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Christopher B Nelson

Christopher B Nelson
Sanofi Pasteur, Swiftwater, Pa USA

PhD MPH

About

77
Publications
62,979
Reads
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27,390
Citations
Additional affiliations
January 2014 - May 2016
Sabin Vaccine Institute
Position
  • Assoc VP
August 1997 - January 2006
World Health Organization WHO
Position
  • Sr scientist

Publications

Publications (77)
Article
Background: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization in the United States. Preterm infants and those with select comorbidities are at highest risk of RSV-related complications. However, morbidity due to RSV infection is not confined to high-risk infants. We estimated the burden of medically attended (MA) RSV-a...
Article
Full-text available
Background RSV-associated lower respiratory tract infection (LRTI) is the leading cause of infant hospitalization. Most studies of RSV have focused on infants with underlying comorbidities, including prematurity. The purpose of this analysis is to describe the burden of RSV LRTI across all medical settings and in all infants experiencing their firs...
Article
Full-text available
Background Seasonal influenza vaccine (SIV) uptake in the US remains suboptimal, requiring new and innovative strategies. Objective To evaluate the impact of a behavioral Peer Comparison (PC) intervention on SIV uptake in community pharmacies across the US. Methods A cluster randomized study was conducted across a national network of Walmart comm...
Article
Full-text available
Background Respiratory syncytial virus (RSV) is a human orthopneumovirus spread by direct contact with symptomatic, infected individuals. An estimated 587,000 RSV LRTIs result in inpatient or outpatient encounters annually among US infants (Rainisch et al 2019). The health care costs associated with RSV include medical costs to insurers, government...
Article
Full-text available
Background Acute respiratory infections (ARI) are a major cause of morbidity and mortality in young children, with viral pathogens being the most common etiologies. However, due to limited and inconsistent clinical diagnostic viral testing in the outpatient (OP) setting compared to the inpatient (IP) setting, the actual burden and distribution of v...
Article
Full-text available
Background Viral acute respiratory infections (ARI) continues to be a significant cause of healthcare visits in young children. We evaluated the clinical presentation and disease severity of common respiratory viruses associated with medically attended ARI in infants. Methods We conducted a prospective viral surveillance study in Davidson County,...
Article
Full-text available
Background Respiratory syncytial virus (RSV) is a common cause of illness and hospitalization for infants and children globally. The objective of this study was to characterize the burden of RSV and all-cause bronchiolitis (ACB) inpatient hospitalizations and emergency room department (ED) visits in U.S. infants aged < 1 year with the most recent y...
Article
Full-text available
Background Respiratory syncytial virus (RSV) accounts for the majority of lower respiratory tract illnesses in hospitalized infants. In the U.S., RSV hospitalizations are well characterized; yet, emergency department (ED) and outpatient (OP) visits are underrecognized. We evaluated the burden of RSV across three distinct healthcare settings during...
Article
Full-text available
A conference on «ARBOVIRUSES, A GLOBAL PUBLIC HEALTH THREAT» was organized on June 20–22, 2018 at the Merieux Foundation Conference Center in Veyrier du Lac, France, to review and raise awareness to the global public health threat of epidemic arboviruses, and to advance the discussion on the control and prevention of arboviral diseases. The present...
Article
Full-text available
There is an enhanced focus on considering the full public health value (FPHV) of vaccination when setting priorities, making regulatory decisions and establishing implementation policy for public health activities. Historically, a therapeutic paradigm has been applied to the evaluation of prophylactic vaccines and focuses on an individual benefit-r...
Article
Full-text available
There is an active discussion in the public health community on how to assess and incorporate, in addition to safety and measures of protective efficacy, the full public health value of preventive vaccines into the evidence-based decision-making process of vaccine licensure and recommendations for public health use. The conference “Beyond efficacy:...
Article
Full-text available
Cholera is an endemic and epidemic disease in Bangladesh. On 3 March 2013, a meeting on cholera and cholera vaccination in Bangladesh was convened by the Foundation Mérieux jointly with the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B). The purpose of the meeting was to discuss the investment case for cholera vaccinati...
Chapter
Salmonella typhi, the bacterium that causes typhoid fever, was one of the first bacterium cultured and isolated. This scourge still affects many children and adults mainly in the poor communities in the developing countries. Discovery of antimicrobials was thought to be the magic bullet for many bacterial diseases including typhoid fever around the...
Technical Report
Full-text available
Epidemic meningitis: Surveillance and response activities during the 2002-2003 season in the countries of the African meningitis belt. Report on an informal consultation Geneva, 24-25 July 2003. (WHO/CDS/CSR/GAR/2003.13)
Article
Full-text available
Meningococcal meningitis is a major cause of disease worldwide, with frequent epidemics particularly affecting an area of sub-Saharan Africa known as the "meningitis belt". Neisseria meningitidis group A (MenA) is responsible for major epidemics in Africa. Recently W-135 has emerged as an important pathogen. Currently, the strategy for control of s...
Article
Full-text available
Phase III studies of an oral, live, pentavalent, human-bovine reassortant rotavirus vaccine (RotaTeq; Merck) in developed countries have demonstrated that it is well tolerated with regard to intussusception and other adverse events and is efficacious in preventing rotavirus gastroenteritis and associated healthcare encounters. However, it cannot be...
Article
A phase II open and parallel reactogenicity, immunogenicity and safety trivalent meningitis vaccine (Mencevax) trial was conducted on 413 volunteer 2-29-year-old rural residents in Ethiopia in November/December 2005. Adverse events (AE) were monitored at 1h, 1, 2, 3, 7 and 28 days after vaccination. No serious AE occurred except for burn injury (on...
Article
During a mass campaign with a newly licensed meningococcal polysaccharide ACW135 vaccine in Burkina Faso, adverse events following immunization (AEFI) were monitored up to 4 weeks after the campaign. Eighty-six AEFI cases (5.9 cases per 100,000 vaccine doses distributed) were reported. Among 22 serious events, 4 severe local reactions were consider...
Article
Full-text available
The immunogenicity and safety of a meningococcal trivalent A/C/W135 polysaccharide vaccine was compared with that of a tetravalent A/C/Y/W135 polysaccharide vaccine in a randomised, double blind trial. The study included 360 adults, who received either a trivalent or tetravalent polysaccharide meningococcal vaccine. Antibody responses were determin...
Article
Following a large Neisseria meningitidis W135 (NmW135) epidemic in Burkina Faso (BF) during 2002, a newly licensed trivalent A/C/W135 meningococcal polysaccharide vaccine was introduced in 2003. We conducted a case-control study to assess the vaccine effectiveness (VE) against meningococcal disease. Thirty-two N. meningitidis A (NmA) and 3 NmW135 m...
Article
Full-text available
With the emergence of epidemic Neisseria meningitidis W135 meningitis in Burkina Faso during early 2002, the public health community was faced with the challenge of providing access to an appropriate and affordable vaccine in time for the upcoming 2003 epidemic season. Recognizing the implications of the emergent threat, the World Health Organizati...
Article
Malawi has extreme poverty and a high-human immunodeficiency virus (HIV) prevalence. Following Haemophilus influenzae type b (Hib) conjugate vaccine introduction during 2002, we evaluated vaccine impact by reviewing hospital surveillance data for acute bacterial meningitis in Blantyre district among children age 1-59 months admitted during 1997-200...
Article
Hepatitis B virus infection is a serious problem globally, and particularly in the Western Pacific Region where the population suffers disproportionately from the infection and its sequelae. By 2001, every immunization programme in the Region had included hepatitis B vaccine in their schedule. However, many challenges remain if every one of the 26...
Technical Report
Full-text available
Vaccine introduction guidelines. Adding a vaccine to a national immunization programme: decision and implementation. (WHO/V&B/05.18)
Article
Causative agent. Meningococcal meningitis is a severe acute infection of the meninges caused by the Gram-negative bacterium Neisseria meningitidis.
Article
Full-text available
Haemophilus influenzae type b (Hib) still causes a substantial number of deaths among children in developing countries, despite the availability of effective conjugate vaccines. A major obstacle in developing a Hib vaccine has been limited awareness about the impact of Hib disease. A tool was developed to estimate the national rates of Hib meningit...
Article
Full-text available
WER. Review panel on Haemophilus influenzae type b (‎Hib)‎ disease burden in Bangladesh, lndonesia and other Asian countries, Bangkok, 28-29 January 2004. WEEKLY EPIDEMIOLOGICAL RECORD, NO. 18, 30 APRIL 2004
Technical Report
Full-text available
Prevention and control of epidemic meningococcal disease in Africa. Report of a WHO technical consultation meeting. Ouagadougou, Burkina Faso, 23-24 September 2002. (WHO/CDS/CSR/GAR/2003.10)
Technical Report
Full-text available
Emergence of W135 Meningococcal Disease. Report of a WHO Consultation, Geneva, 17-18 September 2001. (WHO/CDS/CSR/GAR/2002/1/EN)
Technical Report
Full-text available
International Coordinating Group (ICG) on vaccine provision for epidemic meningitis control. Report of the seventh meeting. Geneva, Switzerland, 18-19 September 2001. (WHO/CDS/CSR/GAR/2002/2/EN)
Technical Report
Full-text available
Estimating the local burden of Haemophilus influenzae type b (Hib) disease preventable by vaccination: a rapid assessment tool. (WHO/V&B/01.27)
Technical Report
Full-text available
Estimating the potential cost-effectiveness of using Haemophilus influenzae type b (Hib) vaccine. Field test version 1 (WHO/V&B/01.36)
Technical Report
Full-text available
Introduction of hepatitis B vaccine into childhood immunization services: Management guidelines, including information for health workers and parents. (WHO/V&B/01.31)
Technical Report
Full-text available
Introduction of Haemophilus influenzae type b vaccine into immunization programmes: Management guidelines, including information for health workers and parents (WHO/V&B/00.05)
Article
The factor structure of DSM-IV substance disorder criteria is examined among alcohol, cannabis, cocaine and opiate users to determine the dimensionality of abuse and dependence criteria within each of these drug classes and whether a common construct can be generalized across drug classes. 12-month criterion prevalence was assessed as part of the W...
Article
The development and psychometric testing of the new World Health Organization (WHO) disablement screening instrument for the general population is described. Two samples were used for the empirical tests: the cross-cultural sample of the WHO Disablement Assessment Schedule (WHO-DAS II) field tests in 19 countries (N = 1323), and an Ontario (Canada)...
Article
Developmental Psychopathology: Epidemiology, Diagnostics and Treatment. Edited by C. A. Essau and F. Peterman. (Pp. 478; £20.00.) Harwood Academic Publishers: Amsterdam. 1998. - - Volume 29 Issue 3 - CHRISTOPHER B. NELSON
Article
Despite the growing body of work on the extent to which PTSD is associated with specific traumas, limited epidemiological data are available on the total population prevalence of PTSD, the kinds of traumatic events most likely to cause PTSD, and the epidemiological risk factors for PTSD. In this chapter, we present data on these issues from the Nat...
Article
Unlabelled: AIMS/DESIGNS: As part of the Early Developmental Stages of Psychopathology (EDSP) study, results from the baseline cross-sectional assessment of DSM-IV alcohol disorders are presented for a sample of 14-24-year-olds residents in Munich, Germany (N = 3021; 71% response rate). Findings: Life-time prevalence of DSM-IV alcohol abuse (men...
Article
General population data are presented on patterns and predictors of temporal progression of alcohol dependence symptoms in the general population. The data come from the National Comorbidity Survey, a nationally representative general population survey of respondents ages 15-54. Lifetime symptom classes were estimated with latent class analysis (LC...
Article
Aims/Design. As part of the Early Developmental Stages of Psychopathology (EDSP) study, results from the baseline cross-sectional assessment of DSM-IV alcohol disorders are presented for a sample of 14-24-yearolds resident in Munich, Germany ( N = 3021; 71% response rate). Findings. Life-time prevalence of DSM-IV alcohol abuse (men: 15.1%; women: 4...
Article
Full-text available
Analyses of trends in the field of psychoactive substance use have shown a general increase in the frequency and severity of problems in most countries. The modern drug epidemics which started in the 1960s in industrialized countries have now spread worldwide with an enormous increase in the use of cocaine, designer drugs, other stimulants, cannabi...
Article
The primary and secondary objectives of the Early Developmental Stages of Substance Abuse Study (EDSP) are described along with a detailed description of the overall design, special design features and instruments used. The EDSP is a 5-year prospective study with three waves of assessments. Special design features are the linkages with family genet...
Article
Ths paper describes the distribution of dependence criteria and diagnoses in a sample of 14- to 24-year-olds from Munich, Germany (n = 3,021; 71% response rate), evaluates differences between nondependent and dependent smokers and examines associations of smoking with other substances, affective and anxiety disorders. Assessment was made using the...
Article
As part of a longitudinal study, prevalence findings of DSM-IV disorders are presented for a random sample of 3021 respondents aged 14 to 24, with response rate 71%. Assessment included various subtypes of disorders, subthreshold conditions and disorders that have only rarely been studied in other epidemiological surveys. The computer-assisted Muni...
Article
Thesis (Ph. D.)--University of Michigan, 1995. Includes bibliographical references. Photocopy. s
Article
Full-text available
To study patterns of co-occurrence of lifetime DSM-III-R alcohol disorders in a household sample. Data came from the National Comorbidity Survey (NCS), a nationally representative household survey. Diagnoses were based on a modified version of the Composite International Diagnostic Interview. Respondents with lifetime NCS/DSM-III-R alcohol abuse or...
Article
Alcohol use frequently begins in adolescence. However, only few studies have reported the prevalence of alcohol use disorders in adolescents. This paper reports results from a representative study in a sample of 3021 adolescents, aged 14-24 years. The Prevalence of alcohol abuse and dependence according to DSM-IV criteria, as well as the prevalence...
Article
The article presents estimates of lifetime prevalence of use of illicit substances and related disorders (abuse and dependence) obtained in 1995 from a general population survey of 3021 adolescents and young adults living in and around Munich, Germany. 32.9% of the total sample have tried cannabis at least one time, followed by hallucinogens (4.8%)...
Article
General population data are presented on the prevalence and correlates of comorbidity between DSM-III-R major depressive disorder (MDD) and other DSM-III-R disorders. The data come from the US National Comorbidity Survey, a large general population survey of persons aged 15-54 years in the non-institutionalised civilian population. Diagnoses are ba...
Article
Synopsis Age of onset reports obtained retrospectively for each symptom of DSM-III-R alcohol dependence (AD) are used to study patterns of lifetime symptom progression in a large general-population survey of people in the United States. It is shown that symptom progression among a substantial majority of respondents can be summarized as movement ac...
Article
Full-text available
Data were obtained on the general population epidemiology of DSM-III-R posttraumatic stress disorder (PTSD), including information on estimated life-time prevalence, the kinds of traumas most often associated with PTSD, sociodemographic correlates, the comorbidity of PTSD with other lifetime psychiatric disorders, and the duration of an index episo...
Article
Full-text available
General population data from the National Comorbidity Survey are presented on co-occurring DSM-III-R addictive and mental disorders. Co-occurrence is highly prevalent in the general population and usually due to the association of a primary mental disorder with a secondary addictive disorder. It is associated with a significantly increased probabil...
Chapter
The World Health Organization (WHO) Composite International Diagnostic Interview (CIDI; WHO 1990) is a comprehensive, fully standardized diagnostic instrument developed for use in epidemiological studies by an international group of researchers under the patronage of the US National Institutes of Health and the WHO. Based on two predecessors, the N...
Article
To analyze nationally representative data on the lifetime and 12-month prevalences of use of and dependence on illegal drugs (marijuana/hashish, cocaine/crack, heroin, hallucinogens), nonmedical prescription psychotropic drugs (sedatives, tranquilizers, stimulants, analgesics), and inhalants; and to examine data on the sociodemographic correlates o...
Article
Full-text available
Higher rates of withdrawal from dialysis have been shown among young diabetic patients. This study examined the hypothesis that diabetic status has a joint effect with age as the result of an age-related increase in co-morbid conditions among nondiabetic ESRD patients. Using data collected during the 1980s by the Michigan Kidney Registry, the exper...
Article
Full-text available
This study presents estimates of lifetime and 12-month prevalence of 14 DSM-III-R psychiatric disorders from the National Comorbidity Survey, the first survey to administer a structured psychiatric interview to a national probability sample in the United States. The DSM-III-R psychiatric disorders among persons aged 15 to 54 years in the noninstitu...
Article
Data from a nationally representative sample of the general population are used to study cohort differences in the prevalence of DSM-III-R Major Depressive Episode (MDE). We document increasing lifetime prevalence of MDE among both men and women in more recent cohorts, but no major change in the sex ratio over the 40-year period retrospectively cov...
Chapter
Selection of treatment options for patients with end stage renal disease (ESRD) has been a focus of much investigation. The treatment of patients with ESRD due to diabetic nephropathy falls primarily into three categories according to the United States Renal Data System Report [1] on prevalent patients treated as of December 31, 1990. Whereas, almo...
Article
Basic epidemiologic prevalence data are presented on sex differences in DSM-III-R major depressive episodes (MDE). The data come from the National Comorbidity Survey (NCS), the first survey in the U.S. to administer a structured psychiatric interview to a nationally representative sample of the general population. Consistent with previous research,...
Chapter
Bloembergen WE, Nelson CB, Port FK. Outcomes of CAPD versus hemodialysis in the elderly. In: Oreopoulos DG, Michelis MF, Hershorn S, eds. Nephrology and Urology in the Aged Patient. Kluwer Academic Publishers, 1993
Chapter
Port FK, Nelson CB, Wolfe RA. Mortality Comparison for Diabetic ESRD Patients Treated with CAPD versus Hemodialysis. In: Friedman EI, ed. Death on Dialysis. Kluwer Academic Publishers, 1993.
Chapter
Over the past decade, the incidence of treated end-stage renal disease (ESRD) has increased rapidly in the U.S. [1] and in many other countries [2–6]. This rise has been greatest among the elderly (Figs. 1 and 2), who now have the highest incidence of ESRD. In the U.S., the median age of the overall ESRD population has increased from 55 years in 19...
Article
Full-text available
To evaluate the mortality of continuous ambulatory peritoneal dialysis (CAPD) patients relative to hemodialysis (HD) patients, all Michigan residents 20 to 59 yr of age who initiated therapy for ESRD during the 1980s (N = 4,288) were studied. The study population was stratified by primary renal diagnosis (glomerulonephritis, hypertension, diabetes,...
Article
Explored the prevalence of alcohol abuse and dependence, according to Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria, in 3,021 adolescents and young adults (aged 14–24 yrs). Prevalence, frequency, and quantity of alcohol use and the first occurring symptoms were also studied. Alcohol abuse was reported by 9.7% of the Ss,...

Projects

Projects (6)
Archived project
The World Health Organization (WHO) Department of Immunization, Vaccines and Biologicals (IVB) publishes documents on a wde range of topics relevant to vaccines and immunization. https://www.who.int/immunization/documents/en/