Christophe Drouet

Christophe Drouet
University of Toulouse · CIRIMAT

CNRS Senior Scientist [(nano)(bio)Materials Science]
Listed in the Stanford survey 2021 on Highly Cited Researchers (rank #302 / 64,425 in Biomedical Engineering)

About

146
Publications
37,223
Reads
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4,527
Citations
Introduction
Research highlight: https://www.christophedrouet.com/highlights.html Main key words: Biomaterials, bioceramics, bioactive coatings Biomimetic calcium phosphates / Nanocrystalline apatites Bone tissue engineering / Biomineralization / Anthropology Antimicrobial materials Medical imaging - luminescent nanoprobes, cell targeting Drug delivery (anti-cancerous,antimicrobials, hemostatic agents…) Thermodynamics of inorganic materials Mineralogy: (hydr)oxides, phosphates...
Additional affiliations
October 2003 - present
Université de Toulouse
October 2003 - present
French National Centre for Scientific Research
Position
  • CNRS - Centre national de la recherche scientifique
Description
  • My research themes deal with (nano)(bio)Materials Science and Engineering. I am interested in both applied and fundamental approaches (biomaterials, colloids for nanomedicine, mineralogy, anthropology...) including thermodynamics.
February 2001 - August 2003
University of California, Davis
Position
  • University of California, Davis, USA
Education
February 2011 - February 2011
Institut National Polytechnique de Toulouse
Field of study
  • Physicochemical and thermodynamic properties of solids
February 2001 - August 2003
University of California, Davis
Field of study
  • Thermochemistry of inorganic hydrated/hydroxylated compounds
May 1999 - July 1999
Universidad Autónoma de Madrid
Field of study
  • Chemisorption processes; Desorption ; XPS surface analyses

Publications

Publications (146)
Chapter
In addition to designing catalytic materials ever more active and selective, the emergence of new classes of greener catalysts remains very challenging. The apatite family system with hydroxyapatite (HA) structure appears as a good candidate for catalysis due to its eco‐compatibility properties, its sorption ability toward organic molecules, and it...
Article
Layered double hydroxides (LDHs) are key inorganic compounds relevant to a wealth of applicative purposes, by exploiting their layered structure allowing for ion/molecular sequestration or release. However, a technological barrier exists in the fabrication of cohesive LDH monoliths in link with their metastability. In this work, a series of cohesiv...
Article
The SuperCam instrument, onboard the Perseverance rover (Mars 2020 mission) is designed to perform remote analysis on the Martian surface employing several spectroscopic techniques such as Laser Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman (TRR), Time-Resolved Fluorescence (TRF) and Visible and Infrared (VISIR) reflectance. In additio...
Article
The Perseverance rover is exploring Jezero crater on Mars since February 2021. SuperCam instrument is part of the scientific payload, combining five different techniques in order to characterize the targets to sample: LIBS (Laser-Induced Breakdown Spectroscopy), Raman and Visible and Infrared (VISIR) spectroscopies, Sound Recording and a colored Im...
Article
Full-text available
A biomaterial that is both bioactive and capable of controlled drug release is highly attractive for bone regeneration. In previous works, we demonstrated the possibility of combining activated carbon fiber cloth (ACC) and biomimetic apatite (such as calcium-deficient hydroxyapatite (CDA)) to develop an efficient material for bone regeneration. The...
Article
Aims: Osteosarcoma represents the second most common cause of death in children and young adults. No biomaterial allowing local drug delivery has been specifically developed. However, a biocompatible bioactive implantable material could prevent some amputations, and the local release of an antitumor agent could limit risks of relapse and metastasis...
Article
Full-text available
Citation: Al-Kattan, A.; Grojo, D.; Drouet, C.; Mouskeftaras, A.; Delaporte, P.; Casanova, A.; Robin, J.D.; Magdinier, F.; Alloncle, P.; Constantinescu, C.; et al. Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges. Nanomaterials 2021, 11, 712. https://
Article
Among thermosetting polymers, epoxy resins are major components of adhesives, sealants, paints and composites. Polymerization is often achieved by reaction of epoxy monomers like DGEBA with amine hardeners such as DETA. Previous works showed that polyamines interact with metal (hydr/oxide) substrates leading to the formation of an interphase involv...
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Full-text available
SuperCam is a highly integrated remote-sensing instrumental suite for NASA’s Mars 2020 mission. It consists of a co-aligned combination of Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), Visible and Infrared Spectroscopy (VISIR), together with sound recording (MIC) and high-magnification imaging techniques...
Article
Epoxy resins are ubiquitously encountered in industrial applications as in adhesives and composites. The properties of epoxy-amine networks are directly impacted by the presence of metal (hydr-oxidized) surfaces, leading to a modification of their glass transition temperature Tg. We propose here an innovative experimental approach, investigating th...
Article
Dicalcium phosphate dihydrate, DCPD (CaHPO4·2H2O), brushite, is an important calcium phosphate compound encountered in mineralized tissues and used in medicine, especially in bone cement formulations. However, the use of DCPD as direct implantable biomaterial has not received dedicated attention. In addition, the possibility to dope DCPD with biolo...
Article
Most treatments of skin pathologies involve local administration of active agents. One issue can however be the partial transcutaneous diffusion of the drug to blood circulation, leading to undesirable effects. In this work, the original use of submicron mineral particles based on bio-inspired calcium phosphate apatite was explored for the first ti...
Chapter
Calcium phosphates (CaP) represent a major class of biominerals present in living organisms. Considering the high biocompatibility and tailorable reactivity/resorbability of these compounds, strategies are developed to prepare synthetic bio-inspired ceramics for biomedical applications such as bone substitution and regeneration, but also in other e...
Book
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Article
Full-text available
In the field of bone regeneration, some clinical conditions require highly-resorbable, reactive bone substitutes to rapidly initiate tissue neo-formation. In this view, Amorphous Calcium Phosphates (ACP) appear as well suited bioceramics taking into account their high metastability. However, the metastability also leads to difficulties of sintering...
Article
Calcium phosphates (CaP) such as biomimetic nanocrystalline apatite or amorphous calcium phosphate are hydrated bioactive compounds particularly suitable for bone repair applications due to their similarity with bone mineral. However, their consolidation in ceramic parts deserves special attention as they are thermodynamically metastable and can de...
Article
Calcium is an essential component of osteogenesis and is often required for imparting significant bioactivity to synthetic bone substitutes and in particular silicate-based materials. However, the mechanism of calcium incorporation inside sol-gel silicates is poorly understood. In this work, we shed light on the determinant parameters for incorpora...
Article
Full-text available
Some compositional and structural features of mature bone mineral particles remain unclear. They have been described as calcium-deficient and hydroxyl-deficient carbonated hydroxyapatite particles in which a fraction of the PO43− lattice sites are occupied by HPO42− ions. The time has come to revise this description since it has now been proven tha...
Article
Biocompatible nanosystems exhibiting long-lifetime (∼millisecond) luminescence features are particularly relevant in the field of bioimaging. In this study, citrate-functionalized calcium-doped europium phosphates nanophosphors of the rhabdophane type were prepared at different synthesis times by a bioinspired crystallization route, consisting in t...
Article
Nanocrystalline apatites mimicking bone mineral represent a versatile platform for biomedical applications thanks to their similarity to bone apatite and the possibility to (multi)functionalize them so as to provide “à la carte” properties. One relevant domain is in particular oncology, where drug-loaded biomaterials and engineered nanosystems may...
Article
Bone is a natural nanocomposite. Its mineral component is nanocrystalline calcium phosphate apatite, whose synthetic biomimetic analogs can be prepared by wet chemistry. The initially formed crystals, whether biological or synthetic, exhibit very peculiar physicochemical features. In particular, they are nanocrystalline, nonstoichiometric, and hydr...
Article
Various carbonated calcium phosphate powders were synthesized by aqueous precipitation and ceramics consolidation by spark plasma sintering (SPS) at very low temperature was investigated. The objective was to preserve low crystallinity and avoid material decarbonation. SPS at low temperature only leads to little or no sintering when crystallized po...
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Full-text available
Nanomedicine covers the application of nanotechnologies in medicine. Of particular interest is the setup of highly-cytocompatible nanoparticles for use as drug carriers and/or for medical imaging. In this context, luminescent nanoparticles are appealing nanodevices with great potential for imaging of tumor or other targetable cells, and several str...
Chapter
The chapter discusses the physical–chemical properties of calcium phosphates (Ca-P), among the most used bioactive ceramics. The main calcium phosphate compounds are presented with a brief description of their synthesis methods, their characterization, using different techniques, including chemical analyzes, X-ray diffraction, Fourier transform inf...
Article
The repair of large bone defects is a major clinical problem for which tissue engineering (association of a biomaterial and cells) constitutes a valuable alternative. In this domain, the architecture and the mechanical properties of the 3D scaffold aimed to support cells is of key importance to succeed in bone reconstruction. In this study, we aim...
Article
Full-text available
Hydroxyapatite (HAp) was known as a bone implant material due to its biocompatibility, bioactive, chemical stability and its compositional similarity to natural bone. In this work nanocrystalline HAp coatings were prepared on 316L stainless steel (316LSS) substrates using a potentio-dynamic method (potential scanning in the range from 0 to −1.6 V/S...
Article
Cryopreservation of red blood cells (RBC) is an important method for maintaining an inventory of rare RBC units and managing special transfusion circumstances. Currently, in a clinical setting, glycerol is used as cryoprotectant against freezing damage. After thawing and before transfusion, glycerol must however be removed to avoid intravascular he...
Article
Laser induced breakdown spectroscopy (LIBS), as performed by the ChemCam instrument, provides a new technique to measure hydrogen at the surface of Mars. Using a laboratory replica of the LIBS instrument onboard the Curiosity rover, different types of hydrated samples (basalts, calcium and magnesium sulfates, opals and apatites) covering a range of...
Article
The nanometer-sized plate-like morphology of bone mineral is necessary for proper bone mechanics and physiology. However, mechanisms regulating the morphology of these mineral nanocrystals remain unclear. The dominant hypothesis attributes the size and shape regulation to organic-mineral interactions. Here, we present data supporting the hypothesis...
Article
Biomimetic nanocrystalline apatites are analogous to bone mineral. They can be exploited not only for bone regeneration applications, but it is also possible to take advantage of their biomimetic features to explore novel domains of research such as in nanomedicine, if the nanoparticles are stabilized as a colloidal formulation. In this contributio...
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Full-text available
This contribution gathers various examples illustrating the fact that nanocrystalline apatites represent a genuine multi-functionalizable platform for a wide range of biomedical applications. It is indeed possible to convey additional functionalities to the already appealing properties of biomimetic apatites, via appropriate ionic substitutions and...
Article
Full-text available
Hydroxyapatite (HAp) coatings were prepared on Ti6Al4V substrate by electrodeposition method from electrolyte solution containing Ca(NO3)2, NH4H2PO4 and NaNO3. The results show that the HAp coatings were single phase crystals of HAp. Scanning electron microscope (SEM) images present that HAp/Ti6Al4V have flake shapes which arrange to form like-cora...
Article
This work proposes to combine tranexamic acid (TAX), a clinically used antifibrinolytic agent, and hydroxyapatite (HA), widely used in bone replacement, to produce a novel bioactive apatitic biomaterial with intrinsic hemostatic properties. The aim of this study was to investigate adsorptive behavior of the TAX molecule onto HA and to point out its...
Article
This contribution investigates the interaction of two types of biomimetic-apatite colloidal nanoparticles (negatively-charged 47nm, and positively-charged 190nm NPs) with blood components, namely red blood cells (RBC) and plasma proteins, with the view to inspect their hemocompatibility. The NPs, preliminarily characterized by XRD, FTIR and DLS, sh...
Article
The development of non-toxic and biodegradable magnetic nanoparticles (NPs) that can be easily functionalized with drugs or biomolecules and employed, under magnetic fields, as targeted nano-carriers or components of scaffolds with on-demand functionalities, is a big challenge in the biomaterials research. In the present work, the feasibility of pr...
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The deposition of TIN on stainless steel substrates may improve the stability and compatibility of this material with bone, which may be advantageously exploited for the elaboration of advanced prosthetic devices. In this work, TiN-coated 316LSS (by way of DC magnetron sputtering) was used as a starting material for investigating the electrochemica...
Article
Full-text available
ATP is a well-known energy supplier in cells. The idea to associate ATP to pharmaceutical formulations/biotechnological devices to promote cells activity by potentially modulating their microen-vironment thus appears as an appealing novel approach. Since biomimetic nanocrystalline apatites have shown great promise for biomedical applications (bone...
Article
Full-text available
ATP is a well-known energy supplier in cells. The idea to associate ATP to pharmaceutical formulations/biotechnological devices to promote cells activity by potentially modulating their microen-vironment thus appears as an appealing novel approach. Since biomimetic nanocrystalline apatites have shown great promise for biomedical applications (bone...
Article
Full-text available
Nanocrystalline calcium phosphate apatites are biomimetic compounds analogous to bone mineral and are at the origin of the bioactivity of most biomaterials used as bone substitutes. Their unique surface reactivity originates from the presence of a hydrated layer containing labile ions (mostly divalent ones). So the setup of 3D biocompatible apatite...
Data
Supplementary material 1 . Supplementary Materials in Online Ressource. Additional analyses of 1H → 31P CPMAS solid state NMR spectra (Figure S1)
Article
Apatites are minerals encountered in many fields including geochemistry, nuclear and environmental sciences as well as medicine. This ubiquity is likely related to the diversity of ion substitutions that the apatite structure can accommodate, making of it an excellent “ion reservoir” either in natural settings or for the intentional production of d...
Article
Biomimetic apatites are appealing compounds for the elaboration of bioactive bone-repair scaffolds due to their intrinsic similarity to bone mineral. Bone surgeries are however often heavy procedures and the infiltration of pathogens may not be totally avoided. To prevent their development, systemic antibiotic prophylaxis is widespread but does not...
Article
Lanthanides “Ln” (rare earths) are critical elements found in natural minerals such as calcium phosphate apatites, in sedimentary and igneous settings as well as in skeletal diagenesis. From a medical point of view, nanoparticles of lanthanide-doped apatites can be produced for conferring luminescence properties of interest in cancer cells detectio...
Chapter
Full-text available
Nanocrystalline nonstoichiometric apatites constitute the mineral part of bones, and synthetic approaches have been developed to prepare "biomimetic analogs" via "soft" chemical routes. These compounds exhibit many differences to stoichiometric hydroxyapatite, in that they are nanocrystalline, hydrated, nonstoichiometric, plate-like shaped, and the...
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Full-text available
The extraction of DNA from skeletal remains is a major step in archeological or forensic contexts. However, diagenesis of mineralized tissues often compromises this task although bones and teeth may represent preservation niches allowing DNA to persist over a wide timescale. This exceptional persistence is not only explained on the basis of complex...
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Full-text available
Adenosine triphosphate (ATP) is the main source of energy for cells. In this article we investigated, with a possible future finality in bone tissue engineering, the original association of ATP molecules and hydroxyapatite (HAp) fine powders. We have in particular inspected, in a preliminary way, the effects of the presence of ATP molecules on the...