Christophe Demattei

Christophe Demattei
Centre Hospitalier Régional Universitaire de Nîmes · BESPIM

Biostatistics PhD

About

106
Publications
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1,481
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Publications

Publications (106)
Article
Full-text available
Background: This prospective multicentre pilot study of patients scheduled for elective major abdominal surgery aimed to validate the fluid challenge (FC) proposed by the closed-loop (CL) system via anaesthesiologist assessment. Methods: This was a phase II trial consisting of two inclusion stages (SIMON method). Each FC (250 mL saline solution...
Article
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Background Although wisdom-tooth extraction is a routine intervention, the postoperative period remains marked by local inflammation classically manifesting as pain, edema and trismus. Furthermore, there is no consensus on the best operative techniques, particularly for the mucosal closure stage on impacted mandibular wisdom teeth. Methods This pa...
Article
Study Design A prospective study of healthy volunteers Objectives The influence of the sagittal alignment of the spine and its influence on the extension reserve have been reported in the literature. However, specific analysis of the intrinsic coxofemoral and extrinsic pelvic component in subjects without any spinal or hip pathologies remains poor...
Article
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Objective To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and at six weeks, overall and according to diagnostic group. Design Prospective, double blind, superiority, randomised placebo controlled trial. Setting Seven French teaching hospitals between 13 April 2015 and 12 March 2019. Eligibility criteria for partic...
Preprint
Background : Although wisdom-tooth extraction is a routine intervention, the postoperative period remains marked by local inflammation classically manifesting as pain, edema and trismus. Furthermore, there is no consensus on the best operative techniques, particularly for the mucosal closure stage on impacted mandibular wisdom teeth. Methods : This...
Article
Introduction: Although arterial hypertension is a major concern in patients with chronic kidney disease (CKD), obtaining accurate systolic blood pressure (SBP) measurement is challenging in this population for whom automatic oscillometric devices may yield erroneous results. Methods: This cross-sectional study was conducted in 89 patients with s...
Article
Objective To explore the regulatory role of soluble CD146 (sCD146) and its interaction with galectin-1(Gal1) in placenta-mediated complications. Design Prospective pilot and experimental studies. Setting University-affiliated hospital and Academic research laboratory. Patient(s) 115 women included in three groups: 30 healthy non-pregnant women,...
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Bacterial species and their role in delaying the healing of pressure ulcers (PU) in spinal cord injury (SCI) patients have not been well described. This pilot study aimed to characterise the evolution of the cutaneous microbiota of PU in SCI cohort. Twenty-four patients with SCI from a French neurological rehabilitation centre were prospectively in...
Article
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Abstract Early gestational diabetes mellitus (eGDM) is diagnosed when fasting plasma glucose before 24 weeks of gestation (WG) is ≥ 5.1 mmol/L, whilst standard GDM is diagnosed between 24 and 28 WG by oral glucose tolerance test (OGTT). eGDM seems to have worse obstetric outcomes than standard GDM. We compared the rates of postpartum glucose metabo...
Article
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Objective: To determine the effects of graduated and progressive elastic compression stockings (ECS) on postural diameter changes and viscoelasticity of leg veins in healthy controls and in limbs with chronic venous disease (CVD). Methods: In 57 patients whose legs presented with C1S, C3, or C5 CEAP classes of CVD and treated primarily with comp...
Article
NETosis is an innate immune response occurring after infection or inflammation: activated neutrophils expel decondensed DNA in complex with histones into the extracellular environment in a controlled manner. It activates coagulation and fuels the risk of thrombosis. Human pregnancy is associated with a mild proinflammatory state characterized by ci...
Article
Objective: To evaluate whether systematic mesh implantation upon primary colostomy creation was effective to prevent PSH. Summary of background data: Previous randomized trials on prevention of PSH by mesh placement have shown contradictory results. Methods: This was a prospective, randomized controlled trial in 18 hospitals in France on patients...
Article
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Objective The noninvasive measurement of venous wall deformation induced by changes in transmural pressure may allow assessing viscoelasticity and differentiating normal from diseased veins. Methods In 57 patients with limbs in C1S, C3, or C5 CEAP category of chronic venous disease (CVD) and 54 matched healthy controls, we measured with ultrasonog...
Article
Background: Placenta-mediated pregnancy complications generate short- and long-term adverse medical outcomes for both the mother and the foetus. Nucleosomes and free DNA (fDNA) have been described in patients suffering from a wide-range of inflammatory conditions. Objective: The objective of our study was to compare nucleosomes and fDNA circulat...
Article
Introduction and hypothesisThe use of new lightweight meshes in pelvic organ prolapse (POP) surgery may reduce complications related to mesh retraction (chronic pain, dyspareunia, and mesh exposure). The aim of this study was to investigate changes in the area and position of Uphold Lite™ mesh 6 weeks and 12 months after anterior and/or apical prol...
Article
Objectives To validate the performance of an automatic tool to estimate a patient’s peak skin dose (PSD) and a skin dose map from data collected by a radiation dose management system (RDMS) during interventional procedures.Methods In total, 288 eligible consecutive patients undergoing abdominopelvic embolisation or planned coronary angioplasty usin...
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Background Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion or 20 min later could affect the results of the FC. Methods This is a prospective, observational, multicenter study including all...
Article
Aims: To evaluate the safety and efficacy of the Uphold LITE mesh in the treatment of pelvic organ prolapse at 12-month follow-up. Methods: Women undergoing a mesh surgery due to an anterior prolapse plus a symptomatic anterior prolapse (classed as pelvic organ prolapse quantification stage ≥2) were included in this prospective, multicentre, obs...
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Background A revised classification of cerebellar infarctions (CI) may uncover unrecognized associations with etiologic stroke subtypes. We hypothesized that obliquely oriented small cortical cerebellar infarction (SCCI) representing end zone infarctions on MRI would be associated with cardiac embolism. Methods We retrospectively analyzed consecut...
Article
Introduction Early detection of preclinical left ventricular (LV) dysfunction in type 2 diabetic (T2D) patients is crucial because of its associated increased cardiovascular morbidity and mortality. Objective The aim of this study was to: – identify the most sensitive and clinically relevant echocardiographic variables in order to detect early lef...
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Objectives: Recent studies have challenged systematic pretreatment with a P2Y12 inhibitor before percutaneous coronary intervention (PCI) in elective and non-ST segment elevation myocardial infarction (NSTEMI) patients. The aim of this study was to assess outcomes after performing PCI immediately after coronary angiography with an exclusive "on-th...
Article
Background: Although studies in diabetic patients demonstrated delayed recovery after long-acting local anesthetic, its effects with short-acting LA remains to be determined. Using mepivacaine, the authors evaluated the duration of axillary nerve blocks in diabetic (DP), renal failure (creatinine clearance < 30 ml.min-1) (RP) and healthy patients...
Article
Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Obje...
Article
Objective Recent studies have challenged systematic pretreatment with a P2Y12 inhibitor before percutaneous coronary intervention (PCI) in elective and non-ST-segment elevation myocardial infarction (NSTEMI) patients. The aim of this study was to assess outcomes after performing PCI immediately after coronary angiography with an exclusive ‘on-the-t...
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Background: Cerebral amyloid angiopathy-related inflammation (CAA-ri) is associated with a cerebrospinal fluid (CSF) biomarker profile similar to that observed in CAA. Few CAA-ri patients have been studied by fibrillar amyloid-β (Aβ) imaging (using 11C-Pittsburgh compound B and 18F-florbetapir, but not 18F-florbetaben). Objective: To describe CS...
Article
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Objective To estimate sacroiliac joint radiographic (X-SIJ) progression in patients with axial spondyloarthritis (axSpA) and to evaluate the effects of inflammation on MRI (MRI-SIJ) on X-SIJ progression. Methods X-SIJ and MRI-SIJ at baseline and after 2 and 5 years in patients with recent onset axSpA from the DESIR cohort were scored by three cent...
Article
Background: Because nefopam's morphine-sparing is debated when combined with paracetamol, this study aimed to assess pain relief by IV nefopam in combination with paracetamol after major abdominal surgery. Methods: This was a prospective, double-blinded randomized controlled study including patients (ASA I-III, > 18 y) scheduled for elective col...
Article
Objective: To evaluate whether cranberries are able to prevent postoperative urinary bacteriuria in patients undergoing pelvic surgery and receiving transurethral catheterisation. Design: Randomised, double-blind, placebo-controlled trial. Settings: French tertiary Care centre, University Hospital. Population: A total of 272 women undergoing...
Article
Background: In patient with cerebral amyloid angiopathy (CAA) presenting with lobar hemorrhage (LH), magnetic resonance imaging (MRI) white matter hyperintensities (WMH) tend to be predominant in posterior regions with the "multiple subcortical spots" WMH pattern as the most frequent topographical WMH pattern. Our aim was to analyze WMH severity a...
Article
Aims: Nasal carriage of Staphylococcus aureus in diabetic patients may be a risk factor for diabetic foot lesion infections. The aims of this study were to compare the genotypic profiles of S. aureus strains isolated from nares and diabetic foot ulcers (DFUs) using microarray technology. Methods: Patients were included if they were admitted for...
Article
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We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1-42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with l...
Data
Table S1: Radiographic progression (e.g. changes (worsening) of at least one grade in at least one SIJ) after 2 years of follow‐up with regard to baseline characteristics and data observed during the 2 years follow‐up in patients with recent onset (<3 years) axial spondyloarthritis.
Data
Table S2: Radiographic progression (e.g. changes (worsening) of at least one grade in at least one SIJ and a final (2 year) absolute grade of at least 2 in the worsened joint during the 2 years follow‐up period in patients with recent onset (<3 years) axial spondyloarthritis.
Article
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Background The aim of our study was to investigate the impact of a new organization of our emergency department (ED) on patients’ mortality and management delays. Methods The ED segmentation consisted of the development of a new patient care geographical layout on a pre-existing site and changing the organization of patient flow. It took place on...
Article
Background and objectives: Single interscalene blocks (ISB) impair pulmonary function (< 24h). We hypothesized that continuous ISBs would prolong pulmonary dysfunction until H48 compared with a single ISB. We compared the time course of spirometric and diaphragmatic dysfunction following single or continuous ISBs. Methods: We prospectively inclu...
Article
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Methods: In this prospective study, enrolled patients underwent bone SPECT/CT with one SPECT acquisition followed by two randomized CT acquisitions: FBP CT (FBP, noise index 25 [NI]) and ASiR CT (70% ASiR, NI 40). Image quality of both attenuation-corrected SPECT and CT images were visually (5-point Likert scale, 2 readers) and quantitatively (con...
Article
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Objective To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years. Methods Patients with recent‐onset axial SpA (from the Devenir des Spondyloarthropathies Indiffe...
Article
Background The natural history (with regard to the structural damage of the Sacroiliac Joints) (SIJ) of axial radiographic (r) and non-radiographic (nr) axial spondyloarthritis (SpA) is not well known. Objectives To evaluate the 2 years SIJ radiological structural changes in early axial r- versus nr-axial SpA according to different definitions. Met...
Article
Background The natural history of axial non radiographic axial spondyloarthritis (SpA) is not well known Objectives To evaluate the predisposing factors of radiographic SIJ progression in early SpA. Methods Patients: inflammatory back pain of less than 3 years duration suggestive of axial SpA (DESIR cohort). Radiographic progression: change in the...
Article
The concept of an ideal sitting posture is often used in practice but lacks a basis in evidence. We designed a cross-sectional, comparative, matched study to determine the effects of chair and posture on lumbar curvature in 10 patients with chronic non-specific low back pain (CLBP; mean pain duration 24 ± 18 months) and 10 healthy matched controls....
Article
Objectifs Évaluation de la dosimétrie TDM et de la qualité des images TEMP/TDM en comparant les méthodes de reconstruction itérative hybride (« Adaptive Statistical iterative Reconstruction » [ASIR]) et par rétroprojection filtrée (FBP). Patients et méthodes Soixante-quinze patients ont bénéficié d’une scintigraphie osseuse sur une γ-caméra GE dis...
Article
Introduction Chitinase-3 like protein 1 (CHI3L1) est une proteine de l inflammation identifiee comme biomarqueur sensible de sclerose en plaques (SEP) dans le liquide cephalorachidien (LCR) et le serum mais semble peu specifique. Objectifs Evaluer l’interet diagnostique en routine de la CHI3L1 dans le LCR et le serum pour differentes maladies neuro...
Article
Full-text available
Despite sensitivity of MRI to diagnose multiple sclerosis (MS), prognostic biomarkers are still needed for optimized treatment. The objective of this paper is to identify cerebrospinal fluid (CSF) diagnostic biomarkers of MS using quantitative proteomics and to analyze their expression at different disease stages. We conducted differential analysis...
Article
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Background: Methods of objectively measuring rotational knee laxity are either experimental or difficult to use in daily practice. A new method has been developed to quantitatively assess rotatory laxity using an open MRI system and new tool, the KneeM device. Purpose/Hypothesis: To perform a preliminary evaluation of a novel knee rotation measure...
Article
Background Influence of uveitis on clinical, epidemiological and imaging features in patients with inflammatory back pain (IBP) related to spondyloarthritis (SpA) needs to be known. Objectives To determine the prevalence of uveitis in patients with recent IBP suggestive of SpA, and to investigate the influence of uveitis on the overall features of...
Article
Background Anterior chest wall pain (ACW) may be suggestive of spondyloarthritis (SpA), but little is known about this clinical feature in recent inflammatory back pain (IBP). Objectives To determine the prevalence of ACW in patients with recent IBP suggestive of SpA, and to investigate the influence of ACW on the overall features of patients prese...
Article
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/st>The infiltration of local anaesthetic (LA), ketorolac, and epinephrine has been suggested to be effective for analgesia after total hip arthroplasty (THA). The part of action of each component of the mixture remains unclear. We investigated the contribution of infiltration of ropivacaine alone on the morphine consumption during the first 24 h a...
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To investigate the impact of a short-term multimodal rehabilitation program for patients with low back pain (LBP) on trunk muscle reflex responses and feedforward activation induced by postural perturbations. Case series (uncontrolled longitudinal study). Thirty chronic patients with LBP (21 women and 19 men, mean age 42.6 +/- 8.6 years, mean weigh...
Article
Objective: To determine the prevalence of anterior chest wall (ACW) pain in patients with recent inflammatory back pain (IBP) suggestive of spondyloarthritis (SpA), and to investigate the influence of ACW pain on the overall features of these patients. Methods: The DESIR cohort is a prospective, multicenter French cohort of patients with early I...
Article
Full-text available
Purpose Local dynamic stability of trunk movements quantified by means of the maximum Lyapunov exponent (λmax) can provide information on trunk motor control and might offer a measure of trunk control in low-back pain patients. It is unknown how many repetitions are necessary to obtain sufficiently precise estimates of λmax and whether fatigue effe...
Article
Context: Blood transfusion has increased significantly during the last decade and blood wastage reduction is a medical and economic challenge in hospital practice and for institutional quality, particularly in the ICU and operating theatre. Objective: To evaluate the impact of multiple strategies in one hospital to reduce red blood cell wastage....
Article
Full-text available
In a malaria-endemic area the distribution of patients is neither constant in time nor homogeneous in space. The WHO recommends the stratification of malaria risk on a fine geographical scale. In the village of Cacao in French Guiana, the study of the spatial and temporal distribution of malaria cases, during an epidemic, allowed a better understan...
Article
Objectif Le nouveau-né de mère diabétique est à risque de syndrome de détresse respiratoire à un âge gestationnel plus avancé que dans la population générale. Nous avons tenté de déterminer si la maturation pulmonaire foetale (MPF) après 34 SA est efficace sur la réduction des détresses respiratoires (DR) dans cette population. Matériels et méthod...
Article
Background Measurement of limb volume is helpful for the evaluation and follow-up of edema, especially in patients with chronic venous insufficiency (CVI) or lymphedema. Water displacement (WD) is the reference method for limb volumetry but is not really suitable for clinical routine. Indirect volumetry based on circumference measurements as well a...
Article
Objectives To compare the performance of anticitrullinated peptides/protein antibodies (ACPA) detected by three immunoassays in the French ESPOIR cohort of patients with early rheumatoid arthritis (RA) and undifferentiated arthritis (UA) and to study the relationship between ACPA and disease activity. Methods A diagnosis of RA (1987 American Colleg...
Article
To determine the prevalence of uveitis in patients with recent inflammatory back pain (IBP) suggestive of spondylarthritis (SpA), and to investigate the impact of uveitis on the overall features of these patients. The Devenir des Spondylarthropathies Indifférenciées Récentes (DESIR; Outcome of Recent Undifferentiated Spondylarthropathies) cohort is...
Article
To investigate the accuracy of prenatal axial three-dimensional (3D) ultrasound in predicting the absence or presence of cleft palate in the presence of cleft lip. Between March 2005 and January 2009, there were 81 cases with a prenatal two-dimensional (2D) ultrasound screening diagnosis of unilateral or bilateral cleft lip at 22-25 weeks of gestat...
Article
The goal of this study was to assess a new pencil-beam densitometer, the Stratos (Diagnostic Medical Systems, Pérols, France). Evaluation of the dosimetry and precision were done together with an in vivo cross-calibration study performed with the fan beam densitometer Discovery A (Hologic, Bedford, MA). The results indicated that the Stratos perfor...