Christophe Boëte

Christophe Boëte
Institute of Research for Development | IRD · 226 - The Institute of Evolutionary Sciences of Montpellier (ISE-M)

PhD Ecology

About

69
Publications
33,681
Reads
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1,117
Citations
Citations since 2016
44 Research Items
499 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
I am an evolutionary biologist working on host-parasite interactions with a focus on vector-borne diseases and public health issues. To do so I am merging lab, field and theoretical approaches. I am also interested in science communication and the relationships between scientists, their object of study and the publics, especially when it concerns innovations and technology. More details here: http://christopheboete.net/ On twitter : @cboete
Additional affiliations
February 2017 - present
Institute of Research for Development
Position
  • Researcher
January 2012 - February 2017
Institute of Research for Development
Position
  • Researcher
January 2011 - present
American University of Paris
Education
September 1999 - June 2003
Sorbonne Université
Field of study
  • Ecologie

Publications

Publications (69)
Article
Full-text available
Gene drive based on the CRISPR/Cas-9 gene editing system is a powerful technology that promotes the inheritance of the gene drive tool itself via sexual reproduction and can therefore spread quickly through a population. It holds great potential for public health and humanitarian purposes, such as reducing the burden of vector-borne diseases like m...
Article
Agricultural genetic technologies typically achieve their agronomic aims by introducing laboratory-generated modifications into target species' chromosomes. However, the speed and flexibility of this approach are limited, because modified chromosomes must be vertically inherited from one generation to the next. In an effort to remove this limitatio...
Article
There is growing theoretical evidence that spatial structure can affect the ecological and evolutionary outcomes of host-parasite interactions. Locally restricted interactions have been shown in particular to affect host resistance and tolerance. In this study we investigate the evolution of several types of host disease resistance strategies, alon...
Article
While modelling is an essential component for an understanding of the epidemiology of malaria, and for designing better control measures, it rarely considers the particular contexts encountered in emergency settings. By linking these situations with the transmission parameters our aim is to correct this bias and call for a better collaboration betw...
Article
Full-text available
Background The use and implementation of novel tools for malaria control such as long lasting impregnated bednets (LLINs) and Indoor Residual Spraying (IRS) over the last decade has contributed to a substantial reduction in malaria burden globally. However numerous challenges exist particularly in relation to vector control in emergency settings. T...
Article
Full-text available
Background The control and prevention of vector-borne and zoonotic diseases is often based on the reduction of host or vector populations, involving but not limited to preventative culling and use of insecticides. Yet, destructive interventions such as these have shown several limitations including ineffectiveness on arthropods and negative impacts...
Article
Background: Insecticide resistance has become a widespread problem causing a decline in the effectiveness of vector control tools in sub-Saharan Africa. In this situation, ongoing monitoring of vector susceptibility to insecticides is encouraged by the WHO to guide national malaria control programmes. Our study was conducted from April to November...
Chapter
Outbreaks of arboviruses have occurred in the last decades in many places around the world and a variety of responses have been taken in order to control them. Responses ranged from vaccination campaigns to the use of conventional vector control methods. Innovative approaches relying on biotechnological novelties, often still under development, hav...
Book
Full-text available
Outbreaks of arboviruses have occurred in the last decades in many places around the world and a variety of responses have been taken in order to control them. Responses ranged from vaccination campaigns to the use of conventional vector control methods. Innovative approaches relying on biotechnological novelties, often still under development, hav...
Article
Full-text available
The probability D that a given CRISPR‐based gene drive element contaminates another, non‐target species can be estimated by the following Drive Risk Assessment Quantitative Estimate (DRAQUE) Equation: D = (hyb + transf).express.cut.flank.immune.nonextinct with hyb = probability of hybridization between the target species and a non‐target species tr...
Article
Full-text available
Background: Many infectious pathogens can be transmitted from animals to humans and vice versa, or by animals (especially arthropods) to humans. Such diseases are called zoonotic and/or vector-borne diseases. To control or prevent them, it is often recommended to target population reduction of host or vector species, through preventive culling or...
Article
Full-text available
Gene Drives are regarded as future tools with a high potential for population control. Due to their inherent ability to overcome the rules ofMendelian inheritance, gene drives (GD) may spread genes rapidly through populations of sexually reproducing organisms. A release of organisms carrying a GD would constitute a paradigm shift in the handling of...
Preprint
Full-text available
The probability D that a given CRISPR-based gene drive element contaminates another, non-target species can be estimated by the following Drive Risk Assessment Quantitative Estimate (DRAQUE) Equation: D = ( hyb+transf).express.cut.flank.immune.nonextinct with hyb = probability of hybridization between the target species and a non-target species tra...
Article
Full-text available
The discovery of CRISPR/ cas9 has opened new avenues in gene editing. This system, usually considered as molecular scissors, permits the cutting of the DNA at a targeted site allowing the introduction of new genes or the removal or the modification of existing ones. The genome-editing, involving gene drive or not, is then considered with a strong i...
Article
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Lobbying and propaganda around gene drive technologies threaten to erode public trust in science.
Article
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It has been proposed that sponsors and supporters of gene drive research voluntarily adopt a code of ethical and scientific conduct. The signatories of that document include the US Foundation of National Institute of Health (FNIH), a public health agency, and the Bill and Melinda Gates Foundation, a well-known non-governmental organization. However...
Article
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Zahra Meghani & Christophe Boëte discuss key ethical questions raised by the use of genetically engineered insects and outline a procedural approach to community decision-making about the use of biotechnology.
Article
Full-text available
"Biodiversity Conservation in Southeast Asia: Challenges in a ChangingEnvironment" is part of the Earthscan Conservation and Development Series. It is edited by W.M. Adams Moran Professor of Conservation and Development, Department of Geography, University of Cambridge. The series includes five volumes dedicated to conservation, environmental manag...
Article
Full-text available
http://www.lemonde.fr/sciences/article/2018/03/06/lobbying-industriel-sur-le-forcage-genetique_5266432_1650684.html
Article
Full-text available
The use of gene drive to control or eradicate pest and disease vector populations is a highly controversial topic. In order to maintain independence and public trust, scientists need know who is representing whom in this debate.
Article
Full-text available
Bats are associated with conflicting perceptions among humans, ranging from affection to disgust. If these attitudes can be associated with various factors among the general public (e.g. social norms, lack of knowledge), it is also important to understand the attitude of scientists who study bats. Such reflexive information on the researchers commu...
Data
Invitation, text of the survey and notes. (RTF)
Data
Repartition of the responders according to the number of families of bats they are working on. (n = 587). (EPS)
Data
Repartition of responders according to their place of work and research activities on bats (n = 587). (EPS)
Data
a) Repartition of the responders according to the families of bats they are working on (n = 587). b) Fig Repartition of the responders according to the type of food of the bats they are working on. (n = 587). (EPS)
Data
Combination of keywords used to select participants in the survey. (RTF)
Data
Statistical analysis of the factors explaining the cause of the global decline of bats according to responders. (RTF)
Data
Analysis on the use of protection tools while manipulating alive bats or samples of alive bats. (DOC)
Article
Full-text available
p>Understanding the impact of altitude and ecological heterogeneity at a fine scale on the populations of malaria vectors is essential to better understand and anticipate eventual epidemiological changes. It could help to evaluate the spread of alleles conferring resistance to insecticides and also determine any increased entomological risk of tran...
Article
Understanding the impact of altitude and ecological heterogeneity at a fine scale on the populations of malaria vectors is essential to better understand and anticipate eventual epidemiological changes. It could indeed permit to evaluate the spread of alleles conferring resistance to insecticides but also to determine any increased entomological ri...
Article
Full-text available
The current epidemiological situation of the Zika outbreak in the Americas has highlighted the need for effective responses to emerging vector-borne diseases. In the absence of a vaccine, mosquito control remains the principle frontline response. While conventional strategies can be very successful they do have established weaknesses. In this light...
Data
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Article
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Pioneering technologies (e.g., nanotechnology, synthetic biology or climate engineering) are often associated with potential new risks and uncertainties that can become sources of controversy. The communication of information during their development and open exchanges between stakeholders is generally considered a key issue in their acceptance. Wh...
Data
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Article
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For many in the scientific world, technologies of genetic modification offer a promising method to control vector-borne infectious diseases such as malaria. Nevertheless, the recent releases of the first genetically modified (GM) mosquitoes into the wild have triggered heated discussions. How is the human – mosquito relationship being reconfigured throu...
Book
Full-text available
Available from: http://www.intechopen.com/books/anopheles-mosquitoes-new-insights-into-malaria-vectors/transgenic-mosquitoes-for-malaria-control-from-the-bench-to-the-public-opinion-survey
Article
Among the hopes for vector-based malaria control, the use of transgenic mosquitoes able to kill malaria parasites is seen as a potential way to interrupt malaria transmission. While this potential solution is gaining some support, the ethical and social aspects related to this high-tech method remain largely unexplored and underestimated. Related t...
Article
Full-text available
Face à la dengue, qui fait plus de vingt mille victimes par an, en majorité dans les pays tropicaux, les méthodes de lutte sont très limitées. Il n’existe ni vaccin ni traitement (préventif ou curatif) contre cette infection virale, transmise par des moustiques du genre Aedes, et notamment Aedes aegypti. Contrairement au vecteur du paludisme, Aedes...
Article
The polymorphism of genes involved in the immunity of malaria vectors has been the subject of several recent studies with mosquitoes from natural populations. Most of the genes examined are known for their role against Plasmodium berghei and not necessarily for their role against Plasmodium falciparum. It seems, therefore, to be highly important no...
Article
In a recent study, SM1-transgenic Anopheles stephensi, which are resistant partially to Plasmodium berghei, had higher fitness than non-transgenic mosquitoes when they were maintained on Plasmodium-infected blood. This result should be interpreted cautiously with respect to malaria control using transgenic mosquitoes because, despite the evolutiona...
Book
Full-text available
Despite a century of research and attempts to control one of the deadliest foes of mankind, the malaria situation remains a major public health problem. Obviously biological explanations (the resistance of parasites and mosquitoes against available drugs and insecticides respectively) are often given, but they remain partial and incomplete. Indeed,...
Article
Full-text available
Le recours à des moustiques génétiquement modifiés capables de détruire le parasite du paludisme est considéré comme un moyen potentiel de lutte contre cette maladie qui tue plusieurs millions de personnes chaque année. Si des questions scientifiques sur le possible succès de cette stratégie relevant de technologies de pointe se posent toujours, il...
Article
There has been a recent revival in attempts to understand changes in patterns of abundance of Plasmodium spp. that infect humans. This has been driven by the purportedly beneficial effects of co-infection on clinical pathology and the recognition of Plasmodium vivax as a public health problem in its own right. In contrast to the attention given to...
Article
Full-text available
A recent study describing the effect of Plasmodium berghei infection on some Anopheles gambiae immune genes demonstrates that P. berghei is responsible for the upregulation of several genes involved in the immune response that affect parasitic development differently during the ookinete-to-oocyst developmental transition. It is important to questio...
Article
Full-text available
Malaria parasites develop as oocysts within the haemocoel of their mosquito vector during a period that is longer than the average lifespan of many of their vectors. How can they escape from the mosquito's immune responses during their long development? Whereas older oocysts might camouflage themselves by incorporating mosquito-derived proteins int...
Article
Full-text available
We describe a model of host-parasite coevolution, where the interaction depends on the investments by the host in its immune response and by the parasite in its ability to suppress (or evade) its host's immune response. We base our model on the interaction between malaria parasites and their mosquito hosts and thus describe the epidemiological dyna...
Article
Full-text available
The release of mosquitoes that are genetically manipulated to destroy the malaria parasite Plasmodium falciparum is being considered as a possible method for malaria control. Hopes for this have been raised by the identification of genes involved in the mosquito's immune response and by advances in the tools required to transform mosquitoes. But, w...
Article
Full-text available
Ecological and population biology issues constitute serious challenges to the application of genetically modified mosquitoes (GMM) for disease control.
Article
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Although the mosquito vectors of malaria have an effective immune system capable of encapsulating many foreign particles, they rarely encapsulate malaria parasites in natural populations. A possible reason for this apparent paradox is that infection by malaria reduces the capability of the mosquito to mount an effective immune response. To investig...
Article
Full-text available
To investigate the evolutionary cost of an immune response, we selected six lines of the mosquito Aedes aegypti for earlier or later pupation and measured the extent to which this selection procedure changed the mosquito's ability to encapsulate and melanize a negatively charged Sephadex bead. After 10 generations of selection, the age at pupation...
Article
Full-text available
Mosquitoes that have been genetically modified to better encapsulate the malaria parasite Plasmodium falciparum are being considered as a possible tool in the control of malaria. Hopes for this have been raised with the identification of genes involved in the encapsulation response and with advances in the tools required to transform mosquitoes. Ho...

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Project
As biodiversity is now being lost at an alarming rate, to an extent that some scientists refer to the current period as the 6th (or Anthropocene) Mass Extinction, conservation of biodiversity and ecosystems are highly promoted across many Sustainable Development Goals (SDGs). Concurrently, the link between biodiversity and human health is increasingly recognized – as in SDG 3 on health – underlining the importance of considering health in an integrative manner, taking into account not only human health but also animal and environmental health in a One Health perspective. Several ethical questions arise from biodiversity conservation itself, but also from the interdisciplinary research so crucial to biodiversity conservation, and from the use of research in science and policy dialogues. Some of the ethical questions resulting from the most recent scientific investigations are considered in this special issue, by specialists of various research areas involved in biodiversity conservation. For a a read-only version of the complete article, even if you are not subscribed to ABR : https://abrjournal.wordpress.com/2019/01/10/abr104/ Link to the ABR special issue: https://link.springer.com/journal/41649/10/4