized to contribute to early initiation and escalation of drinking, but existing evidence supports both hyposensitivity and hypersensitivity as risk-markers; research employing effective indices of reward processing is needed for cla...

Understanding the neurobiological systems involved in psychopathology has been hindered by the limitations of categorical nosologies, spurring the development of alternative dimensional systems for characterizing psychopathology. The Hierarchical Taxonomy of Psychopathology (HiTOP) is one such system, derived from quantitative studies of covariatio...

Now in its fourth edition, the acclaimed Oxford Textbook of Psychopathology aims for both depth and breadth, with a focus on adult disorders and special attention given to personality disorders. It provides an unparalleled guide for professionals and students alike. Esteemed editors Robert F. Krueger and Paul H. Blaney selected the most eminent res...

Now in its fourth edition, the acclaimed Oxford Textbook of Psychopathology aims for both depth and breadth, with a focus on adult disorders and special attention given to personality disorders. It provides an unparalleled guide for professionals and students alike. Esteemed editors Robert F. Krueger and Paul H. Blaney selected the most eminent res...

The triarchic model of psychopathy emphasizes the role of three phenotypic personality domains (boldness, meanness, and disinhibition) that have been operationalized using the well-established Multidimensional Personality Questionnaire. The present study sought to further validate the MPQ-Tri scales and examine their temporal stability and predicti...

Given growing evidence for a joint hierarchical framework of clinical and personality symptomatology, situating triarchic traits within this model would acknowledge transdiagnostic trait-related variance and provide a basis for linking the DSM-5 Alternative Model of Personality Disorders (AMPD) domains to established indicators of these neurobehavi...

The Externalizing Spectrum Inventory–Brief Form (ESI-BF) measures tendencies toward disinhibition, lack of control, aggression, and substance use. This study adapts the ESI-BF to the Spanish population and assesses its psychometric properties. The study included 742 community adults obtained by stratified random sampling with proportional allocatio...

The field of experimental psychopathology has emerged and matured over the past century. It has emphasized the use of experimental psychology laboratory methods to leverage insights into the etiology and pathogenesis of psychopathology. The authors briefly review the history of experimental psychopathology and advance a number of viewpoints, argume...

Scott O. Lilienfeld maintained an intense and probing interest in the interface of personality and psychopathology. He was especially intrigued by the personality systems subserving the clinical construct/disorder of psychopathy. Each of us knew Lilienfeld at various junctures in his academic career, and here we celebrate his scientific interest in...

Historically, researchers have proposed higher-order factors to explicate the structure of psychopathology, including Externalizing, Internalizing, Fear, Distress, Thought Disorder, and a general factor. Despite extensive research in this domain, the underlying structure of psychopathology remains unresolved. Herein, we examine several issues in ad...

This study explored the generality versus specificity of two trait-liability factors for externalizing problems-disinhibition and callousness-in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperactivity disorder (ADHD), and substance use (i.e., alcohol use disorder and history of illicit substance us...

Purpose Resting heart rate (RHR) is a well-established biological risk factor for criminal behavior. However, potential moderating effects of social risk factors like socioeconomic status on this relationship remain unclear. The current study sought to clarify the moderating impact of socioeconomic status on the relation between low RHR in childhoo...

Low resting heart rate (HR) is a known risk indicator for the development of antisocial behavior (ASB) and other clinical problems. Stimulation seeking and fearlessness have been explored as factors underlying the HR/ASB relationship, but these have often been conflated, which has complicated interpretation. We examined HR’s associations with ASB a...

Background Reward sensitivity is a dimensional construct central to understanding the nature of depression. Psychophysiological research on this construct has primarily focused on the reward positivity (RewP), an event-related potential (ERP) that indexes consummatory reward sensitivity. The current study extended prior research by focusing on ERPs...

The triarchic model of psychopathy posits that three distinct trait dispositions-disinhibition, meanness, and boldness-contribute to the interpersonal, affective, and impulsive-unrestrained features of this condition and is represented to varying degrees in all conceptualizations and measures of psychopathy. Using data for incarcerated males (n = 2...

Recent initiatives have focused on integrating transdiagnostic biobehavioral processes or dispositions with dimensional models of psychopathology. Toward this goal, biobehavioral traits of affiliative capacity (AFF) and inhibitory control (INH) hold particular promise as they demonstrate transdiagnostic stability and predictive validity across deve...

Understanding factors that influence behavioral performance in high-pressure contexts is relevant to critical occupations such as first responders, military personnel, and frontline medical workers. A recent study by Yancey et al. (2019) demonstrated an association between boldness, a biobehavioral trait reflecting social dominance and fearlessness...

Antisocial behavior has been linked to an increased tolerance of painful stimuli; however, there is evidence that pain behavior is multidetermined. The current study used pain measures from 3 different modalities (pain tolerance, pain ratings, electrocortical reactivity) and assessed triarchic traits of boldness and meanness to clarify the disposit...

The present study sought to extend knowledge of the role of boldness, a transdiagnostic bipolar trait dimension involving low sensitivity to threat, in emotional reactivity and regulation using physiological and report-based measures. One prior study found that boldness was associated with reduced late positive potential (LPP) while passively viewi...

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological system that addresses shortcomings of traditional mental disorder diagnoses, including arbitrary boundaries between psychopathology and normality, frequent disorder co-occurrence, substantial heterogeneity within disorders, and diagnostic unreliability over time and...

Background We examined associations of adverse perinatal events with offspring violent and non-violent criminal convictions in men and women. Methods All singleton births between 1973 and 1995 (n = 1,146,570 men, n = 1,085,217 women) were identified through Swedish population-based registers. Information about adverse perinatal events was retrieve...

The triarchic model of psychopathy conceptualizes variants of this clinical condition as expressions of three distinct biobehavioral dispositions, termed boldness, meanness, and disinhibition. As a trait-oriented model, the triarchic model situates psychopathy within a broader nomological network of personality and psychopathology, and has proven u...

Multiple theoretical perspectives posit that drug use leads to biased valuation of drug‐related reward, at the expense of naturally occurring rewarding activities (i.e., reward dysregulation). Recent research suggests that the comparative balance of drug‐related and nondrug‐related reward valuation is a powerful determinant of substance misuse and...

The validity of self-report psychopathy assessment has been questioned, especially in forensic settings where clinical evaluations influence critical decision-making (e.g., institutional placement, parole eligibility). Informant-based assessment offers a potentially valuable supplement to self-report but is challenging to acquire in under-resourced...

The startle reflex has been suggested to operate as a psychophysiological marker of psychopathic personality, based on findings from studies using a range of different methodologies and participant samples. The present review aims at synthesizing existing evidence of the relationship between psychopathy and the startle reflex across task paradigms,...

Neuropsychiatric symptoms are common, comorbid, and often disabling for patients with traumatic brain injury (TBI). Identifying transdiagnostic symptom dimensions post-TBI may help overcome limitations of traditional psychiatric diagnoses and advance treatment development. We characterized the dimensional structure of neuropsychiatric symptoms at 2...

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations of traditional mental disorder diagnoses. These include arbitrary boundaries between disorder and normality, disorder co‐occurrence in the modal case, heterogeneity of presentation within dis­orders, and instability of diagnosis within patients. This...

Background Recent efforts to classify subtypes of major depressive disorder marked by different psychophysiological indicators have identified blunted reward-related brain activation in gambling tasks as a characteristic linked specifically to depressed participants with impaired mood reactivity. Methods The current study compared individuals diag...

Antisocial behavior has been linked to an increased tolerance of painful stimuli; however, there is evidence that pain behavior is multi-determined. The current study used pain measures from three different modalities (pain tolerance, pain ratings, electrocortical reactivity) and assessed triarchic traits of boldness and meanness to clarify the dis...

Aberrant reward processing is a cardinal feature of various forms of psychopathology. However, recent research indicates that aberrant reward processing may manifest at temporally distinct substages and involve interdependent subcomponents of reward processing. To improve our understanding of both the temporal dynamics and distinct subcomponents of...

To establish a trait-dispositional variable as an indicator of liability for the development of substance use disorders (SUDs), the trait must share heritable variance with SUDs and its association should not be primarily attributable to a direct impact of SUDs on characteristics that define the trait. The current work applied a co-twin control (CT...

Psychopathic traits have been routinely associated with poor treatment outcomes in correctional settings. Less is known about how psychopathic traits relate to treatment processes (e.g., perceptions of treatment; adjustment to treatment), particularly in nonforensic settings. The current study tested for relationships between psychopathic traits, a...

The present study compared the primary models used in research on the structure of psychopathology (i.e., correlated factor, higher-order, and bifactor models) in terms of structural validity (model fit and factor reliability), longitudinal measurement invariance, concurrent and prospective predictive validity in relation to important outcomes, and...

Shortcomings of approaches to classifying psychopathology based on expert consensus have given rise to contemporary efforts to classify psychopathology quantitatively. In this paper, we review progress in achieving a quantitative and empirical classification of psychopathology. A substantial empirical literature indicates that psychopathology is ge...

This chapter examines the relationships between psychopathy and personality disorders (PDs) as defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5), with a focus on comorbidity, or the co‐occurrence of PDs with one another and with psychopathy. PDs listed in Section II of the DSM‐5 are grouped by themati...

A growing body of research supports the value of a multimodal assessment approach, drawing on measures from different response modalities, for clarifying how core biobehavioral processes relate to various clinical problems and dimensions of psychopathology. Using data for 507 healthy adults, the current study was undertaken to integrate self-report...

In the psychological science field, there is substantial interest in quantifying individual differences in self-regulatory capacity because of its transdiagnostic relevance to various forms of psychopathology. Trait disinhibition and impulsiveness are popular conceptualizations of dispositions reflecting self-regulation of behavioral and emotional...

A robust literature demonstrates that psychopathology and personality pathology are well-represented within quantitatively-derived, hierarchical dimensional models. Nevertheless, the location of core traits comprising psychopathic personality (psychopathy) as defined by the triarchic model has not been clearly explicated. We extended hierarchical s...

We critique Roy et al.'s (2020; this issue) approach to characterizing the item-level factor structure of the three scales of the Triarchic Psychopathy Measure (TriPM), in light of the manner in which the TriPM scales were developed, the purposes they were designed to serve, and the growing body of evidence supporting their construct validity. We f...

The DSM-5 alternative model for personality disorders (AMPD) groups traits into domains based on factor analyses of self-report data. AMPD traits may need to be configured differently to interface with neurobiology. Focusing on biobehavioral risk for externalizing problems in 334 adults, the authors used structural modeling to evaluate how well alt...

Recent initiatives emphasize the need to consider developmental and transdiagnostic contributions of temperamental variation to psychopathological expression. Triarchic neurobehavioral trait dimensions (boldness, meanness, disinhibition), which demonstrate compatibility with established temperament models and can be quantified using items from diff...

The triarchic model of psychopathy includes a disinhibition dimension related to externalizing outcomes, a meanness dimension pertaining to callous-unemotional traits, and a boldness dimension referring to emotional stability and high confidence in peer relationships. Some dimensions of psychopathy have been extensively investigated in samples of c...

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural model of psychological symptoms formulated to improve the reliability and validity of clinical assessment. Neurobiology can inform assessments of early risk and intervention strategies, and the HiTOP model has greater potential to interface with neurobiological measures...

The Hierarchical Taxonomy of Psychopathology (HiTOP) represents a crucial step forward in the empirical refinement of psychiatric nosology. Although grounded in factor analyses of clinical symptoms and affiliated traits, HiTOP encourages research using measures of other types, including neural‐system variables, to clarify coherent processes contrib...

Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorder...

Biologically relevant personality traits of weak inhibitory control (disinhibition) and threat sensitivity confer vulnerability to various clinical problems. Difficulties with emotion regulation have also been studied extensively in relation to risk for and maintenance of psychopathology. However, it remains unclear how emotion regulation strategie...

Objective: Diagnosis is a cornerstone of clinical practice for mental health care providers, yet traditional diagnostic systems have well-known shortcomings, including inadequate reliability, high comorbidity, and marked within-diagnosis heterogeneity. The Hierarchical Taxonomy of Psychopathology (HiTOP) is a data-driven, hierarchically based alte...

To establish a trait-dispositional variable as an indicator of liability for the development of substance use disorders (SUDs), the trait must share heritable variance with SUDs and its association should not be primarily attributable to a direct impact of SUDs on characteristics that define the trait. The current work applied a co-twin control (CT...

The biobehavioral traits of the triarchic model of psychopathy have well-known correlates with externalizing psychopathology. Although evidence also suggests associations with internalizing disorders, research has yet to formally model relationships between dimensions of internalizing psychopathology and triarchic traits. Employing a sample of 218...

Psychopathy, as described by the triarchic model, encompasses three distinct phenotypes: boldness, meanness, and disinhibition. The current study sought to operationalize these in a sample of 100 Dutch male forensic-psychiatric patients with differing forms of personality pathology who participated in a multi-site randomized clinical trial. Using a...

Callousness encompasses a lack of guilt, shallow affect, and deficient affiliative tendencies and relates to severe antisocial behavior. Across developmental stages, callousness is associated with abnormalities in emotional processing, including decreased physiological reactivity to emotional faces. The current study recruited an adult participant...

Structural models of psychopathology provide dimensional alternatives to traditional categorical classification systems. Competing models, such as the bifactor and correlated factors models, are typically compared via statistical indices to assess how well each model fits the same data. However, simulation studies have found evidence for probifacto...

The categorical model of personality disorder classification in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM–5]; American Psychiatric Association, 2013) is highly and fundamentally problematic. Proposed for DSM–5 and provided within Section III (for Emerging Measures and Models) was the...

The latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) bridges a significant gap in psychiatric nosology by providing trait-based characterizations of psychopathy along with antisocial personality disorder within the Section III alternative model for personality disorders (AMPD). However, the representation of psych...

Reward-deficit models of addiction posit weaknesses in reward sensitivity to be promotive of substance dependence, whereas the externalizing spectrum model views substance problems as arising in large part from a general disinhibitory liability. In the current study we sought to integrate these perspectives by testing for separate and interactive a...

Integrando Psicoterapia con la Taxonomía Jerárquica de Psicopatología (HiTOP) En este artículo, presentamos la Taxonomía Jerárquica de Psicopatología (HiTOP), una alternativa basada en evidencia al enfoque categórico para la clasificación diagnóstica que tiene una promesa considerable para la investigación y práctica de psicoterapia integrativa. Pr...

Set shifting involves the capacity to effectively and efficiently direct mental resources in the service of dynamically changing goal representations. This capacity is important in everyday life and may be vital in situations where processing resources needed for adaptive action may be diverted by cues for external danger or threat (e.g., first res...

The Research Domain Criteria initiative aims to reorient the focus of psychopathology research toward biobehavioral constructs that cut across different modalities of measurement, including self-report and neurophysiology. Constructs within the Research Domain Criteria framework are intentionally transdiagnostic, with the construct of “acute threat...

The etiology of major depressive disorder is heterogeneous, and differing pathways leading to the development of depression are proposed to account for alternative variants of depressive illness and their distinct comorbidity patterns. The present study was undertaken as a step toward developing a model for conceptualizing and quantifying dispositi...

Recent scientific initiatives have called for increased use of neurobiological variables in clinical and other applied assessments. However, the task of incorporating neural measures into psychological assessments entails significant methodological challenges that have not been effectively addressed to date. As a result, neurophysiological measures...

For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of mental illness. Here we outline one such dimensional system-the Hierarchical Taxonomy of Psychopathology (HiTOP)-that is...

We describe efforts to formulate a quantitative measurement model for boldness, a construct that has been intensively discussed and investigated in the psychopathy literature in recent years. Although the Fearless Dominance factor of the Psychopathic Personality Inventory (PPI-FD) has served as a major referent for studying this dispositional const...