Christopher Miles

Christopher Miles
University of California, Irvine | UCI · Department of Mathematics

Ph.D.

About

15
Publications
1,098
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101
Citations

Publications

Publications (15)
Preprint
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Intracellular forces shape cellular organization and function. One example is the mitotic spindle, a cellular machine consisting of multiple chromosomes and centrosomes which interact via dynamic microtubule filaments and motor proteins, resulting in complicated spatially dependent forces. For a cell to divide properly, is important for the spindle...
Chapter
Cells constantly need to move molecules and organelles throughout their interior. RNA produced in the nucleus must be exported to then be translated into proteins. Some of these proteins must then be imported back into the nucleus. Others are packaged into membrane vesicles, which in turn must be trafficked to the plasma membrane and exocytosed fro...
Article
Full-text available
The distance between fluorescent spots formed by various kinetochore proteins (delta) is commonly interpreted as a manifestation of intrakinetochore tension (IKT) caused by microtubule-mediated forces. However, large-scale changes of the kinetochore architecture (such as its shape or dimensions) may also contribute to the value of delta. To assess...
Article
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The time that it takes a diffusing particle to find a small target has emerged as a critical quantity in many systems in molecular and cellular biology. In this paper, we extend the theory for calculating this time to account for several ubiquitous biological features which have largely been ignored in the mathematics and physics literature on this...
Preprint
Full-text available
Distance between fluorescent spots formed by various kinetochore proteins ('Delta') is proposed to reflect the level of intrakinetochore tension (IKT). However, larger-scale changes in the kinetochore architecture may also affect Delta. To test this possibility, we measure Delta in long kinetochores of Indian muntjac (IM) whose shape, size, and ori...
Preprint
Cell morphogenesis employs a diversity of membrane protrusions. They are discriminated by differences in force generation. Actin polymerization is the best studied mechanism of force generation, but growing interest in how variable molecular conditions and microenvironments alter morphogenesis has revealed other mechanisms, including intracellular...
Article
Full-text available
We report a minimal microtubule-based motile system displaying signatures of unconventional diffusion. The system consists of a single model cargo driven by an ensemble of N340K NCD motors along a single microtubule. Despite the absence of cytosolic or cytoskeleton complexity, the system shows complex behavior, characterized by sub-diffusive motion...
Article
Full-text available
Many biological processes are initiated when diffusing extracellular reactants reach receptors on a cell membrane. Calculating this arrival rate has therefore attracted theoretical interest for decades. However, previous work has largely ignored the fact that receptors diffuse on the two-dimensional cell membrane in a process called surface or late...
Article
Full-text available
We propose a general framework for studying jump-diffusion systems driven by both Gaussian noise and a jump process with state-dependent intensity. Of particular natural interest are the jump locations: the system evaluated at the jump times. However, the state-dependence of the jump rate provides direct coupling between the diffusion and jump comp...
Article
Molecular motor proteins serve as an essential component of intracellular transport by generating forces to haul cargoes along cytoskeletal filaments. In some circumstances, two species of motors that are directed oppositely (e.g. kinesin, dynein) can be attached to the same cargo. The resulting net motion is known to be bidirectional, but the mech...

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